Garcinia fusca
Species
KNApSAcK Entry
| Organism name | Garcinia fusca |
|---|---|
| Genus | Garcinia |
| Family | Clusiaceae / Clusiaceae-Guttiferae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Garcinia |
|---|---|
| Linked NCBI taxonomy ID | 58227 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Clusiaceae |
|---|---|
| ID | 55961 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002963
|
Mangostin
/ alpha-Mangostin |
CHEMBL323197
|
C021053
|
25 / 27 / 58 | 0 / 3 | No. 14 | No. 15 |
|
|
C00029819
|
beta-Mangostin
|
CHEMBL261706
|
3 / 0 / 0 | No. 14 | No. 15 |
|
||
|
C00030834
|
Norcowanin
|
CHEMBL463409
|
No. 14 | No. 15 |
|
|||
|
C00031249
|
Rubraxanthone
|
CHEMBL458846
|
C472155
|
No. 14 | No. 15 |
|
||
|
C00034821
|
Cowanin
|
CHEMBL458845
|
No. 14 | No. 15 |
|
|||
|
C00034822
|
Cowanol
|
CHEMBL463408
|
No. 14 | No. 15 |
|
|||
|
C00034823
|
Cowaxanthone
|
CHEMBL517161
|
No. 14 | No. 15 |
|
|||
|
C00034845
|
Fuscaxanthone C
|
CHEMBL464524
|
1 / 0 / 0 | No. 14 | No. 15 |
|
||
|
C00044771
|
Fuscaxanthone E
|
No. 14 | No. 15 |
|
||||
|
C00044772
|
Fuscaxanthone F
|
No. 14 | No. 15 |
|
||||
|
C00044770
|
Fuscaxanthone D
|
No. 14 | No. 15 |
|
||||
|
C00044768
|
Fuscaxanthone A
|
No. 44 |
|
|||||
|
C00044777
|
Garbogiol
|
No. 1835 |
|
|||||
|
C00044774
|
Fuscaxanthone H
|
No. 2081 |
|
|||||
|
C00044773
|
Fuscaxanthone G
|
No. 2081 |
|
|||||
|
C00044769
|
Fuscaxanthone B
|
No. 2081 |
|
Human Protein / Gene in interactions
25 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q04206 | Transcription factor p65 | Transcription Factor | C00002963 C00029819 C00034845 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00002963 C00029819 | 0 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00002963 C00029819 | 0 / 0 |
| Q00987 | E3 ubiquitin-protein ligase Mdm2 | Other nuclear protein | C00002963 | 1 / 5 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002963 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002963 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002963 | 2 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002963 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00002963 | 2 / 2 |
| O60906 | Sphingomyelin phosphodiesterase 2 | Enzyme | C00002963 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002963 | 2 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002963 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002963 | 1 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002963 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002963 | 2 / 2 |
| O14763 | Tumor necrosis factor receptor superfamily member 10B | Unclassified protein | C00002963 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002963 | 7 / 37 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002963 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002963 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002963 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002963 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002963 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002963 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002963 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002963 | 1 / 2 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (27)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614401 | Accelerated tumor formation, susceptibility to; actfs |
Q00987
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
O14763
P04637 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (58)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) Q00987 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
Q00987 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) Q00987 (related) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) Q00987 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00037 | Alveolar rhabdomyosarcoma |
Q00987
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|