Huperzia serrata
Species
KNApSAcK Entry
| Organism name | Huperzia serrata |
|---|---|
| Genus | Huperzia |
| Family | Lycopodiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Huperzia serrata |
|---|---|
| Linked NCBI taxonomy ID | 355589 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lycopodiaceae |
|---|---|
| ID | 3250 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Embryophyta |
|---|---|
| ID | 3193 |
Natural Activity
List (4)
| Species | Activity |
|---|---|
| Huperzia serrata | Antiacetylcholinesterase |
| Huperzia serrata | Antiamnesic |
| Huperzia serrata | Antiglutamate |
| Huperzia serrata | Memorigenic |
Metabolite list (45)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00001937
|
Fawcettimine
|
No. 280 |
|
|||||
|
C00027765
|
6alpha-Hydroxylycopodine
|
No. 280 |
|
|||||
|
C00001948
|
Lycopodine
|
CHEMBL1738973
|
C016542
|
No. 280 |
|
|||
|
C00025389
|
Lycodoline
/ Lycopodan-5-one |
No. 280 |
|
|||||
|
C00025387
|
Lucidioline
/ Deacetyldehydrolycoclavine |
No. 617 |
|
|||||
|
C00025396
|
Serratidine
|
No. 617 |
|
|||||
|
C00044441
|
3alpha,21beta,24-Trihydroxyserrat-14-en-16-one
/ (+)-3alpha,21beta,24-Trihydroxyserrat-14-en-16-one |
CHEMBL509120
|
No. 642 |
|
||||
|
C00044442
|
3alpha,21beta-Dihydroxyserrat-14-en-16-one
|
No. 642 |
|
|||||
|
C00044444
|
3beta-Hydroxyserrat-14-en-21alpha-yl acetate
|
C058372
|
No. 642 |
|
||||
|
C00044440
|
3alpha,21alpha-Dihydroxyserrat-14-en-24-oic acid
|
CHEMBL452254
|
No. 642 |
|
||||
|
C00044445
|
3beta-Hydroxyserrat-14-en-21-one
/ (-)-3beta-Hydroxyserrat-14-en-21-one |
No. 642 |
|
|||||
|
C00028374
|
Huperzine S
|
No. 1185 |
|
|||||
|
C00029003
|
Serratinine
|
C009245
|
No. 1185 |
|
||||
|
C00028827
|
Phlegmariurine B
|
C469768
|
No. 1248 |
|
||||
|
C00027781
|
8beta-Hydroxyphlegmariurine B
|
No. 1248 |
|
|||||
|
C00027658
|
11alpha-Hydroxyphlegmariurine B
|
No. 1248 |
|
|||||
|
C00028826
|
Phlegmariurine A
|
No. 1248 |
|
|||||
|
C00027772
|
7alpha-Hydroxyphlegmariurine B
|
No. 1248 |
|
|||||
|
C00027780
|
8alpha-Hydroxyphlegmariurine B
|
No. 1248 |
|
|||||
|
C00028375
|
Huperzine T
|
No. 1248 |
|
|||||
|
C00028365
|
Huperzine G
|
No. 1579 |
|
|||||
|
C00028367
|
Huperzine I
|
No. 1709 |
|
|||||
|
C00028362
|
Huperzine C
|
No. 1751 |
|
|||||
|
C00028378
|
Huperzinine
|
CHEMBL470349
|
C058370
|
No. 1751 |
|
|||
|
C00028703
|
N-Methyl-huperzine B
|
CHEMBL611808
|
C058369
|
1 / 1 / 0 | No. 1751 |
|
||
|
C00001939
|
Huperzine B
|
CHEMBL183649
CHEMBL245079 |
C053016
|
1 / 1 / 0 | No. 1751 |
|
||
|
C00028363
|
Huperzine D
|
No. 1751 |
|
|||||
|
C00001944
|
Lycodine
|
No. 2163 |
|
|||||
|
C00028361
|
Kimpukan A
/ Huperzine A |
CHEMBL77494
CHEMBL395280 CHEMBL394259 CHEMBL1255901 |
C050426
|
90 / 36 / 31 | 1 / 5 | No. 2402 |
|
|
|
C00027768
|
6beta-HYdroxyhuperzine A
|
No. 2402 |
|
|||||
|
C00028634
|
N,N-Dimethylhuperzine A
|
No. 2402 |
|
|||||
|
C00028369
|
Huperzine K
|
CHEMBL395790
|
No. 3525 |
|
||||
|
C00028368
|
Huperzine J
|
No. 3525 |
|
|||||
|
C00028370
|
Huperzine L
|
No. 3525 |
|
|||||
|
C00028668
|
Neohuperzinine
|
No. 3565 |
|
|||||
|
C00028371
|
Huperzine O
|
No. 3565 |
|
|||||
|
C00028373
|
Huperzine Q
|
No. 5436 |
|
|||||
|
C00028738
|
N-Oxyhuperzine Q
|
No. 5436 |
|
|||||
|
C00028372
|
Huperzine P
|
No. 6529 |
|
|||||
|
C00028376
|
Huperzine U
|
No. 7411 |
|
|||||
|
C00028366
|
Huperzine H
|
No. 7478 |
|
|||||
|
C00028377
|
Huperzine W
|
No. 7638 |
|
|||||
|
C00037280
|
Huperzine
|
No. 7679 |
|
|||||
|
C00028360
|
Huperserratinine
|
No. 7791 |
|
|||||
|
C00028364
|
Huperzine E
|
No. 8392 |
|
Human Protein / Gene in interactions
90 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P22303 | Acetylcholinesterase | Hydrolase | C00001939 C00028361 C00028703 | 1 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00028361 | 2 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00028361 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00028361 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00028361 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00028361 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00028361 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00028361 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00028361 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00028361 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00028361 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00028361 | 2 / 2 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00028361 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00028361 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00028361 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00028361 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00028361 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00028361 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00028361 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00028361 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00028361 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00028361 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00028361 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00028361 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00028361 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00028361 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00028361 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00028361 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00028361 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00028361 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00028361 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00028361 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00028361 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00028361 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00028361 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00028361 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00028361 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00028361 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00028361 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00028361 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00028361 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00028361 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00028361 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00028361 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00028361 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00028361 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00028361 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00028361 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00028361 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00028361 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00028361 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00028361 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00028361 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00028361 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00028361 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00028361 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00028361 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00028361 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00028361 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00028361 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00028361 | 0 / 0 |
| P06276 | Cholinesterase | Hydrolase | C00028361 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00028361 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00028361 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00028361 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00028361 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00028361 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00028361 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00028361 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00028361 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00028361 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00028361 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00028361 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00028361 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00028361 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00028361 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00028361 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00028361 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00028361 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00028361 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00028361 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00028361 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00028361 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00028361 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00028361 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00028361 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00028361 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00028361 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00028361 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00028361 | 0 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00028361
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (36)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (31)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|