KEGG   PATHWAY: bmy04010
Entry
bmy04010                    Pathway                                
Name
MAPK signaling pathway - Brugia malayi (filaria)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
bmy04010  MAPK signaling pathway
bmy04010

Other DBs
GO: 0000165
Organism
Brugia malayi (filaria) [GN:bmy]
Gene
BM_BM2825  Bma-egl-19; Uncharacterized protein [KO:K04851]
BM_BM2929  Bma-cca-1; cation channel family protein [KO:K04854]
BM_BM6074  Bma-ccb-1; Voltage-dependent L-type calcium channel beta-2 subunit, putative [KO:K04863]
BM_BM3320  Bma-stg-2; Uncharacterized protein [KO:K04870]
BM_BM7586  Bma-kin-1; cAMP-dependent protein kinase catalytic subunit, putative [KO:K04345] [EC:2.7.11.11]
BM_BM3442  Bma-gpa-12; Guanine nucleotide-binding protein alpha-12 subunit, putative [KO:K04346]
BM_BM1917  Bma-tax-6; Uncharacterized protein [KO:K04348] [EC:3.1.3.16]
BM_BM4420  Bma-cnb-1; Uncharacterized protein [KO:K06268]
BM_BM5795  Bma-pxf-1; Uncharacterized protein [KO:K08018]
BM_BM9765  Bma-gap-3; SH2 domain containing protein [KO:K04352]
BM_BM2428  Bma-rap-1; Uncharacterized protein [KO:K04353]
BM_BM1980  Bma-let-756; Fibroblast growth factor family protein [KO:K04358]
BM_BM7615  Bma-let-23; Uncharacterized protein [KO:K04361] [EC:2.7.10.1]
BM_BM5314  Bm5314; Uncharacterized protein [KO:K05096] [EC:2.7.10.1]
BM_BM5789  Bma-svh-2; Uncharacterized protein [KO:K05099] [EC:2.7.10.1]
BM_BM2205  Bma-sem-5; Uncharacterized protein [KO:K04364]
BM_BM6081  Bma-sos-1; Uncharacterized protein [KO:K03099]
BM_BM16898  Bma-let-60; Uncharacterized protein [KO:K07827]
BM_BM2760  Bma-ras-1; T-cell receptor beta chain ANA 11, putative [KO:K07830]
BM_BM3416  Bma-ras-2; Ras-related protein M-Ras, putative [KO:K07831]
BM_BM7093  Bma-lin-45; Uncharacterized protein [KO:K04365] [EC:2.7.11.1]
BM_BM6799  Bma-mek-2; Uncharacterized protein [KO:K04368] [EC:2.7.12.2]
BM_BM10547  Bma-lmtr-3; uncharacterized protein [KO:K04370]
BM_BM4047  Bma-mpk-1; Uncharacterized protein [KO:K04371] [EC:2.7.11.24]
BM_BM5443  Bma-mnk-1; Protein kinase domain containing protein [KO:K04372] [EC:2.7.11.1]
BM_BM8603  Bma-rskn-1; ribosomal protein S6 kinase alpha 3, putative [KO:K04373] [EC:2.7.11.1]
BM_BM6228  Bma-zip-3; Uncharacterized protein [KO:K04374]
BM_BM7152  Bma-lin-1; Hexokinase family protein [KO:K04375]
BM_BM12004  Bma-daf-1; Uncharacterized protein [KO:K04674] [EC:2.7.11.30]
BM_BM2610  Bma-mig-2; Uncharacterized protein [KO:K04392]
BM_BM2115  Bm2115; Ras-related protein Rac1, putative [KO:K04392]
BM_BM5286  Bma-cdc-42; GTP-binding protein, putative [KO:K04393]
BM_BM4945  Bma-pik-1; Uncharacterized protein [KO:K04730] [EC:2.7.11.1]
BM_BM6309  Bm6309; CG10610-PA, putative [KO:K04405]
BM_BM3378  Bm3378; Uncharacterized protein [KO:K04412]
BM_BM5676  Bm5676; Protein kinase domain containing protein [KO:K04420] [EC:2.7.11.25]
BM_BM9342  Bm9342; Protein kinase domain containing protein [KO:K04417] [EC:2.7.11.25]
BM_BM12235  Bma-nsy-1; Neuronal symmetry protein 1, putative [KO:K04426] [EC:2.7.11.25]
BM_BM6488  Bma-mtk-1; Uncharacterized protein [KO:K04428] [EC:2.7.11.25]
BM_BM4039  Bm4039; Serine/threonine-protein kinase F42G10.2, putative [KO:K04430] [EC:2.7.12.2]
BM_BM9351  Bma-sek-3; Protein kinase domain containing protein [KO:K04430] [EC:2.7.12.2]
BM_BM6989  Bma-fln-1.2; Uncharacterized protein [KO:K04437]
BM_BM2319  Bma-fln-2; Uncharacterized protein [KO:K04437]
BM_BM6990  Bma-fln-1.1; Filamin/ABP280 repeat family protein [KO:K04437]
BM_BM6517  Bma-ced-2; Uncharacterized protein [KO:K04438]
BM_BM4328  Bma-arr-1; Uncharacterized protein [KO:K04439]
BM_BM9350  Bm9350; Uncharacterized protein [KO:K04440] [EC:2.7.11.24]
BM_BM1820  Bma-jnk-1; Uncharacterized protein [KO:K04440] [EC:2.7.11.24]
BM_BM1712  Bma-pmk-1; P38 map kinase family protein 2, isoform b, putative [KO:K04441] [EC:2.7.11.24]
BM_BM4029  Bma-pmk-3; Mitogen-activated protein kinase, putative [KO:K04441] [EC:2.7.11.24]
BM_BM2936  Bma-rskn-2; Protein kinase domain containing protein [KO:K04445] [EC:2.7.11.1]
BM_BM5997  Bma-jun-1; Conserved hypothetical protein, putative [KO:K04448]
BM_BM5839  Bma-mxl-1; Helix-loop-helix DNA-binding domain containing protein [KO:K04453]
BM_BM2161  Bma-akt-1; Uncharacterized protein [KO:K04456] [EC:2.7.11.1]
BM_BM10945  Bm10945; Uncharacterized protein [KO:K04458] [EC:3.1.3.48]
BM_BM13716  Bma-pph-5; serine/threonine protein phosphatase 5, putative [KO:K04460] [EC:3.1.3.16]
BM_BM3570  Bma-ppm-1; Protein phosphatase 2C containing protein [KO:K04461] [EC:3.1.3.16]
BM_BM3611  Bma-hsp-1; Uncharacterized protein [KO:K03283]
BM_BM6215  Bma-lit-1; MGC81364 protein, putative [KO:K04468] [EC:2.7.11.24]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
bmy04070  Phosphatidylinositol signaling system
bmy04310  Wnt signaling pathway
KO pathway
ko04010   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (59)   
   KEGG GENES (59)   
All databases (60)   

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