PCIDB

Amsonia illustris

Family in NCBI taxonomy	Apocynaceae
ID	4056

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class	asterids
ID	71274

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster
C00001773	Tabersonine	CHEMBL1971886 CHEMBL2011511	C009373			No. 61	No. 4
C00025061	(+)-Eburnamenine	CHEMBL1097688				No. 502	No. 4
C00027628	(+)-Vincamone / d-Eburnamonine / (+)-Eburnamonine / (+)-cis-Vincamone / (+)-cis-Eburnamonine	CHEMBL1318553 CHEMBL1553441 CHEMBL1733074 CHEMBL1892145	C016422	14 / 20 / 16	2 / 0	No. 502	No. 4

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00027628	1 / 0
Q99700	Ataxin-2	Unclassified protein	C00027628	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00027628	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00027628	3 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00027628	0 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00027628	2 / 0
O75496	Geminin	Unclassified protein	C00027628	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00027628	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00027628	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00027628	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00027628	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00027628	0 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00027628	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00027628	1 / 0

gene	gene name	gene description	KNApSAcK metabolite in interactions
1129	CHRM2, HM2	cholinergic receptor, muscarinic 2	C00027628
1132	CHRM4, HM4, M4R	cholinergic receptor, muscarinic 4	C00027628

OMIM	preferred title	UniProt
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#114500	Colorectal cancer; crc	P84022
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#137800	Glioma susceptibility 1; glm1	O75874
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#603373	Hyperthyroidism, familial gestational	P16473
#609152	Hyperthyroidism, nonautoimmune	P16473
#275200	Hypothyroidism, congenital, nongoitrous, 1; chng1	P16473
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#613795	Loeys-dietz syndrome, type 3; lds3	P84022
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#275210	Restrictive dermopathy, lethal	P02545
#183090	Spinocerebellar ataxia 2; sca2	Q99700

KEGG	name	UniProt
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H01205	Coumarin resistance	P11712 (related)
H00250	Congenital nongoitrous hypothyroidism (CHNG)	P16473 (related)
H01269	Congenital hyperthyroidism	P16473 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)
H00063	Spinocerebellar ataxia (SCA)	Q99700 (related)