Species

KNApSAcK Entry

Organism name Lawsonia alba
Genus Lawsonia
Family Lythraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lythraceae
Linked NCBI taxonomy ID 3928
Linked level family

Family

Family in NCBI taxonomy Lythraceae
ID 3928

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00037409 External link 512 Lawsonin
/ (+)-Lawsonin
No. 78
C00037408 External link 512 Lawsonic acid
/ (+)-Lawsonic acid
CHEMBL451046
CHEMBL504666
No. 78
C00002837 External link 512 Lawsone
CHEMBL240963
C005090
16 / 12 / 13 1 / 3 No. 1047 No. 80

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00002837 0 / 0
P22894 Neutrophil collagenase M10A C00002837 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002837 2 / 2
P11473 Vitamin D3 receptor NR1I1 C00002837 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002837 0 / 0
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00002837 0 / 0
P03956 Interstitial collagenase M10A C00002837 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002837 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002837 0 / 0
P08253 72 kDa type IV collagenase M10A C00002837 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002837 2 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002837 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002837 4 / 3
P08254 Stromelysin-1 M10A C00002837 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002837 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002837 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00002837

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#600274 Frontotemporal dementia; ftd P10636
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (13)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005533 Foot Dermatoses C00002837
D006229 Hand Dermatoses C00002837
D010292 Paresthesia C00002837