KEGG   PATHWAY: dme00564
Entry
dme00564                    Pathway                                
Name
Glycerophospholipid metabolism - Drosophila melanogaster (fruit fly)
Class
Metabolism; Lipid metabolism
Pathway map
dme00564  Glycerophospholipid metabolism
dme00564

Module
dme_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:dme00564]
Other DBs
GO: 0006650
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
Dmel_CG3215  Gpdh2; Glycerol-3-phosphate dehydrogenase 2 [KO:K00006] [EC:1.1.1.8]
Dmel_CG9042  Gpdh1; Glycerol-3-phosphate dehydrogenase 1, isoform F [KO:K00006] [EC:1.1.1.8]
Dmel_CG2137  Gpo2; glycerophosphate oxidase 2 [KO:K00111] [EC:1.1.5.3]
Dmel_CG7311  Gpo3; glycerophosphate oxidase 3, isoform E [KO:K00111] [EC:1.1.5.3]
Dmel_CG8256  Gpo1; glycerophosphate oxidase 1, isoform D [KO:K00111] [EC:1.1.5.3]
Dmel_CG5508  mino; minotaur, isoform E [KO:K00629] [EC:2.3.1.15]
Dmel_CG3209  Gpat4; Glycerol-3-phosphate acyltransferase 4, isoform D [KO:K13506] [EC:2.3.1.15]
Dmel_CG15450  CG15450; uncharacterized protein [KO:K13506] [EC:2.3.1.15]
Dmel_CG3812  Agpat1; 1-Acylglycerol-3-phosphate O-acyltransferase 1, isoform C [KO:K13509] [EC:2.3.1.51]
Dmel_CG4753  Agpat4; 1-Acylglycerol-3-phosphate O-acyltransferase 4, isoform C [KO:K13523] [EC:2.3.1.51 2.3.1.-]
Dmel_CG4729  Agpat3; 1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E [KO:K13523] [EC:2.3.1.51 2.3.1.-]
Dmel_CG4625  Gnpat; glyceronephosphate O-acyltransferase, isoform B [KO:K00649] [EC:2.3.1.42]
Dmel_CG8804  wun; wunen, isoform B [KO:K01080] [EC:3.1.3.4]
Dmel_CG8805  wun2; wunen-2, isoform B [KO:K01080] [EC:3.1.3.4]
Dmel_CG11440  laza; lazaro [KO:K01080] [EC:3.1.3.4]
Dmel_CG11438  CG11438; uncharacterized protein, isoform B [KO:K01080] [EC:3.1.3.4]
Dmel_CG11437  CG11437; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dmel_CG11426  CG11426; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dmel_CG11425  CG11425; uncharacterized protein [KO:K01080] [EC:3.1.3.4]
Dmel_CG8709  Lpin; lipin, isoform B [KO:K15728] [EC:3.1.3.4]
Dmel_CG12746  CG12746; uncharacterized protein, isoform E [KO:K18693] [EC:3.6.1.75 3.1.3.4]
Dmel_CG8657  Dgkepsilon; diacyl glycerol kinase epsilon, isoform B [KO:K00901] [EC:2.7.1.107]
Dmel_CG34384  CG34384; uncharacterized protein, isoform A [KO:K00901] [EC:2.7.1.107]
Dmel_CG34361  Dgk; diacyl glycerol kinase, isoform E [KO:K00901] [EC:2.7.1.107]
Dmel_CG31140  CG31140; uncharacterized protein, isoform D [KO:K00901] [EC:2.7.1.107]
Dmel_CG42667  rdgA; retinal degeneration A, isoform A [KO:K00901] [EC:2.7.1.107]
Dmel_CG12110  Pld; phospholipase D, isoform F [KO:K01115] [EC:3.1.4.4]
Dmel_CG9248  Pld3; phospholipase D family member 3, isoform C [KO:K16860] [EC:3.1.4.4]
Dmel_CG43345  CG43345; uncharacterized protein, isoform C [KO:K16860] [EC:3.1.4.4]
Dmel_CG14507  CG14507; uncharacterized protein [KO:K01047] [EC:3.1.1.4]
Dmel_CG3009  CG3009; uncharacterized protein, isoform B [KO:K01047] [EC:3.1.1.4]
Dmel_CG1583  GIIIspla2; phospholipase A2 group III, isoform C [KO:K01047] [EC:3.1.1.4]
Dmel_CG17035  GXIVsPLA2; GXIVsPLA2, isoform C [KO:K01047] [EC:3.1.1.4]
Dmel_CG11124  sPLA2; secretory phospholipase A2, isoform C [KO:K01047] [EC:3.1.1.4]
Dmel_CG30503  CG30503; uncharacterized protein, isoform B [KO:K01047] [EC:3.1.1.4]
Dmel_CG6718  iPLA2-VIA; calcium-independent phospholipase A2 VIA, isoform A [KO:K16343] [EC:3.1.1.4]
Dmel_CG32699  LPCAT; lysophosphatidylcholine acyltransferase [KO:K13510] [EC:2.3.1.23 2.3.1.67]
Dmel_CG9655  nes; nessy, isoform A [KO:K13515] [EC:2.3.1.23 2.3.1.-]
Dmel_CG31683  CG31683; uncharacterized protein, isoform B [KO:K06129] [EC:3.1.1.5]
Dmel_CG18858  CG18858; uncharacterized protein, isoform B [KO:K06129] [EC:3.1.1.5]
Dmel_CG18815  Apt1; Acyl-protein thioesterase 1, isoform D [KO:K06130] [EC:3.1.1.5]
Dmel_CG2212  sws; swiss cheese, isoform A [KO:K14676] [EC:3.1.1.5]
Dmel_CG2818  CG2818; uncharacterized protein, isoform A [KO:K18695] [EC:3.1.4.2]
Dmel_CG12345  ChAT; choline acetyltransferase, isoform A [KO:K00623] [EC:2.3.1.6]
Dmel_CG17907  Ace; acetylcholine esterase, isoform B [KO:K01049] [EC:3.1.1.7]
Dmel_CG4757  CG4757; uncharacterized protein, isoform B [KO:K01049] [EC:3.1.1.7]
Dmel_CG2201  CG2201; uncharacterized protein, isoform E [KO:K14156] [EC:2.7.1.32 2.7.1.82]
Dmel_CG1049  Pcyt1; phosphocholine cytidylyltransferase 1, isoform E [KO:K00968] [EC:2.7.7.15]
Dmel_CG18330  Pcyt2; phosphocholine cytidylyltransferase 2 [KO:K00968] [EC:2.7.7.15]
Dmel_CG6016  bbc; bb in a boxcar, isoform C [KO:K00993] [EC:2.7.8.1]
Dmel_CG33116  CG33116; uncharacterized protein [KO:K00993] [EC:2.7.8.1]
Dmel_CG7149  CG7149; uncharacterized protein, isoform B [KO:K00993] [EC:2.7.8.1]
Dmel_CG3525  eas; easily shocked, isoform A [KO:K00894] [EC:2.7.1.82]
Dmel_CG5547  Pect; phosphoethanolamine cytidylyltransferase, isoform E [KO:K00967] [EC:2.7.7.14]
Dmel_CG8745  CG8745; uncharacterized protein [KO:K14286] [EC:4.2.3.2]
Dmel_CG7962  Cds; CDP-diacylglycerol synthase, isoform B [KO:K00981] [EC:2.7.7.41]
Dmel_CG4825  Pss; phosphatidylserine synthase, isoform A [KO:K08729] [EC:2.7.8.-]
Dmel_CG5991  Pisd; phosphatidylserine decarboxylase, isoform A [KO:K01613] [EC:4.1.1.65]
Dmel_CG7718  PGS1; phosphatidylglycerophosphate synthase 1 [KO:K00995] [EC:2.7.8.5]
Dmel_CG4774  CLS; cardiolipin synthase, isoform D [KO:K08744] [EC:2.7.8.41]
Dmel_CG8766  Taz; tafazzin, isoform A [KO:K13511] [EC:2.3.1.-]
Dmel_CG9245  Pis; phosphatidylinositol synthase, isoform A [KO:K00999] [EC:2.7.8.11]
Dmel_CG9526  frj; farjavit, isoform A [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
dme00010  Glycolysis / Gluconeogenesis
dme00260  Glycine, serine and threonine metabolism
dme00561  Glycerolipid metabolism
dme00562  Inositol phosphate metabolism
dme00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
dme00565  Ether lipid metabolism
dme00620  Pyruvate metabolism
KO pathway
ko00564   

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