Entry |
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Name |
mTOR signaling pathway - Drosophila pseudoobscura pseudoobscura
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Description |
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
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Class |
Environmental Information Processing; Signal transduction
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Pathway map |

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Organism |
Drosophila pseudoobscura pseudoobscura [GN: dpo]
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Gene |
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Compound |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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Reference |
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Authors |
Kennedy BK, Lamming DW |
Title |
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. |
Journal |
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Reference |
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Authors |
Shimobayashi M, Hall MN |
Title |
Making new contacts: the mTOR network in metabolism and signalling crosstalk. |
Journal |
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Reference |
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Authors |
Huang K, Fingar DC |
Title |
Growing knowledge of the mTOR signaling network. |
Journal |
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Reference |
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Authors |
Bockaert J, Marin P |
Title |
mTOR in Brain Physiology and Pathologies. |
Journal |
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Reference |
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Authors |
Caron A, Richard D, Laplante M |
Title |
The Roles of mTOR Complexes in Lipid Metabolism. |
Journal |
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Reference |
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Authors |
Shimobayashi M, Hall MN |
Title |
Multiple amino acid sensing inputs to mTORC1. |
Journal |
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Reference |
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Authors |
Bar-Peled L, Sabatini DM |
Title |
Regulation of mTORC1 by amino acids. |
Journal |
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Reference |
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Authors |
Fingar DC |
Title |
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling. |
Journal |
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Reference |
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Authors |
Cai H, Dong LQ, Liu F |
Title |
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects. |
Journal |
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Reference |
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Authors |
Eyre TA, Collins GP, Goldstone AH, Cwynarski K |
Title |
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies. |
Journal |
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Reference |
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Authors |
Jewell JL, Guan KL |
Title |
Nutrient signaling to mTOR and cell growth. |
Journal |
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Reference |
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Authors |
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB |
Title |
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. |
Journal |
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Reference |
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Authors |
Kim SG, Buel GR, Blenis J |
Title |
Nutrient regulation of the mTOR complex 1 signaling pathway. |
Journal |
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Reference |
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Authors |
Laplante M, Sabatini DM |
Title |
mTOR signaling at a glance. |
Journal |
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Reference |
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Authors |
Alessi DR, Sakamoto K, Bayascas JR |
Title |
LKB1-dependent signaling pathways. |
Journal |
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Reference |
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Authors |
Dan HC, Antonia RJ, Baldwin AS |
Title |
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha. |
Journal |
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Reference |
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Authors |
Saxton RA, Sabatini DM |
Title |
mTOR Signaling in Growth, Metabolism, and Disease. |
Journal |
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Related pathway |
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KO pathway |
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