Species

KNApSAcK Entry

Organism name Prunella vulgaris
Genus Prunella
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Prunella vulgaris
Linked NCBI taxonomy ID 39358
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (27)

Species Activity
Prunella vulgaris L. Alterative
Prunella vulgaris L. Analgesic
Prunella vulgaris L. Antiinflammatory
Prunella vulgaris L. Antimutagenic
Prunella vulgaris L. Antioxidant
Prunella vulgaris L. Antipyretic
Prunella vulgaris L. Antirheumatic
Prunella vulgaris L. Antiseptic
Prunella vulgaris L. Antispasmodic
Prunella vulgaris L. Antitumor
Prunella vulgaris L. Antiviral
Prunella vulgaris L. Astringent
Prunella vulgaris L. Bitter
Prunella vulgaris L. Carminative
Prunella vulgaris L. Collyrium
Prunella vulgaris L. COX-2 Iinhibitor
Prunella vulgaris L. Depurative
Prunella vulgaris L. Diuretic
Prunella vulgaris L. Emetic
Prunella vulgaris L. Expectorant
Prunella vulgaris L. Hemostat
Prunella vulgaris L. Hepatoprotective
Prunella vulgaris L. Hypotensive
Prunella vulgaris L. RT Inhibitor
Prunella vulgaris L. Stomachic
Prunella vulgaris L. Tonic
Prunella vulgaris L. Vulnerary

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00006751 External link 512 Hirsutin
No. 1 No. 15
C00006884 External link 512 Awobanin
/ Delphinidin-3-(6-O-p-coumarylglucoside)-5-glucoside
No. 7 No. 15
C00003558 External link 512 Ursolic acid
CHEMBL297810
CHEMBL56048
CHEMBL300594
CHEMBL169
CHEMBL176234
CHEMBL491715
CHEMBL1316667
CHEMBL1555307
CHEMBL1593360
CHEMBL1979720
C005466
47 / 26 / 33 15 / 12 No. 13 No. 51
C00003045 External link 512 Fenchone
/ (+)-Fenchone
C027327
No. 1921 No. 35

Human Protein / Gene in interactions

47 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003558 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003558 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003558 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003558 0 / 3
P06746 DNA polymerase beta Enzyme C00003558 0 / 0
Q13547 Histone deacetylase 1 Hydrolase C00003558 0 / 0
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00003558 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003558 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003558 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003558 11 / 10
P08047 Transcription factor Sp1 Unclassified protein C00003558 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003558 3 / 1
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00003558 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003558 0 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003558 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00003558 1 / 1
Q9UQL6 Histone deacetylase 5 Hydrolase C00003558 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003558 0 / 0
P15121 Aldose reductase Enzyme C00003558 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003558 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00003558 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003558 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003558 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003558 2 / 2
Q96RI1 Bile acid receptor NR1H4 C00003558 0 / 0
O15379 Histone deacetylase 3 Hydrolase C00003558 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00003558 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003558 0 / 0
P56524 Histone deacetylase 4 Hydrolase C00003558 1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003558 0 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00003558 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003558 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003558 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003558 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003558 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00003558 0 / 1
Q9UBN7 Histone deacetylase 6 Hydrolase C00003558 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00003558 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003558 1 / 1
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00003558 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003558 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003558 1 / 0
O00255 Menin Unclassified protein C00003558 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003558 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00003558 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00003558 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00003558 0 / 0

15 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003558
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00003558
581 BAX, BCL2L4 BCL2-associated X protein C00003558
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00003558
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003558
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003558
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00003558
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003558
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003558
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00003558
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003558
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003558
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00003558
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003558
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003558

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600430 Brachydactyly-mental retardation syndrome; bdmr P56524
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (33)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00408 Type I diabetes mellitus P17706 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00561 Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome P56524 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

12 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001284 Atrophy C00003558
D006528 Carcinoma, Hepatocellular C00003558
D002471 Cell Transformation, Neoplastic C00003558
D003921 Diabetes Mellitus, Experimental C00003558
D006943 Hyperglycemia C00003558
D006949 Hyperlipidemias C00003558
D006965 Hyperplasia C00003558
D007249 Inflammation C00003558
D008103 Liver Cirrhosis C00003558
D017202 Myocardial Ischemia C00003558
D009369 Neoplasms C00003558
D012878 Skin Neoplasms C00003558