Mimosa pudica
Species
KNApSAcK Entry
| Organism name | Mimosa pudica |
|---|---|
| Genus | Mimosa |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Mimosa pudica |
|---|---|
| Linked NCBI taxonomy ID | 76306 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (63)
| Species | Activity |
|---|---|
| Mimosa pudica L. | Abortifacient |
| Mimosa pudica L. | Abortifacient |
| Mimosa pudica L. | Adrenergic |
| Mimosa pudica L. | Alexiteric |
| Mimosa pudica L. | Alopecic |
| Mimosa pudica L. | Alterative |
| Mimosa pudica L. | Analgesic |
| Mimosa pudica L. | Analgesic |
| Mimosa pudica L. | Antibacterial |
| Mimosa pudica L. | Anticonvulsant |
| Mimosa pudica L. | Antidepressant |
| Mimosa pudica L. | Antidote |
| Mimosa pudica L. | Antifertility |
| Mimosa pudica L. | Antiinflammatory |
| Mimosa pudica L. | Antiinflammatory |
| Mimosa pudica L. | Antiophidic |
| Mimosa pudica L. | Antipyretic |
| Mimosa pudica L. | Antiseptic |
| Mimosa pudica L. | Antispasmodic |
| Mimosa pudica L. | Antispasmodic |
| Mimosa pudica L. | Antiviral |
| Mimosa pudica L. | Antiviral |
| Mimosa pudica L. | Anxiolytic |
| Mimosa pudica L. | Aphrodisiac |
| Mimosa pudica L. | Bactericide |
| Mimosa pudica L. | Bitter |
| Mimosa pudica L. | Carminative |
| Mimosa pudica L. | Contraceptive |
| Mimosa pudica L. | Depurative |
| Mimosa pudica L. | Depurative |
| Mimosa pudica L. | Diaphoretic |
| Mimosa pudica L. | Diuretic |
| Mimosa pudica L. | Diuretic |
| Mimosa pudica L. | Emetic |
| Mimosa pudica L. | Emetic |
| Mimosa pudica L. | Febrifuge |
| Mimosa pudica L. | Goitrogenic |
| Mimosa pudica L. | Hemostat |
| Mimosa pudica L. | Herbistat |
| Mimosa pudica L. | Hyaluronidase-Inhibitor |
| Mimosa pudica L. | Hyperglycemic |
| Mimosa pudica L. | Lactagogue |
| Mimosa pudica L. | Larvicide |
| Mimosa pudica L. | Litholytic |
| Mimosa pudica L. | Myorelaxant |
| Mimosa pudica L. | Myorelaxant |
| Mimosa pudica L. | Nematocide |
| Mimosa pudica L. | Nephrotoxic |
| Mimosa pudica L. | Neurogenic |
| Mimosa pudica L. | Protease-Inhibitor |
| Mimosa pudica L. | Purgative |
| Mimosa pudica L. | Sedative |
| Mimosa pudica L. | Sedative |
| Mimosa pudica L. | Spasmogenic |
| Mimosa pudica L. | Sudorific |
| Mimosa pudica L. | Tonic |
| Mimosa pudica L. | Tonic |
| Mimosa pudica L. | toxic |
| Mimosa pudica L. | Tranquilizer |
| Mimosa pudica L. | Vermifuge |
| Mimosa pudica L. | Vermifuge |
| Mimosa pudica L. | Vibriocide |
| Mimosa pudica L. | Vulnerary |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00014063
|
2''-O-alpha-L-Rhamnosyl-6-C-fucosyl-luteolin
|
No. 1 | No. 15 |
|
||||
|
C00014065
|
Cassiaoccidentalin B
/ 6-[6-Deoxy-2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-L-ribo-hexopyranos-3-ulos-1-yl]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
CHEMBL1224898
|
No. 1 | No. 15 |
|
|||
|
C00000218
|
Jasmonic acid
/ trans-Jasmonic acid / 3-Oxo-2-(2Z-pentenyl)cyclotentylacetic acid |
CHEMBL445499
CHEMBL449572 |
C011006
|
4 / 1 / 0 | No. 707 | No. 70 |
|
|
|
C00001424
|
Norepinephrine
/ L-Noradrenaline / (-)-Norepinephrine |
CHEMBL432
CHEMBL18824 CHEMBL1437 CHEMBL2311152 |
D009638
|
50 / 33 / 35 | 36 / 90 | No. 3197 |
|
|
|
C00002679
|
Turgorin
|
No. 7099 |
|
|||||
|
C00001383
|
L-Mimosine
|
CHEMBL245416
CHEMBL251433 CHEMBL1741949 |
D008898
|
92 / 36 / 31 | 8 / 1 | No. 8003 |
|
|
|
C00037507
|
Mimopudine
|
No. 8915 |
|
Human Protein / Gene in interactions
130 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001383 C00001424 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001383 C00001424 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001383 C00001424 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001383 C00001424 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00001383 C00001424 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001383 C00001424 | 0 / 1 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001383 C00001424 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001383 C00001424 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001383 C00001424 | 2 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001383 C00001424 | 0 / 1 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001383 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001424 | 11 / 10 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001424 | 3 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001383 | 1 / 2 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001424 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001383 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001383 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001383 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001383 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001383 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001383 | 2 / 2 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001383 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001383 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001383 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001383 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001383 | 0 / 1 |
| P14920 | D-amino-acid oxidase | Enzyme | C00001424 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001424 | 1 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001424 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001383 | 1 / 8 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001424 | 2 / 3 |
| P17252 | Protein kinase C alpha type | Alpha | C00001383 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001383 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001383 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001383 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001383 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001383 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001383 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001383 | 1 / 1 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001424 | 0 / 0 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001383 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001383 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001383 | 0 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000218 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001424 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001424 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001383 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001383 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001383 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001383 | 0 / 0 |
| P35348 | Alpha-1A adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001383 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001383 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001383 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001383 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001383 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001383 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001383 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001383 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001383 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001383 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001424 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00001383 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001383 | 0 / 0 |
| Q9GZT4 | Serine racemase | Enzyme | C00001424 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00001424 | 0 / 0 |
| P50224 | Sulfotransferase 1A3/1A4 | Enzyme | C00001424 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001424 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001383 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001383 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001383 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001383 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001383 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001383 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001383 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001383 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001383 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001383 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001383 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001383 | 1 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001383 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001383 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001383 | 0 / 0 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000218 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001424 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001424 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001383 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001383 | 1 / 1 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001383 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001383 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001383 | 0 / 0 |
| Q99489 | D-aspartate oxidase | Enzyme | C00001424 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001383 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001383 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001383 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001383 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001383 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001383 | 1 / 1 |
| P08246 | Neutrophil elastase | S1A | C00001383 | 2 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001383 | 0 / 0 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000218 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001424 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001424 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001424 | 4 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001383 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001383 | 0 / 3 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001383 | 1 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001383 | 0 / 0 |
| P35368 | Alpha-1B adrenergic receptor | Adrenergic receptor | C00001424 | 0 / 0 |
| O15244 | Solute carrier family 22 member 2 | Drug uniporter | C00001424 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001383 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001383 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001383 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001424 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000218 | 1 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001424 | 0 / 0 |
| Q9Y2I1 | Nischarin | Other cytosolic protein | C00001424 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001424 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001424 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001424 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001424 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001424 | 1 / 4 |
| O75751 | Solute carrier family 22 member 3 | Unclassified protein | C00001424 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001424 | 0 / 0 |
43 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001383
C00001424
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00001424
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001383
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001383
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001383
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00001383
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001383
|
| 7132 | TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 | tumor necrosis factor receptor superfamily, member 1A |
C00001383
|
| 148 | ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR | adrenoceptor alpha 1A |
C00001424
|
| 147 | ADRA1B, ADRA1, ALPHA1BAR | adrenoceptor alpha 1B |
C00001424
|
| 146 | ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2 | adrenoceptor alpha 1D |
C00001424
|
| 150 | ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 | adrenoceptor alpha 2A |
C00001424
|
| 151 | ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR | adrenoceptor alpha 2B |
C00001424
|
| 152 | ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR | adrenoceptor alpha 2C |
C00001424
|
| 153 | ADRB1, ADRB1R, B1AR, BETA1AR, RHR | adrenoceptor beta 1 |
C00001424
|
| 154 | ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR | adrenoceptor beta 2, surface |
C00001424
|
| 155 | ADRB3, BETA3AR | adrenoceptor beta 3 |
C00001424
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001424
|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00001424
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00001424
|
| 1813 | DRD2, D2DR, D2R | dopamine receptor D2 |
C00001424
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001383
|
| 2778 | GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH | GNAS complex locus |
C00001424
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00001424
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001424
|
| 4128 | MAOA, MAO-A | monoamine oxidase A (EC:1.4.3.4) |
C00001424
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001424
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001424
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00001424
|
| 4879 | NPPB, BNP | natriuretic peptide B |
C00001424
|
| 4852 | NPY, PYY4 | neuropeptide Y |
C00001424
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001424
|
| 6279 | S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 | S100 calcium binding protein A8 |
C00001424
|
| 6280 | S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14 | S100 calcium binding protein A9 |
C00001424
|
| 6285 | S100B, NEF, S100, S100-B, S100beta | S100 calcium binding protein B |
C00001424
|
| 6570 | SLC18A1, CGAT, VAT1, VMAT1 | solute carrier family 18 (vesicular monoamine transporter), member 1 |
C00001424
|
| 6571 | SLC18A2, SVAT, SVMT, VAT2, VMAT2 | solute carrier family 18 (vesicular monoamine transporter), member 2 |
C00001424
|
| 6530 | SLC6A2, NAT1, NET, NET1, SLC6A5 | solute carrier family 6 (neurotransmitter transporter), member 2 |
C00001424
|
| 6531 | SLC6A3, DAT, DAT1, PKDYS | solute carrier family 6 (neurotransmitter transporter), member 3 |
C00001424
|
| 6532 | SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT | solute carrier family 6 (neurotransmitter transporter), member 4 |
C00001424
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00001424
|
| 134864 | TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 | trace amine associated receptor 1 |
C00001424
|
| 7391 | USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11 | upstream transcription factor 1 |
C00001424
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (66)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (63)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
91 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006130 | Growth Disorders |
C00001383
|
| D058186 | Acute Kidney Injury |
C00001424
|
| D000647 | Amnesia |
C00001424
|
| D019969 | Amphetamine-Related Disorders |
C00001424
|
| D017542 | Aneurysm, Ruptured |
C00001424
|
| D000860 | Anoxia |
C00001424
|
| D001002 | Anuria |
C00001424
|
| D001008 | Anxiety Disorders |
C00001424
|
| D001145 | Arrhythmias, Cardiac |
C00001424
|
| D001237 | Asphyxia |
C00001424
|
| D001321 | Autistic Disorder |
C00001424
|
| D001766 | Blindness |
C00001424
|
| D001919 | Bradycardia |
C00001424
|
| D002545 | Brain Ischemia |
C00001424
|
| D002037 | Bundle-Branch Block |
C00001424
|
| D002100 | Cachexia |
C00001424
|
| D002303 | Cardiac Output, Low |
C00001424
|
| D006332 | Cardiomegaly |
C00001424
|
| D009202 | Cardiomyopathies |
C00001424
|
| D002375 | Catalepsy |
C00001424
|
| D002543 | Cerebral Hemorrhage |
C00001424
|
| D019970 | Cocaine-Related Disorders |
C00001424
|
| D003922 | Diabetes Mellitus, Type 1 |
C00001424
|
| D004409 | Dyskinesia, Drug-Induced |
C00001424
|
| D004421 | Dystonia |
C00001424
|
| D004827 | Epilepsy |
C00001424
|
| D005901 | Glaucoma |
C00001424
|
| D005921 | Glomerulonephritis |
C00001424
|
| D005923 | Glomerulosclerosis, Focal Segmental |
C00001424
|
| D006261 | Headache |
C00001424
|
| D006323 | Heart Arrest |
C00001424
|
| D006331 | Heart Diseases |
C00001424
|
| D006333 | Heart Failure |
C00001424
|
| D006470 | Hemorrhage |
C00001424
|
| D006930 | Hyperalgesia |
C00001424
|
| D006935 | Hypercapnia |
C00001424
|
| D006940 | Hyperemia |
C00001424
|
| D006973 | Hypertension |
C00001424
|
| D006974 | Hypertension, Malignant |
C00001424
|
| D006976 | Hypertension, Pulmonary |
C00001424
|
| D006984 | Hypertrophy |
C00001424
|
| D017379 | Hypertrophy, Left Ventricular |
C00001424
|
| D007008 | Hypokalemia |
C00001424
|
| D007022 | Hypotension |
C00001424
|
| D007024 | Hypotension, Orthostatic |
C00001424
|
| D007035 | Hypothermia |
C00001424
|
| D007511 | Ischemia |
C00001424
|
| D007674 | Kidney Diseases |
C00001424
|
| D008113 | Liver Neoplasms |
C00001424
|
| D008114 | Liver Neoplasms, Experimental |
C00001424
|
| D009203 | Myocardial Infarction |
C00001424
|
| D017202 | Myocardial Ischemia |
C00001424
|
| D015428 | Myocardial Reperfusion Injury |
C00001424
|
| D009336 | Necrosis |
C00001424
|
| D009410 | Nerve Degeneration |
C00001424
|
| D009798 | Ocular Hypertension |
C00001424
|
| D009846 | Oliguria |
C00001424
|
| D009901 | Optic Nerve Diseases |
C00001424
|
| D010146 | Pain |
C00001424
|
| D010243 | Paralysis |
C00001424
|
| D010554 | Personality Disorders |
C00001424
|
| D011183 | Postoperative Complications |
C00001424
|
| D011249 | Pregnancy Complications, Cardiovascular |
C00001424
|
| D011297 | Prenatal Exposure Delayed Effects |
C00001424
|
| D011507 | Proteinuria |
C00001424
|
| D011605 | Psychoses, Substance-Induced |
C00001424
|
| D029424 | Pulmonary Disease, Chronic Obstructive |
C00001424
|
| D051437 | Renal Insufficiency |
C00001424
|
| D012120 | Respiration Disorders |
C00001424
|
| D012131 | Respiratory Insufficiency |
C00001424
|
| D012164 | Retinal Diseases |
C00001424
|
| D012206 | Rhabdomyolysis |
C00001424
|
| D012640 | Seizures |
C00001424
|
| D018805 | Sepsis |
C00001424
|
| D012769 | Shock |
C00001424
|
| D012770 | Shock, Cardiogenic |
C00001424
|
| D012771 | Shock, Hemorrhagic |
C00001424
|
| D012772 | Shock, Septic |
C00001424
|
| D013035 | Spasm |
C00001424
|
| D013226 | Status Epilepticus |
C00001424
|
| D013274 | Stomach Neoplasms |
C00001424
|
| D013345 | Subarachnoid Hemorrhage |
C00001424
|
| D013375 | Substance Withdrawal Syndrome |
C00001424
|
| D013610 | Tachycardia |
C00001424
|
| D013616 | Tachycardia, Sinus |
C00001424
|
| D017180 | Tachycardia, Ventricular |
C00001424
|
| D014511 | Uremia |
C00001424
|
| D056987 | Vasoplegia |
C00001424
|
| D018754 | Ventricular Dysfunction |
C00001424
|
| D018487 | Ventricular Dysfunction, Left |
C00001424
|
| D014693 | Ventricular Fibrillation |
C00001424
|