KEGG   Homo sapiens (human): 4052
Entry
4052              CDS       T01001                                 
Symbol
LTBP1, ARCL2E
Name
(RefSeq) latent transforming growth factor beta binding protein 1
  KO
K19559  latent transforming growth factor beta binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04350  TGF-beta signaling pathway
Network
nt06507  TGFB signaling
  Element
N01460  Plasmin mediated activation of latent TGF-beta
Disease
H00557  Cutis laxa
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    4052 (LTBP1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:hsa04990]
    4052 (LTBP1)
Domain-containing proteins not elsewhere classified [BR:hsa04990]
 EGF-like domain-containing proteins
  hEGF / cEGF domain-containing proteins
   4052 (LTBP1)
SSDB
Motif
Pfam: EGF_CA cEGF TB EGF EGF_3 hEGF FXa_inhibition EGF_MSP1_1 EGF_TEN Plasmod_Pvs28
Other DBs
NCBI-GeneID: 4052
NCBI-ProteinID: NP_996826
OMIM: 150390
HGNC: 6714
Ensembl: ENSG00000049323
UniProt: Q14766
Structure
Position
2:32946953..33399509
AA seq 1721 aa
MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNA
RYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHP
NPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKA
PGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAAS
SWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIH
HGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSI
CKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQ
CPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPP
NIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSH
QQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKK
PSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDP
TFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLP
GTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEP
VEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPV
VIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCIC
YEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDE
CLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSY
QCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDI
DECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEG
SFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTC
QDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFC
DNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEY
SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGW
GDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGF
CLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLD
ASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGM
QCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEEL
QAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAK
CINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE
NT seq 5166 nt   +upstreamnt  +downstreamnt
atggcgggggcctggctcaggtgggggctcctgctctgggcagggctcctcgcgtcctcg
gcgcacggccggctgcggaggatcacctacgtggtgcacccgggccccggcctggcagcc
ggcgccttgcccctgagcgggcccccgcgttcgcggacattcaacgtcgcgctcaacgcc
aggtacagccgcagctcggcggctgccggcgcccccagccgtgcctcccccggggtcccc
tcggagaggacccggcgcacgagcaagccgggcggcgcggccctgcaggggctcagaccg
ccgccgccgccgccgccggagcctgcgcgtcccgcggtccccggcgggcagctccacccc
aatcccggcggccacccggcagccgccccgttcaccaaacaaggcaggcaagttgtgcgc
tccaaggtgccgcaggagacccagagcggcggaggctctaggctgcaggttcaccagaag
cagcagctgcagggggtcaatgtctgtggagggcggtgctgtcatggctggagtaaggcc
cctggctcccagaggtgcaccaaacctagctgtgttccgccatgtcagaatggagggatg
tgtctccggccacaactctgtgtgtgtaaaccagggaccaagggcaaagcctgtgaaaca
atagctgcccaggacacctcgtcaccagtctttggagggcagagtcctggggctgcttcc
tcgtggggccctcctgagcaagcagcaaagcatacttcatctaagaaggcagacactcta
ccaagagtcagccctgtggcccagatgaccttaaccctcaagccgaagccttcagtggga
ctcccccagcagatacattctcaagtgactcctctttcttcccagagtgtggtgattcac
catggccagacccaggaatacgtgctcaagcccaagtactttccagcccagaaggggatt
tcaggagagcagtccactgaaggttctttccctttaagatatgtgcaggatcaagttgcg
gcaccttttcagctgagtaaccacactggccgcatcaaggtggtctttactccgagcatc
tgtaaagtgacctgcaccaagggcagctgtcagaacagctgtgagaaggggaacaccacc
actctcattagtgagaatggtcatgctgccgacaccctgacggccacgaacttccgagtg
gtaatttgccatcttccatgtatgaatggtggccagtgcagttcaagggacaaatgtcag
tgccctccaaatttcacaggaaaactttgtcagatcccagtccatggtgccagcgtgcct
aaactttatcagcattcccagcagccaggcaaggcgttggggacgcatgtcatccattca
acacataccttgcctctgaccgtgactagccagcaaggagtcaaagtgaaatttcctcct
aacatagtcaatatccatgtgaaacatcctcctgaagcttccgtccagatacatcaggtt
tcaagaattgatggcccaacaggccagaagacaaaagaagctcaaccaggccaatcccaa
gtctcgtaccaagggcttcctgtccagaagacccagaccatacattccacatactcccac
cagcaggtcattcctcacgtctaccccgtggctgctaagacacagcttggccggtgcttc
caggaaaccattgggtcacagtgtggcaaagcgctccctggcctttcaaagcaagaggac
tgctgtggaactgtgggtacctcctggggctttaacaaatgccagaaatgccccaagaaa
ccatcttatcatggatacaaccaaatgatggaatgcctaccgggttataagcgggttaac
aacaccttttgccaagatattaatgaatgtcagctacaaggtgtatgccctaatggtgag
tgtttgaataccatgggcagctatcgatgtacctgcaaaataggatttgggccggatcct
accttttcaagttgtgttcctgatccccctgtgatctcggaagagaaagggccctgttac
cgacttgtcagttctggaagacagtgtatgcaccctctgtctgttcacctcaccaagcag
ctctgctgttgtagtgtgggcaaggcctggggcccacactgtgagaaatgtccccttcca
ggcacagctgcttttaaggaaatctgtcctggtggaatgggttatacggtttctggcgtt
catagacgcaggccaatccatcaccatgtaggtaaaggacctgtatttgtcaagccaaag
aacactcaacctgttgctaaaagtactcatcctccacctctcccagccaaggaagagcca
gtggaggccctgaccttctcccgggaacacgggccaggagtggcggagccagaagtggca
actgcaccccctgaaaaggaaataccttcattggatcaagagaaaaccaaacttgagcct
ggtcaaccccagctgtctccaggcatttccactattcatctgcatccacagtttccagta
gtgattgaaaaaacatcacctcctgtgcctgttgaagtagctcctgaagcttctacgtct
agtgccagccaagtgattgctcctactcaagtgacagaaatcaatgaatgtactgtgaac
cctgatatctgtggagcaggacactgcattaacctaccagtgagatatacctgtatatgc
tacgagggctacaggttcagtgaacaacagaggaaatgtgtggatattgatgagtgtact
caggtccaacacctctgctcccagggccgctgtgaaaacaccgagggaagtttcttgtgc
atttgcccagcaggatttatggccagtgaggagggtactaactgcatagatgttgacgaa
tgcctgaggccggacgtctgtggggaggggcactgtgtcaatactgtgggggccttccgg
tgtgaatactgtgacagcgggtaccgcatgactcagagaggccgttgtgaggatattgat
gaatgtttgaatccaagcacttgtccagatgagcagtgtgtgaattctcctggatcttac
cagtgcgttccctgcacagaaggattccgaggctggaatggacagtgccttgatgtggac
gagtgcctggaaccaaacgtctgcgcaaatggtgattgttccaaccttgaaggctcctac
atgtgttcatgccacaaaggctatacccggactccggaccacaagcactgtagagatatt
gatgaatgtcagcaagggaatctatgtgtaaacgggcagtgcaaaaataccgagggctcc
ttcaggtgcacctgtggacaggggtaccagctgtcggcagctaaagaccagtgtgaagac
attgatgaatgccagcaccgtcatctctgtgctcatgggcagtgcaggaacactgagggc
tcttttcaatgtgtgtgtgaccagggttacagagcatctgggcttggagaccactgtgaa
gatatcaatgaatgcttggaggacaagagtgtttgccagagaggagactgcattaatact
gcagggtcctatgattgtacttgtccggatggatttcagctagatgacaataaaacatgt
caagatattaatgaatgtgaacatccagggctctgtggtccgcaaggggagtgcctaaac
acagagggttctttccattgtgtctgccagcagggtttctcaatctctgcagatggccgt
acgtgtgaagatattgatgaatgtgtaaacaacactgtttgtgacagtcacgggttttgt
gacaatacagctggctccttccgctgcctctgttatcagggctttcaagccccacaggat
gggcaagggtgtgtggatgtgaatgaatgtgaactgctcagtggggtgtgtggtgaagcc
ttctgtgaaaacgtggaagggtccttcctgtgcgtgtgtgctgatgaaaaccaagagtac
agccccatgactgggcagtgccgctcccggacctccacagatttagatgtagatgtagat
caacccaaagaagaaaagaaagaatgctactataatctcaatgacgccagtctctgtgat
aatgtgttggcccccaatgtcacgaaacaagaatgctgctgtacatcaggcgtgggatgg
ggagataactgcgaaatcttcccctgcccggtcttgggaactgctgagttcactgaaatg
tgtcccaaagggaaaggttttgtgcctgctggagaatcatcttctgaagctggtggtgag
aactataaagatgcagatgaatgcctactttttggacaagaaatctgcaaaaatggtttc
tgtttgaacactcggcctgggtatgaatgctactgtaagcaagggacgtactatgatcct
gtgaaactgcagtgctttgatatggatgaatgtcaagaccccagtagttgtattgatggc
cagtgtgttaatacagagggctcttacaactgcttctgtactcaccccatggtcctggat
gcgtcagaaaaaagatgtatacgaccggctgagtcaaacgaacaaatagaagaaactgat
gtctaccaagatttgtgctgggaacatctgagtgatgaatacgtgtgtagccggcctctt
gtgggcaagcagacaacgtacactgagtgctgctgtctgtatggagaggcctggggcatg
cagtgtgccctctgccccctgaaggattcagatgactatgctcagctgtgtaacatcccc
gtgacgggacgccggcagccatatggacgggacgccttggttgacttcagtgaacagtat
actccagaagccgatccctacttcatccaagaccgttttctaaatagctttgaggagtta
caggctgaggaatgcggcatcctcaatggatgtgaaaatggtcgctgtgtgagggtccag
gaaggttacacctgcgattgctttgatgggtatcacttggatacggccaagatgacctgt
gtcgatgtaaatgaatgcgatgagttgaacaaccggatgtctctctgcaagaatgccaag
tgcattaacaccgatggttcctacaagtgtttgtgtctgccaggctacgtgccttctgac
aagccaaactactgcactccgttgaataccgccttgaatttagagaaagacagtgacctg
gagtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (67)   
   RefGene (62)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (105)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (103)   
DNA sequence (145)   
   RefSeq(nuc) (103)   
   GenBank (21)   
   EMBL (21)   
3D Structure (1)   
   PDB (1)   
Protein domain (10)   
   Pfam (10)   
All databases (330)   

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