Species

KNApSAcK Entry

Organism name Helianthus heterophyllus
Genus Helianthus
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Helianthus heterophyllus
Linked NCBI taxonomy ID 73292
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003776 External link 512 Lutein
/ (all-E)-Lutein
/ all-trans-(+)-Xanthophyll
/ (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol
CHEMBL173929
CHEMBL172477
CHEMBL1559643
CHEMBL1979448
D014975
4 / 2 / 3 7 / 2 No. 26 No. 59
C00000258 External link 512 2,6-Dimethoxy-p-benzoquinone
CHEMBL448515
C030511
22 / 32 / 55 No. 2517
C00029298 External link 512 Dehydrovomifoliol
/ (+)-Dehydrovomifoliol
/ S-(+)-Dehydrovomifoliol
CHEMBL461278
No. 3492

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11473 Vitamin D3 receptor NR1I1 C00000258 C00003776 2 / 3
O75496 Geminin Unclassified protein C00000258 C00003776 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000258 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000258 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000258 7 / 37
P39748 Flap endonuclease 1 Enzyme C00000258 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000258 2 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000258 4 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000258 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000258 7 / 3
P83916 Chromobox protein homolog 1 Unclassified protein C00000258 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003776 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000258 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000258 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000258 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000258 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000258 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000258 0 / 0
Q2TB90 Putative hexokinase HKDC1 Enzyme C00000258 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003776 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000258 1 / 0
O00255 Menin Unclassified protein C00000258 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000258 1 / 2
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00000258 2 / 1

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00003776
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00003776
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00003776
847 CAT catalase (EC:1.11.1.6) C00003776
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00003776
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00003776
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00003776

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P84022
Q14191
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#166350 Osseous heteroplasia, progressive; poh P63092
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (55)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007939 Leukemia L1210 C00003776
D014605 Uveitis C00003776