Species

KNApSAcK Entry

Organism name Senecio grisebachii
Genus Senecio
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Senecio
Linked NCBI taxonomy ID 18794
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002109 External link 512 Retrorsine
CHEMBL520570
CHEMBL496894
CHEMBL1321908
CHEMBL1599718
C003300
15 / 4 / 9 2 / 0 No. 622 No. 2

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002109 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002109 0 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00002109 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00002109 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002109 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002109 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002109 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002109 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002109 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002109 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002109 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002109 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002109 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00002109 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002109 1 / 4

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00002109
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002109

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#612219 Ewing sarcoma; es P11308
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196

KEGG DISEASE (9)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)