Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor

medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

a medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R00392]

R00392 > R01175 R01279 R03777 R03857 R03990 R04095 R04751 R04754;
(other) R02661 R03172

medium-chain acyl-CoA [CPD:C21926];
electron-transfer flavoprotein [CPD:C04253]

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [2]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.

EC 1.3.8.7 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.7