KEGG   PATHWAY: rno04914
Entry
rno04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Rattus norvegicus (rat)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
rno04914  Progesterone-mediated oocyte maturation
rno04914

Other DBs
GO: 0001556
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360936  Anapc16; anaphase-promoting complex subunit 16 isoform 1 [KO:K25229]
114486  Braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
114494  Ccna2; cyclin-A2 [KO:K06627]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117269  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
134484121  [KO:K00922] [EC:2.7.1.153]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
171102  Cdc25a; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
171103  Cdc25b; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:3.1.3.48]
192209  Spdya; speedy protein A [KO:K08694]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24482  Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24525  Kras; GTPase KRas [KO:K07827]
24559  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
25154  Pgr; progesterone receptor [KO:K08556]
25203  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
25515  Plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25718  Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087] [EC:2.7.10.1]
261730  Aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
287101  Pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
288671  Anapc5; anaphase-promoting complex subunit 5 isoform 1 [KO:K03352]
290875  Cdc16; cell division cycle protein 16 homolog [KO:K03353]
291689  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
293056  Cpeb1; cytoplasmic polyadenylation element-binding protein 1 [KO:K02602]
293155  Anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
293502  Kif22; kinesin-like protein KIF22 [KO:K10403]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
29398  Stk10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
295052  Ccna1; cyclin-A1 [KO:K06627]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
29516  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
296137  Bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
296558  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
297176  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
299331  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
301252  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
303010  Cpeb4; cytoplasmic polyadenylation element-binding protein 4 [KO:K02602]
304490  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
305420  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
307511  Cdc25c; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
309510  Cpeb3; cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
311412  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
313702  Mad2l2; mitotic spindle assembly checkpoint protein MAD2B isoform 2 [KO:K13728]
314642  Fzr1; fizzy-related protein homolog [KO:K03364]
317203  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
317389  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
360643  Cdc27; cell division cycle protein 27 homolog isoform 2 [KO:K03350]
360949  Cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
361389  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
363088  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
366381  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
498030  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
498146  Spdye4; speedy protein E4 [KO:K08694]
499886  Spdye4c; uncharacterized protein LOC499886 [KO:K08694]
501560  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:2.7.11.24]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
54237  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
64363  Araf; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
680006  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
685029  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
81771  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
rno04010  MAPK signaling pathway
rno04110  Cell cycle
KO pathway
ko04914   

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