| Organism name | Senecio platyphylloides | 
|---|---|
| Genus | Senecio | 
| Family | Asteraceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Senecio | 
|---|---|
| Linked NCBI taxonomy ID | 18794 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Asteraceae | 
|---|---|
| ID | 4210 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | asterids | 
|---|---|
| ID | 71274 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | 
                        # of proteins in
                         ChEMBL interaction / related OMIM / related KEGG DISEASE  | 
                      
                        # of genes in
                         CTD interaction / related diseases  | 
                      
                        KCF-S
                         cluster  | 
                      
                        phytochemical
                         cluster  | 
                      figure | 
|---|---|---|---|---|---|---|---|---|
| 
                        C00002117
                        
                           | 
                      
                        Seneciphylline
                         | 
                      
                        CHEMBL523911
                         CHEMBL1396368 CHEMBL1439490 CHEMBL1591009  | 
                      
                        C013678
                         | 
                      14 / 12 / 13 | No. 622 | No. 2 | 
                         
                       | 
                    |
| 
                        C00002107
                        
                           | 
                      
                        Platyphylline
                         | 
                      
                        CHEMBL1585045
                         | 
                      
                        C008937
                         | 
                      4 / 0 / 0 | No. 1044 | No. 2 | 
                         
                       | 
                    |
| 
                        C00034076
                        
                           | 
                      
                        Neoplatyphylline
                         | 
                      
                        CHEMBL1585045
                         | 
                      4 / 0 / 0 | No. 1044 | No. 2 | 
                         
                       | 
                    ||
| 
                        C00026219
                        
                           | 
                      
                        Platyphylline N-oxide
                         / Platyphylline,12-oxide  | 
                      No. 2356 | 
                         
                       | 
                    |||||
| 
                        C00026228
                        
                           | 
                      
                        Seneciphylline oxide
                         / Seneciphylline N-oxide  | 
                      No. 2356 | 
                         
                       | 
                    |||||
| 
                        C00002113
                        
                           | 
                      
                        Sarracine
                         | 
                      
                        CHEMBL1979573
                         | 
                      
                        C011104
                         | 
                      No. 2382 | No. 2 | 
                         
                       | 
                    
| accession | description | class description | KNApSAcK metabolite in interactions | 
                          # of diseases
                           (OMIM / KEGG)  | 
                      
|---|---|---|---|---|
| P06746 | DNA polymerase beta | Enzyme | C00002107 C00034076 | 0 / 0 | 
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002107 C00034076 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002107 C00034076 | 0 / 0 | 
| O75496 | Geminin | Unclassified protein | C00002107 C00034076 | 0 / 0 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002117 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002117 | 0 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002117 | 0 / 1 | 
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002117 | 7 / 3 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002117 | 1 / 0 | 
| P11473 | Vitamin D3 receptor | NR1I1 | C00002117 | 2 / 3 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002117 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002117 | 0 / 1 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002117 | 0 / 0 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002117 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002117 | 0 / 0 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002117 | 0 / 0 | 
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002117 | 0 / 1 | 
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002117 | 1 / 4 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah | 
                            P63092
                             | 
                        
| #609535 | Drug metabolism, poor, cyp2c19-related | 
                            P33261
                             | 
                        
| #608902 | Drug metabolism, poor, cyp2d6-related | 
                            P10635
                             | 
                        
| #174800 | Mccune-albright syndrome; mas | 
                            P63092
                             | 
                        
| #607948 | Mycobacterium tuberculosis, susceptibility to | 
                            P11473
                             | 
                        
| #166350 | Osseous heteroplasia, progressive; poh | 
                            P63092
                             | 
                        
| #102200 | Pituitary adenoma, growth hormone-secreting | 
                            P63092
                             | 
                        
| #601399 | Platelet disorder, familial, with associated myeloid malignancy | 
                            Q01196
                             | 
                        
| #103580 | Pseudohypoparathyroidism, type ia; php1a | 
                            P63092
                             | 
                        
| #603233 | Pseudohypoparathyroidism, type ib; php1b | 
                            P63092
                             | 
                        
| #612462 | Pseudohypoparathyroidism, type ic; php1c | 
                            P63092
                             | 
                        
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a | 
                            P11473
                             | 
                        
| KEGG | name | UniProt | 
|---|---|---|
| H00036 | Osteosarcoma | 
                            P08684
                            (marker)
                             | 
                        
| H00342 | Tuberculosis | 
                            P11473
                            (related)
                             | 
                        
| H00784 | Localized autosomal recessive hypotrichosis | 
                            P11473
                            (related)
                             | 
                        
| H01143 | Vitamin D-dependent rickets | 
                            P11473
                            (related)
                             | 
                        
| H01205 | Coumarin resistance | 
                            P11712
                            (related)
                             | 
                        
| H01171 | Poor drug metabolism (PM) | 
                            P33261
                            (related)
                             | 
                        
| H00244 | Pseudohypoparathyroidism | 
                            P63092
                            (related)
                             | 
                        
| H00441 | Progressive osseous heteroplasia (POH) | 
                            P63092
                            (related)
                             | 
                        
| H00501 | Fibrous dysplasia, polyostotic | 
                            P63092
                            (related)
                             | 
                        
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | 
                            Q01196
                            (related)
                             Q01196 (marker)  | 
                        
| H00003 | Acute myeloid leukemia (AML) | 
                            Q01196
                            (related)
                             Q01196 (marker) Q13951 (marker)  | 
                        
| H00004 | Chronic myeloid leukemia (CML) | 
                            Q01196
                            (related)
                             | 
                        
| H00978 | Thrombocytopenia (THC) | 
                            Q01196
                            (related)
                             |