Species

KNApSAcK Entry

Organism name Mentha arvensis
Genus Mentha
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Mentha arvensis
Linked NCBI taxonomy ID 292239
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (11)

Species Activity
Mentha arvensis L. Analgesic
Mentha arvensis L. Antibacterial
Mentha arvensis L. Antiitch
Mentha arvensis L. Antipyretic
Mentha arvensis L. Antiseptic
Mentha arvensis L. Carminative
Mentha arvensis L. Cholagogue
Mentha arvensis L. Detoxicant
Mentha arvensis L. Secretolytic
Mentha arvensis L. Stimulant
Mentha arvensis L. Tonic

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00010895 External link 512 (1R,2R,4R,5S)-(+)-p-Menthane-2,5-diol
No. 901 No. 35
C00003047 External link 512 Linalool
/ (R)-linalool
/ (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol
CHEMBL25306
CHEMBL235672
C018584
6 / 8 / 2 35 / 4 No. 958 No. 34
C00010901 External link 512 (-)-Carvomenthone
No. 1288 No. 35
C00010807 External link 512 2-Isopropylcyclopentanone
No. 1288 No. 35
C00010902 External link 512 (+)-Isomenthone
CHEMBL276311
CHEMBL1719455
1 / 0 / 0 No. 1288 No. 35
C00010904 External link 512 (-)-Isomenthone
CHEMBL276311
CHEMBL1719455
1 / 0 / 0 No. 1288 No. 35

Human Protein / Gene in interactions

7 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q92830 Histone acetyltransferase KAT2A Enzyme C00010902 C00010904 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003047 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00003047 3 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00003047 3 / 1
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00003047 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00003047 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003047 5 / 1

35 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00003047
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00003047
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC:2.3.1.48) C00003047
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00003047
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003047
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003047
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00003047
1028 CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 cyclin-dependent kinase inhibitor 1C (p57, Kip2) C00003047
1030 CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) C00003047
1447 CSN2, CASB casein beta C00003047
1509 CTSD, CLN10, CPSD cathepsin D (EC:3.4.23.5) C00003047
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003047
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00003047
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003047
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00003047
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00003047
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00003047
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00003047
3297 HSF1, HSTF1 heat shock transcription factor 1 C00003047
3320 HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 C00003047
3308 HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY heat shock 70kDa protein 4 C00003047
3316 HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP heat shock 27kDa protein 2 C00003047
3398 ID2, GIG8, ID2A, ID2H, bHLHb26 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein C00003047
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00003047
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00003047
8850 KAT2B, CAF, P, P/CAF, PCAF K(lysine) acetyltransferase 2B (EC:2.3.1.48) C00003047
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00003047
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00003047
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00003047
4852 NPY, PYY4 neuropeptide Y C00003047
100124292 C00003047
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00003047
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00003047
7471 WNT1, BMND16, INT1, OI15 wingless-type MMTV integration site family, member 1 C00003047
26118 WSB1, SWIP1, WSB-1 WD repeat and SOCS box containing 1 C00003047

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#143500 Gilbert syndrome P22309
P22310
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (2)

KEGG name UniProt
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00208 Hyperbilirubinemia P22309 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D017453 Dermatitis, Irritant C00003047
D006937 Hypercholesterolemia C00003047
D007938 Leukemia C00003047
D009369 Neoplasms C00003047