PCIDB

Rubia cordifolia

Species

KNApSAcK Entry

Organism name Rubia cordifolia
Genus Rubia
Family Rubiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rubia cordifolia
Linked NCBI taxonomy ID 339321
Linked level species

Family

Family in NCBI taxonomy Rubiaceae
ID 24966

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002786 External link 512 Alizarin 2-methyl ether
/ 1-Hydroxy-2-methoxyanthraquinone
CHEMBL451977
6 / 9 / 11 No. 41 No. 62
C00002857 External link 512 Purpurin
CHEMBL294264
C410870
33 / 27 / 26 5 / 0 No. 41 No. 62

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10636 Microtubule-associated protein tau Unclassified protein C00002786 C00002857 4 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002786 C00002857 1 / 2
O00255 Menin Unclassified protein C00002786 C00002857 2 / 5
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002857 2 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00002857 0 / 0
P50281 Matrix metalloproteinase-14 M10A C00002857 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002857 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002857 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00002786 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00002857 4 / 2
Q9Y253 DNA polymerase eta Enzyme C00002857 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002857 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00002857 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00002857 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002857 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002857 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002857 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002857 3 / 3
P11473 Vitamin D3 receptor NR1I1 C00002857 2 / 3
O15118 Niemann-Pick C1 protein Unclassified protein C00002786 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00002857 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002857 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002857 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002857 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002857 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002857 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00002857 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002857 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002857 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002857 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00002857 1 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00002786 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002857 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002857 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00002857 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002857 1 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002857
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002857
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002857
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002857
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00002857

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P18054
Q14191
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P18054
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (27)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)