PCIDB

Piper regnellii

Species

KNApSAcK Entry

Organism name Piper regnellii
Genus Piper
Family Piperaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Piper
Linked NCBI taxonomy ID 13215
Linked level genus

Family

Family in NCBI taxonomy Piperaceae
ID 16739

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002714 External link 512 Apiol
/ Apiole
/ Parsley apiole
CHEMBL1560118
3 / 0 / 1 No. 1917 No. 6
C00002762 External link 512 Myristicin
CHEMBL481044
C005246
6 / 4 / 2 2 / 0 No. 1917 No. 6
C00048706 External link 512 Eupomatenoid 3
No. 3329
C00048708 External link 512 Eupomatenoid 6
CHEMBL463574
C452812
14 / 18 / 17 No. 3329
C00048707 External link 512 Eupomatenoid 5
C452811
No. 3329
C00048666 External link 512 Conocarpan
/ (-)-Conocarpan
CHEMBL2147421
6 / 5 / 4 No. 5795

Human Protein / Gene in interactions

20 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein C00002762 C00048708 4 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00048666 C00048708 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00048666 C00048708 0 / 0
O14684 Prostaglandin E synthase Enzyme C00048666 C00048708 0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00048666 C00048708 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002762 C00048708 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002714 C00002762 0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00048666 C00048708 5 / 3
P04150 Glucocorticoid receptor NR3C1 C00048666 C00048708 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00048708 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002714 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00048708 2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme C00002714 0 / 0
O75496 Geminin Unclassified protein C00002762 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00002762 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00048708 4 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002762 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00048708 0 / 0
O00255 Menin Unclassified protein C00048708 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00048708 1 / 2

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002762
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00002762

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (18)

OMIM preferred title UniProt
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#119900 Digital clubbing, isolated congenital P15428
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (18)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)