Peucedanum ostruthium
Species
KNApSAcK Entry
| Organism name | Peucedanum ostruthium |
|---|---|
| Genus | Peucedanum |
| Family | Apiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Peucedanum ostruthium |
|---|---|
| Linked NCBI taxonomy ID | 52477 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Apiaceae |
|---|---|
| ID | 4037 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (12)
| Species | Activity |
|---|---|
| Peucedanum ostruthium (L.) W. D. J. Koch. | Antidote, spider |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Antispasmodic |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Aphrodisiac |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Carminative |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Depurative |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Diaphoretic |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Diuretic |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Emmenagogue |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Expectorant |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Sedative |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Stimulant |
| Peucedanum ostruthium (L.) W. D. J. Koch. | Stomachic |
Metabolite list (6)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002488
|
Osthol
/ Osthole |
CHEMBL52229
|
C046627
|
12 / 6 / 5 | 7 / 4 | No. 466 | No. 25 |
|
|
C00035717
|
(+)-Oxypeucedanin
/ Oxypeucedanin hydrate |
CHEMBL454060
CHEMBL1438253 |
13 / 5 / 8 | No. 579 | No. 25 |
|
||
|
C00002489
|
Ostruthin
|
CHEMBL1812645
|
C008719
|
No. 1758 | No. 25 |
|
||
|
C00002490
|
Oxypeucedanin
|
CHEMBL510120
CHEMBL1510267 CHEMBL1609439 |
C031535
|
8 / 14 / 11 | No. 2896 | No. 25 |
|
|
|
C00013140
|
Alatol
/ Alatol(Euonymus) |
No. 4206 |
|
|||||
|
C00033066
|
Isooxypeucedanin
|
No. 4290 |
|
Human Protein / Gene in interactions
26 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P56817 | Beta-secretase 1 | A1A | C00002488 C00002490 C00035717 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00002488 C00002490 C00035717 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002490 C00035717 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002490 C00035717 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002488 C00002490 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002488 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002488 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002490 | 11 / 10 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00035717 | 2 / 2 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002488 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002488 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00035717 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00035717 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002490 | 3 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002488 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00002488 | 6 / 4 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002488 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00035717 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00035717 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00035717 | 0 / 0 |
| O14980 | Exportin-1 | Unclassified protein | C00002488 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002488 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002490 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00035717 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00035717 | 1 / 4 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00035717 | 1 / 1 |
7 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 2180 | ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 | acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) |
C00002488
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00002488
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002488
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002488
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002488
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002488
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002488
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (25)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (24)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|