PATHWAY: ko00512
Help
Entry
ko00512 Pathway
Name
Mucin type O-glycan biosynthesis
Description
O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
ko00512
Mucin type O-glycan biosynthesis
Ortholog table
Module
M00056
O-glycan biosynthesis, mucin type core [PATH:
ko00512
]
Disease
H00020
Colorectal cancer
H01188
Tn syndrome
H01193
Familial tumoral calcinosis
Other DBs
GO:
0006493
Orthology
K00710
polypeptide N-acetylgalactosaminyltransferase [EC:
2.4.1.41
]
K00731
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:
2.4.1.122
]
K09653
C1GALT1-specific chaperone 1
K00727
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase [EC:
2.4.1.102
]
K09662
N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]
K09663
beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]
K00780
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:
2.4.99.4
]
K03368
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B) [EC:
2.4.99.4
]
K03479
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:
2.4.99.3
]
K00739
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase [EC:
2.4.1.147
]
K09905
beta-1,4-galactosyltransferase 5 [EC:2.4.1.-]
Compound
C02189
[Protein]-L-serine
G00023
Tn antigen
G00024
T antigen
G00025
G00026
G00027
G00028
G00029
G00030
G00031
G00032
G00033
G00034
G00035
Sialyl-Tn antigen
G10611
UDP-N-acetyl-D-galactosamine
Reference
PMID:
10580130
Authors
Brockhausen I.
Title
Pathways of O-glycan biosynthesis in cancer cells.
Journal
Biochim Biophys Acta 1473:67-95 (1999)
DOI:
10.1016/S0304-4165(99)00170-1
Reference
PMID:
11821425
Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
Journal
J Biol Chem 277:12802-9 (2002)
DOI:
10.1074/jbc.M112457200
Reference
PMID:
12626393
Authors
Korekane H, Taguchi T, Sakamoto Y, Honke K, Dohmae N, Salminen H, Toivonen S, Helin J, Takio K, Renkonen O, Taniguchi N.
Title
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
Journal
Glycobiology 13:387-400 (2003)
DOI:
10.1093/glycob/cwg044
Reference
PMID:
10350056
Authors
van Die I, van Tetering A, Schiphorst WE, Sato T, Furukawa K, van den Eijnden DH.
Title
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.
Journal
FEBS Lett 450:52-6 (1999)
DOI:
10.1016/S0014-5793(99)00462-7
Related
pathway
ko00533
Glycosaminoglycan biosynthesis - keratan sulfate
All links
Gene (11)
KEGG ORTHOLOGY (11)
All databases (11)
Download RDF
DBGET
integrated database retrieval system