KEGG   PATHWAY: ko00512
Entry
ko00512                     Pathway                                

Name
Mucin type O-glycan biosynthesis
Description
O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
ko00512  Mucin type O-glycan biosynthesis
ko00512

Module
M00056  O-glycan biosynthesis, mucin type core [PATH:ko00512]
Disease
H00020  Colorectal cancer
H01188  Tn syndrome
H01193  Familial tumoral calcinosis
Other DBs
GO: 0006493
Orthology
K00710  polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]
K00731  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase [EC:2.4.1.122]
K09653  C1GALT1-specific chaperone 1
K00727  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase [EC:2.4.1.102]
K09662  N-acetylglucosaminyltransferase 3, mucin type [EC:2.4.1.-]
K09663  beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]
K00780  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A) [EC:2.4.99.4]
K03368  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B) [EC:2.4.99.4]
K03479  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A) [EC:2.4.99.3]
K00739  acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.147]
K09905  beta-1,4-galactosyltransferase 5 [EC:2.4.1.-]
Compound
C02189  [Protein]-L-serine
G00023  Tn antigen
G00024  T antigen
G00025   
G00026   
G00027   
G00028   
G00029   
G00030   
G00031   
G00032   
G00033   
G00034   
G00035  Sialyl-Tn antigen
G10611  UDP-N-acetyl-D-galactosamine
Reference
  Authors
Brockhausen I.
  Title
Pathways of O-glycan biosynthesis in cancer cells.
  Journal
Biochim Biophys Acta 1473:67-95 (1999)
DOI:10.1016/S0304-4165(99)00170-1
Reference
  Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
  Journal
J Biol Chem 277:12802-9 (2002)
DOI:10.1074/jbc.M112457200
Reference
  Authors
Korekane H, Taguchi T, Sakamoto Y, Honke K, Dohmae N, Salminen H, Toivonen S, Helin J, Takio K, Renkonen O, Taniguchi N.
  Title
Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.
  Journal
Glycobiology 13:387-400 (2003)
DOI:10.1093/glycob/cwg044
Reference
  Authors
van Die I, van Tetering A, Schiphorst WE, Sato T, Furukawa K, van den Eijnden DH.
  Title
The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.
  Journal
FEBS Lett 450:52-6 (1999)
DOI:10.1016/S0014-5793(99)00462-7
Related
pathway
ko00533  Glycosaminoglycan biosynthesis - keratan sulfate

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