Dalbergia frutescens
Species
KNApSAcK Entry
| Organism name | Dalbergia frutescens |
|---|---|
| Genus | Dalbergia |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Dalbergia frutescens |
|---|---|
| Linked NCBI taxonomy ID | 450026 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00009400
|
8-O-Methylretusin
|
CHEMBL477720
|
No. 3 | No. 15 |
|
|||
|
C00002525
|
Formononetin
/ 7-Hydroxy-4'-methoxyisoflavone |
CHEMBL242341
|
C007768
|
24 / 36 / 58 | 13 / 0 | No. 3 | No. 15 |
|
|
C00009392
|
Glycitein
/ 7,4'-Dihydroxy-6-methoxyisoflavone |
CHEMBL513024
|
C086566
|
2 / 2 / 2 | 40 / 4 | No. 3 | No. 15 |
|
|
C00009407
|
Odoratin
|
CHEMBL469824
|
No. 3 | No. 15 |
|
|||
|
C00009404
|
Cuneatin
/ Maximaisoflavone G |
CHEMBL519221
|
No. 27 | No. 15 |
|
|||
|
C00009406
|
Fujikinetin
/ 7-Hydroxy-6-methoxy-3',4'-methylenedioxyisoflavone |
CHEMBL485985
|
No. 27 | No. 15 |
|
|||
|
C00002507
|
Castanin
/ Afromosin / Afrormosin / 7-Hydroxy-6,4'-dimethoxyisoflavone |
CHEMBL464404
|
C080240
|
7 / 14 / 39 | 1 / 0 | No. 35 | No. 15 |
|
|
C00018987
|
(+)-Medicarpin
/ (+)-(6aS,11aS)-Medicarpin |
CHEMBL238845
CHEMBL413297 |
3 / 1 / 1 | No. 66 | No. 15 |
|
Human Protein / Gene in interactions
32 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002507 C00002525 | 7 / 37 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002525 C00018987 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002507 C00002525 | 4 / 2 |
| O75496 | Geminin | Unclassified protein | C00002507 C00018987 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002525 | 5 / 3 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002525 | 4 / 1 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002525 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00009392 | 1 / 1 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00002525 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002525 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002525 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002507 | 2 / 2 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002525 | 1 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002507 | 0 / 0 |
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00002525 | 1 / 1 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002525 | 0 / 0 |
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00002525 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002525 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002525 | 2 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002507 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00009392 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002525 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002525 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002525 | 4 / 3 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00002525 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00002525 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002525 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002507 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00002525 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002525 | 1 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002525 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00018987 | 1 / 1 |
51 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00002507
C00002525
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00002525
C00009392
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00002525
C00009392
|
| 56776 | FMN2 | formin 2 |
C00009392
|
| 2056 | EPO, EP, MVCD2 | erythropoietin |
C00002525
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002525
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002525
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00002525
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002525
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002525
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002525
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002525
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002525
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00009392
|
| 119 | ADD2, ADDB | adducin 2 (beta) |
C00009392
|
| 396 | ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 | Rho GDP dissociation inhibitor (GDI) alpha |
C00009392
|
| 23545 | ATP6V0A2, A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS | ATPase, H+ transporting, lysosomal V0 subunit a2 (EC:3.6.3.6) |
C00009392
|
| 11177 | BAZ1A, ACF1, WALp1, WCRF180, hACF1 | bromodomain adjacent to zinc finger domain, 1A |
C00009392
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00009392
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00009392
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00009392
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00009392
|
| 1795 | DOCK3, MOCA, PBP | dedicator of cytokinesis 3 |
C00009392
|
| 2041 | EPHA1, EPH, EPHT, EPHT1 | EPH receptor A1 (EC:2.7.10.1) |
C00009392
|
| 83715 | ESPN, DFNB36 | espin |
C00009392
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002525
|
| 7866 | IFRD2, IFNRP, SKMc15, SM15 | interferon-related developmental regulator 2 |
C00009392
|
| 26145 | IRF2BP1 | interferon regulatory factor 2 binding protein 1 |
C00009392
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00009392
|
| 26251 | KCNG2, KCNF2, KV6.2 | potassium voltage-gated channel, subfamily G, member 2 |
C00009392
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00009392
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00009392
|
| 4314 | MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) |
C00009392
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00009392
|
| 8204 | NRIP1, RIP140 | nuclear receptor interacting protein 1 |
C00009392
|
| 56944 | OLFML3, HNOEL-iso, OLF44 | olfactomedin-like 3 |
C00009392
|
| 5111 | PCNA | proliferating cell nuclear antigen |
C00009392
|
| 64236 | PDLIM2, MYSTIQUE, SLIM | PDZ and LIM domain 2 (mystique) |
C00009392
|
| 5411 | PNN, DRS, DRSP, SDK3, memA | pinin, desmosome associated protein |
C00009392
|
| 5458 | POU4F2, BRN3.2, BRN3B, Brn-3b | POU class 4 homeobox 2 |
C00009392
|
| 6197 | RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1) |
C00009392
|
| 81537 | SGPP1, SPPase1 | sphingosine-1-phosphate phosphatase 1 |
C00009392
|
| 6558 | SLC12A2, BSC, BSC2, NKCC1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
C00009392
|
| 6667 | SP1 | Sp1 transcription factor |
C00009392
|
| 6781 | STC1, STC | stanniocalcin 1 |
C00009392
|
| 6870 | TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL | tachykinin receptor 3 |
C00009392
|
| 7130 | TNFAIP6, TSG-6, TSG6 | tumor necrosis factor, alpha-induced protein 6 |
C00009392
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00009392
|
| 9537 | TP53I11, PIG11 | tumor protein p53 inducible protein 11 |
C00009392
|
| 7345 | UCHL1, NDGOA, PARK5, PGP_9.5, PGP9.5, PGP95, Uch-L1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) |
C00009392
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00009392
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (41)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #606824 | Glucose/galactose malabsorption; ggm |
P13866
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #601665 | Obesity |
P37231
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #233100 | Renal glucosuria; glys1 |
P31639
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #278300 | Xanthinuria, type i |
P47989
|
KEGG DISEASE (61)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|