Entry |
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Name |
Mitophagy - animal - Drosophila melanogaster (fruit fly)
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Description |
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
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Class |
Cellular Processes; Transport and catabolism
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Pathway map |

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Other DBs |
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Organism |
Drosophila melanogaster (fruit fly) [GN: dme]
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Gene |
Dmel_CG3869 | Marf; mitochondrial assembly regulatory factor, isoform C [KO:K06030] [EC:3.6.5.-] |
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Reference |
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Authors |
Pickrell AM, Youle RJ |
Title |
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. |
Journal |
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Reference |
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Authors |
Durcan TM, Fon EA |
Title |
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. |
Journal |
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Reference |
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Authors |
Shirihai OS, Song M, Dorn GW 2nd |
Title |
How mitochondrial dynamism orchestrates mitophagy. |
Journal |
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Reference |
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Authors |
Hamacher-Brady A, Brady NR |
Title |
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. |
Journal |
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Reference |
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Authors |
Yamano K, Matsuda N, Tanaka K |
Title |
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation. |
Journal |
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Reference |
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Authors |
Yamaguchi O, Murakawa T, Nishida K, Otsu K |
Title |
Receptor-mediated mitophagy. |
Journal |
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Reference |
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Authors |
Roberts RF, Tang MY, Fon EA, Durcan TM |
Title |
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles. |
Journal |
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Reference |
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Authors |
Arena G, Valente EM |
Title |
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease. |
Journal |
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Related pathway |
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KO pathway |
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