KEGG   PATHWAY: dpo04150
Entry
dpo04150                    Pathway                                

Name
mTOR signaling pathway - Drosophila pseudoobscura pseudoobscura
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dpo04150  mTOR signaling pathway
dpo04150

Organism
Drosophila pseudoobscura pseudoobscura [GN:dpo]
Gene
Dpse_GA23621  uncharacterized protein, isoform A [KO:K13780]
Dpse_GA19336  uncharacterized protein [KO:K13780]
Dpse_GA11552  uncharacterized protein, isoform A [KO:K13780]
Dpse_GA15464  uncharacterized protein, isoform A [KO:K06519]
Dpse_GA11612  uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dpse_GA28953  uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dpse_GA18641  uncharacterized protein [KO:K02145] [EC:7.1.2.2]
Dpse_GA14484  uncharacterized protein, isoform A [KO:K02147]
Dpse_GA12092  uncharacterized protein [KO:K02149]
Dpse_GA20878  uncharacterized protein [KO:K02149]
Dpse_GA20975  uncharacterized protein [KO:K02149]
Dpse_GA10614  uncharacterized protein [KO:K02150]
Dpse_GA20901  Dpse_Vha14; Vha14 [KO:K02151]
Dpse_GA26491  uncharacterized protein, isoform A [KO:K02151]
Dpse_GA13911  uncharacterized protein [KO:K02151]
Dpse_GA19444  uncharacterized protein [KO:K02152]
Dpse_GA14464  uncharacterized protein, isoform A [KO:K02144]
Dpse_GA12812  uncharacterized protein [KO:K20397]
Dpse_GA18722  uncharacterized protein [KO:K20398]
Dpse_GA18666  uncharacterized protein [KO:K04370]
Dpse_GA13399  uncharacterized protein [KO:K20399]
Dpse_GA13265  uncharacterized protein [KO:K16344]
Dpse_GA21211  uncharacterized protein [KO:K09594]
Dpse_GA17671  uncharacterized protein [KO:K20401]
Dpse_GA11302  uncharacterized protein [KO:K16185]
Dpse_GA21270  uncharacterized protein [KO:K16186]
Dpse_GA20081  uncharacterized protein, isoform A [KO:K20407]
Dpse_GA21281  uncharacterized protein [KO:K14299]
Dpse_GA20478  uncharacterized protein [KO:K20408]
Dpse_GA18371  uncharacterized protein [KO:K20409]
Dpse_GA19854  uncharacterized protein [KO:K14004]
Dpse_GA11387  uncharacterized protein, isoform C [KO:K20404]
Dpse_GA21545  uncharacterized protein [KO:K20405]
Dpse_GA21319  uncharacterized protein [KO:K20406]
Dpse_GA22024  uncharacterized protein [KO:K03875]
Dpse_GA32390  uncharacterized protein [KO:K07204]
Dpse_GA18654  uncharacterized protein, isoform A [KO:K07203] [EC:2.7.11.1]
Dpse_GA15597  uncharacterized protein [KO:K08266]
Dpse_GA14211  uncharacterized protein [KO:K20403]
Dpse_GA25935  uncharacterized protein, isoform A [KO:K10421]
Dpse_GA21271  uncharacterized protein, isoform A [KO:K15728] [EC:3.1.3.4]
Dpse_GA10675  uncharacterized protein [KO:K08269] [EC:2.7.11.1]
Dpse_GA28658  uncharacterized protein, isoform A [KO:K03259]
Dpse_GA26519  uncharacterized protein, isoform B [KO:K03259]
Dpse_GA28380  uncharacterized protein [KO:K03259]
Dpse_GA24628  uncharacterized protein [KO:K03259]
Dpse_GA28599  uncharacterized protein [KO:K03259]
Dpse_GA28966  uncharacterized protein [KO:K03259]
Dpse_GA10383  uncharacterized protein [KO:K04688] [EC:2.7.11.1]
Dpse_GA10657  uncharacterized protein [KO:K02991]
Dpse_GA23494  uncharacterized protein [KO:K02991]
Dpse_GA21739  uncharacterized protein, isoform A [KO:K07298] [EC:2.7.11.1]
Dpse_GA17944  uncharacterized protein [KO:K08272]
Dpse_GA15892  uncharacterized protein [KO:K07198] [EC:2.7.11.11]
Dpse_GA19391  uncharacterized protein, isoform A [KO:K07206]
Dpse_GA19997  uncharacterized protein [KO:K07207]
Dpse_GA19418  uncharacterized protein [KO:K20396]
Dpse_GA10574  uncharacterized protein [KO:K07208]
Dpse_GA18504  Dpse_wg; wg [KO:K03209]
Dpse_GA19569  uncharacterized protein [KO:K00444]
Dpse_GA18561  uncharacterized protein [KO:K00445]
Dpse_GA24226  uncharacterized protein, isoform A [KO:K00572]
Dpse_GA21093  uncharacterized protein [KO:K00714]
Dpse_GA25881  uncharacterized protein, isoform A [KO:K01064]
Dpse_GA18562  uncharacterized protein [KO:K01357]
Dpse_GA14615  uncharacterized protein [KO:K02432]
Dpse_GA18313  uncharacterized protein [KO:K02354]
Dpse_GA28694  uncharacterized protein [KO:K02354]
Dpse_GA23719  uncharacterized protein [KO:K02354]
Dpse_GA21999  uncharacterized protein [KO:K02375]
Dpse_GA14147  uncharacterized protein [KO:K04690]
Dpse_GA19223  uncharacterized protein, isoform A [KO:K03068]
Dpse_GA14904  uncharacterized protein [KO:K02353]
Dpse_GA22660  uncharacterized protein, isoform H [KO:K03083] [EC:2.7.11.26]
Dpse_GA15928  uncharacterized protein [KO:K03083] [EC:2.7.11.26]
Dpse_GA18716  uncharacterized protein [KO:K03083] [EC:2.7.11.26]
Dpse_GA18025  uncharacterized protein [KO:K07209] [EC:2.7.11.10]
Dpse_GA23860  uncharacterized protein [KO:K04526]
Dpse_GA12803  uncharacterized protein [KO:K04526]
Dpse_GA23862  uncharacterized protein [KO:K04526]
Dpse_GA19821  uncharacterized protein [KO:K04526]
Dpse_GA22847  uncharacterized protein [KO:K05459]
Dpse_GA26307  uncharacterized protein [KO:K05087] [EC:2.7.10.1]
Dpse_GA19310  uncharacterized protein [KO:K04364]
Dpse_GA28770  uncharacterized protein [KO:K03099]
Dpse_GA21740  uncharacterized protein [KO:K07827]
Dpse_GA15481  uncharacterized protein, isoform A [KO:K04365] [EC:2.7.11.1]
Dpse_GA13960  uncharacterized protein, isoform A [KO:K04368] [EC:2.7.12.2]
Dpse_GA14570  uncharacterized protein [KO:K04373] [EC:2.7.11.1]
Dpse_GA19056  uncharacterized protein [KO:K16172]
Dpse_GA15435  uncharacterized protein [KO:K02649]
Dpse_GA17984  uncharacterized protein, isoform A [KO:K00922] [EC:2.7.1.153]
Dpse_GA19047  uncharacterized protein, isoform E [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Dpse_GA28399  uncharacterized protein, isoform A [KO:K06276] [EC:2.7.11.1]
Dpse_GA17848  uncharacterized protein [KO:K04456] [EC:2.7.11.1]
Dpse_GA10075  uncharacterized protein [KO:K20410]
Dpse_GA20757  uncharacterized protein [KO:K08267]
Dpse_GA25121  uncharacterized protein, isoform A [KO:K04513]
Dpse_GA19732  uncharacterized protein, isoform A [KO:K02677] [EC:2.7.11.13]
Dpse_GA19657  uncharacterized protein [KO:K19662] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dpo00561  Glycerolipid metabolism
dpo04140  Autophagy - animal
KO pathway
ko04150   

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