KEGG   ORTHOLOGY: K04451Help
Entry
K04451                      KO                                     

Name
TP53, P53
Definition
tumor protein p53
Pathway
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04071  Sphingolipid signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04137  Mitophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04216  Ferroptosis
ko04218  Cellular senescence
ko04310  Wnt signaling pathway
ko04722  Neurotrophin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05016  Huntington disease
ko05131  Shigellosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00004  Chronic myeloid leukemia
H00005  Chronic lymphocytic leukemia
H00006  Hairy cell leukemia
H00008  Burkitt lymphoma
H00009  Adult T-cell leukemia
H00010  Multiple myeloma
H00013  Small cell lung cancer
H00014  Non-small cell lung cancer
H00015  Malignant pleural mesothelioma
H00016  Oral cancer
H00017  Esophageal cancer
H00018  Gastric cancer
H00019  Pancreatic cancer
H00020  Colorectal cancer
H00022  Bladder cancer
H00025  Penile cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00029  Vulvar cancer
H00031  Breast cancer
H00032  Thyroid cancer
H00033  Adrenal carcinoma
H00036  Osteosarcoma
H00038  Melanoma
H00039  Basal cell carcinoma
H00040  Squamous cell carcinoma
H00041  Kaposi sarcoma
H00042  Glioma
H00044  Cancer of the anal canal
H00046  Cholangiocarcinoma
H00047  Gallbladder cancer
H00048  Hepatocellular carcinoma
H00055  Laryngeal cancer
H00881  Li-Fraumeni syndrome
H01007  Choroid plexus papilloma
H01463  Mycosis fungoides
H01464  Mantle cell lymphoma
H01470  Giant cell tumor of bone
H01481  Myelodysplastic syndrome
H01554  Fallopian tube cancer
H01555  Merkel cell carcinoma
H01557  Hepatic angiosarcoma
H01559  Oropharyngeal cancer
H01667  Medulloblastoma
H02301  Nephroblastoma
H02411  Chronic myelomonocytic leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04451  TP53, P53; tumor protein p53
   04310 Wnt signaling pathway
    K04451  TP53, P53; tumor protein p53
   04071 Sphingolipid signaling pathway
    K04451  TP53, P53; tumor protein p53
   04151 PI3K-Akt signaling pathway
    K04451  TP53, P53; tumor protein p53
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04451  TP53, P53; tumor protein p53
  09143 Cell growth and death
   04110 Cell cycle
    K04451  TP53, P53; tumor protein p53
   04210 Apoptosis
    K04451  TP53, P53; tumor protein p53
   04216 Ferroptosis
    K04451  TP53, P53; tumor protein p53
   04115 p53 signaling pathway
    K04451  TP53, P53; tumor protein p53
   04218 Cellular senescence
    K04451  TP53, P53; tumor protein p53
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04451  TP53, P53; tumor protein p53
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04451  TP53, P53; tumor protein p53
  09149 Aging
   04211 Longevity regulating pathway
    K04451  TP53, P53; tumor protein p53
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04451  TP53, P53; tumor protein p53
   05202 Transcriptional misregulation in cancer
    K04451  TP53, P53; tumor protein p53
   05206 MicroRNAs in cancer
    K04451  TP53, P53; tumor protein p53
   05205 Proteoglycans in cancer
    K04451  TP53, P53; tumor protein p53
   05203 Viral carcinogenesis
    K04451  TP53, P53; tumor protein p53
   05230 Central carbon metabolism in cancer
    K04451  TP53, P53; tumor protein p53
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04451  TP53, P53; tumor protein p53
   05212 Pancreatic cancer
    K04451  TP53, P53; tumor protein p53
   05225 Hepatocellular carcinoma
    K04451  TP53, P53; tumor protein p53
   05226 Gastric cancer
    K04451  TP53, P53; tumor protein p53
   05214 Glioma
    K04451  TP53, P53; tumor protein p53
   05216 Thyroid cancer
    K04451  TP53, P53; tumor protein p53
   05220 Chronic myeloid leukemia
    K04451  TP53, P53; tumor protein p53
   05217 Basal cell carcinoma
    K04451  TP53, P53; tumor protein p53
   05218 Melanoma
    K04451  TP53, P53; tumor protein p53
   05219 Bladder cancer
    K04451  TP53, P53; tumor protein p53
   05215 Prostate cancer
    K04451  TP53, P53; tumor protein p53
   05213 Endometrial cancer
    K04451  TP53, P53; tumor protein p53
   05224 Breast cancer
    K04451  TP53, P53; tumor protein p53
   05222 Small cell lung cancer
    K04451  TP53, P53; tumor protein p53
   05223 Non-small cell lung cancer
    K04451  TP53, P53; tumor protein p53
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04451  TP53, P53; tumor protein p53
   05014 Amyotrophic lateral sclerosis (ALS)
    K04451  TP53, P53; tumor protein p53
   05016 Huntington disease
    K04451  TP53, P53; tumor protein p53
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04451  TP53, P53; tumor protein p53
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K04451  TP53, P53; tumor protein p53
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04451  TP53, P53; tumor protein p53
   05162 Measles
    K04451  TP53, P53; tumor protein p53
   05161 Hepatitis B
    K04451  TP53, P53; tumor protein p53
   05160 Hepatitis C
    K04451  TP53, P53; tumor protein p53
   05168 Herpes simplex virus 1 infection
    K04451  TP53, P53; tumor protein p53
   05163 Human cytomegalovirus infection
    K04451  TP53, P53; tumor protein p53
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04451  TP53, P53; tumor protein p53
   05169 Epstein-Barr virus infection
    K04451  TP53, P53; tumor protein p53
   05165 Human papillomavirus infection
    K04451  TP53, P53; tumor protein p53
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04451  TP53, P53; tumor protein p53
   01522 Endocrine resistance
    K04451  TP53, P53; tumor protein p53
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04451  TP53, P53; tumor protein p53
   03036 Chromosome and associated proteins
    K04451  TP53, P53; tumor protein p53
   03400 DNA repair and recombination proteins
    K04451  TP53, P53; tumor protein p53
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   p53
    K04451  TP53, P53; tumor protein p53
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     K04451  TP53, P53; tumor protein p53
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K04451  TP53, P53; tumor protein p53
BRITE hierarchy
Genes
HSA: 7157(TP53)
PTR: 455214(TP53)
PPS: 100973941(TP53)
GGO: 101133524(TP53)
PON: 100435218(TP53)
NLE: 100583326(TP53)
MCC: 716170(TP53)
MCF: 102135998(TP53)
CSAB: 103242323(TP53)
RRO: 104661662(TP53)
RBB: 108514363(TP53)
CJC: 100415710(TP53)
SBQ: 101043647(TP53)
MMU: 22059(Trp53)
MCAL: 110305297(Tp53)
MPAH: 110331731(Tp53)
RNO: 24842(Tp53)
MUN: 110555127(Tp53)
CGE: 100682525(Tp53)
NGI: 103752115(Tp53)
HGL: 101701769(Tp53)
CCAN: 109674834(Tp53)
OCU: 100009292(TP53)
TUP: 102503238(TP53)
CFA: 403869(TP53)
VVP: 112924853(TP53)
AML: 100468516(TP53)
UMR: 103660368(TP53)
UAH: 113271152(TP53)
ORO: 101362427(TP53)
ELK: 111161133
FCA: 493847(TP53)
PTG: 102962571(TP53)
PPAD: 109245932(TP53)
AJU: 106972437(TP53)
BTA: 281542(TP53)
BOM: 102272370(TP53)
BIU: 109574238(TP53)
BBUB: 102402069(TP53)
CHX: 102169621(TP53)
OAS: 443421(TP53)
SSC: 397276(TP53)
CFR: 102524476(TP53)
CDK: 105103011(TP53)
BACU: 103003426(TP53)
LVE: 103089875(TP53)
OOR: 101285670(TP53)
DLE: 111185755(TP53)
PCAD: 102985658(TP53)
ECB: 100062044(TP53)
EPZ: 103557703(TP53)
EAI: 106844218(TP53)
MYB: 102244768(TP53)
MYD: 102759012(TP53)
MNA: 107538830 107544572(TP53)
HAI: 109394672(TP53)
DRO: 112308825(TP53)
PALE: 102889604(TP53)
RAY: 107515689(TP53)
MJV: 108404266(TP53)
LAV: 100663725(TP53)
TMU: 101351852
MDO: 497248(TP53)
SHR: 100922473(TP53)
PCW: 110194271(TP53)
OAA: 100092821(TP53)
LSR: 110480316(TP53)
PHI: 102101491(TP53)
ASN: 102376594(TP53)
AMJ: 102570618(TP53)
PSS: 102448135(TP53)
CMY: 102934531
CPIC: 101942845(TP53)
ACS: 103282543
PVT: 110087754(TP53)
PBI: 103061365(TP53) 112542108
PMUR: 107299049
TSR: 106537915
PMUA: 114608083(TP53)
GJA: 107121079(TP53)
XLA: 108703451(tp53.S) 397926(tp53.L)
XTR: 431679(tp53)
NPR: 108784730
DRE: 30590(tp53)
SRX: 107726386 107744460
SANH: 107672786 107687672
SGH: 107592291 107599945
CCAR: 109082764 109083614
IPU: 100304476(tp53) 108267915
PHYP: 113540585
AMEX: 103037427 103046742(tp53)
EEE: 113570174(tp53) 113577352
TRU: 101079595
TNG: GSTEN00019217G001
LCO: 104923960(tp53)
NCC: 104945430(tp53)
MZE: 101480650 112432676
ONL: 100702587(p53)
OLA: 100049321(tp53)
XMA: 102219062(tp53)
XCO: 114157824(tp53)
PRET: 103480460(tp53)
CVG: 107087774(tp53)
NFU: 107377392(tp53)
KMR: 108228351
ALIM: 106525321(tp53)
AOCE: 111577187
CSEM: 103387239(tp53)
POV: 109634900
LCF: 108879980
SDU: 111233015
SLAL: 111650698
HCQ: 109528457
BPEC: 110159471(tp53)
MALB: 109951400(tp53)
SASA: 106577554 106602901(tp53) 106608673(P53)
OTW: 112214763 112229014 112260048
SALP: 111950504 111954968 111960314
ELS: 105008589 105020676
SFM: 108921730(tp53) 108923185
PKI: 111850623(tp53) 111854492
LCM: 102366539(TP53)
BMOR: 100384887(p53)
BMAN: 114240525
PRAP: 111001134
HAW: 110371726
TNL: 113502856
API: 100575088
DNX: 107172567
AGS: 114120933
RMD: 113548792
CLEC: 106661944
FCD: 110858146
ISC: IscW_ISCW012889 IscW_ISCW018042
LOA: LOAG_07717
NAI: NECAME_18530
TSP: Tsp_05266
HRO: HELRODRAFT_107137
EPA: 110233133 110241777
HMG: 100207213
SRE: PTSG_07599
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bourdon JC, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP, Saville MK, Lane DP
  Title
p53 isoforms can regulate p53 transcriptional activity.
  Journal
Genes Dev 19:2122-37 (2005)
DOI:10.1101/gad.1339905
  Sequence
[hsa:7157]
Reference
PMID:9840937
  Authors
Schneider E, Montenarh M, Wagner P
  Title
Regulation of CAK kinase activity by p53.
  Journal
Oncogene 17:2733-41 (1998)
DOI:10.1038/sj.onc.1202504
  Sequence
[hsa:7157]
Reference
PMID:4006916
  Authors
Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M
  Title
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells.
  Journal
EMBO J 4:1251-5 (1985)
DOI:10.1002/j.1460-2075.1985.tb03768.x
  Sequence
[hsa:7157]

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (100)   
   KEGG PATHWAY (100)   
Disease (47)   
   KEGG DISEASE (47)   
Drug (1)   
   KEGG DRUG (1)   
Gene (269)   
   KEGG GENES (163)   
   KEGG MGENES (8)   
   RefGene (91)   
   OC (7)   
Protein sequence (95)   
   UniProt (77)   
   SWISS-PROT (18)   
Literature (3)   
   PubMed (3)   
All databases (519)   

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