Species

KNApSAcK Entry

Organism name Lactuca sativa L.
Genus Lactuca
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lactuca sativa
Linked NCBI taxonomy ID 4236
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00012170 External link 512 Melampolide
CHEMBL86416
CHEMBL190377
CHEMBL1575037
10 / 7 / 15 No. 107 No. 38
C00034019 External link 512 Lactuside C
No. 212
C00029376 External link 512 11beta,13-Dihydrolactucin
No. 298 No. 38
C00034017 External link 512 Lactucin-15-oxalate
No. 596 No. 38
C00033534 External link 512 15-p-Hydroxyphenylacetyl-lactucin-8-sulfate
No. 2969 No. 38
C00003312 External link 512 Lactupicrin
/ Lactucopicrin
/ (+)-Lactucopicrin
No. 2969 No. 38
C00034018 External link 512 Lactucopicrin-15-oxalate
No. 2969 No. 38
C00033530 External link 512 15-Deoxylactucin-8-sulfate
No. 5275

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00012170 0 / 3
P11473 Vitamin D3 receptor NR1I1 C00012170 2 / 3
Q04206 Transcription factor p65 Transcription Factor C00012170 0 / 0
P03372 Estrogen receptor NR3A1 C00012170 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00012170 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00012170 1 / 1
O00255 Menin Unclassified protein C00012170 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00012170 1 / 2
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor C00012170 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00012170 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#615363 Estrogen resistance; estrr P03372
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (15)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)