KEGG   PATHWAY: nmel00830Help
Entry
nmel00830                   Pathway                                

Name
Retinol metabolism - Numida meleagris (helmeted guineafowl)
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
nmel00830  Retinol metabolism
nmel00830

Ortholog table
Other DBs
GO: 0006776
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110404561  BCO1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
110397265  alcohol dehydrogenase 1 isoform X1 [KO:K13951] [EC:1.1.1.1]
110397267  alcohol dehydrogenase 1-like isoform X1 [KO:K13951] [EC:1.1.1.1]
110397269  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
110408680  DHRS3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
110391420  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
110399582  dehydrogenase/reductase SDR family member 9-like [KO:K11149] [EC:1.1.-.-]
110388681  RDH8; retinol dehydrogenase 8 isoform X1 [KO:K11150] [EC:1.1.1.-]
110402562  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
110393823  RDH10; retinol dehydrogenase 10 isoform X1 [KO:K11151] [EC:1.1.1.-]
110401302  retinol dehydrogenase 12-like [KO:K11153] [EC:1.1.1.300]
110389190  retinol dehydrogenase 16-like [KO:K11154] [EC:1.1.1.-]
110393074  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
110395001  epidermal retinol dehydrogenase 2-like [KO:K15734] [EC:1.1.1.105]
110398861  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
110405528  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
110402639  RPE65; retinoid isomerohydrolase isoform X1 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
110391116  RDH5; 11-cis retinol dehydrogenase [KO:K00061] [EC:1.1.1.315]
110403626  ALDH1A2; retinal dehydrogenase 2 isoform X1 [KO:K07249] [EC:1.2.1.36]
110390028  ALDH1A1; retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
110400547  cytochrome P450 26A1 isoform X1 [KO:K07437]
110398722  cytochrome P450 26B1 [KO:K12664]
110399532  cytochrome P450 26C1 [KO:K12665]
110403949  cytochrome P450 1A5 isoform X1 [KO:K07408] [EC:1.14.14.1]
110399446  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
110387101  RETSAT; all-trans-retinol 13,14-reductase [KO:K09516] [EC:1.3.99.23]
110388620  putative all-trans-retinol 13,14-reductase isoform X1 [KO:K09516] [EC:1.3.99.23]
110398466  UDP-glucuronosyltransferase 2A2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
110399743  UDP-glucuronosyltransferase 1-9-like isoform X1 [KO:K00699] [EC:2.4.1.17]
110399800  cytochrome P450 27C1 isoform X1 [KO:K17951] [EC:1.14.19.53]
110400571  uncharacterized protein LOC110400571 [KO:K00699] [EC:2.4.1.17]
110400687  AOX1; aldehyde oxidase isoform X1 [KO:K00157] [EC:1.2.3.1]
110400690  LOW QUALITY PROTEIN: aldehyde oxidase 2-like
110403826  cytochrome P450 1A4 [KO:K07408] [EC:1.14.14.1]
110405948  cytochrome P450 3A29-like isoform X1
110406034  cytochrome P450 3A9-like
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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Genome (1)   
   KEGG GENOME (1)   
Gene (36)   
   KEGG GENES (36)   
All databases (37)   

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