Species

KNApSAcK Entry

Organism name Brunfelsia grandiflora D.DON
Genus Brunfelsia
Family Solanaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Brunfelsia grandiflora
Linked NCBI taxonomy ID 1035550
Linked level species

Family

Family in NCBI taxonomy Solanaceae
ID 4070

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029968 External link 512 Cirensenoside P
/ 3-O-beta-D-glucopyranosyl, 28-O-beta-D-glucopyranosyl(1->6)-beta-D-glucopyranosyl betulinate
No. 9 No. 51
C00002724 External link 512 Heriguard
/ Chlorogenic acid
/ 3-O-Caffeoylquinic acid
CHEMBL284616
CHEMBL230481
CHEMBL249450
CHEMBL1332980
CHEMBL1394423
CHEMBL1419611
CHEMBL1473644
CHEMBL1552319
D002726
30 / 19 / 22 37 / 9 No. 314 No. 6
C00002499 External link 512 Scopoletin
CHEMBL71851
D012603
48 / 37 / 34 9 / 0 No. 864 No. 25

Human Protein / Gene in interactions

65 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002499 C00002724 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002499 C00002724 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002499 C00002724 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002499 C00002724 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002499 C00002724 1 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002499 C00002724 3 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002499 C00002724 0 / 0
P15121 Aldose reductase Enzyme C00002499 C00002724 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002499 C00002724 0 / 3
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002499 C00002724 0 / 0
O75496 Geminin Unclassified protein C00002499 C00002724 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002499 C00002724 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002499 C00002724 0 / 1
P55210 Caspase-7 C14 C00002499 0 / 0
P29466 Caspase-1 C14 C00002499 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00002499 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002499 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00002499 0 / 0
P55789 FAD-linked sulfhydryl oxidase ALR Enzyme C00002499 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00002724 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00002499 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002499 1 / 2
P10253 Lysosomal alpha-glucosidase Hydrolase C00002499 1 / 1
P04062 Glucosylceramidase Enzyme C00002499 6 / 4
O43570 Carbonic anhydrase 12 Lyase C00002499 1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00002499 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002499 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002724 3 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002724 2 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002499 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002499 0 / 0
P10145 Interleukin-8 Secreted protein C00002724 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002499 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002724 1 / 2
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002499 7 / 3
Q04206 Transcription factor p65 Transcription Factor C00002499 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002724 0 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002724 0 / 0
P06280 Alpha-galactosidase A Enzyme C00002499 1 / 1
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00002724 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002499 0 / 1
Q99700 Ataxin-2 Unclassified protein C00002499 1 / 1
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002724 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002499 2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002499 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00002499 0 / 0
P22303 Acetylcholinesterase Hydrolase C00002499 1 / 0
Q00796 Sorbitol dehydrogenase Enzyme C00002499 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002499 0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002499 0 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00002499 1 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002724 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002724 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002499 5 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002724 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002724 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002724 0 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00002499 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002499 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002724 3 / 3
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002499 3 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002724 1 / 1
O00255 Menin Unclassified protein C00002499 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002499 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002724 0 / 0

42 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002499 C00002724
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002499 C00002724
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002499 C00002724
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002499 C00002724
5241 PGR, NR3C3, PR progesterone receptor C00002724
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00002724
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002724
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00002724
114757 CYGB, HGB, STAP cytoglobin C00002724
1830 DSG3, CDHF6, PVA desmoglein 3 C00002724
1950 EGF, HOMG4, URG epidermal growth factor C00002724
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00002724
2201 FBN2, CCA, DA9 fibrillin 2 C00002724
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00002724
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00002724
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00002724
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00002724
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002724
3852 KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A keratin 5 C00002724
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00002724
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002724
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00002724
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00002724
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002724
5886 RAD23A, HHR23A, HR23A RAD23 homolog A (S. cerevisiae) C00002724
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00002724
6256 RXRA, NR2B1 retinoid X receptor, alpha C00002724
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00002724
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00002724
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00002724
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002724
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002724
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00002724
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00002724
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00002724
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00002724
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00002724
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002499
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00002499
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002499
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002499
7508 XPC, RAD4, XP3, XPCC xeroderma pigmentosum, complementation group C C00002499

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#614162 Candidiasis, familial, 7; candf7 P42224
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#301500 Fabry disease P06280
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#613688 Long qt syndrome 2; lqt2 Q12809
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#613076 Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay P55789
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168600 Parkinson disease, late-onset; pd P04062
#102200 Pituitary adenoma, growth hormone-secreting P63092
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (46)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00002724
D056486 Drug-Induced Liver Injury C00002724
D006937 Hypercholesterolemia C00002724
D006951 Hyperlipoproteinemias C00002724
D015228 Hypertriglyceridemia C00002724
D052456 Hypoalphalipoproteinemias C00002724
D008545 Melanoma C00002724
D009336 Necrosis C00002724
D015431 Weight Loss C00002724