Lawsonia inermis
Species
KNApSAcK Entry
| Organism name | Lawsonia inermis |
|---|---|
| Genus | Lawsonia |
| Family | Lythraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Lawsonia inermis |
|---|---|
| Linked NCBI taxonomy ID | 141191 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lythraceae |
|---|---|
| ID | 3928 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (38)
| Species | Activity |
|---|---|
| Lawsonia inermis L. | Abortifacient |
| Lawsonia inermis L. | Allergenic |
| Lawsonia inermis L. | Alterative |
| Lawsonia inermis L. | Anhyaluronidase |
| Lawsonia inermis L. | Antibacterial |
| Lawsonia inermis L. | Antiedemic |
| Lawsonia inermis L. | Antifertility |
| Lawsonia inermis L. | Antiinflammatory |
| Lawsonia inermis L. | Antileukokemic |
| Lawsonia inermis L. | Antiperspirant |
| Lawsonia inermis L. | Antipyretic |
| Lawsonia inermis L. | Antiseptic |
| Lawsonia inermis L. | Antispasmodic |
| Lawsonia inermis L. | Antiviral |
| Lawsonia inermis L. | Astringent |
| Lawsonia inermis L. | Candidicide |
| Lawsonia inermis L. | Cardiodepressant |
| Lawsonia inermis L. | Cerebrotonic |
| Lawsonia inermis L. | Diuretic |
| Lawsonia inermis L. | Emetic |
| Lawsonia inermis L. | Emmenagogue |
| Lawsonia inermis L. | Emollient |
| Lawsonia inermis L. | Expectorant |
| Lawsonia inermis L. | Fungicide |
| Lawsonia inermis L. | Hepatoprotective |
| Lawsonia inermis L. | Hypotensive |
| Lawsonia inermis L. | Nematicide |
| Lawsonia inermis L. | Nitrate-Reductase Inhibitor |
| Lawsonia inermis L. | Peroxidase Inhibitor |
| Lawsonia inermis L. | Propecic |
| Lawsonia inermis L. | Protopectinase Inhibitor |
| Lawsonia inermis L. | RT Inhibitor |
| Lawsonia inermis L. | Sedative |
| Lawsonia inermis L. | Soporific |
| Lawsonia inermis L. | Sunscreen |
| Lawsonia inermis L. | Tuberculostatic |
| Lawsonia inermis L. | Uterosedative |
| Lawsonia inermis L. | Vulnerary |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00037410
|
Laxanthone I
/ (+)-Laxanthone I |
No. 3 | No. 15 |
|
||||
|
C00002837
|
Lawsone
|
CHEMBL240963
|
C005090
|
16 / 12 / 13 | 1 / 3 | No. 1047 | No. 80 |
|
|
C00037411
|
Laxanthone II
|
No. 4442 |
|
|||||
|
C00037412
|
Laxanthone III
|
No. 4442 |
|
Human Protein / Gene in interactions
16 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00002837 | 0 / 0 |
| P22894 | Neutrophil collagenase | M10A | C00002837 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002837 | 2 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002837 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002837 | 0 / 0 |
| P14902 | Indoleamine 2,3-dioxygenase 1 | Enzyme | C00002837 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002837 | 0 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002837 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002837 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002837 | 1 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002837 | 2 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002837 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002837 | 4 / 3 |
| P08254 | Stromelysin-1 | M10A | C00002837 | 1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002837 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002837 | 0 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002837
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (12)
| OMIM | preferred title | UniProt |
|---|---|---|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|