KEGG   ORTHOLOGY: K04850
Entry
K04850                      KO                                     
Symbol
CACNA1C, CAV1.2
Name
voltage-dependent calcium channel L type alpha-1C
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04260  Cardiac muscle contraction
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04713  Circadian entrainment
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04742  Taste transduction
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04929  GnRH secretion
map04930  Type II diabetes mellitus
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05031  Amphetamine addiction
map05207  Chemical carcinogenesis - receptor activation
map05410  Hypertrophic cardiomyopathy
map05412  Arrhythmogenic right ventricular cardiomyopathy
map05414  Dilated cardiomyopathy
Disease
H00720  Long QT syndrome
H00728  Brugada syndrome
H02397  Neurodevelopmental disorder with movement abnormalities or hypotonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04020 Calcium signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04024 cAMP signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04022 cGMP-PKG signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04929 GnRH secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04912 GnRH signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04921 Oxytocin signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04935 Growth hormone synthesis, secretion and action
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04924 Renin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04925 Aldosterone synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04927 Cortisol synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04261 Adrenergic signaling in cardiomyocytes
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04270 Vascular smooth muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09156 Nervous system
   04724 Glutamatergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04727 GABAergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04725 Cholinergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04728 Dopaminergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04726 Serotonergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04720 Long-term potentiation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04723 Retrograde endocannabinoid signaling
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09157 Sensory system
   04742 Taste transduction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05020 Prion disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05022 Pathways of neurodegeneration - multiple diseases
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09165 Substance dependence
   05031 Amphetamine addiction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05414 Dilated cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04934 Cushing syndrome
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
Other DBs
GO: 0005245
TC: 1.A.1.11.4 1.A.1.11.6
Genes
HSA: 775(CACNA1C)
PTR: 466915(CACNA1C)
PPS: 100971701(CACNA1C)
GGO: 101134060(CACNA1C)
PON: 100442085(CACNA1C)
NLE: 100580437(CACNA1C)
HMH: 116472525(CACNA1C)
MCC: 721721(CACNA1C)
MCF: 101865175(CACNA1C)
MTHB: 126930225
MNI: 105484109(CACNA1C)
CSAB: 103218385(CACNA1C)
CATY: 105582968(CACNA1C)
PANU: 101026237(CACNA1C)
TGE: 112634000(CACNA1C)
MLEU: 105529889(CACNA1C)
RRO: 104659017(CACNA1C)
RBB: 108522695(CACNA1C)
TFN: 117090701
PTEH: 111520328(CACNA1C)
CANG: 105503912(CACNA1C)
CJC: 100406735(CACNA1C)
SBQ: 101040048(CACNA1C)
CIMI: 108315880(CACNA1C)
CSYR: 103259018(CACNA1C)
MMUR: 105861596(CACNA1C)
LCAT: 123640189(CACNA1C)
PCOQ: 105815791(CACNA1C)
OGA: 100964267(CACNA1C)
MMU: 12288(Cacna1c)
MCAL: 110295755
MPAH: 110317086(Cacna1c)
RNO: 24239(Cacna1c)
MCOC: 116099482(Cacna1c)
ANU: 117715086(Cacna1c)
MUN: 110541273(Cacna1c)
CGE: 100754788(Cacna1c)
MAUA: 101834428(Cacna1c)
PROB: 127236163(Cacna1c)
PLEU: 114700762(Cacna1c)
MORG: 121441414(Cacna1c)
MFOT: 126505446
AAMP: 119806908(Cacna1c)
NGI: 103739378(Cacna1c)
HGL: 101717129(Cacna1c)
CPOC: 100135490(Cacna1c)
DORD: 105991064(Cacna1c)
PLOP: 125342716(Cacna1c)
NCAR: 124982084
MMMA: 107154890(Cacna1c)
OCU: 100101555(CACNA1C)
OPI: 101536063(CACNA1C)
GVR: 103595029(CACNA1C)
CFA: 403516(CACNA1C)
CLUD: 112668971(CACNA1C)
VVP: 112917426(CACNA1C)
VLG: 121479835(CACNA1C)
NPO: 129503382(CACNA1C)
AML: 100479715(CACNA1C)
UMR: 103675706(CACNA1C)
UAH: 113258052(CACNA1C)
UAR: 123777895(CACNA1C)
ELK: 111159674
LLV: 125107204
MPUF: 101679746(CACNA1C)
MNP: 132019988(CACNA1C)
MLK: 131838359(CACNA1C)
NVS: 122892214(CACNA1C)
ORO: 101365624(CACNA1C)
EJU: 114222521(CACNA1C)
ZCA: 113921757(CACNA1C)
MLX: 118025809(CACNA1C)
NSU: 110581023(CACNA1C)
FCA: 101082923(CACNA1C)
PYU: 121022112(CACNA1C)
PCOO: 112867221(CACNA1C)
PBG: 122473119(CACNA1C)
PVIV: 125170417(CACNA1C)
LRUF: 124501399
PTG: 102956322(CACNA1C)
PPAD: 109276255(CACNA1C)
PUC: 125920056
AJU: 106965473
HHV: 120243774(CACNA1C)
BTA: 408015(CACNA1C)
BOM: 102277590(CACNA1C)
BIU: 109558615(CACNA1C)
BBUB: 102407190(CACNA1C)
BBIS: 104992358(CACNA1C)
CHX: 100861292(CACNA1C)
OAS: 101116562(CACNA1C)
BTAX: 128048945(CACNA1C)
ODA: 120857839(CACNA1C)
CCAD: 122424089(CACNA1C)
MBEZ: 129535727(CACNA1C)
SSC: 100518733(CACNA1C)
CFR: 102524149(CACNA1C)
CBAI: 105076642(CACNA1C)
CDK: 105100748(CACNA1C)
VPC: 102538871(CACNA1C)
BACU: 103019389(CACNA1C)
BMUS: 118901684(CACNA1C)
LVE: 103087340(CACNA1C)
OOR: 101272740(CACNA1C)
DLE: 111176594(CACNA1C)
PCAD: 102989784(CACNA1C)
PSIU: 116760103(CACNA1C)
NASI: 112391637(CACNA1C)
ECB: 100049924(CACNA1C)
EAI: 106839455(CACNA1C)
MYB: 102240225(CACNA1C)
MYD: 102753812(CACNA1C)
MMYO: 118652154(CACNA1C)
MLF: 102424719(CACNA1C)
PKL: 118730029(CACNA1C)
EFUS: 103296724(CACNA1C)
MNA: 107546425(CACNA1C)
DRO: 112309331(CACNA1C)
SHON: 118999983(CACNA1C)
AJM: 119051688(CACNA1C)
PDIC: 114512949(CACNA1C)
PHAS: 123813423(CACNA1C)
MMF: 118624255(CACNA1C)
PPAM: 129073529(CACNA1C)
HAI: 109388950(CACNA1C)
RFQ: 117029264(CACNA1C)
PALE: 102882682(CACNA1C)
PGIG: 120607351(CACNA1C)
PVP: 105297298(CACNA1C)
RAY: 107500540(CACNA1C)
MJV: 108387253(CACNA1C)
TOD: 119247058(CACNA1C)
SARA: 101557862(CACNA1C)
SETR: 126022196(CACNA1C)
TMU: 101360945
ETF: 101656925(CACNA1C)
DNM: 101431301(CACNA1C)
MDO: 100021421(CACNA1C)
GAS: 123250056(CACNA1C)
SHR: 100926503
AFZ: 127564847
PCW: 110218748(CACNA1C)
OAA: 100082618(CACNA1C)
GGA: 395891(CACNA1C)
PCOC: 116226870(CACNA1C)
MGP: 100547459 104911865
CJO: 107315213(CACNA1C)
TPAI: 128073122(CACNA1C)
LMUT: 125693421(CACNA1C)
NMEL: 110395457(CACNA1C)
APLA: 101790062(CACNA1C)
ACYG: 106030933(CACNA1C)
CATA: 118250054(CACNA1C)
AFUL: 116489537(CACNA1C)
TGU: 100218244(CACNA1C)
LSR: 110472925(CACNA1C)
SCAN: 103820462(CACNA1C)
PMOA: 120501729(CACNA1C)
OTC: 121332892(CACNA1C)
PRUF: 121362733(CACNA1C)
GFR: 102031898
FAB: 101815051(CACNA1C)
OMA: 130263585(CACNA1C)
PHI: 102106069(CACNA1C)
PMAJ: 107204397(CACNA1C)
CCAE: 111928486
CCW: 104692245(CACNA1C)
CBRC: 103624725(CACNA1C)
ETL: 114069083(CACNA1C)
ZAB: 102070167(CACNA1C)
ACHL: 103806638(CACNA1C)
SVG: 106849354(CACNA1C)
MMEA: 130588985(CACNA1C)
HRT: 120751816(CACNA1C)
FPG: 101916694(CACNA1C)
FCH: 102048150(CACNA1C)
CLV: 102095010(CACNA1C)
EGZ: 104134399(CACNA1C)
NNI: 104020209(CACNA1C)
PLET: 104620166
EHS: 104511013
ACUN: 113475961(CACNA1C)
TALA: 104361153(CACNA1C)
PADL: 103924366(CACNA1C)
AFOR: 103898648(CACNA1C)
ACHC: 115352314(CACNA1C)
HALD: 104325178
HLE: 104830930(CACNA1C)
AGEN: 126047933
GCL: 127013811
CSTI: 104563363
CMAC: 104487032(CACNA1C)
MUI: 104544630
FGA: 104072796
LDI: 104353406(CACNA1C)
MNB: 103768936(CACNA1C)
OHA: 104330270(CACNA1C)
NNT: 104410749
SHAB: 115605742(CACNA1C)
DPUB: 104299582(CACNA1C)
PGUU: 104469827
CPEA: 104386585(CACNA1C)
AVIT: 104278438(CACNA1C)
CVF: 104281606(CACNA1C)
RTD: 128909658(CACNA1C)
CUCA: 104055901(CACNA1C)
AAM: 106488364(CACNA1C)
AROW: 112968301(CACNA1C)
DNE: 112993380(CACNA1C)
SCAM: 104147270(CACNA1C)
ASN: 102377475(CACNA1C)
AMJ: 102575519(CACNA1C)
CPOO: 109316457(CACNA1C)
GGN: 109296233(CACNA1C)
PSS: 102451554(CACNA1C)
CMY: 102940198(CACNA1C)
CCAY: 125625969(CACNA1C)
DCC: 119848353(CACNA1C)
CPIC: 101946823(CACNA1C)
TST: 117882551(CACNA1C)
CABI: 116834346
MRV: 120408934(CACNA1C)
ACS: 100553244(cacna1c)
ASAO: 132775772(CACNA1C)
PVT: 110076659(CACNA1C)
SUND: 121932087(CACNA1C)
PMUR: 107288329(CACNA1C)
CTIG: 120315478(CACNA1C)
PGUT: 117655788(CACNA1C)
APRI: 131202696(CACNA1C)
PTEX: 113447447(CACNA1C)
NSS: 113419359(CACNA1C)
VKO: 123016508(CACNA1C)
PMUA: 114605885
PRAF: 128422166(CACNA1C)
ZVI: 118090932(CACNA1C)
HCG: 128326984(CACNA1C)
GJA: 107120231(CACNA1C)
STOW: 125434341(CACNA1C)
EMC: 129335461(CACNA1C)
XLA: 100462911(cacna1c.S) 108704565(cacna1c.L)
XTR: 100488055(cacna1c)
NPR: 108791575
RTEM: 120932711(CACNA1C)
BBUF: 121004433(CACNA1C)
BGAR: 122928487(CACNA1C)
MUO: 115477346(CACNA1C)
GSH: 117363429(CACNA1C)
DRE: 170581(cacna1c)
SRX: 107732972
SANH: 107694143
SGH: 107589041 107590584
CCAR: 109104295
CAUA: 113048094 113062313
CGIB: 127956189 127973732
PTET: 122342654(cacna1c)
LROH: 127164112(cacna1c)
OMC: 131538945(cacna1c)
PPRM: 120476944(cacna1c)
RKG: 130072307(cacna1c)
MAMB: 125245652(cacna1c)
CIDE: 127511476
MASI: 127435437 127436755
TROS: 130547673(cacna1c)
TDW: 130420342(cacna1c)
MANU: 129431773(cacna1c)
IPU: 108279829(cacna1c)
IFU: 128622995(cacna1c)
PHYP: 113544629
SMEO: 124401221(cacna1c)
TFD: 113663733(cacna1c)
TVC: 132858817(cacna1c)
AMEX: 103041474
CMAO: 118812645(cacna1c)
EEE: 113576556
CHAR: 105911367(cacna1c)
TRU: 101064574(cacna1c)
TFS: 130519478(cacna1c)
LCO: 104940547
TBEN: 117484877(cacna1c)
CGOB: 115028206(cacna1c)
PGEO: 117468450(cacna1c)
GACU: 117536109(cacna1c)
EMAC: 134879379(cacna1c)
ELY: 117249155(cacna1c)
EFO: 125883250(cacna1c)
PLEP: 121961140
SLUC: 116059999(cacna1c)
ECRA: 117938808(cacna1c)
ESP: 116672836
PFLV: 114549894
GAT: 120818340(cacna1c)
PPUG: 119210128(cacna1c)
AFB: 129112503(cacna1c)
CLUM: 117726173(cacna1c)
PSWI: 130200799(cacna1c)
MSAM: 119918210(cacna1c)
SCHU: 122871614(cacna1c)
CUD: 121505730(cacna1c)
ALAT: 119032303(cacna1c)
MZE: 101471946(cacna1c)
ONL: 100711294(cacna1c)
OAU: 116309817(cacna1c)
OLA: 101173517
OML: 112156742(cacna1c)
CSAI: 133424498(cacna1c)
XMA: 102230290(cacna1c)
XCO: 114161254
XHE: 116736851
PRET: 103459268
PFOR: 103146495
PLAI: 106962096
PMEI: 106922075
GAF: 122826690(cacna1c)
PPRL: 129375629(cacna1c)
CVG: 107095494
CTUL: 119786207(cacna1c)
GMU: 124882886(cacna1c)
NFU: 107385235(cacna1c)
KMR: 108235074(cacna1c)
ALIM: 106515158
NWH: 119428184(cacna1c)
AOCE: 111571438
MCEP: 124999862(cacna1c)
CSEM: 103382787(cacna1c)
POV: 109632862
SSEN: 122767001(cacna1c)
HHIP: 117757229(cacna1c)
HSP: 118101730(cacna1c)
SMAU: 118292530(cacna1c)
LCF: 108879625(cacna1c)
SDU: 111224579(cacna1c)
SLAL: 111658797(cacna1c)
XGL: 120800940(cacna1c)
HCQ: 109520063
SSCV: 125992468
SBIA: 133493429(cacna1c)
PEE: 133397145(cacna1c)
PTAO: 133471941(cacna1c)
BPEC: 110162494
MALB: 109959866
BSPL: 114862070(cacna1c)
SJO: 128353427(cacna1c)
OTW: 112240960
OMY: 110518351 110518394
OGO: 123995860 124020959 124024504
OKI: 109882530
OKE: 127925063(cacna1c)
SNH: 120032122(cacna1c)
CCLU: 121553635(cacna1c)
ELS: 105023097(cacna1c)
SFM: 108920904(cacna1c)
PKI: 111843125(cacna1c)
AANG: 118231977(cacna1c)
LOC: 102684408(cacna1c)
PSPA: 121318589 121319532
ARUT: 117415426 117419745
PSEX: 120540046
LCM: 102357941(CACNA1C)
CMK: 103179419(cacna1c)
CPLA: 122559424(cacna1c)
HOC: 132824959(cacna1c)
LERI: 129706126(cacna1c)
PMRN: 116942266
LRJ: 133349342 133356809
SCLV: 120345351
TPAL: 117651643
LPOL: 106472247
PMEO: 129580634 129598907
PVUL: 126827870
BGT: 106052266
CRG: 105345994
CVN: 111110350
CANU: 128158970
MCAF: 127726928
MMER: 123528805
DPOL: 127857582
OSN: 115222732
XEN: 124434873 124452949
HSY: 130624947
 » show all
Reference
PMID:17071743
  Authors
Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM
  Title
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.
  Journal
Proc Natl Acad Sci U S A 103:17024-9 (2006)
DOI:10.1073/pnas.0606539103
  Sequence
[hsa:775]
Reference
PMID:1316612
  Authors
Soldatov NM
  Title
Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.
  Journal
Proc Natl Acad Sci U S A 89:4628-32 (1992)
DOI:10.1073/pnas.89.10.4628
  Sequence
[hsa:775]

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Ontology (5)   
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