Toxylon pomiferum
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00029600
|
8-Deoxygartanin
|
CHEMBL488606
|
3 / 2 / 2 | No. 14 | No. 15 |
|
||
|
C00002947
|
6-Deoxyjacareubin
|
CHEMBL457949
|
No. 24 | No. 15 |
|
|||
|
C00002893
|
Oxyresveratrol
/ 2,3,4,5'-Tetrahydroxystilbene |
CHEMBL43065
|
20 / 32 / 49 | No. 295 | No. 13 |
|
Human Protein / Gene in interactions
23 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002893 | 7 / 37 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002893 | 0 / 3 |
| P39900 | Macrophage metalloelastase | M10A | C00002893 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002893 | 2 / 2 |
| P37840 | Alpha-synuclein | Unclassified protein | C00002893 | 4 / 2 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00002893 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002893 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002893 | 2 / 2 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002893 | 4 / 2 |
| P03956 | Interstitial collagenase | M10A | C00002893 | 0 / 1 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00029600 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00029600 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00002893 | 4 / 2 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00002893 | 4 / 4 |
| P45452 | Collagenase 3 | M10A | C00002893 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002893 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002893 | 1 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002893 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00029600 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002893 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00002893 | 1 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002893 | 1 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002893 | 1 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (34)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #133239 | Esophageal cancer |
P04637
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P37840
|
| #604229 | Peters anomaly |
Q16678
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
KEGG DISEASE (51)
| KEGG | name | UniProt |
|---|---|---|
| H00028 | Choriocarcinoma |
P03956
(related)
P04637 (related) P08253 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) P35354 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00066 | Lewy body dementia (LBD) |
P37840
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|