Species

KNApSAcK Entry

Organism name Wedelia calendulacea
Genus Wedelia
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Wedelia
Linked NCBI taxonomy ID 183097
Linked level genus

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002585 External link 512 Wedelolactone
/ 1,8,9-Trihydroxy-3-methoxycoumestan
/ 5,11,12-Trihydroxy-7-methoxycoumestan
CHEMBL97453
C051122
22 / 13 / 20 No. 54 No. 17
C00009765 External link 512 Norwedelolactone
/ Demethylwedelolactone
/ Desmethylwedelolactone
CHEMBL2089002
C051123
6 / 4 / 6 No. 54 No. 17
C00010052 External link 512 Norwedelic acid
/ 5,6-Dihydroxy-2-(2',4',6'-trihydroxyphenyl)benzofuran-3-carboxylic acid
No. 3428

Human Protein / Gene in interactions

24 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P25963 NF-kappa-B inhibitor alpha Other cytosolic protein C00002585 C00009765 1 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00002585 C00009765 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002585 C00009765 0 / 0
Q05397 Focal adhesion kinase 1 Fak C00002585 C00009765 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00002585 3 / 1
P14780 Matrix metalloproteinase-9 M10A C00009765 2 / 2
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00002585 0 / 0
P54132 Bloom syndrome protein Enzyme C00002585 1 / 2
P11473 Vitamin D3 receptor NR1I1 C00002585 2 / 3
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00002585 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002585 0 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00002585 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002585 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00002585 0 / 0
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha Other serine/threonine protein kinase C00002585 1 / 1
P08253 72 kDa type IV collagenase M10A C00009765 1 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002585 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002585 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002585 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002585 1 / 1
O00255 Menin Unclassified protein C00002585 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002585 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00002585 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002585 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#613630 Cocoon syndrome O15111
#612132 Ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency, autosomal dominant P25963
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (24)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00882 Cocoon syndrome O15111 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00007 Hodgkin lymphoma P25963 (related)
H00095 Ectodermal dysplasia associated immunodeficiency (EDA-ID) P25963 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)