| Organism name | Iris tenuifolia | 
|---|---|
| Genus | Iris | 
| Family | Iridaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Iris tenuifolia | 
|---|---|
| Linked NCBI taxonomy ID | 198827 | 
| Linked level | species | 
| Family in NCBI taxonomy | Iridaceae | 
|---|---|
| ID | 26339 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | Liliopsida | 
|---|---|
| ID | 4447 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00033051   | Irisoid A | No. 3 | No. 15 |   | ||||
| C00009825   | 5,7-Dihydroxy-2',6-dimethoxyisoflavone / 5,7-Dihydroxy-6,2'-dimethoxyisoflavone | CHEMBL479118 | No. 3 | No. 15 |   | |||
| C00004536   | Izalpinin / 7-O-Methylgalangin / Galangin 7-methyl ether / 3,5-Dihydroxy-7-methoxyflavone / 3,5-Dihydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one | CHEMBL464966 | No. 3 | No. 15 |   | |||
| C00014131   | 5,2',3'-Trihydroxy-6,7-methylenedioxyflavanone | CHEMBL1807889 | No. 25 | No. 14 |   | |||
| C00014118   | 5,2',3'-Trihydroxy-7-methoxyflavanone | No. 25 | No. 14 |   | ||||
| C00014125   | 5,3'-Dihydroxy-7,2'-dimethoxyflavanone | No. 25 | No. 14 |   | ||||
| C00014115   | 5,2'-Dihydroxy-6,7-methylenedioxyflavanone | No. 25 | No. 14 |   | ||||
| C00002509   | Betavulgarin / 2'-Hydroxy-5-methoxy-6,7-methylenedioxyisoflavone | No. 27 | No. 15 |   | ||||
| C00009857   | Irisone A / 5-Hydroxy-2'-methoxy-6,7-methylenedioxyisoflavone | CHEMBL509631 | C053587 | No. 27 | No. 15 |   | ||
| C00009856   | Irisone B / 5,2'-Dihydroxy-6,7-methylenedioxyisoflavone | CHEMBL443974 | C053588 | No. 27 | No. 15 |   | ||
| C00034310   | Tenuifone | No. 27 | No. 15 |   | ||||
| C00014366   | 3,5,2',3'-Tetrahydroxy-7-methoxyflavanone | No. 42 | No. 14 |   | ||||
| C00008549   | Alpinone | CHEMBL1081328 | No. 42 | No. 14 |   | |||
| C00014367   | 3,5,3'-Trihydroxy-7,2'-dimethoxyflavanone | No. 42 | No. 14 |   | ||||
| C00003672   | Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol | CHEMBL221542 CHEMBL1398443 CHEMBL1875388 | 17 / 19 / 12 | No. 53 | No. 11 |   | ||
| C00033651   | Arborinone | No. 198 | No. 52 |   | ||||
| C00034309   | Tenuifodione | No. 5627 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 | 
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 | 
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 | 
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 | 
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 | 
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 | 
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 | 
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 | 
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 | 0 / 1 | 
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness | P14679 | 
| #203100 | Albinism, oculocutaneous, type ia; oca1a | P14679 | 
| #606952 | Albinism, oculocutaneous, type ib; oca1b | P14679 | 
| #218030 | Apparent mineralocorticoid excess; ame | P80365 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #615363 | Estrogen resistance; estrr | P03372 | 
| #603373 | Hyperthyroidism, familial gestational | P16473 | 
| #609152 | Hyperthyroidism, nonautoimmune | P16473 | 
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | P16473 | 
| #612244 | Inflammatory bowel disease 13; ibd13 | P08183 | 
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 | P00734 | 
| #613679 | Prothrombin deficiency, congenital | P00734 | 
| #604906 | Schizophrenia 9; sczd9 | P49798 | 
| #181500 | Schizophrenia; sczd | P49798 | 
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 | P14679 | 
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | Q9NUW8 | 
| #601367 | Stroke, ischemic | P00734 | 
| #188050 | Thrombophilia due to thrombin defect; thph1 | P00734 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00223 | Inherited thrombophilia | P00734
                            (related) | 
| H01254 | Congenital prothrombin deficiency | P00734
                            (related) | 
| H00026 | Endometrial Cancer | P03372
                            (marker) | 
| H00036 | Osteosarcoma | P08684
                            (marker) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00168 | Oculocutaneous albinism (OCA) | P14679
                            (related) | 
| H00038 | Malignant melanoma | P14679
                            (marker) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | P16473
                            (related) | 
| H01269 | Congenital hyperthyroidism | P16473
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00259 | Apparent mineralocorticoid excess syndrome | P80365
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q9NUW8
                            (related) |