Species

KNApSAcK Entry

Organism name Glycyrrhiza glabra var. typica
Genus Glycyrrhiza
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Glycyrrhiza
Linked NCBI taxonomy ID 46347
Linked level genus

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00008611 External link 512 3-Hydroxyglabrol
CHEMBL463947
No. 19 No. 14
C00009730 External link 512 3'-Methoxyglabridin
CHEMBL463948
No. 135 No. 15
C00002529 External link 512 Glabridin
CHEMBL480477
CHEMBL1360535
C107601
19 / 21 / 42 0 / 2 No. 135 No. 15
C00009726 External link 512 4'-O-Methylglabridin
CHEMBL511536
No. 135 No. 15
C00002534 External link 512 Hispaglabridin A
CHEMBL464581
No. 352 No. 15
C00009735 External link 512 Hispaglabridin B
CHEMBL464582
No. 881
C00009755 External link 512 Glabrene
No. 2189

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00002529 7 / 37
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002529 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002529 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002529 0 / 0
P20813 Cytochrome P450 2B6 Cytochrome P450 2B6 C00002529 1 / 0
P14735 Insulin-degrading enzyme Enzyme C00002529 0 / 0
P37840 Alpha-synuclein Unclassified protein C00002529 4 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00002529 2 / 0
O75496 Geminin Unclassified protein C00002529 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002529 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002529 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002529 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00002529 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00002529 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002529 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002529 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002529 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00002529 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002529 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
#127750 Dementia, lewy body; dlb P37840
#614546 Efavirenz, poor metabolism of P20813
#133239 Esophageal cancer P04637
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (42)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00002529
D009765 Obesity C00002529