PCIDB

Cotinus spp.

Species

KNApSAcK Entry

Organism name Cotinus spp.
Genus Cotinus
Family Anacardiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cotinus
Linked NCBI taxonomy ID 263461
Linked level genus

Family

Family in NCBI taxonomy Anacardiaceae
ID 4011

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002933 External link 512 Pentagalloyl-beta-D-glucose
/ 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
/ (+)-1,2,3,4,6-Penta-O-galloyl-beta-D-glucose
CHEMBL127911
CHEMBL262173
CHEMBL206710
CHEMBL207164
CHEMBL382408
CHEMBL377052
CHEMBL425946
CHEMBL383306
CHEMBL207014
CHEMBL1224764
CHEMBL1500249
C013185
46 / 53 / 44 5 / 0 No. 302 No. 81
C00008026 External link 512 Sulfuretin
/ Sulphuretin
/ 6,3',4'-Trihydroxyaurone
CHEMBL490355
CHEMBL513487
C054989
42 / 37 / 34 No. 450 No. 13

Human Protein / Gene in interactions

74 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002933 C00008026 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00002933 C00008026 1 / 4
Q13951 Core-binding factor subunit beta Unclassified protein C00002933 C00008026 0 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00002933 C00008026 0 / 0
O00255 Menin Unclassified protein C00002933 C00008026 2 / 5
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002933 C00008026 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00002933 C00008026 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002933 C00008026 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002933 C00008026 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00002933 C00008026 4 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002933 C00008026 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00002933 C00008026 3 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002933 C00008026 1 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00002933 C00008026 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00008026 0 / 0
Q9HBX9 Relaxin receptor 1 Relaxin receptor C00008026 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00008026 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00008026 2 / 3
P47901 Vasopressin V1b receptor Vasopressin and oxytocin receptor C00008026 0 / 0
P39748 Flap endonuclease 1 Enzyme C00008026 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00002933 0 / 0
P42858 Huntingtin Unclassified protein C00002933 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00008026 2 / 0
O75496 Geminin Unclassified protein C00002933 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00008026 4 / 2
P00742 Coagulation factor X S1A C00002933 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00008026 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00008026 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00008026 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00008026 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00008026 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00002933 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00008026 1 / 2
P03951 Coagulation factor XI S1A C00002933 1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00008026 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00008026 0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00002933 5 / 4
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002933 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002933 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00008026 0 / 1
P56817 Beta-secretase 1 A1A C00002933 0 / 0
P08253 72 kDa type IV collagenase M10A C00008026 1 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002933 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00008026 1 / 1
Q8WXD0 Relaxin receptor 2 Relaxin receptor C00008026 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00008026 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00008026 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002933 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002933 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00002933 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00008026 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008026 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00002933 4 / 2
P04062 Glucosylceramidase Enzyme C00002933 6 / 4
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002933 1 / 1
P54132 Bloom syndrome protein Enzyme C00002933 1 / 2
O00487 26S proteasome non-ATPase regulatory subunit 14 Enzyme C00008026 0 / 0
P06746 DNA polymerase beta Enzyme C00002933 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002933 4 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00002933 0 / 0
Q05513 Protein kinase C zeta type Iota C00002933 0 / 0
Q04759 Protein kinase C theta type Delta C00002933 0 / 1
Q02156 Protein kinase C epsilon type Eta C00002933 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002933 0 / 0
P17252 Protein kinase C alpha type Alpha C00002933 0 / 0
Q05655 Protein kinase C delta type Delta C00002933 0 / 0
P05129 Protein kinase C gamma type Alpha C00002933 1 / 1
P05771 Protein kinase C beta type Alpha C00002933 0 / 0
P24723 Protein kinase C eta type Eta C00002933 1 / 0
P41743 Protein kinase C iota type Iota C00002933 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002933 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00008026 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00008026 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00008026 2 / 1

5 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00002933
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00002933
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00002933
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00002933
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00002933

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (77)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
P84022
Q14191
#219050 Cryptorchidism, unilateral or bilateral Q8WXD0
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#119900 Digital clubbing, isolated congenital P15428
#246200 Donohue syndrome P06213
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#612219 Ewing sarcoma; es P11308
#227600 Factor x deficiency P00742
#612416 Factor xi deficiency P03951
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#156250 Metachondromatosis; metcds Q06124
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#163950 Noonan syndrome 1; ns1 Q06124
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (62)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00938 Factor XI deficiency P03951 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00025 Penile cancer P08253 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00609 46,XY disorders of sex development (Other) Q8WXD0 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)