Species

KNApSAcK Entry

Organism name Dianthus caryophyllus L.
Genus Dianthus
Family Caryophyllaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Dianthus caryophyllus
Linked NCBI taxonomy ID 3570
Linked level species

Family

Family in NCBI taxonomy Caryophyllaceae
ID 3568

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Natural Activity

List (10)

Species Activity
Dianthus caryophyllus L. Alexeteric
Dianthus caryophyllus L. Allergenic
Dianthus caryophyllus L. Anthelminthic
Dianthus caryophyllus L. Anti-HIV
Dianthus caryophyllus L. Antiribosomal
Dianthus caryophyllus L. Antiviral
Dianthus caryophyllus L. Cardiotonic
Dianthus caryophyllus L. Diaphoretic
Dianthus caryophyllus L. Fungicide
Dianthus caryophyllus L. Vermifuge

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
CHEMBL445740
CHEMBL448700
2 / 3 / 7 No. 478 No. 38
C00029811 External link 512 Benzyl alcohol
/ (Hydroxymethyl)benzene
CHEMBL720
D019905
94 / 41 / 36 1 / 6 No. 885
C00036546 External link 512 3-Hexen-1-ol
No. 1746
C00030828 External link 512 Nonanal
/ n-Nonanal
C008664
1 / 1 No. 1993
C00019221 External link 512 Benzyl benzoate
CHEMBL1239
C006723
12 / 5 / 8 3 / 2 No. 2308
C00036488 External link 512 2-Hexanol
CHEMBL45425
C037076
No. 2707
C00000351 External link 512 trans-2-Hexenal
No. 2883
C00000357 External link 512 Hexanal
CHEMBL280331
C010463
7 / 0 No. 3593
C00000358 External link 512 n-Hexanol
CHEMBL14085
C036260
3 / 6 / 3 No. 3722
C00034452 External link 512 Benzaldehyde
CHEMBL15972
C032175
8 / 7 / 3 3 / 1 No. 6311

Human Protein / Gene in interactions

112 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000358 C00019221 C00029811 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003110 C00019221 1 / 2
P03372 Estrogen receptor NR3A1 C00029811 C00034452 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000358 C00029811 3 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00029811 C00034452 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00019221 C00029811 1 / 1
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00029811 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00029811 0 / 0
P29466 Caspase-1 C14 C00029811 0 / 0
P17252 Protein kinase C alpha type Alpha C00029811 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00029811 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00034452 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00029811 2 / 2
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00029811 1 / 0
P30556 Type-1 angiotensin II receptor Angiotensin receptor C00019221 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00000358 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00029811 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00029811 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00029811 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00029811 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00029811 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00029811 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00029811 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00029811 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00029811 0 / 0
P40925 Malate dehydrogenase, cytoplasmic Enzyme C00019221 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00029811 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00029811 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00029811 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00029811 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00029811 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00029811 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00029811 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00029811 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00029811 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00029811 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00029811 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00029811 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00029811 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00029811 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00029811 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00029811 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00034452 0 / 0
P08246 Neutrophil elastase S1A C00029811 2 / 1
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00034452 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00034452 2 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00029811 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00029811 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00029811 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00029811 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00029811 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00029811 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00029811 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00029811 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00029811 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00029811 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00029811 0 / 0
P10145 Interleukin-8 Secreted protein C00034452 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00029811 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00029811 0 / 0
P08311 Cathepsin G S1A C00029811 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00029811 1 / 0
P03956 Interstitial collagenase M10A C00029811 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00029811 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00029811 2 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00019221 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00019221 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00029811 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00029811 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00029811 0 / 0
P14679 Tyrosinase Oxidoreductase C00034452 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00029811 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00029811 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00029811 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00029811 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00029811 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00029811 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00029811 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00029811 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00019221 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00029811 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00029811 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00029811 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00029811 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00029811 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00029811 0 / 3
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00029811 1 / 0
P22303 Acetylcholinesterase Hydrolase C00029811 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00029811 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00029811 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00029811 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00029811 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00029811 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00029811 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00029811 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00029811 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00029811 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00029811 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00019221 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00029811 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00029811 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00029811 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00029811 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00029811 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00029811 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00029811 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00029811 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00029811 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00019221 1 / 1
O00255 Menin Unclassified protein C00003110 2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein C00019221 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00019221 1 / 4

10 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
231 AKR1B1, ADR, ALDR1, ALR2, AR aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) C00000357 C00029811 C00030828
217 ALDH2, ALDH-E2, ALDHI, ALDM aldehyde dehydrogenase 2 family (mitochondrial) (EC:1.2.1.3) C00000357 C00034452
221 ALDH3B1, ALDH4, ALDH7 aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) C00000357 C00034452
218 ALDH3A1, ALDH3, ALDHIII aldehyde dehydrogenase 3 family, member A1 (EC:1.2.1.5) C00000357 C00034452
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00019221
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00019221
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00019221
501 ALDH7A1, ATQ1, EPD, PDE aldehyde dehydrogenase 7 family, member A1 (EC:1.2.1.3 1.2.1.8 1.2.1.31) C00000357
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00000357
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000357

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (56)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#267430 Renal tubular dysgenesis; rtd P30556
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (51)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00575 Renal tubular dysgenesis P30556 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003877 Dermatitis, Contact C00019221
D012532 Scabies C00019221
D009336 Necrosis C00030828
D012640 Seizures C00034452
D001145 Arrhythmias, Cardiac C00029811
D017453 Dermatitis, Irritant C00029811
D004342 Drug Hypersensitivity C00029811
D007022 Hypotension C00029811
D010264 Paraplegia C00029811
D011843 Radiculopathy C00029811