KEGG ORTHOLOGY: K04467

ORTHOLOGY: K04467

Entry

K04467                      KO

Symbol

IKBKA, IKKA, CHUK

Name

inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]

Pathway

map01523

Antifolate resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04068

FoxO signaling pathway

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04625

C-type lectin receptor signaling pathway

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map04668

TNF signaling pathway

map04920

Adipocytokine signaling pathway

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05135

Yersinia infection

map05142

Chagas disease

map05145

Toxoplasmosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05212

Pancreatic cancer

map05215

Prostate cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

map05222

Small cell lung cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Disease

H00882

Cocoon syndrome

H01931

Lethal-type popliteal pterygium syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04014 Ras signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04064 NF-kappa B signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04668 TNF signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04068 FoxO signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04151 PI3K-Akt signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04150 mTOR signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04621 NOD-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04622 RIG-I-like receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04623 Cytosolic DNA-sensing pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04625 C-type lectin receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04660 T cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04658 Th1 and Th2 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04659 Th17 cell differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04657 IL-17 signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04662 B cell receptor signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   04062 Chemokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05208 Chemical carcinogenesis - reactive oxygen species
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05221 Acute myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05220 Chronic myeloid leukemia
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05215 Prostate cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05222 Small cell lung cancer
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05170 Human immunodeficiency virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05161 Hepatitis B
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05160 Hepatitis C
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05171 Coronavirus disease - COVID-19
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05164 Influenza A
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05162 Measles
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05168 Herpes simplex virus 1 infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05163 Human cytomegalovirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05169 Epstein-Barr virus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05165 Human papillomavirus infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05130 Pathogenic Escherichia coli infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05132 Salmonella infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05131 Shigellosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05135 Yersinia infection
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05142 Chagas disease
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
   05418 Fluid shear stress and atherosclerosis
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  IKK family [OT]
   K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha

Other DBs

GO:

0008384

Genes

HSA:	1147(CHUK)

PTR:	450673(CHUK)

PPS:	100995228(CHUK)

GGO:	101137405(CHUK)

PON:	100174735(CHUK)

PPYG:

129006790(CHUK)

NLE:	100596225(CHUK)

HMH:	116485121(CHUK)

SSYN:

129467595(CHUK)

MCC:	709511(CHUK)

MCF:	102115964(CHUK)

MTHB:

126963067

MNI:	105478402(CHUK)

CSAB:

103216382(CHUK)

CATY:

105581830(CHUK)

PANU:

100998877(CHUK)

TGE:	112632013(CHUK)

MLEU:

105537745(CHUK)

RRO:	104656469(CHUK)

RBB:	108535077(CHUK)

TFN:	117068535(CHUK)

PTEH:

111538794(CHUK)

CANG:

105507149(CHUK)

SBQ:	101044006(CHUK)

CIMI:

108306378(CHUK)

ANAN:

105708229(CHUK)

CSYR:

103263189(CHUK)

MMUR:

105867131 105873508(CHUK)

LCAT:

123650134(CHUK)

PCOQ:

105824261(CHUK)

OGA:	100949554(CHUK)

MMU:	12675(Chuk)

MCAL:

110285285(Chuk)

MPAH:

110334538(Chuk)

RNO:	309361(Chuk)

MCOC:

116103881(Chuk)

ANU:	117701914 117712831(Chuk)

MUN:	110544653 110552966(Chuk)

CGE:	100754432(Chuk)

MAUA:

101837015(Chuk)

PROB:

127233576(Chuk)

PLEU:

114706431(Chuk)

MORG:

121454691(Chuk)

MFOT:

126504083

AAMP:

119816335(Chuk)

NGI:	103743976(Chuk)

HGL:	101719306(Chuk)

CPOC:

100726357(Chuk)

CCAN:

109681514(Chuk)

DORD:

105986731(Chuk)

DSP:	122115917(Chuk)

PLOP:

125346167(Chuk)

NCAR:

124985256

MMMA:

107149793(Chuk)

OCU:

100355888

OPI:	101536073(CHUK)

TUP:	102501308(CHUK)

GVR:	103588798(CHUK)

CFA:	477796(CHUK)

CLUD:

112672189(CHUK)

VVP:	112914804(CHUK)

VLG:	121484113(CHUK)

NPO:	129493669(CHUK)

AML:	100464675(CHUK)

UMR:	103658916(CHUK)

UAH:	113251823(CHUK)

UAR:	123795860(CHUK)

ELK:

111144921

LLV:

125084339

MPUF:

101680658(CHUK)

MNP:	132016695(CHUK)

MLK:	131828549(CHUK)

NVS:	122901015(CHUK)

ORO:	101364103(CHUK)

EJU:	114205217(CHUK)

ZCA:	113923411(CHUK)

MLX:	118024839(CHUK)

NSU:	110589216(CHUK)

LWW:	102728853(CHUK)

FCA:	101095617(CHUK)

PYU:	121037105(CHUK)

PCOO:

112854253(CHUK)

PBG:	122493134(CHUK)

PVIV:

125147812(CHUK)

LRUF:

124507057

PTG:	102949289(CHUK)

PPAD:

109272766(CHUK)

PUC:

125932873

AJU:

106966935

HHV:	120243217(CHUK)

BTA:	281073(CHUK)

BOM:	102281886(CHUK)

BIU:	109553086(CHUK)

BBUB:

102399613(CHUK)

BBIS:

105002719(CHUK)

CHX:	102181262(CHUK)

OAS:	101111143(CHUK)

BTAX:

128067677(CHUK)

ODA:	120873530(CHUK)

CCAD:

122446045(CHUK)

MBEZ:

129555451(CHUK)

SSC:	100135662(CHUK)

CFR:	102503497(CHUK)

CBAI:

105081887(CHUK)

CDK:	105084316(CHUK)

VPC:	102534431(CHUK)

BACU:

103015414(CHUK)

BMUS:

118883002(CHUK)

LVE:	103085220(CHUK)

OOR:	101281072(CHUK)

DLE:	111172396(CHUK)

PCAD:

102977668(CHUK)

PSIU:

116741676(CHUK)

NASI:

112392983(CHUK)

ECB:	100070393(CHUK)

EPZ:	103567228(CHUK)

EAI:	106846705(CHUK)

MYB:	102261467(CHUK)

MYD:	102760888(CHUK)

MMYO:

118669852(CHUK)

MLF:	102425603(CHUK)

PKL:	118719404(CHUK)

EFUS:

103288473(CHUK)

MNA:	107542599(CHUK)

DRO:	112300474(CHUK)

SHON:

118999523(CHUK)

AJM:	119064546(CHUK)

PDIC:

114496345(CHUK)

PHAS:

123828668(CHUK)

MMF:	118632312(CHUK)

PPAM:

129077110(CHUK)

HAI:	109379632(CHUK)

RFQ:	117036177(CHUK)

PALE:

102879469(CHUK)

PGIG:

120609204(CHUK)

PVP:	105304619(CHUK)

RAY:	107499756(CHUK)

MJV:	108409586(CHUK)

TOD:	119233588(CHUK)

SARA:

101538389(CHUK)

SETR:

126033816(CHUK)

LAV:	100664361(CHUK)

TMU:

101341290

ETF:	101649582(CHUK)

DNM:	101429772(CHUK)

MDO:	100027952(CHUK)

GAS:	123236476(CHUK)

SHR:	100913624(CHUK)

PCW:	110213919(CHUK)

TVP:	118828849(CHUK)

OAA:	100082351(CHUK)

GGA:	423669(CHUK)

PCOC:

116234780(CHUK)

MGP:	100542478(CHUK)

CJO:	107315625(CHUK)

TPAI:

128078052(CHUK)

LMUT:

125693118(CHUK)

NMEL:

110390496(CHUK)

APLA:

119717337(CHUK)

ACYG:

106030064(CHUK)

CATA:

118247527(CHUK)

AFUL:

116491240(CHUK)

TGU:	100221281(CHUK)

LSR:	110474031(CHUK)

SCAN:

103814234(CHUK)

PMOA:

120499710(CHUK)

OTC:	121336198(CHUK)

PRUF:

121358096(CHUK)

GFR:	102042264(CHUK)

FAB:	101812706(CHUK)

OMA:	130255162(CHUK)

PHI:	102107801(CHUK)

PMAJ:

107206726(CHUK)

CCW:	104695067(CHUK)

CBRC:

103615287(CHUK)

ETL:	114067570(CHUK)

ZAB:	102074629(CHUK)

ZLE:	135449409(CHUK)

ACHL:

103805825(CHUK)

SVG:	106856724(CHUK)

MMEA:

130582408

HRT:	120755651(CHUK)

FCH:	102053491(CHUK)

CLV:	102084658(CHUK)

EGZ:	104125140(CHUK)

PCRI:

104039002(CHUK)

PLET:

104620793(CHUK)

EHS:	104507608(CHUK)

PCAO:

104041028(CHUK)

ACUN:

113481883(CHUK)

TALA:

104364060(CHUK)

PADL:

103924297(CHUK)

AFOR:

103895497

ACHC:

115348471(CHUK)

HALD:

104315548(CHUK)

HLE:	104833467(CHUK)

AGEN:

126043236

GCL:

127017902

CCRI:

104165202(CHUK)

CSTI:

104549225(CHUK)

CMAC:

104482587(CHUK)

MUI:	104546789(CHUK)

BREG:

104642304(CHUK)

FGA:	104069270(CHUK)

GSTE:

104260485(CHUK)

LDI:	104352921(CHUK)

MNB:	103769846(CHUK)

OHA:	104330387(CHUK)

NNT:	104406104(CHUK)

SHAB:

115609102(CHUK)

DPUB:

104302590(CHUK)

PGUU:

104457773(CHUK)

CPEA:

104397776(CHUK)

AVIT:

104267618(CHUK)

CVF:	104283555(CHUK)

RTD:	128911744(CHUK)

CUCA:

104060058(CHUK)

TEO:	104380199(CHUK)

BRHI:

104488253(CHUK)

AAM:	106495295(CHUK)

AROW:

112962239(CHUK) 112977217

NPD:	112948431(CHUK)

TGT:	104567814(CHUK)

DNE:

112981613

SCAM:

104149540(CHUK)

ASN:	102374729(CHUK)

AMJ:	106736873(CHUK)

CPOO:

109318435(CHUK)

GGN:	109293915(CHUK)

PSS:	102454064(CHUK)

CMY:	102932800(CHUK)

CCAY:

125640184(CHUK)

DCC:	119858630(CHUK)

CPIC:

101931080(CHUK)

TST:	117879818(CHUK)

CABI:

116834403(CHUK)

MRV:	120368653(CHUK)

ACS:	100565922(chuk)

ASAO:

132771394(CHUK)

PVT:	110087236(CHUK)

SUND:

121925441(CHUK)

PBI:	103061898(CHUK)

PMUR:

107291445(CHUK) 114923654

CTIG:

120309925(CHUK)

TSR:	106548462(CHUK)

PGUT:

117667309 132709271(CHUK)

APRI:

131199180(CHUK)

PTEX:

113449389(CHUK)

NSS:	113425188(CHUK)

VKO:	123018301(CHUK)

PMUA:

114596983(CHUK)

PRAF:

128413638(CHUK)

ZVI:	118096210(CHUK)

HCG:	128350445(CHUK)

GJA:	107117758(CHUK)

STOW:

125437877(CHUK)

EMC:	129332264(CHUK)

XLA:	444556(chuk.S)

XTR:	549654(chuk)

NPR:	108797654(CHUK)

RTEM:

120909050(CHUK)

BBUF:

121003342(CHUK)

BGAR:

122939970(CHUK)

MUO:	115470218(CHUK)

GSH:	117358706(CHUK)

DRE:	393287(chuk)

SRX:	107726965 107743510

SANH:

107655432(chuk) 107666359

SGH:	107559325 107601877

CCAR:

109092137 109100658(chuk)

CAUA:

113056969 113112701

CGIB:

127970460 128026207

PTET:

122356355(chuk)

LROH:

127175327(chuk)

OMC:	131552635(chuk)

PPRM:

120479686(chuk)

RKG:	130089640(chuk)

MAMB:

125276913(chuk)

CIDE:

127524669

MASI:

127412362 127413967

TROS:

130559223(chuk)

TDW:	130431939(chuk)

MANU:

129416144(chuk)

IPU:

108263650

IFU:	128605794(chuk)

PHYP:

113542836(chuk)

SMEO:

124396202(chuk)

TFD:	113636298(chuk)

TVC:	132847409(chuk)

TRN:	134314813(chuk)

AMEX:

103033415(chuk)

CMAO:

118810516 118810719

EEE:	113582078(chuk)

CHAR:

105902233 105903749(chuk)

TRU:	101068225 101069880

TFS:	130533672 130538131(chuk)

TNG:	GSTEN00022283G001 GSTEN00030651G001

LCO:	104928982 104930409

NCC:	104960684 104961343

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117247242 117247863

EFO:	125880386 125903733

PLEP:

121954423 121958640

SLUC:

116053123 116060936

ECRA:

117936511 117960217

ESP:	116670894 116705198

PFLV:

114548159 114571888

GAT:	120819606 120820624

PPUG:

119213096 119214000

AFB:	129091327 129092009

CLUM:

PSWI:

MSAM:

SCHU:

CUD:	121511183 121528381

ALAT:

119010013 119033964

MZE:	101486267 101487089

ONL:	100692869 100698148

OAU:	116321245 116322782

OLA:	101159621 101171857

OML:	112154264(chuk) 112162018

CSAI:

133419240 133463692

XMA:	102221657 102226088

XCO:	114138537 114151890

XHE:	116713354 116727210

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122823466 122842298

PPRL:

129368162(chuk)

CVG:	107086576 107089566

CTUL:

119782488 119790655

GMU:	124858595 124875252

NFU:	107375593 107387313(chuk)

KMR:	108234021 108250658

ALIM:

106521989(chuk) 106533626

NWH:	119418051 119424196

AOCE:

111567460 111581409

MCEP:

125018358 125022650

CSEM:

103387400 103398848

POV:	109629542 109644018

SSEN:

122759323 122782266

HHIP:

117753178 117775975

HSP:	118100852 118118677

PPLT:

128427368 128453181

SMAU:

118283502 118287850

LCF:	108891107 108892003

SDU:	111220255 111234378

SLAL:

111655428 111658207

XGL:	120794257 120796054

HCQ:	109516272 109518553

SSCV:

125978312 125991640

SBIA:

133495343 133509979

PEE:	133410156 133417719

PTAO:

133469133 133485849

BPEC:

110154188 110157171

MALB:

109961044 109962729(kctd2)

BSPL:

114845361 114870842

SJO:	128372978 128381630

SASA:

106579286 106579422 106589264

STRU:

115158948 115162780 115201018

OTW:	112223622 112223895 112224128

OMY:	110491527 110491813 110499151

OGO:	124039858 124048289 124048544

ONE:	115106499 115106755 115143915

OKI:	109865430 109865571 109869960

OKE:	118357674 118363556 118366609

SALP:

111967645 111978057 111978258

SNH:	120029505 120046219 120046430

CCLU:

121542592 121547254 121568297

ELS:	105006906 105010696

SFM:	108933554(chuk)

PKI:	111836749(chuk)

AANG:

118220615(chuk)

LOC:	102691336(chuk)

PSPA:

121321809(chuk)

ARUT:

117416037(chuk)

PSEX:

120541713(chuk)

LCM:	102361819(CHUK)

CMK:	103181859(chuk)

RTP:	109918795(chuk)

CPLA:

122541851(chuk)

HOC:	132835109(chuk)

LERI:

129712925(chuk)

SCLV:

120347579

LPIC:

129282029

ARUN:

117304139

SKO:	100375591 102806810

BPYO:

FVI:

OBB:

OLG:

NMEA:

CGIG:

VPS:

VCRB:

CSOL:

MDL:

AGIF:

VCAN:

AGB:

NLU:

MQU:

FOC:

ZNE:

CSEC:

BROR:

IEL:

FCD:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

MNZ:

LSM:

TCF:

DSV:

RSAN:

RMP:

ABRU:

SDM:

HRO:	HELRODRAFT_191565

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:	105343370 105343371

CANU:

128165598 128165600

CVN:	111120947 111121090

OED:	125668035 125670715

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

LAK:

LLON:

EPA:

ATEN:

HMG:

RES:

TAD:	TRIADDRAFT_62259

» show all

Reference

PMID:9244310

Authors

Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M

Title

Identification and characterization of an IkappaB kinase.

Journal

Cell 90:373-83 (1997)
DOI:10.1016/S0092-8674(00)80344-X

Sequence

[hsa:1147]

Reference

PMID:20501937

Authors

Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G

Title

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.

Journal

Sci Signal 3:ra41 (2010)
DOI:10.1126/scisignal.2000778

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (106)   
   KEGG PATHWAY (106)   
Disease (2)   
   KEGG DISEASE (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1026)   
   KEGG GENES (566)   
   KEGG MGENES (237)   
   RefGene (217)   
   OC (6)   
Literature (2)   
   PubMed (2)   
All databases (1141)   

Download RDF

ORTHOLOGY: K07210

Entry

K07210                      KO

Symbol

IKBKG, IKKG, NEMO

Name

inhibitor of nuclear factor kappa-B kinase subunit gamma

Pathway

map01523

Antifolate resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04625

C-type lectin receptor signaling pathway

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map04668

TNF signaling pathway

map04920

Adipocytokine signaling pathway

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05135

Yersinia infection

map05142

Chagas disease

map05145

Toxoplasmosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05203

Viral carcinogenesis

map05208

Chemical carcinogenesis - reactive oxygen species

map05212

Pancreatic cancer

map05215

Prostate cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

map05222

Small cell lung cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05340

Primary immunodeficiency

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Disease

H00089

IFN-gamma/IL-12 axis

H00095

Ectodermal dysplasia and immunodeficiency

H00540

Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)

H00645

Incontinentia pigmenti

H01245

Immunodeficiency without anhidrotic ectodermal dysplasia

H02621

X-linked systemic autoinflammatory disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04014 Ras signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04064 NF-kappa B signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04668 TNF signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04151 PI3K-Akt signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04621 NOD-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04622 RIG-I-like receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04623 Cytosolic DNA-sensing pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04625 C-type lectin receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04660 T cell receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04658 Th1 and Th2 cell differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04659 Th17 cell differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04657 IL-17 signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04662 B cell receptor signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   04062 Chemokine signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05208 Chemical carcinogenesis - reactive oxygen species
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05203 Viral carcinogenesis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05221 Acute myeloid leukemia
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05220 Chronic myeloid leukemia
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05215 Prostate cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05222 Small cell lung cancer
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05170 Human immunodeficiency virus 1 infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05161 Hepatitis B
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05160 Hepatitis C
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05171 Coronavirus disease - COVID-19
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05164 Influenza A
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05162 Measles
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05168 Herpes simplex virus 1 infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05163 Human cytomegalovirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05169 Epstein-Barr virus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05165 Human papillomavirus infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05130 Pathogenic Escherichia coli infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05132 Salmonella infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05131 Shigellosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05135 Yersinia infection
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05142 Chagas disease
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09163 Immune disease
   05340 Primary immunodeficiency
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
   05418 Fluid shear stress and atherosclerosis
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  IKK family [OT]
   K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma

Genes

HSA:	8517(IKBKG)

PTR:	100609537(IKBKG) 100610002

PPS:	100987483(IKBKG) 117977645

GGO:	101145841(IKBKG) 115932121

PON:	100449496(IKBKG)

PPYG:

129023798(IKBKG)

NLE:	100603768(IKBKG)

HMH:	116464818(IKBKG)

SSYN:

129476172(IKBKG)

MCC:	701237(IKBKG)

MCF:	102115368(IKBKG) 135964355

MTHB:

126945470

MNI:

105471007

CSAB:

103232832(IKBKG)

CATY:

105573773(IKBKG)

TGE:	112616513(IKBKG) 112616847

MLEU:

105534277(IKBKG)

RRO:	104667046(IKBKG)

RBB:	108518784(IKBKG)

TFN:	117078341(IKBKG)

CANG:

105527033(IKBKG)

CJC:	100390258(IKBKG)

SBQ:	101043425(IKBKG)

CIMI:

108298093(IKBKG)

ANAN:

105727270(IKBKG)

CSYR:

103255498(IKBKG)

MMUR:

105867816(IKBKG)

LCAT:

123628501(IKBKG)

PCOQ:

105824538(IKBKG)

OGA:	100958883(IKBKG)

MMU:	16151(Ikbkg)

MCAL:

110287188(Ikbkg)

MPAH:

110313464(Ikbkg)

RNO:	309295(Ikbkg)

MCOC:

116086280(Ikbkg)

ANU:	117695513(Ikbkg)

MUN:	110562528(Ikbkg)

CGE:	100759762(Ikbkg)

MAUA:

101824046(Ikbkg)

PROB:

127217362(Ikbkg)

PLEU:

114706175(Ikbkg)

MORG:

121437198 121440264

MFOT:

126490256

AAMP:

119804668(Ikbkg)

NGI:	103731232(Ikbkg)

HGL:	101712077(Ikbkg)

CPOC:

100722308(Ikbkg)

CCAN:

109691919(Ikbkg)

DORD:

106000155(Ikbkg)

DSP:	122097005(Ikbkg)

PLOP:

125343265(Ikbkg)

NCAR:

124971778

MMMA:

107160284(Ikbkg)

OCU:	100328905(IKBKG)

OPI:	101535976(IKBKG)

TUP:	102476758(IKBKG)

GVR:	103604367(IKBKG)

CLUD:

112668352(IKBKG)

VVP:	112911512(IKBKG)

VLG:	121482779(IKBKG)

NPO:	129517602(IKBKG)

AML:	100470223(IKBKG)

UMR:	103679680(IKBKG)

UAR:

123791737

ELK:

111139191

LLV:

125091312

MPUF:

101671648(IKBKG)

MNP:	132006829(IKBKG)

MLK:	131822182(IKBKG)

NVS:	122897563(IKBKG)

ORO:	101384959(IKBKG)

EJU:	114203804(IKBKG)

ZCA:	113930597 113930605(IKBKG) 118356554

MLX:	118014480(IKBKG)

NSU:	110574194(IKBKG)

LWW:	102742694(IKBKG)

FCA:	101086544(IKBKG)

PYU:	121025049(IKBKG)

PCOO:

112871176(IKBKG)

PBG:	122477442(IKBKG)

PVIV:

125159286(IKBKG)

LRUF:

124525847

PPAD:

109261148(IKBKG) 109261721

PUC:

125932096

AJU:

106988817

HHV:	120226622(IKBKG)

BTA:	281855(IKBKG)

BOM:	102287968(IKBKG)

BBUB:

102394706(IKBKG)

CHX:	102171591(IKBKG)

OAS:	101107332(IKBKG)

BTAX:

128069947(IKBKG)

ODA:	120881825(IKBKG)

CCAD:

122434540(IKBKG)

MBEZ:

129564146(IKBKG)

SSC:	100127355(IKBKG)

CFR:	102519782(IKBKG)

CBAI:

105076053(IKBKG) 105076396

CDK:	105106603(IKBKG)

VPC:	102541871(IKBKG)

BACU:

103017855

BMUS:

118889045(IKBKG)

LVE:	103074882(IKBKG)

OOR:	101272428(IKBKG)

DLE:	111170969(IKBKG)

PCAD:

102980964(IKBKG) 114485485

PSIU:

116747398(IKBKG)

NASI:

112400454(IKBKG)

ECB:	100058432(IKBKG)

EPZ:

103543979

EAI:	106828814(IKBKG)

MYB:	102252013(IKBKG)

MYD:	102772051(IKBKG)

MMYO:

118653690(IKBKG)

MLF:	102436137(IKBKG)

PKL:	118706407(IKBKG)

EFUS:

103302255(IKBKG)

MNA:	107544156(IKBKG)

DRO:	112296261(IKBKG)

SHON:

118994325(IKBKG)

AJM:	119053789(IKBKG)

PDIC:

114504586(IKBKG)

PHAS:

123823081(IKBKG)

MMF:	118635619(IKBKG)

PPAM:

129074378(IKBKG)

HAI:	109377344(IKBKG)

RFQ:	117020791(IKBKG)

PALE:

102880203(IKBKG)

PGIG:

120605919(IKBKG)

PVP:	105302532(IKBKG)

RAY:	107499585(IKBKG)

MJV:	108400819(IKBKG)

TOD:	119245781(IKBKG)

SARA:

101536840(IKBKG)

SETR:

125999080(IKBKG)

LAV:	100661492(IKBKG)

TMU:

101347574

ETF:	101648136(IKBKG)

DNM:	101439489(IKBKG)

MDO:	100022918(IKBKG)

GAS:	123253779(IKBKG)

SHR:	100926701(IKBKG)

AFZ:

127542289

PCW:	110200334(IKBKG)

TVP:	118833128(IKBKG)

OAA:	100073613(IKBKG)

TGU:	115491960(IKBKG)

PMOA:

120504128(IKBKG)

OTC:	121337229(IKBKG)

PRUF:

121357727(IKBKG)

FAB:

101821038

OMA:	130266109(IKBKG)

PHI:

102113899

PMAJ:

107198881(IKBKG)

CCAE:

111942179(IKBKG)

CCW:	120412233(IKBKG)

ZLE:	135461073(IKBKG)

AGEN:

126035169

ASN:	102374662(IKBKG)

AMJ:	102561500(IKBKG)

PSS:	102445093(IKBKG)

CMY:	102938812(IKBKG)

CCAY:

125628486(IKBKG)

DCC:	119847100(IKBKG)

CPIC:

101942490(IKBKG)

CABI:

116823432(IKBKG)

MRV:	120388769(IKBKG)

ACS:	100567119(ikbkg)

ASAO:

132767870(IKBKG)

PVT:	110089205(IKBKG)

SUND:

121922695(IKBKG)

PBI:	103053675(IKBKG)

PMUR:

107284206(IKBKG)

CTIG:

120301305(IKBKG)

PGUT:

117675545(IKBKG)

APRI:

131191305(IKBKG)

PTEX:

113443435(IKBKG)

NSS:	113417663(IKBKG)

VKO:	123030004(IKBKG)

PMUA:

114588195(IKBKG)

PRAF:

128404911(IKBKG)

ZVI:	118078861(IKBKG)

HCG:	128345404(IKBKG)

GJA:

107114301

STOW:

125425434(IKBKG)

EMC:	129345981(IKBKG)

XLA:	735069(ikbkg.L)

XTR:	100145270(ikbkg)

NPR:	108791352(IKBKG)

RTEM:

120914229(IKBKG)

BBUF:

121009140(IKBKG)

BGAR:

122946400(IKBKG)

MUO:	115463580(IKBKG)

GSH:	117348290(IKBKG)

DRE:	541530(ikbkg)

SRX:	107737639 107741321

SANH:

107657029 107672044

SGH:	107560912 107562470

CCAR:

109088214 109088584

CAUA:

113069111 113094667

CGIB:

127945040 128012000

PTET:

122328953(ikbkg)

LROH:

127155107(ikbkg)

OMC:	131532646(ikbkg)

PPRM:

120463432(ikbkg)

RKG:	130081706(ikbkg)

MAMB:

125260117(ikbkg)

CIDE:

127505066

MASI:

127419435 127420114

TROS:

130545480(ikbkg)

TDW:	130409812(ikbkg)

MANU:

129430990(ikbkg)

IPU:

108275953

IFU:	128619519(ikbkg)

PHYP:

113530655(ikbkg)

SMEO:

124399204(ikbkg)

TFD:	113658245(ikbkg)

TVC:	132862050(ikbkg)

TRN:	134333573(ikbkg)

AMEX:

103043929(ikbkg)

CMAO:

118822022(ikbkg)

EEE:	113587986(ikbkg)

CHAR:

105894130(ikbkg)

TRU:

101069645

TFS:	130530458(ikbkg)

TNG:	GSTEN00004906G001

LCO:	104933745(ikbkg)

TBEN:

117491093(ikbkg)

CGOB:

115010596(ikbkg)

PGEO:

117448867 117448869

GACU:

117541485(ikbkg)

EMAC:

134870957(ikbkg)

ELY:	117258475(ikbkg)

EFO:	125892420(ikbkg)

SLUC:

116040658(ikbkg)

ECRA:

117947160(ikbkg)

ESP:	116693209(ikbkg)

PFLV:

114558815(ikbkg)

GAT:	100174893(ikbkg)

PPUG:

119200280 119222208

AFB:	129100170(ikbkg)

CLUM:

117732959(ikbkg)

PSWI:

130199061(ikbkg)

MSAM:

119905773 119919380

SCHU:

122883045(ikbkg)

CUD:	121517148(ikbkg)

ALAT:

119022646(ikbkg)

MZE:	101466977(ikbkg)

ONL:	100703664(ikbkg)

OAU:	116325151(ikbkg)

OLA:	101162681(ikbkg)

OML:	112158682(ikbkg)

CSAI:

133456872(ikbkg)

XMA:	102233509(ikbkg)

XCO:	114140444(ikbkg)

XHE:	116724200(ikbkg)

PRET:

103466941(ikbkg)

PFOR:

103150228(ikbkg)

PLAI:

106955713(ikbkg)

PMEI:

106907785(ikbkg)

GAF:	122836700(ikbkg)

PPRL:

129371690(ikbkg)

CVG:

107093789

CTUL:

119775467(ikbkg)

GMU:	124876519(ikbkg)

NFU:	107391543(ikbkg)

KMR:	108249185(ikbkg)

ALIM:

106523021(ikbkg)

NWH:	119417767(ikbkg)

AOCE:

111582017

MCEP:

125022415(ikbkg)

CSEM:

103384713(ikbkg)

POV:	109630748(ikbkg)

SSEN:

122777508(ikbkg)

HHIP:

117765388(ikbkg)

HSP:	118110546(ikbkg)

PPLT:

128443156(ikbkg)

SMAU:

118316602(ikbkg)

LCF:

108899625

SDU:	111236982(ikbkg)

SLAL:

111659926(ikbkg)

XGL:	120803427(ikbkg)

HCQ:	109528595(ikbkg)

SSCV:

125987862

SBIA:

133512340(ikbkg)

PEE:	133408750(ikbkg)

PTAO:

133487166(ikbkg)

BPEC:

110162114(ikbkg)

MALB:

109969980

BSPL:

114858847(ikbkg)

SJO:	128357039(ikbkg)

SASA:

106572992 106590733(ikbkg) 106592447

STRU:

115165245(ikbkg) 115168741

OTW:	112221359(ikbkg) 112239880 121840490

OMY:	110492712(ikbkg) 110532862

OGO:	124032432(ikbkg) 124045443

OKI:	109881207(ikbkg) 109885021

OKE:	118376297 118379875

SALP:

112072968

SNH:	120039965 120061717(ikbkg)

CCLU:

121537221 121555481

ELS:	105030753(ikbkg)

SFM:	108918214 108939062

PKI:	111837508(ikbkg) 111855295

AANG:

118210597(ikbkg)

LOC:

102682818

PSPA:

121329109(ikbkg)

ARUT:

117401606 117404249 117962689

PSEX:

120543156(ikbkg)

LCM:	102351908(IKBKG)

HOC:	132809022(ikbkg)

PMRN:

LRJ:

ABRU:

Reference

PMID:9751060

Authors

Rothwarf DM, Zandi E, Natoli G, Karin M

Title

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.

Journal

Nature 395:297-300 (1998)
DOI:10.1038/26261

Sequence

[hsa:8517]

Reference

PMID:14695475

Authors

Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM

Title

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

Journal

Nature 427:167-71 (2004)
DOI:10.1038/nature02273

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (106)   
   KEGG PATHWAY (106)   
Disease (6)   
   KEGG DISEASE (6)   
Gene (531)   
   KEGG GENES (350)   
   KEGG MGENES (83)   
   RefGene (96)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (647)   

Download RDF

ORTHOLOGY: K07209

Entry

K07209                      KO

Symbol

IKBKB, IKKB

Name

inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]

Pathway

map01523

Antifolate resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04064

NF-kappa B signaling pathway

map04068

FoxO signaling pathway

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04210

Apoptosis

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04623

Cytosolic DNA-sensing pathway

map04624

Toll and Imd signaling pathway

map04625

C-type lectin receptor signaling pathway

map04657

IL-17 signaling pathway

map04658

Th1 and Th2 cell differentiation

map04659

Th17 cell differentiation

map04660

T cell receptor signaling pathway

map04662

B cell receptor signaling pathway

map04668

TNF signaling pathway

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04920

Adipocytokine signaling pathway

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04932

Non-alcoholic fatty liver disease

map04936

Alcoholic liver disease

map05010

Alzheimer disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05135

Yersinia infection

map05142

Chagas disease

map05145

Toxoplasmosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05163

Human cytomegalovirus infection

map05164

Influenza A

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05212

Pancreatic cancer

map05215

Prostate cancer

map05220

Chronic myeloid leukemia

map05221

Acute myeloid leukemia

map05222

Small cell lung cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04014 Ras signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04064 NF-kappa B signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04668 TNF signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04068 FoxO signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04151 PI3K-Akt signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04150 mTOR signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04624 Toll and Imd signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04621 NOD-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04622 RIG-I-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04623 Cytosolic DNA-sensing pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04625 C-type lectin receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04660 T cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04658 Th1 and Th2 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04659 Th17 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04657 IL-17 signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04662 B cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04062 Chemokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04920 Adipocytokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05206 MicroRNAs in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05208 Chemical carcinogenesis - reactive oxygen species
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05221 Acute myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05220 Chronic myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05215 Prostate cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05222 Small cell lung cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05170 Human immunodeficiency virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05161 Hepatitis B
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05160 Hepatitis C
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05171 Coronavirus disease - COVID-19
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05164 Influenza A
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05162 Measles
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05168 Herpes simplex virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05163 Human cytomegalovirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05169 Epstein-Barr virus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05165 Human papillomavirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05130 Pathogenic Escherichia coli infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05132 Salmonella infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05131 Shigellosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05135 Yersinia infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05142 Chagas disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05418 Fluid shear stress and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04936 Alcoholic liver disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04932 Non-alcoholic fatty liver disease
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04931 Insulin resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  IKK family [OT]
   K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta

Other DBs

GO:

0008384

Genes

HSA:	3551(IKBKB)

PTR:	472749(IKBKB)

PPS:	100989390(IKBKB)

GGO:	101141659(IKBKB)

PON:	100440586(IKBKB)

PPYG:

129043119(IKBKB)

NLE:	100588081(IKBKB)

HMH:	116461632(IKBKB)

SSYN:

129491548(IKBKB)

MCC:	704683(IKBKB)

MCF:	102146604(IKBKB)

MTHB:

126960750

MNI:	105476527(IKBKB)

CSAB:

103215686(IKBKB)

CATY:

105595759(IKBKB)

PANU:

101016447(IKBKB)

TGE:	112629970(IKBKB)

MLEU:

105554929(IKBKB)

RRO:	104666046(IKBKB)

RBB:	108540719(IKBKB)

TFN:	117095630(IKBKB)

PTEH:

111544093(IKBKB)

CANG:

105525125(IKBKB)

CJC:	100393096(IKBKB)

SBQ:	101052971(IKBKB)

CIMI:

108316185(IKBKB)

ANAN:

105733545(IKBKB)

CSYR:

103256847(IKBKB)

MMUR:

105878144(IKBKB)

LCAT:

123626609(IKBKB)

PCOQ:

105819687(IKBKB)

OGA:	100946157(IKBKB)

MMU:	16150(Ikbkb)

MCAL:

110300158(Ikbkb)

MPAH:

110336182(Ikbkb)

RNO:	84351(Ikbkb)

MCOC:

116069014(Ikbkb)

ANU:	117721547(Ikbkb)

MUN:	110556613(Ikbkb)

CGE:	100750488(Ikbkb)

MAUA:

101834429(Ikbkb)

PROB:

127220313(Ikbkb)

PLEU:

114705738(Ikbkb)

MORG:

121462326(Ikbkb)

MFOT:

126504411

AAMP:

119812324(Ikbkb)

NGI:	103726621(Ikbkb)

HGL:	101711077(Ikbkb)

CPOC:

100724538(Ikbkb)

CCAN:

109696400(Ikbkb)

DORD:

105991714(Ikbkb)

DSP:	122107663(Ikbkb)

PLOP:

125339226(Ikbkb)

NCAR:

124983354

MMMA:

107159633(Ikbkb)

OCU:

100356401

OPI:	101517015(IKBKB)

TUP:	102467954(IKBKB)

GVR:	103589266(IKBKB)

CFA:	482839(IKBKB)

CLUD:

112656000(IKBKB)

VVP:	112916156(IKBKB)

VLG:	121489510(IKBKB)

NPO:	129515857(IKBKB)

AML:	100471679(IKBKB)

UMR:	103677059(IKBKB)

UAH:	113245546(IKBKB)

UAR:	123780295(IKBKB)

ELK:

111144397

LLV:

125094028

MPUF:

101686932(IKBKB)

MNP:	132006530(IKBKB)

MLK:	131820342(IKBKB)

NVS:	122889856(IKBKB)

ORO:	101375346(IKBKB)

EJU:	114224851(IKBKB)

ZCA:	113924180(IKBKB)

MLX:	118009921(IKBKB)

NSU:	110573165(IKBKB)

LWW:	102750184(IKBKB)

FCA:	100142682(IKBKB)

PYU:	121012848(IKBKB)

PCOO:

112858003(IKBKB)

PBG:	122472994(IKBKB)

PVIV:

125163712(IKBKB)

LRUF:

124521298

PTG:	102963734(IKBKB)

PPAD:

109262264(IKBKB)

PUC:

125923306

AJU:

106990012

HHV:	120233999(IKBKB)

BTA:	281854(IKBKB)

BOM:	102281443(IKBKB)

BIU:	109553353(IKBKB)

BBUB:

102398886(IKBKB)

BBIS:

104993223(IKBKB)

CHX:	102177406(IKBKB)

OAS:	780484(IKBKB)

BTAX:

128068238(IKBKB)

ODA:	120865846(IKBKB)

CCAD:

122432633(IKBKB)

MBEZ:

129549430(IKBKB)

SSC:	100101471(IKBKB)

CFR:	102508142(IKBKB)

CBAI:

105071245(IKBKB)

CDK:	105086448(IKBKB)

VPC:	102528824(IKBKB)

BACU:

103015119(IKBKB)

BMUS:

118887797(IKBKB)

LVE:	103088633(IKBKB)

OOR:	101285763(IKBKB)

DLE:	111173552(IKBKB)

PCAD:

102976706(IKBKB)

PSIU:

116746707(IKBKB)

NASI:

112413114(IKBKB)

ECB:	100050167(IKBKB)

EPZ:	103562903(IKBKB)

EAI:	106828957(IKBKB)

MYB:	102261405(IKBKB)

MYD:	102773824(IKBKB)

MMYO:

118650776(IKBKB)

MLF:	102417312(IKBKB)

PKL:	118728482(IKBKB)

EFUS:

103288179(IKBKB)

MNA:	107523913(IKBKB)

DRO:	112321547(IKBKB)

SHON:

118993207(IKBKB)

AJM:	119047140(IKBKB)

PDIC:

114508493(IKBKB)

PHAS:

123807522(IKBKB)

MMF:	118622317(IKBKB)

PPAM:

129064790(IKBKB)

HAI:	109386279(IKBKB)

RFQ:	117021384(IKBKB)

PALE:

102893261(IKBKB)

PGIG:

120595665(IKBKB)

PVP:	105301022(IKBKB)

RAY:	107501353(IKBKB)

MJV:	108399795(IKBKB)

TOD:	119257853(IKBKB)

SARA:

101540472(IKBKB)

SETR:

126006407(IKBKB)

LAV:	100657363(IKBKB)

TMU:

101351256

ETF:	101657011(IKBKB)

DNM:	101411204(IKBKB)

MDO:	100033031(IKBKB)

GAS:	123233417(IKBKB)

SHR:	100928932(IKBKB)

AFZ:

127548272

PCW:	110196387(IKBKB)

TVP:	118843636(IKBKB)

OAA:	100078925(IKBKB)

GGA:	426792(IKBKB)

PCOC:

116234507(IKBKB)

MGP:	100542558(IKBKB)

CJO:	107323740(IKBKB)

TPAI:

128071868(IKBKB)

LMUT:

125685336(IKBKB)

NMEL:

110387184(IKBKB)

APLA:

101790255(IKBKB)

ACYG:

106044397(IKBKB)

CATA:

118256066(IKBKB)

AFUL:

116499350(IKBKB)

TGU:	100225072(IKBKB) 116807244

LSR:	110473406(IKBKB)

SCAN:

103822735(IKBKB)

PMOA:

120504880(IKBKB)

OTC:	121346776(IKBKB)

PRUF:

121359273(IKBKB)

GFR:	102035648(IKBKB)

FAB:	101809821(IKBKB)

OMA:	130261961(IKBKB)

PHI:	102100562(IKBKB)

PMAJ:

107213912(IKBKB)

CCAE:

111938770(IKBKB)

CCW:	104694916(IKBKB)

CBRC:

103615481(IKBKB)

ETL:	114066442(IKBKB)

ZAB:	102073615(IKBKB)

ZLE:	135456823(IKBKB)

ACHL:

103798520(IKBKB)

SVG:	106862058(IKBKB)

MMEA:

130584481(IKBKB)

HRT:	120764068(IKBKB)

FPG:	101922064(IKBKB)

FCH:	102058892(IKBKB)

CLV:	102087238(IKBKB)

EGZ:	104135306(IKBKB)

NNI:	104016028(IKBKB)

PCRI:

104024544(IKBKB)

PLET:

104614493(IKBKB)

EHS:	104514410(IKBKB)

PCAO:

104039708(IKBKB)

ACUN:

113488090(IKBKB)

TALA:

104360558(IKBKB)

PADL:

103920554(IKBKB)

AFOR:

103901011(IKBKB)

ACHC:

115350500(IKBKB)

HALD:

104315998(IKBKB)

HLE:	104828788(IKBKB)

AGEN:

126051568

GCL:

127025388

CCRI:

104155069(IKBKB)

CSTI:

104549271(IKBKB)

CMAC:

104484702(IKBKB)

MUI:	104533819(IKBKB)

BREG:

104630091(IKBKB)

FGA:

104069132

GSTE:

104250915(IKBKB)

LDI:	104340350(IKBKB)

MNB:	103775251(IKBKB)

OHA:	104333228(IKBKB)

NNT:	104399565(IKBKB)

SHAB:

115618527(IKBKB)

DPUB:

104301261(IKBKB)

PGUU:

104458456(IKBKB)

ACAR:

104518147(IKBKB)

CPEA:

104384891(IKBKB)

AVIT:

104274892(IKBKB)

CVF:	104285155(IKBKB)

RTD:	128919567(IKBKB)

CUCA:

104068591(IKBKB)

TEO:	104374606(IKBKB)

BRHI:

104487936(IKBKB)

AAM:	106487776(IKBKB)

AROW:

112974186(IKBKB)

NPD:	112953853(IKBKB)

TGT:	104566044(IKBKB)

DNE:	112990458(IKBKB)

SCAM:

104148759(IKBKB)

ASN:	102377560(IKBKB)

AMJ:	102561936(IKBKB)

CPOO:

109317391(IKBKB)

PSS:	102454676(IKBKB)

CMY:	102932073(IKBKB)

CCAY:

125626298(IKBKB)

DCC:	119848740(IKBKB)

CPIC:

101945515(IKBKB)

TST:	117873054(IKBKB)

CABI:

116819035(IKBKB)

MRV:	120397038(IKBKB)

ACS:	100551699(ikbkb)

ASAO:

132782482(IKBKB)

PVT:	110072148(IKBKB)

SUND:

121933447(IKBKB)

PBI:	103052688(IKBKB)

PMUR:

107287960(IKBKB)

CTIG:

120318799(IKBKB)

TSR:

106550867

PGUT:

117676049(IKBKB)

APRI:

131203844(IKBKB)

PTEX:

113445889(IKBKB)

NSS:	113427675(IKBKB)

VKO:	123027007(IKBKB)

PMUA:

114602842(IKBKB)

PRAF:

128420119(IKBKB)

ZVI:	118085966(IKBKB)

HCG:	128333575(IKBKB)

GJA:	107107812(IKBKB)

STOW:

125441474(IKBKB)

EMC:	129342159(IKBKB)

XLA:	432200(ikbkb.L)

XTR:	448125(ikbkb)

NPR:	108791446(IKBKB)

RTEM:

120933164(IKBKB)

BBUF:

120986314(IKBKB)

BGAR:

122927292(IKBKB)

MUO:	115469431(IKBKB)

GSH:	117362659(IKBKB)

DRE:	563560(ikbkb)

SRX:	107722850 107754415

SANH:

107671012

SGH:	107559596(ikbkb)

CCAR:

109095150(ikbkb)

CAUA:

113052773 113106968

CGIB:

127963498 128019162

PTET:

122350917(ikbkb)

LROH:

127169911(ikbkb)

OMC:	131545292(ikbkb)

PPRM:

120489071(ikbkb)

MAMB:

125279685(ikbkb)

CIDE:

127517699

MASI:

127424113

TROS:

130567729(ikbkb)

TDW:	130439789(ikbkb)

MANU:

129414665(ikbkb)

IPU:

108265675

IFU:	128607709(ikbkb)

PHYP:

113533569(ikbkb)

SMEO:

124400022(ikbkb)

TFD:	113656040(ikbkb)

TVC:	132853312(ikbkb)

TRN:	134318101(ikbkb)

AMEX:

103040024(ikbkb)

CMAO:

118813511(ikbkb)

EEE:	113584916(ikbkb)

CHAR:

105898455(ikbkb)

TRU:	101062431(ikbkb)

TFS:	130526093(ikbkb)

TNG:	GSTEN00029571G001

LCO:	104921662(ikbkb)

NCC:	104956687(ikbkb)

TBEN:

117472510(ikbkb)

CGOB:

115013798(ikbkb)

PGEO:

117452298(ikbkb)

GACU:

117560475(ikbkb)

EMAC:

134873220(ikbkb)

ELY:	117252591(ikbkb)

EFO:	125889921(ikbkb)

PLEP:

121944151(ikbkb)

SLUC:

116054000(ikbkb)

ECRA:

117945478(ikbkb)

ESP:	116688937(ikbkb)

PFLV:

114555052(ikbkb)

GAT:	120830767(ikbkb)

PPUG:

119224939(ikbkb)

AFB:	129101396(ikbkb)

CLUM:

117736821(ikbkb)

PSWI:

130196210(ikbkb)

MSAM:

119891193(ikbkb)

SCHU:

122875692(ikbkb)

CUD:	121510304(ikbkb)

ALAT:

119019038(ikbkb)

MZE:	101472803(ikbkb)

ONL:	100698072(ikbkb)

OAU:	116311015(ikbkb)

OLA:	101170684(ikbkb)

OML:	112148770(ikbkb)

CSAI:

133450689(ikbkb)

XMA:	102223773(ikbkb)

XCO:	114154613(ikbkb)

XHE:	116729844(ikbkb)

PRET:

103470025(ikbkb)

PFOR:

103145827(ikbkb)

PLAI:

106956804(ikbkb)

PMEI:

106921755(ikbkb)

GAF:	122826476(ikbkb)

PPRL:

129365887(ikbkb)

CVG:	107089660(ikbkb)

CTUL:

119778144(ikbkb)

GMU:	124877211(ikbkb)

NFU:	107394259(ikbkb)

KMR:	108233707(ikbkb)

ALIM:

106536414(ikbkb)

NWH:	119413028(ikbkb)

AOCE:

111577292(ikbkb)

MCEP:

125011866(ikbkb)

CSEM:

103397763(ikbkb)

POV:	109637101(ikbkb)

SSEN:

122768945(ikbkb)

HHIP:

117767714(ikbkb)

HSP:	118114623(ikbkb)

PPLT:

128437788(ikbkb)

SMAU:

118313444(ikbkb)

LCF:

108881598

SDU:	111236497(ikbkb)

SLAL:

111665990(ikbkb)

XGL:	120805086(ikbkb)

HCQ:

109525796

SSCV:

125994011

SBIA:

133500035

PEE:	133399974(ikbkb)

PTAO:

133475135(ikbkb)

BPEC:

110155462(ikbkb)

MALB:

109956664(ikbkb)

BSPL:

114861862(ikbkb)

SJO:	128364098(ikbkb)

SASA:

106580426(ikbkb)

STRU:

115200286(ikbkb)

OTW:	112263933(ikbkb)

OMY:	110536185(ikbkb)

OGO:	124036437(ikbkb)

ONE:	115140184(ikbkb)

OKI:

109896029

OKE:	118371603(ikbkb)

SALP:

111958214

SNH:	120039020(ikbkb)

CCLU:

121573284

ELS:	105014298(ikbkb)

SFM:	108920198(ikbkb)

PKI:	111854363(ikbkb)

AANG:

118206636(ikbkb)

LOC:	102690045(ikbkb)

PSPA:

121302294 121303214

ARUT:

117397678

PSEX:

120538805(ikbkb)

LCM:	102358966(IKBKB)

RTP:	109927975(ikbkb)

CPLA:

122543166(ikbkb)

HOC:	132836867(ikbkb)

LERI:

129713371(ikbkb)

PMRN:

116945032(IKBKB)

LRJ:	133341906(IKBKB)

BFO:

118411310

BBEL:

109478257

CIN:

778921

DME:	Dmel_CG4201(IKKbeta)

DER:

6553147

DSE:

6606172

DSI:	Dsimw501_GD20310(Dsim_ird5)

DYA:	Dyak_GE26340(Dyak_ird5)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10102

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015672

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

MGEN:

SOC:

MPHA:

AEC:

ACEP:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VVE:

NVI:

CGLO:

FAS:

DAM:

CCIN:

AROA:

TCA:	655324 658393(ikkb)

DPA:

SOY:

CSET:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202564

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CCRN:

CLEC:

HHAL:

HVI:

PHU:	Phum_PHUM605130

TPAL:

117643604

DPX:	DAPPUDRAFT_317376

DMK:

HAZT:

EAF:

PPOI:

VDE:

VJA:

DPTE:

DFR:

CSCU:

PTEP:

UDV:

OBI:

OSN:

NVE:

AMIL:

DGT:

XEN:

HSY:

Reference

PMID:15084260

Authors

Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC

Title

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

Journal

Cell 117:225-37 (2004)
DOI:10.1016/S0092-8674(04)00302-2

Reference

PMID:9346485

Authors

Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV

Title

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.

Journal

Science 278:866-9 (1997)
DOI:10.1126/science.278.5339.866

Sequence

[hsa:3551]

DBGET integrated database retrieval system