KEGG   ORTHOLOGY: K06618
Entry
K06618                      KO                                     
Symbol
RB1
Name
retinoblastoma-associated protein
Pathway
map01522  Endocrine resistance
map04110  Cell cycle
map04218  Cellular senescence
map04934  Cushing syndrome
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05212  Pancreatic cancer
map05214  Glioma
map05215  Prostate cancer
map05218  Melanoma
map05219  Bladder cancer
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H00004  Chronic myeloid leukemia
H00013  Small cell lung cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00036  Osteosarcoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H01513  Retinoblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06618  RB1; retinoblastoma-associated protein
   04218 Cellular senescence
    K06618  RB1; retinoblastoma-associated protein
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06618  RB1; retinoblastoma-associated protein
   05207 Chemical carcinogenesis - receptor activation
    K06618  RB1; retinoblastoma-associated protein
   05203 Viral carcinogenesis
    K06618  RB1; retinoblastoma-associated protein
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K06618  RB1; retinoblastoma-associated protein
   05225 Hepatocellular carcinoma
    K06618  RB1; retinoblastoma-associated protein
   05226 Gastric cancer
    K06618  RB1; retinoblastoma-associated protein
   05214 Glioma
    K06618  RB1; retinoblastoma-associated protein
   05220 Chronic myeloid leukemia
    K06618  RB1; retinoblastoma-associated protein
   05218 Melanoma
    K06618  RB1; retinoblastoma-associated protein
   05219 Bladder cancer
    K06618  RB1; retinoblastoma-associated protein
   05215 Prostate cancer
    K06618  RB1; retinoblastoma-associated protein
   05224 Breast cancer
    K06618  RB1; retinoblastoma-associated protein
   05222 Small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
   05223 Non-small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06618  RB1; retinoblastoma-associated protein
   05161 Hepatitis B
    K06618  RB1; retinoblastoma-associated protein
   05160 Hepatitis C
    K06618  RB1; retinoblastoma-associated protein
   05163 Human cytomegalovirus infection
    K06618  RB1; retinoblastoma-associated protein
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06618  RB1; retinoblastoma-associated protein
   05169 Epstein-Barr virus infection
    K06618  RB1; retinoblastoma-associated protein
   05165 Human papillomavirus infection
    K06618  RB1; retinoblastoma-associated protein
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K06618  RB1; retinoblastoma-associated protein
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K06618  RB1; retinoblastoma-associated protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06618  RB1; retinoblastoma-associated protein
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K06618  RB1; retinoblastoma-associated protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06618  RB1; retinoblastoma-associated protein
Transcription factors [BR:ko03000]
 Eukaryotic type
  Other transcription factors
   Pocket domain Rb
    K06618  RB1; retinoblastoma-associated protein
Genes
HSA: 5925(RB1)
PTR: 452715(RB1)
PPS: 100973837(RB1)
GGO: 101133237(RB1)
PON: 100462155(RB1)
PPYG: 129011272(RB1)
NLE: 100588629(RB1)
HMH: 116467261(RB1)
SSYN: 129464058(RB1)
MCC: 704871(RB1)
MCF: 102145859(RB1)
MTHB: 126940411
MNI: 105490695(RB1)
CSAB: 103214406(RB1)
CATY: 105587764(RB1)
PANU: 101017005(RB1)
TGE: 112610754(RB1)
MLEU: 105552849(RB1)
RRO: 104662760(RB1)
RBB: 108530701(RB1)
TFN: 117063258(RB1)
PTEH: 111523077(RB1)
CANG: 105510064(RB1)
CJC: 100397928(RB1)
SBQ: 101038309(RB1)
CIMI: 108309540(RB1)
ANAN: 105725921(RB1)
CSYR: 103259274(RB1)
MMUR: 105855966(RB1)
LCAT: 123649357(RB1)
PCOQ: 105813707(RB1)
OGA: 100951476(RB1)
MMU: 19645(Rb1)
MCAL: 110309179(Rb1)
MPAH: 110325233(Rb1)
RNO: 24708(Rb1)
MCOC: 116085075(Rb1)
ANU: 117705264(Rb1)
MUN: 110553592(Rb1)
CGE: 100752928(Rb1)
MAUA: 101831842(Rb1)
PROB: 127230188(Rb1)
PLEU: 114698792(Rb1)
MORG: 121459112(Rb1)
AAMP: 119800094(Rb1)
NGI: 103726779(Rb1)
HGL: 101703701(Rb1)
CPOC: 100716297(Rb1)
CCAN: 109691094(Rb1)
DORD: 105980484(Rb1)
DSP: 122112815(Rb1)
PLOP: 125348277(Rb1)
NCAR: 124985088
MMMA: 107141039(Rb1)
OCU: 100357431
OPI: 101517612(RB1)
TUP: 102499507(RB1)
GVR: 103593663(RB1)
CFA: 476915(RB1)
CLUD: 112678896(RB1)
VVP: 112933932(RB1)
VLG: 121476853(RB1)
NPO: 129516428(RB1)
AML: 100477714(RB1)
UMR: 103677688(RB1)
UAH: 113251325(RB1)
UAR: 123791847(RB1)
ELK: 111146911
LLV: 125096420
MPUF: 101685420(RB1)
MNP: 132002924(RB1)
MLK: 131813843(RB1)
NVS: 122907082(RB1)
ORO: 101386367(RB1)
EJU: 114210238(RB1)
ZCA: 113919651(RB1)
MLX: 118009434(RB1)
NSU: 110579773(RB1)
LWW: 102737296(RB1)
FCA: 101101356(RB1)
PYU: 121012950(RB1)
PCOO: 112860822(RB1)
PBG: 122482016(RB1)
PVIV: 125163349(RB1)
LRUF: 124512196
PTG: 102952365(RB1)
PPAD: 109265951(RB1)
PUC: 125933773
AJU: 106971960
HHV: 120220837(RB1)
BTA: 534712(RB1)
BOM: 102267169(RB1)
BIU: 109566987(RB1)
BBUB: 102400134(RB1)
BBIS: 104984371(RB1)
CHX: 102183886(RB1)
OAS: 100144755(RB1)
BTAX: 128057539(RB1)
ODA: 120883039(RB1)
CCAD: 122447603(RB1)
MBEZ: 129556262(RB1)
SSC: 100151828(RB1)
CFR: 102516870(RB1)
CBAI: 105066145(RB1)
CDK: 105101803(RB1)
VPC: 102545797(RB1)
BACU: 103013752(RB1)
BMUS: 118884336(RB1)
LVE: 103072166(RB1)
OOR: 101272870(RB1)
DLE: 111175081(RB1)
PCAD: 102995201(RB1)
PSIU: 116743055(RB1)
NASI: 112406557(RB1)
ECB: 100057080(RB1)
EPZ: 103549440(RB1)
EAI: 106829635(RB1)
MYB: 102251785(RB1)
MYD: 102766251(RB1)
MMYO: 118651068(RB1)
MLF: 102436007(RB1)
PKL: 118728588(RB1)
EFUS: 103289677(RB1)
MNA: 107531399(RB1)
DRO: 112313044(RB1)
SHON: 118983966(RB1)
AJM: 119054193(RB1)
PDIC: 114508470(RB1)
PHAS: 123818741(RB1)
MMF: 118622512(RB1)
PPAM: 129080865(RB1)
HAI: 109387138(RB1)
RFQ: 117021434(RB1)
PALE: 102893019(RB1)
PGIG: 120583848(RB1)
PVP: 105300023(RB1)
RAY: 107520925(RB1)
MJV: 108384777(RB1)
TOD: 119258908(RB1)
SARA: 101548470(RB1)
SETR: 126016198(RB1)
LAV: 100673196(RB1)
TMU: 101355952
ETF: 101646101(RB1)
DNM: 101441708
MDO: 100022630(RB1)
GAS: 123240551(RB1)
SHR: 100914196(RB1)
AFZ: 127555178
PCW: 110213446(RB1)
TVP: 118839187(RB1)
OAA: 100083537(RB1)
GGA: 386582(RB1)
PCOC: 116244252(RB1)
MGP: 100549197 104917517
CJO: 107308151(RB1)
TPAI: 128071636(RB1)
LMUT: 125698667(RB1)
NMEL: 110387715(RB1)
APLA: 101793414(RB1)
ACYG: 106035039(RB1)
CATA: 118251390(RB1)
AFUL: 116496385(RB1)
TGU: 100217687(RB1)
LSR: 110469557(RB1)
SCAN: 103812574(RB1)
PMOA: 120505765(RB1)
OTC: 121337243(RB1)
PRUF: 121353236(RB1)
GFR: 102036868(RB1)
FAB: 101806985(RB1)
OMA: 130256748(RB1)
PHI: 102105165(RB1)
PMAJ: 107203084(RB1)
CCAE: 111938847(RB1)
CCW: 104690005(RB1)
CBRC: 103615188(RB1)
ETL: 114060928(RB1)
ZAB: 102066585(RB1)
ZLE: 135448624(RB1)
ACHL: 103797711(RB1)
SVG: 106848718(RB1)
MMEA: 130574252(RB1)
HRT: 120748645(RB1)
FPG: 101918471(RB1)
FCH: 102054877(RB1)
CLV: 102084576(RB1)
EGZ: 104131621(RB1)
NNI: 104010954(RB1)
PCRI: 104037946(RB1)
PLET: 104624256
EHS: 104512355(RB1)
PCAO: 104053328(RB1)
ACUN: 113489292(RB1)
TALA: 104360771(RB1)
PADL: 103913489(RB1)
AFOR: 103903669
ACHC: 115350578(RB1)
HALD: 104320178(RB1)
HLE: 104841601(RB1)
AGEN: 126045065
GCL: 127013874
CCRI: 104155081(RB1)
CSTI: 104553276(RB1)
MUI: 104533923(RB1)
LDI: 104340408(RB1)
MNB: 103780398(RB1)
OHA: 104336922(RB1)
NNT: 104402086(RB1)
SHAB: 115603985(RB1)
DPUB: 104305425(RB1)
PGUU: 104469099
ACAR: 104532091(RB1)
CPEA: 104390012(RB1)
AVIT: 104273024(RB1)
CVF: 104281590(RB1)
RTD: 128904457(RB1)
CUCA: 104066185(RB1)
TEO: 104378595(RB1)
BRHI: 104501873(RB1)
AAM: 106489167(RB1)
AROW: 112960560(RB1)
NPD: 112959296(RB1)
TGT: 104579245(RB1)
DNE: 112988163(RB1)
SCAM: 104146563(RB1)
ASN: 102379703(RB1)
AMJ: 102564411(RB1)
CPOO: 109306521(RB1)
GGN: 109302248(RB1)
PSS: 102445665(RB1)
CMY: 102937814(RB1)
CCAY: 125636578(RB1)
DCC: 119849617(RB1)
CPIC: 101930889(RB1)
TST: 117870967(RB1)
CABI: 116829358(RB1)
MRV: 120395436(RB1)
ACS: 100567638(rb1)
ASAO: 132780951(RB1)
PVT: 110091007(RB1)
SUND: 121932724(RB1)
PBI: 103062466(RB1)
PMUR: 107284299(RB1)
CTIG: 120300330(RB1)
TSR: 106543703(RB1)
PGUT: 117671148(RB1)
APRI: 131198789(RB1)
PTEX: 113440957(RB1)
NSS: 113419577(RB1)
VKO: 123024270(RB1)
PMUA: 114582635(RB1)
PRAF: 128400876(RB1)
ZVI: 118097177(RB1)
HCG: 128339583(RB1)
GJA: 107112871(RB1)
STOW: 125435959(RB1)
EMC: 129331342(RB1)
XLA: 108709804(rb1.S)
XTR: 100493114(rb1)
NPR: 108792451(RB1)
RTEM: 120929606(RB1)
BBUF: 120995935(RB1)
BGAR: 122933462(RB1)
MUO: 115468634(RB1)
GSH: 117362174(RB1)
DRE: 777733(rb1)
SRX: 107718950 107731452
SANH: 107681157 107703523
SGH: 107548180 107551603
CCAR: 109079645 109082733(rb1)
CAUA: 113038593 113064297(rb1)
CGIB: 127941810 127986424
PTET: 122326096
LROH: 127152067(rb1)
OMC: 131528756(rb1)
PPRM: 120494516
RKG: 130096514(rb1)
MAMB: 125253471(rb1)
CIDE: 127503257
MASI: 127428902 127431366
TROS: 130570003(rb1)
TDW: 130407652(rb1)
MANU: 129423489(rb1)
IPU: 108279123
IFU: 128622184(rb1)
PHYP: 113541559(rb1)
SMEO: 124397827(rb1)
TFD: 113634924(rb1)
TVC: 132860203(rb1)
TRN: 134330402(rb1)
AMEX: 103040648(rb1)
CMAO: 118820006(rb1)
EEE: 113574008(rb1)
CHAR: 105904470(rb1)
TRU: 101069848 115246431
TFS: 130537381(rb1)
TNG: GSTEN00022163G001
LCO: 104919743(rb1)
NCC: 104954675(rb1)
TBEN: 117468953(rb1)
CGOB: 115018956(rb1)
PGEO: 117458662(rb1)
GACU: 117538439(rb1)
EMAC: 134872717(rb1)
ELY: 117270312(rb1)
EFO: 125898125(rb1)
PLEP: 121952289(rb1)
SLUC: 116064830(rb1)
ECRA: 117955615(rb1)
ESP: 116700602(rb1)
PFLV: 114567128(rb1)
GAT: 120822017(rb1) 120822825
PPUG: 119215275(rb1)
AFB: 129113372(rb1)
CLUM: 117742541(rb1)
PSWI: 130191681(rb1)
MSAM: 119895662(rb1)
SCHU: 122888821(rb1)
CUD: 121518872(rb1)
ALAT: 119031215(rb1)
MZE: 101480728(rb1)
ONL: 100708745(rb1)
OAU: 116330222(rb1)
OLA: 100049519(rb1)
OML: 112142671(rb1)
CSAI: 133459663(rb1)
XMA: 102230233(rb1)
XCO: 114153224(rb1)
XHE: 116728394
PRET: 103475763 103475858
PFOR: 103145620(rb1)
PLAI: 106953355(rb1)
PMEI: 106922174(rb1)
GAF: 122844854(rb1)
PPRL: 129368571(rb1)
CVG: 107098241(rb1)
CTUL: 119789582(rb1)
GMU: 124876124(rb1)
NFU: 107386518(rb1)
KMR: 108248278(rb1)
ALIM: 106516385(rb1)
NWH: 119420677(rb1)
AOCE: 111577644(rb1)
MCEP: 125020956(rb1)
CSEM: 103395441(rb1)
POV: 109628702(rb1)
SSEN: 122779444(rb1)
HHIP: 117774464(rb1)
HSP: 118122075(rb1)
PPLT: 128456700(rb1)
SMAU: 118300850(rb1)
LCF: 108893878
SDU: 111234349(rb1)
SLAL: 111653978(rb1)
XGL: 120802463(rb1)
HCQ: 109512505(rb1)
SSCV: 125981768
SBIA: 133491667(rb1)
PEE: 133415773(rb1)
PTAO: 133466870(rb1)
BPEC: 110168135(rb1)
MALB: 109959496(rb1)
BSPL: 114869635(rb1)
SJO: 128370993(rb1)
SASA: 100380330(rb1)
STRU: 115154441(rb1)
OTW: 112228649(rb1)
OMY: 100135880(rb1)
OGO: 124009678(rb1)
ONE: 115135821(rb1)
OKI: 109875635(rb1)
OKE: 118390180(rb1)
SALP: 111950388(rb1)
SNH: 120057128(rb1)
CCLU: 121580008(rb1)
ELS: 105023905(rb1)
SFM: 108934475(rb1)
PKI: 111838068(rb1)
AANG: 118235087(rb1)
LOC: 102694078(rb1)
PSPA: 121302804 121321153 121321154
ARUT: 117407442(rb1)
PSEX: 120524037(rb1)
LCM: 102347219 102366565(RB1)
CMK: 103177409(rb1)
RTP: 109937908
CPLA: 122554942(rb1)
HOC: 132820962(rb1)
LERI: 129702828(rb1)
PMRN: 116957122(RB1)
LRJ: 133361004 133361005
BFO: 118427291
BBEL: 109463769
SPU: 585399
LPIC: 129279535
APLC: 110981738
ARUN: 117298523
SKO: 102809503
DSV: 119458037
RSAN: 119373902
PTEP: 107446515
ABRU: 129963105
SDM: 118203952
PCAN: 112555129
BGT: 106056388
GAE: 121370264
HRF: 124123172
HRJ: 124260136 124261083
CRG: 105341190
CANU: 128181086
CVN: 111101110
OED: 125659620
MYI: 110447895
PMAX: 117342388
RPHI: 132736783
DPOL: 127833605 127835820
MAEA: 128220509 128220794
OBI: 106877521
OSN: 115209261
LJP: 135479695
LAK: 106159872 106169307
LLON: 135494573
ADF: 107336100
AMIL: 114955152
PDAM: 113676241
SPIS: 111331032
TAD: TRIADDRAFT_60210
CME: CYME_CMT038C
DFA: DFA_11907(rblA)
PTM: GSPATT00022277001
PIF: PITG_16462
PSOJ: PHYSODRAFT_354183
SPAR: SPRG_08426
NGR: NAEGRDRAFT_80903
 » show all
Reference
PMID:1756735
  Authors
Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E
  Title
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
  Journal
EMBO J 10:4279-90 (1991)
DOI:10.1002/j.1460-2075.1991.tb05006.x
  Sequence
[hsa:5925]
Reference
PMID:15084261
  Authors
Ren S, Rollins BJ
  Title
Cyclin C/cdk3 promotes Rb-dependent G0 exit.
  Journal
Cell 117:239-51 (2004)
DOI:10.1016/S0092-8674(04)00300-9
  Sequence
[hsa:5925]
Reference
PMID:3823889
  Authors
Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY
  Title
Human retinoblastoma susceptibility gene: cloning, identification, and sequence.
  Journal
Science 235:1394-9 (1987)
DOI:10.1126/science.3823889
  Sequence
[hsa:5925]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (50)   
   KEGG PATHWAY (50)   
Disease (8)   
   KEGG DISEASE (8)   
Gene (1057)   
   KEGG GENES (454)   
   KEGG MGENES (352)   
   RefGene (244)   
   OC (7)   
Literature (3)   
   PubMed (3)   
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