Cosmos sulphureus
Species
KNApSAcK Entry
| Organism name | Cosmos sulphureus |
|---|---|
| Genus | Cosmos |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cosmos sulphureus |
|---|---|
| Linked NCBI taxonomy ID | 459758 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00007218
|
Coreopsin
|
No. 36 | No. 13 |
|
||||
|
C00003240
|
Costunolide
|
CHEMBL86416
CHEMBL190377 CHEMBL1575037 |
C002602
|
10 / 7 / 15 | 0 / 3 | No. 107 | No. 38 |
|
|
C00008026
|
Sulfuretin
/ Sulphuretin / 6,3',4'-Trihydroxyaurone |
CHEMBL490355
CHEMBL513487 |
C054989
|
42 / 37 / 34 | No. 450 | No. 13 |
|
Human Protein / Gene in interactions
48 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | C00003240 C00008026 | 2 / 3 |
| O00255 | Menin | Unclassified protein | C00003240 C00008026 | 2 / 5 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00003240 C00008026 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003240 C00008026 | 1 / 2 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00008026 | 0 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00008026 | 3 / 1 |
| Q9HBX9 | Relaxin receptor 1 | Relaxin receptor | C00008026 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00008026 | 1 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00008026 | 0 / 0 |
| P47901 | Vasopressin V1b receptor | Vasopressin and oxytocin receptor | C00008026 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00008026 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00008026 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00008026 | 2 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00008026 | 4 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00008026 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00008026 | 7 / 3 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003240 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00008026 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00008026 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00008026 | 3 / 1 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00008026 | 1 / 2 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00008026 | 1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00008026 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00008026 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00008026 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00008026 | 1 / 3 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00008026 | 1 / 1 |
| Q8WXD0 | Relaxin receptor 2 | Relaxin receptor | C00008026 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00008026 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003240 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00008026 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00008026 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00008026 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00008026 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00008026 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003240 | 0 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00008026 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003240 | 1 / 1 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00008026 | 0 / 0 |
| O00487 | 26S proteasome non-ATPase regulatory subunit 14 | Enzyme | C00008026 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00008026 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00008026 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00008026 | 1 / 4 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | C00003240 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003240 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00008026 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00008026 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00008026 | 2 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (39)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #219050 | Cryptorchidism, unilateral or bilateral |
Q8WXD0
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (38)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P35354 (related) |
| H00028 | Choriocarcinoma |
P08253
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
Q8WXD0
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|