PCIDB

Melia azedarach

Species

KNApSAcK Entry

Organism name Melia azedarach
Genus Melia
Family Meliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Melia azedarach
Linked NCBI taxonomy ID 155640
Linked level species

Family

Family in NCBI taxonomy Meliaceae
ID 43707

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (39)

Species Activity
Melia azedarach L. Abortifacient
Melia azedarach L. Alexeteric
Melia azedarach L. Analgesic
Melia azedarach L. Anthelminthic
Melia azedarach L. Antibacterial
Melia azedarach L. Antifeedant
Melia azedarach L. Antipyretic
Melia azedarach L. Antiseptic
Melia azedarach L. Antispasmodic
Melia azedarach L. Antiviral
Melia azedarach L. Aperitif
Melia azedarach L. Astringent
Melia azedarach L. Bitter
Melia azedarach L. Cerebrotonic
Melia azedarach L. CNS-Depressant
Melia azedarach L. Deobstruent
Melia azedarach L. Depurative
Melia azedarach L. Diuretic
Melia azedarach L. Emetic
Melia azedarach L. Emmenagogue
Melia azedarach L. Emollient
Melia azedarach L. Hemostat
Melia azedarach L. Insecticide
Melia azedarach L. Insectifuge
Melia azedarach L. Larvicide
Melia azedarach L. Laxative
Melia azedarach L. Litholytic
Melia azedarach L. Narcotic
Melia azedarach L. Parasiticide
Melia azedarach L. Pediculicide
Melia azedarach L. Piscicide
Melia azedarach L. Poison
Melia azedarach L. Pulicide
Melia azedarach L. Resolvent
Melia azedarach L. Sedative
Melia azedarach L. Stimulant
Melia azedarach L. Stomachic
Melia azedarach L. Tonic
Melia azedarach L. Vermicide

Metabolite list (19)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00032575 External link 512 1-(2-methylpropanoyl)-3-acetyl-11-methoxymeliacarpinin
/ (-)-1-(2-methylpropanoyl)-3-acetyl-11-methoxymeliacarpinin
No. 487 No. 51
C00040782 External link 512 1-Cinnamoyl-3-methacrylyl-11-hydroxymeliacarpin
No. 487 No. 51
C00040781 External link 512 1-Cinnamoyl-3-acetyl-11-hydroxymeliacarpin
/ (+)-1-Cinnamoyl-3-acetyl-11-hydroxymeliacarpin
No. 487 No. 51
C00033188 External link 512 Meliacarpinin D
/ (-)-Meliacarpinin D
No. 487 No. 51
C00040753 External link 512 1,3-Dicinnamoyl-11-hydroxymeliacarpin
/ (+)-1,3-Dicinnamoyl-11-hydroxymeliacarpin
No. 487 No. 51
C00031514 External link 512 15-O-Deacetyl-15-O-methylnimbolidin A
No. 591 No. 51
C00031515 External link 512 15-O-Deacetyl-15-O-methylnimbolidin B
No. 591 No. 51
C00043791 External link 512 Ohchinolal
CHEMBL501420
No. 591 No. 51
C00031499 External link 512 12-O-Deacetyltrichilin H
No. 836 No. 51
C00030806 External link 512 Neoazedarachin B
/ (-)-Neoazedarachin B
No. 836 No. 51
C00029765 External link 512 Azedarachin B
No. 836 No. 51
C00002682 External link 512 Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid
CHEMBL120568
D014641
5 / 3 / 3 5 / 0 No. 1073
C00036671 External link 512 9beta-Hydroxyfraxinellone
/ (-)-9beta-Hydroxyfraxinellone
CHEMBL257169
No. 1461
C00011939 External link 512 Fraxinellone
CHEMBL257170
CHEMBL1595442
C075391
3 / 5 / 4 No. 1461
C00029609 External link 512 9alpha-Hydroxyfraxinellone
CHEMBL257169
No. 1461
C00033189 External link 512 Melianin B
CHEMBL446959
No. 2887
C00040889 External link 512 Azedararide
/ (+)-Azedararide
No. 7126
C00037490 External link 512 Melazolide A
/ (-)-Melazolide A
No. 7510
C00030329 External link 512 Fraxinellonone
CHEMBL403869
No. 8112

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10253 Lysosomal alpha-glucosidase Hydrolase C00011939 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00011939 3 / 2
P42858 Huntingtin Unclassified protein C00002682 1 / 1
P15121 Aldose reductase Enzyme C00002682 0 / 0
P03372 Estrogen receptor NR3A1 C00002682 1 / 1
P51580 Thiopurine S-methyltransferase Enzyme C00002682 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002682 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00011939 1 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002682
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002682
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002682
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002682
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002682

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#615363 Estrogen resistance; estrr P03372
#232300 Glycogen storage disease ii P10253
#143100 Huntington disease; hd P42858
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#610460 Thiopurine s-methyltransferase deficiency P51580

KEGG DISEASE (7)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00964 Thiopurine S-methyltransferase deficiency (TPMT deficiency) P51580 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)