Species

KNApSAcK Entry

Organism name Diospyros canaliculata
Genus Diospyros
Family Ebenaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Diospyros
Linked NCBI taxonomy ID 13492
Linked level genus

Family

Family in NCBI taxonomy Ebenaceae
ID 19955

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003749 External link 512 Lupeol
/ Lupenol
/ (+)-Lupenol
CHEMBL289191
CHEMBL459702
C010480
3 / 0 / 0 2 / 6 No. 23 No. 51
C00003740 External link 512 Betulin
CHEMBL23236
CHEMBL140040
CHEMBL1610940
CHEMBL2000891
CHEMBL2069124
C002503
18 / 16 / 17 0 / 2 No. 23 No. 51
C00003741 External link 512 Betulinic acid
CHEMBL269277
CHEMBL71690
CHEMBL519059
CHEMBL1318530
CHEMBL2005635
C002070
34 / 17 / 14 10 / 2 No. 23 No. 51
C00021224 External link 512 Betunal
/ (+)-Betunal
/ Betulinaldehyde
CHEMBL512622
CHEMBL476675
No. 23 No. 51
C00002852 External link 512 Plumbagin
/ Plumbagine
CHEMBL295316
C014758
28 / 30 / 59 14 / 3 No. 1047 No. 80
C00043490 External link 512 epi-Isoshinanolone
/ (+)-epi-Isoshinanolone
CHEMBL1094242
CHEMBL2023569
No. 1520
C00043426 External link 512 Cyclocanaliculatin
No. 7374

Human Protein / Gene in interactions

62 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11387 DNA topoisomerase 1 Isomerase C00002852 C00003740 C00003741 C00003749 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002852 C00003740 C00003741 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00003740 C00003741 C00003749 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00002852 C00003741 0 / 0
P05771 Protein kinase C beta type Alpha C00003740 C00003741 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003740 C00003741 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003740 C00003741 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002852 C00003740 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003740 C00003741 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003740 C00003741 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003740 C00003741 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003740 C00003741 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003740 C00003741 11 / 10
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003740 C00003741 1 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002852 C00003741 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003740 C00003741 0 / 1
Q02156 Protein kinase C epsilon type Eta C00003740 C00003741 0 / 0
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme C00003741 0 / 0
Q99558 Mitogen-activated protein kinase kinase kinase 14 Unique STE serine/threonine protein kinase C00002852 0 / 0
P54132 Bloom syndrome protein Enzyme C00002852 1 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00003740 3 / 1
P08047 Transcription factor Sp1 Unclassified protein C00003749 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00002852 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00002852 0 / 0
P29466 Caspase-1 C14 C00002852 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002852 0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00003741 0 / 0
O75496 Geminin Unclassified protein C00003741 0 / 0
P15121 Aldose reductase Enzyme C00003741 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003741 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003741 0 / 0
P06746 DNA polymerase beta Enzyme C00003741 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00003741 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00003741 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00002852 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003740 0 / 3
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003741 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00003741 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002852 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003741 2 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00003741 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002852 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002852 2 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003741 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002852 4 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00002852 0 / 0
P55210 Caspase-7 C14 C00002852 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002852 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003740 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002852 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002852 4 / 3
P04049 RAF proto-oncogene serine/threonine-protein kinase Raf C00002852 2 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00002852 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002852 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002852 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002852 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003741 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00003741 0 / 0
O00255 Menin Unclassified protein C00002852 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002852 1 / 2
Q9UBT2 SUMO-activating enzyme subunit 2 Enzyme C00003741 0 / 0
Q9UBE0 SUMO-activating enzyme subunit 1 Unclassified protein C00003741 0 / 0

23 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00002852 C00003741
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00002852 C00003741
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00002852 C00003741
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00003749
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00003741
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003741
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00003741
581 BAX, BCL2L4 BCL2-associated X protein C00003741
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003741
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003741
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00003749
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003741
2730 GCLM, GLCLR glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) C00002852
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00002852
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00002852
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00002852
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00002852
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00002852
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002852
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002852
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002852
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002852
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002852

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (50)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#611554 Leopard syndrome 2 P04049
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#611553 Noonan syndrome 5; ns5 P04049
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (73)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

13 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D008103 Liver Cirrhosis C00003741
D008545 Melanoma C00003741
D003110 Colonic Neoplasms C00003740
D064420 Drug-Related Side Effects and Adverse Reactions C00003740
D006528 Carcinoma, Hepatocellular C00003749
D009202 Cardiomyopathies C00003749
D006937 Hypercholesterolemia C00003749
D009374 Neoplasms, Experimental C00003749
D012878 Skin Neoplasms C00003749
D014947 Wounds and Injuries C00003749
D001284 Atrophy C00002852
D006968 Hypersensitivity, Delayed C00002852
D020244 Infarction, Middle Cerebral Artery C00002852