Species

KNApSAcK Entry

Organism name Litsea garciae
Genus Litsea
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Litsea garciae
Linked NCBI taxonomy ID 384306
Linked level species

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001790 External link 512 Actinodaphnine
/ (+)-Actinodaphnine
/ 1,2-Methylenedioxy-9-hydroxy-10-methoxynoraporphine
CHEMBL518088
CHEMBL1588263
C060992
30 / 32 / 24 No. 20 No. 4
C00001822 External link 512 Boldine
/ d-Boldine
CHEMBL388342
CHEMBL1321247
CHEMBL1437753
C011686
34 / 32 / 35 No. 20 No. 4
C00027433 External link 512 Laurolitsine
/ (+)-Norboldine
/ (+)-Laurolitsine
CHEMBL487388
C109133
No. 20 No. 4
C00027551 External link 512 Isodomesticine
/ (+)-1-Methoxy-2-hydroxy-9,10-methylenedioxyaporphine
No. 20 No. 4
C00001910 External link 512 Reticuline
/ (+)-Reticuline
CHEMBL235212
CHEMBL401501
CHEMBL464734
C003298
1 / 0 / 0 No. 345 No. 4

Human Protein / Gene in interactions

46 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001790 C00001822 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001790 C00001822 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001790 C00001822 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001790 C00001822 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001790 C00001822 1 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00001790 C00001822 4 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001790 C00001822 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001790 C00001822 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001790 C00001822 11 / 10
Q9UNA4 DNA polymerase iota Enzyme C00001790 C00001822 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001790 C00001822 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001790 C00001822 2 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001790 C00001822 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001790 C00001822 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001790 C00001822 1 / 2
Q9Y253 DNA polymerase eta Enzyme C00001790 C00001822 1 / 1
P39748 Flap endonuclease 1 Enzyme C00001790 C00001822 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001790 C00001822 0 / 0
O75496 Geminin Unclassified protein C00001790 C00001822 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001790 0 / 0
P42858 Huntingtin Unclassified protein C00001790 1 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00001822 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001822 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001790 2 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001790 2 / 2
P11021 78 kDa glucose-regulated protein Unclassified protein C00001790 0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00001822 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001822 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001822 3 / 3
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha C00001822 1 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta C00001822 1 / 1
P35372 Mu-type opioid receptor Opioid receptor C00001910 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001822 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001822 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001822 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00001790 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001822 1 / 1
P06746 DNA polymerase beta Enzyme C00001790 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001822 1 / 0
Q16637 Survival motor neuron protein Unclassified protein C00001790 4 / 1
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00001790 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001790 1 / 0
O00255 Menin Unclassified protein C00001822 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00001822 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001822 1 / 4
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001790 2 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (43)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (40)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)