Species

KNApSAcK Entry

Organism name Cyclea peltata Diels
Genus Cyclea
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cyclea
Linked NCBI taxonomy ID 152372
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (16)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001870 External link 512 Isobebeerin
/ Isobebeerine
/ Isochondodendrine
CHEMBL509310
CHEMBL1169628
No. 10 No. 4
C00025265 External link 512 Homoaromoline
/ Homothalicrine
/ (+)-Homoaromoline
/ (+)-Thalrugosamine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00025276 External link 512 Thalrugosine
/ (+)-Thalrugosine
C060802
0 / 1 No. 10 No. 4
C00025306 External link 512 Fangchinoline
/ dl-Fangchinoline
/ 7-O-Demethyltetrandrine
CHEMBL504256
CHEMBL509803
CHEMBL500614
12 / 6 / 3 No. 10 No. 4
C00025320 External link 512 Limacine
/ (-)-Limacine
CHEMBL504256
CHEMBL509803
CHEMBL500614
12 / 6 / 3 No. 10 No. 4
C00025571 External link 512 Tetrandrine N-2'-oxide
/ Tetrandrine 2'beta-N-oxide
/ Tetrandrine mono-N-2'-oxide
No. 10 No. 4
C00025594 External link 512 2'-N-Norlimacine
/ (-)-2'-Norlimacine
/ 2'-Demethyllimacine
/ 2'-Demethyl-(-)-fangchinoline
CHEMBL508608
C085399
No. 10 No. 4
C00025602 External link 512 l-Curine
/ (-)-Curine
/ l-Bebeerine
/ Aristolochine
/ (-)-Bebeerine
/ Aristolochine(C36 alkaloid)
CHEMBL1169627
13 / 6 / 5 No. 10 No. 4
C00025831 External link 512 Cycleacurin
/ Cycleacurine
No. 10 No. 4
C00025833 External link 512 Cycleahomine
No. 10 No. 4
C00025624 External link 512 Repandin
/ Repandine
/ (-)-Repandine
/ N-Methyldemerarine
CHEMBL510022
CHEMBL509999
CHEMBL1983122
5 / 4 / 1 No. 10 No. 4
C00025832 External link 512 Cycleadrine
CHEMBL504256
CHEMBL509803
CHEMBL500614
12 / 6 / 3 No. 10 No. 4
C00025656 External link 512 (+)-Cycleabarbatine
C085398
No. 10 No. 4
C00025605 External link 512 Faralaotrine
/ Cycleapeltin
/ Cycleapeltine
/ (-)-Cycleapeltine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00025652 External link 512 d-Coclaurine
/ Sanjoinine K
/ (R)-Coclaurine
/ (+)-Coclaurine
/ (+)-R-Coclaurine
CHEMBL256448
CHEMBL453291
CHEMBL446211
8 / 17 / 10 No. 253 No. 4
C00025619 External link 512 (-)-N-Methylcoclaurine
/ (R)-N-Methylcoclaurine
CHEMBL453292
CHEMBL513109
No. 253 No. 4

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00025306 C00025320 C00025602 C00025652 C00025832 0 / 0
Q99700 Ataxin-2 Unclassified protein C00025306 C00025320 C00025602 C00025624 C00025832 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00025306 C00025320 C00025602 C00025624 C00025832 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00025306 C00025320 C00025624 C00025832 1 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025306 C00025320 C00025624 C00025832 2 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00025306 C00025320 C00025832 0 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00025306 C00025320 C00025832 1 / 1
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025306 C00025320 C00025832 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00025306 C00025320 C00025832 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025306 C00025320 C00025832 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00025306 C00025320 C00025832 0 / 0
P08183 Multidrug resistance protein 1 drug C00025306 C00025320 C00025832 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025602 C00025652 4 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025602 C00025652 0 / 0
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025602 C00025624 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00025602 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025602 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025652 7 / 3
P42858 Huntingtin Unclassified protein C00025602 1 / 1
O43603 Galanin receptor type 2 Galanin receptor C00025602 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025602 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025652 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00025602 0 / 0
P04062 Glucosylceramidase Enzyme C00025652 6 / 4
P14618 Pyruvate kinase PKM Enzyme C00025652 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025652 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025602 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#143100 Huntington disease; hd P42858
#612244 Inflammatory bowel disease 13; ibd13 P08183
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (14)

KEGG name UniProt
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00079 Asthma P07550 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D013927 Thrombosis C00025276