KEGG   PATHWAY: sma00230
Entry
sma00230                    Pathway                                
Name
Purine metabolism - Streptomyces avermitilis
Class
Metabolism; Nucleotide metabolism
Pathway map
sma00230  Purine metabolism
sma00230

Module
sma_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:sma00230]
sma_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sma00230]
sma_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sma00230]
sma_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sma00230]
sma_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sma00230]
sma_M00546  Purine degradation, xanthine => urea [PATH:sma00230]
sma_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:sma00230]
Other DBs
GO: 0006163 0042278
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_803  pgmA; putative phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
SAVERM_3562  prsA1; putative ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
SAVERM_7451  prsA2; putative ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
SAVERM_4135  purF; putative phosphoribosylpyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
SAVERM_4149  purD; putative phosphoribosylglycinamide synthetase [KO:K01945] [EC:6.3.4.13]
SAVERM_3445  purN; putative phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
SAVERM_4138  purL; putative phosphoribosyl formylglycinamidine synthase II [KO:K23269] [EC:6.3.5.3]
SAVERM_4140  purS; putative phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [KO:K23264] [EC:6.3.5.3]
SAVERM_4139  purQ; putative phosphoribosyl formylglycinamidine synthase I [KO:K23265] [EC:6.3.5.3 3.5.1.2]
SAVERM_4134  purM; putative phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
SAVERM_5021  purK; putative phosphoribosylaminoimidazole carboxylase ATPase subunit [KO:K01589] [EC:6.3.4.18]
SAVERM_5022  purE; putative phosphoribosylaminoimidazole carboxylase catalytic subunit [KO:K01588] [EC:5.4.99.18]
SAVERM_4146  purC; putative phosphoribosylaminoimidazole-succinocarboxamide synthetase [KO:K01923] [EC:6.3.2.6]
SAVERM_7077  purB; putative adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
SAVERM_3444  purH; putative bifunctional purine biosynthesis protein [KO:K00602] [EC:2.1.2.3 3.5.4.10]
SAVERM_6839  apt; putative adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
SAVERM_4057  ushA; putative 5'-nucleotidase, secreted [KO:K01081] [EC:3.1.3.5]
SAVERM_5214  nagD; putative N-acetyl-glucosamine catabolism protein [KO:K02566] [EC:3.1.3.5]
SAVERM_3342  deoD; putative purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
SAVERM_6125  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
SAVERM_4665  hprT; putative hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
SAVERM_5000  guaB1; putative inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
SAVERM_5001  guaB2; putative inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
SAVERM_5454  ndkA; putative nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
SAVERM_5172  putative nucleoside-triphosphatase [KO:K01519] [EC:3.6.1.66]
SAVERM_7384  putative oxidoreductase [KO:K11177] [EC:1.17.1.4]
SAVERM_1537  putative oxidoreductase [KO:K11177] [EC:1.17.1.4]
SAVERM_7383  putative oxidoreductase molybdopterin binding subunit [KO:K11178] [EC:1.17.1.4]
SAVERM_1539  putative oxidoreductase molybdopterin binding subunit [KO:K11178] [EC:1.17.1.4]
SAVERM_1540  pucE; putative xanthine dehydrogenase [KO:K13483]
SAVERM_3479  guaA; putative GMP synthase [KO:K01951] [EC:6.3.5.2]
SAVERM_6884  guaB3; putative inosine-5'-monophosphate dehydrogenase [KO:K26110] [EC:1.7.1.7]
SAVERM_6871  gmk; putative guanylate kinase [KO:K00942] [EC:2.7.4.8]
SAVERM_7533  putative phosphotransferase [KO:K00942] [EC:2.7.4.8]
SAVERM_3026  nrdL; putative ribonucleoside-diphosphate reductase alpha chain [KO:K00525] [EC:1.17.4.1]
SAVERM_2461  nrdA; putative vitamin B12-dependent ribonucleotide reductase [KO:K00525] [EC:1.17.4.1]
SAVERM_3027  nrdM; putative ribonucleoside-diphosphate reductase beta chain [KO:K00526] [EC:1.17.4.1]
SAVERM_5674  dgt; putative deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
SAVERM_6840  relA; ppGpp synthetase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SAVERM_2472  rshA; putative RelA homolog [KO:K01139] [EC:2.7.6.5 3.1.7.2]
SAVERM_4713  ppx2; putative exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SAVERM_3530  ppx1; putative exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
SAVERM_3329  cyaA; putative adenylate cyclase [KO:K01768] [EC:4.6.1.1]
SAVERM_4547  purA; putative adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
SAVERM_6045  putative carbohydrate kinase [KO:K00856] [EC:2.7.1.20]
SAVERM_1165  add1; putative adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SAVERM_4906  add4; putative adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SAVERM_3358  add3; putative adenosine deaminase [KO:K01488] [EC:3.5.4.4]
SAVERM_5577  add5; putative adenosine deaminase [KO:K21053] [EC:3.5.4.2]
SAVERM_6215  cpdB; putative 2',3'-cyclic-nucleotide 2'-phosphodiesterase, secreted [KO:K01119] [EC:3.1.4.16 3.1.3.6]
SAVERM_4947  adk; putative adenylate kinase [KO:K00939] [EC:2.7.4.3]
SAVERM_1247  cpdA; putative cyclic nucleotide phosphodiesterase [KO:K03651] [EC:3.1.4.53]
SAVERM_6823  hit; putative histidine triad (HIT) family protein [KO:K19710] [EC:2.7.7.53]
SAVERM_2312  cysC2; putative adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
SAVERM_2130  cysC1; putative adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
SAVERM_2314  cysN2; putative sulfate adenylyltransferase large subunit [KO:K00956] [EC:2.7.7.4]
SAVERM_2132  cysN1; putative sulfate adenylyltransferase large subunit [KO:K00956] [EC:2.7.7.4]
SAVERM_2313  cysD2; putative sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
SAVERM_2131  cysD1; putative sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
SAVERM_2018  pucL; putative uricase [KO:K00365] [EC:1.7.3.3]
SAVERM_2019  hypothetical protein [KO:K07127] [EC:3.5.2.17]
SAVERM_2020  hypothetical protein [KO:K16840] [EC:4.1.1.97]
SAVERM_3394  hypothetical protein [KO:K16840] [EC:4.1.1.97]
SAVERM_1996  pucH; putative allantoinase [KO:K01466] [EC:3.5.2.5]
SAVERM_1995  alc; putative allantoicase [KO:K01477] [EC:3.5.3.4]
SAVERM_7106  ureC1; putative urease alpha subunit [KO:K01428] [EC:3.5.1.5]
SAVERM_2715  ureC2; putative urease alpha subunit [KO:K01428] [EC:3.5.1.5]
SAVERM_7105  ureB; putative urease beta subunit [KO:K01429] [EC:3.5.1.5]
SAVERM_7104  ureA; putative urease gamma subunit [KO:K01430] [EC:3.5.1.5]
SAVERM_2716  ureAB; putative urease beta/gamma subunit [KO:K14048] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
sma00030  Pentose phosphate pathway
sma00220  Arginine biosynthesis
sma00250  Alanine, aspartate and glutamate metabolism
sma00260  Glycine, serine and threonine metabolism
sma00340  Histidine metabolism
sma00630  Glyoxylate and dicarboxylate metabolism
sma00730  Thiamine metabolism
sma00740  Riboflavin metabolism
sma00790  Folate biosynthesis
KO pathway
ko00230   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (70)   
   KEGG GENES (70)   
All databases (71)   

Download RDF
DBGET integrated database retrieval system