KEGG PATHWAY: hsa05134

PATHWAY: hsa05134

Entry

hsa05134                    Pathway

Name

Legionellosis - Homo sapiens (human)

Description

Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated with Legionella species: Legionnaires' disease is the more severe form of the infection, which may involve pneumonia, and Pontiac fever is a milder respiratory illness.
The pathogenesis of L. pneumophila is derived from its growth within lung macrophages. One of the L. pneumophila's type IV secretion systems, the Dot/Icm secretion system, is of critical importance for its ability to replicate and to cause disease. The Dot/Icm substrates modulate multiple host cell processes and in particular, redirect trafficking of the L. pneumophila phagosome and mediate its conversion into an ER-derived organelle competent for intracellular bacterial replication. L. pneumophila also manipulates host cell death and survival pathways in a way that allows continued intracellular replication.

Class

Human Diseases; Infectious disease: bacterial

Pathway map

hsa05134

Legionellosis

Disease

H00311

Legionellosis

Organism

Homo sapiens (human) [GN:hsa]

Gene

3329	HSPD1; heat shock protein family D (Hsp60) member 1 [KO:K04077] [EC:5.6.1.7]

718	C3; complement C3 [KO:K03990]

1378	CR1; complement C3b/C4b receptor 1 (Knops blood group) [KO:K04011]

1379	CR1L; complement C3b/C4b receptor 1 like [KO:K04011]

3684	ITGAM; integrin subunit alpha M [KO:K06461]

3689	ITGB2; integrin subunit beta 2 [KO:K06464]

375	ARF1; ADP ribosylation factor 1 [KO:K07937]

5861	RAB1A; RAB1A, member RAS oncogene family [KO:K07874]

81876

RAB1B; RAB1B, member RAS oncogene family [KO:K07875]

9554	SEC22B; SEC22 homolog B, vesicle trafficking protein [KO:K08517]

56681

SAR1A; secretion associated Ras related GTPase 1A [KO:K07953] [EC:3.6.5.-]

51128

SAR1B; secretion associated Ras related GTPase 1B [KO:K07953] [EC:3.6.5.-]

7415	VCP; valosin containing protein [KO:K13525]

317	APAF1; apoptotic peptidase activating factor 1 [KO:K02084]

54205

CYCS; cytochrome c, somatic [KO:K08738]

842	CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]

836	CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]

841	CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]

664	BNIP3; BCL2 interacting protein 3 [KO:K15464]

23786

BCL2L13; BCL2 like 13 [KO:K15485]

4791	NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]

4792	NFKBIA; NFKB inhibitor alpha [KO:K04734]

4790	NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]

5970	RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]

57396

CLK4; CDC like kinase 4 [KO:K23561] [EC:2.7.12.1]

1195	CLK1; CDC like kinase 1 [KO:K23561] [EC:2.7.12.1]

10767

HBS1L; HBS1 like translational GTPase [KO:K14416]

1915	EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]

1917	EEF1A2; eukaryotic translation elongation factor 1 alpha 2 [KO:K03231]

3297	HSF1; heat shock transcription factor 1 [KO:K09414]

3312	HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]

3303	HSPA1A; heat shock protein family A (Hsp70) member 1A [KO:K03283]

3305	HSPA1L; heat shock protein family A (Hsp70) member 1 like [KO:K03283]

3304	HSPA1B; heat shock protein family A (Hsp70) member 1B [KO:K03283]

3310	HSPA6; heat shock protein family A (Hsp70) member 6 [KO:K03283]

1937	EEF1G; eukaryotic translation elongation factor 1 gamma [KO:K03233]

4671	NAIP; NLR family apoptosis inhibitory protein [KO:K12807]

840	CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]

58484

NLRC4; NLR family CARD domain containing 4 [KO:K12805]

29108

PYCARD; PYD and CARD domain containing [KO:K12799]

834	CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]

3606	IL18; interleukin 18 [KO:K05482]

3553	IL1B; interleukin 1 beta [KO:K04519]

7100	TLR5; toll like receptor 5 [KO:K10168]

7097	TLR2; toll like receptor 2 [KO:K10159]

929	CD14; CD14 molecule [KO:K04391]

7099	TLR4; toll like receptor 4 [KO:K10160]

4615	MYD88; MYD88 innate immune signal transduction adaptor [KO:K04729]

7124	TNF; tumor necrosis factor [KO:K03156]

3569	IL6; interleukin 6 [KO:K05405]

3592	IL12A; interleukin 12A [KO:K05406]

3593	IL12B; interleukin 12B [KO:K05425]

3576	CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]

2919	CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505]

2920	CXCL2; C-X-C motif chemokine ligand 2 [KO:K05505]

2921	CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505]

Compound

C00338

Lipopolysaccharide

C01277

1-Phosphatidyl-1D-myo-inositol 4-phosphate

Reference

PMID:20375353

Authors

Newton HJ, Ang DK, van Driel IR, Hartland EL

Title

Molecular pathogenesis of infections caused by Legionella pneumophila.

Journal

Clin Microbiol Rev 23:274-98 (2010)
DOI:10.1128/CMR.00052-09

Reference

PMID:18363881

Authors

Shin S, Roy CR

Title

Host cell processes that influence the intracellular survival of Legionella pneumophila.

Journal

Cell Microbiol 10:1209-20 (2008)
DOI:10.1111/j.1462-5822.2008.01145.x

Reference

PMID:19157961

Authors

Ensminger AW, Isberg RR

Title

Legionella pneumophila Dot/Icm translocated substrates: a sum of parts.

Journal

Curr Opin Microbiol 12:67-73 (2009)
DOI:10.1016/j.mib.2008.12.004

Reference

PMID:15972519

Authors

Chang B, Kura F, Amemura-Maekawa J, Koizumi N, Watanabe H

Title

Identification of a novel adhesion molecule involved in the virulence of Legionella pneumophila.

Journal

Infect Immun 73:4272-80 (2005)
DOI:10.1128/IAI.73.7.4272-4280.2005

Reference

PMID:18549456

Authors

Liu M, Conover GM, Isberg RR

Title

Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages.

Journal

Cell Microbiol 10:1906-23 (2008)
DOI:10.1111/j.1462-5822.2008.01180.x

Reference

PMID:19021631

Authors

Weber SS, Ragaz C, Hilbi H

Title

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.

Journal

Cell Microbiol 11:442-60 (2009)
DOI:10.1111/j.1462-5822.2008.01266.x

Reference

PMID:16495539

Authors

Newton HJ, Sansom FM, Bennett-Wood V, Hartland EL

Title

Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry.

Journal

Infect Immun 74:1683-91 (2006)
DOI:10.1128/IAI.74.3.1683-1691.2006

Reference

PMID:18048909

Authors

De Buck E, Anne J, Lammertyn E

Title

The role of protein secretion systems in the virulence of the intracellular pathogen Legionella pneumophila.

Journal

Microbiology 153:3948-53 (2007)
DOI:10.1099/mic.0.2007/012039-0

Reference

PMID:19687203

Authors

Chong A, Lima CA, Allan DS, Nasrallah GK, Garduno RA

Title

The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization.

Journal

Infect Immun 77:4724-39 (2009)
DOI:10.1128/IAI.00150-09

Reference

PMID:1721820

Authors

Cooper NR

Title

Complement evasion strategies of microorganisms.

Journal

Immunol Today 12:327-31 (1991)
DOI:10.1016/0167-5699(91)90010-Q

Reference

PMID:16824952

Authors

Machner MP, Isberg RR

Title

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.

Journal

Dev Cell 11:47-56 (2006)
DOI:10.1016/j.devcel.2006.05.013

Reference

PMID:12427954

Authors

Neumeister B, Faigle M, Lauber K, Northoff H, Wesselborg S

Title

Legionella pneumophila induces apoptosis via the mitochondrial death pathway.

Journal

Microbiology 148:3639-50 (2002)
DOI:10.1099/00221287-148-11-3639

Reference

PMID:17124169

Authors

Laguna RK, Creasey EA, Li Z, Valtz N, Isberg RR

Title

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.

Journal

Proc Natl Acad Sci U S A 103:18745-50 (2006)
DOI:10.1073/pnas.0609012103

Reference

PMID:19666608

Authors

Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F

Title

A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors.

Journal

Proc Natl Acad Sci U S A 106:13725-30 (2009)
DOI:10.1073/pnas.0907200106

Reference

PMID:18284575

Authors

Kubori T, Hyakutake A, Nagai H

Title

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.

Journal

Mol Microbiol 67:1307-19 (2008)
DOI:10.1111/j.1365-2958.2008.06124.x

Reference

PMID:19386084

Authors

Shen X, Banga S, Liu Y, Xu L, Gao P, Shamovsky I, Nudler E, Luo ZQ

Title

Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response.

Journal

Cell Microbiol 11:911-26 (2009)
DOI:10.1111/j.1462-5822.2009.01301.x

Reference

PMID:19478083

Authors

Belyi Y, Stahl M, Sovkova I, Kaden P, Luy B, Aktories K

Title

Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase.

Journal

J Biol Chem 284:20167-74 (2009)
DOI:10.1074/jbc.M109.008441

Reference

PMID:18281405

Authors

Belyi Y, Tabakova I, Stahl M, Aktories K

Title

Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila.

Journal

J Bacteriol 190:3026-35 (2008)
DOI:10.1128/JB.01798-07

Reference

PMID:19343209

Authors

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO

Title

Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

Journal

PLoS Pathog 5:e1000361 (2009)
DOI:10.1371/journal.ppat.1000361

Reference

PMID:20941588

Authors

Palusinska-Szysz M, Janczarek M

Title

Innate immunity to Legionella and toll-like receptors - review.

Journal

Folia Microbiol (Praha) 55:508-14 (2010)
DOI:10.1007/s12223-010-0084-8

Related
pathway

hsa04210

Apoptosis

hsa04610

Complement and coagulation cascades

hsa04620

Toll-like receptor signaling pathway

KO pathway

ko05134

All links

Disease (1)   
   KEGG DISEASE (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (56)   
   KEGG GENES (56)   
All databases (58)   

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