Heliotropium indicum
Species
KNApSAcK Entry
| Organism name | Heliotropium indicum |
|---|---|
| Genus | Heliotropium |
| Family | Boraginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Heliotropium indicum |
|---|---|
| Linked NCBI taxonomy ID | 248297 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Boraginaceae |
|---|---|
| ID | 21571 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (47)
| Species | Activity |
|---|---|
| Heliotropium indicum L. | Abortifacient |
| Heliotropium indicum L. | Abortifacient |
| Heliotropium indicum L. | Analgesic |
| Heliotropium indicum L. | Analgesic |
| Heliotropium indicum L. | Antiabortive |
| Heliotropium indicum L. | Antiabortive |
| Heliotropium indicum L. | Anticancer |
| Heliotropium indicum L. | Anticancer |
| Heliotropium indicum L. | Antileukemic |
| Heliotropium indicum L. | Antileukemic |
| Heliotropium indicum L. | Antimelanomic |
| Heliotropium indicum L. | Antimelanomic |
| Heliotropium indicum L. | Antispasmodic |
| Heliotropium indicum L. | Antispasmodic |
| Heliotropium indicum L. | Astringent |
| Heliotropium indicum L. | Astringent |
| Heliotropium indicum L. | Carcinogenic |
| Heliotropium indicum L. | Carcinogenic |
| Heliotropium indicum L. | Collyrium |
| Heliotropium indicum L. | Collyrium |
| Heliotropium indicum L. | Depurative |
| Heliotropium indicum L. | Diaphoretic |
| Heliotropium indicum L. | Diaphoretic |
| Heliotropium indicum L. | Diuretic |
| Heliotropium indicum L. | Diuretic |
| Heliotropium indicum L. | Emmenagogue |
| Heliotropium indicum L. | Emmenagogue |
| Heliotropium indicum L. | Emollient |
| Heliotropium indicum L. | Emollient |
| Heliotropium indicum L. | Fungicide |
| Heliotropium indicum L. | Hepatotoxic |
| Heliotropium indicum L. | Hepatotoxic |
| Heliotropium indicum L. | Hypotensive |
| Heliotropium indicum L. | Hypouricemic |
| Heliotropium indicum L. | Hypouricemic |
| Heliotropium indicum L. | Litholytic |
| Heliotropium indicum L. | Pectoral |
| Heliotropium indicum L. | Pectoral |
| Heliotropium indicum L. | Sterilant |
| Heliotropium indicum L. | Stomachic |
| Heliotropium indicum L. | Stomachic |
| Heliotropium indicum L. | Tonic |
| Heliotropium indicum L. | toxic |
| Heliotropium indicum L. | Uterotonic |
| Heliotropium indicum L. | Uterotonic |
| Heliotropium indicum L. | Vulnerary |
| Heliotropium indicum L. | Vulnerary |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00007271
|
24-Methylenecholesterol
/ 24-Methylene cholesterol / 24-Methylcholesta-5,24(28)-dien-3beta-ol |
CHEMBL477971
|
C002537
|
No. 53 | No. 11 |
|
||
|
C00003647
|
Campesterol
/ 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol |
CHEMBL520535
CHEMBL485421 CHEMBL1836653 |
C021273
|
No. 53 | No. 11 |
|
||
|
C00002090
|
Heliotrine
|
CHEMBL1474445
CHEMBL1978598 CHEMBL2165593 |
C010178
|
6 / 3 / 4 | No. 308 | No. 2 |
|
|
|
C00002121
|
Supinine
|
No. 308 | No. 2 |
|
||||
|
C00002091
|
Indicine
|
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
C018336
|
No. 308 | No. 2 |
|
||
|
C00026205
|
Indicine N-oxide
|
CHEMBL352202
CHEMBL512655 CHEMBL516869 |
C013095
|
No. 1570 |
|
Human Protein / Gene in interactions
22 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002090 C00003672 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002090 C00003672 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002090 C00003672 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002090 C00003672 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00023774 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002090 C00003672 | 0 / 1 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002090 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (20)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (12)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |