KEGG   PATHWAY: nmel00830
Entry
nmel00830                   Pathway                                
Name
Retinol metabolism - Numida meleagris (helmeted guineafowl)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
nmel00830  Retinol metabolism
nmel00830

Other DBs
GO: 0006776
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110387101  RETSAT; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
110388620  [KO:K09516] [EC:1.3.99.23]
110388681  RDH8; retinol dehydrogenase 8 isoform X1 [KO:K11150] [EC:1.1.1.-]
110389190  [KO:K11154] [EC:1.1.1.-]
110390028  ALDH1A1; retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
110391116  RDH5; 11-cis retinol dehydrogenase [KO:K00061] [EC:1.1.1.315]
110391420  [KO:K11147] [EC:1.1.-.-]
110393074  [KO:K15734] [EC:1.1.1.105]
110393823  RDH10; retinol dehydrogenase 10 isoform X1 [KO:K11151] [EC:1.1.1.-]
110395001  [KO:K15734] [EC:1.1.1.105]
110397265  [KO:K13951] [EC:1.1.1.1]
110397267  [KO:K13951] [EC:1.1.1.1]
110397269  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
110398466  [KO:K00699] [EC:2.4.1.17]
110398722  [KO:K12664] [EC:1.14.14.-]
110398861  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
110399446  [KO:K07413] [EC:1.14.14.1]
110399532  [KO:K12665] [EC:1.14.14.-]
110399582  [KO:K11149] [EC:1.1.-.-]
110399743  [KO:K00699] [EC:2.4.1.17]
110399800  [KO:K17951] [EC:1.14.19.53]
110400547  [KO:K07437] [EC:1.14.14.-]
110400571  [KO:K00699] [EC:2.4.1.17]
110400687  AOX1; aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
110401302  [KO:K11153] [EC:1.1.1.300]
110402562  [KO:K11150] [EC:1.1.1.-]
110402639  RPE65; retinoid isomerohydrolase isoform X1 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
110403577  ALDH1A3; aldehyde dehydrogenase family 1 member A3 isoform X1 [KO:K07249] [EC:1.2.1.36]
110403626  ALDH1A2; retinal dehydrogenase 2 isoform X1 [KO:K07249] [EC:1.2.1.36]
110404561  BCO1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
110405528  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
110405948  [KO:K07424] [EC:1.14.14.1]
110406034  [KO:K07424] [EC:1.14.14.1]
110406122  [KO:K07423] [EC:1.14.14.-]
110406123  [KO:K07423] [EC:1.14.14.-]
110408680  DHRS3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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