KEGG   ENZYME: 3.2.1.198Help
Entry
EC 3.2.1.198                Enzyme                                 

Name
alpha-mannan endo-1,2-alpha-mannanase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-mannan 1,2-[alpha-D-mannosyl-(1->3)-alpha-D-mannose] hydrolase
Reaction(IUBMB)
Hydrolysis of the terminal alpha-D-mannosyl-(1->3)-alpha-D-mannose disaccharide from alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl side chains in fungal cell wall alpha-mannans.
Comment
The enzyme, characterized from the gut bacteria Bacteroides thetaiotaomicron and Bacteroides xylanisolvens, can also catalyse the reaction of EC 3.2.1.130, glycoprotein endo-alpha-1,2-mannosidase.
History
EC 3.2.1.198 created 2016
Orthology
K21132  alpha-mannan endo-1,2-alpha-mannanase / glycoprotein endo-alpha-1,2-mannosidase
Genes
BTH: BT_3862
BTHO: Btheta7330_00449
BXY: BXY_34140
Taxonomy
Reference
1  [PMID:25487964]
  Authors
Hakki Z, Thompson AJ, Bellmaine S, Speciale G, Davies GJ, Williams SJ
  Title
Structural and kinetic dissection of the endo-alpha-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp.
  Journal
Chemistry 21:1966-77 (2015)
DOI:10.1002/chem.201405539
  Sequence
[bth:BT_3862] [bxy:BXY_34140]
Reference
2  [PMID:25567280]
  Authors
Cuskin F, Lowe EC, Temple MJ, Zhu Y, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munoz-Munoz JL, Day A, Pena MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ
  Title
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism.
  Journal
Nature 517:165-9 (2015)
DOI:10.1038/nature13995
  Sequence
[bth:BT_3862]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.198
IUBMB Enzyme Nomenclature: 3.2.1.198
ExPASy - ENZYME nomenclature database: 3.2.1.198
BRENDA, the Enzyme Database: 3.2.1.198

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