Croton zambesicus
Species
KNApSAcK Entry
| Organism name | Croton zambesicus |
|---|---|
| Genus | Croton |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Croton zambesicus |
|---|---|
| Linked NCBI taxonomy ID | 323089 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003737
|
alpha-Amyrin
/ alpha-Amyrine / alpha-Amyrenol |
No. 23 | No. 51 |
|
||||
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023770
|
Sitosterol
/ Stigmasta-5,22-dien-3beta-ol / (24R)24-Ethylcholesta-5,22-dien-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00003674
|
Stigmasterol
/ beta-Stigmasterol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00034864
|
Isopimara-7,15-dien-3beta-ol
/ (-)-Isopimara-7,15-dien-3beta-ol |
CHEMBL225866
|
No. 208 | No. 48 |
|
|||
|
C00038866
|
Crotonadiol
/ (+)-Crotonadiol |
No. 347 |
|
|||||
|
C00003467
|
Phytol
/ trans-Phytol |
CHEMBL390773
CHEMBL1644111 |
D010836
|
0 / 5 | No. 641 | No. 38 |
|
|
|
C00036945
|
Crotozambefuran C
/ (-)-Crotozambefuran C |
No. 731 |
|
|||||
|
C00036942
|
Crotocorylifuran
/ (-)-Crotocorylifuran |
No. 731 |
|
|||||
|
C00036943
|
Crotozambefuran A
/ (-)-Crotozambefuran A |
No. 731 |
|
|||||
|
C00037924
|
Trachyloban-7beta,18-diol
|
No. 2921 |
|
|||||
|
C00035605
|
ent-Trachyloban-3-one
|
CHEMBL461825
|
No. 2921 |
|
||||
|
C00036644
|
7beta-Acetoxytrachyloban-18-oic acid
|
CHEMBL497899
|
No. 4025 |
|
||||
|
C00036944
|
Crotozambefuran B
/ (-)-Crotozambefuran B |
No. 7136 |
|
Human Protein / Gene in interactions
22 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00003674 C00023770 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00003749 C00023770 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00023770 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 C00023770 | 1 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00023770 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 C00023770 | 3 / 2 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 C00023770 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 C00023770 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 C00023770 | 2 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 C00023770 | 1 / 1 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003674 C00003749 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00023770 | 1 / 1 |
| P00734 | Prothrombin | S1A | C00003672 C00023770 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00023770 | 4 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00023770 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 C00023770 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 C00023770 | 0 / 1 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00023770 | 0 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00003674 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003749 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00003674 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003674 | 0 / 0 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00003674
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (12)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006528 | Carcinoma, Hepatocellular |
C00003749
|
| D009202 | Cardiomyopathies |
C00003749
|
| D006937 | Hypercholesterolemia |
C00003749
|
| D009374 | Neoplasms, Experimental |
C00003749
|
| D012878 | Skin Neoplasms |
C00003749
|
| D014947 | Wounds and Injuries |
C00003749
|
| D056486 | Drug-Induced Liver Injury |
C00003467
|
| D006965 | Hyperplasia |
C00003467
|
| D006984 | Hypertrophy |
C00003467
|
| D009336 | Necrosis |
C00003467
|
| D015431 | Weight Loss |
C00003467
|