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Database: PDB
Entry: 3JAP
LinkDB: 3JAP
Original site: 3JAP 
HEADER    TRANSLATION                             18-JUN-15   3JAP              
TITLE     STRUCTURE OF A PARTIAL YEAST 48S PREINITIATION COMPLEX IN CLOSED      
TITLE    2 CONFORMATION                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: MET-TRNAI (U31:A39 VARIANT);                               
COMPND   3 CHAIN: 1;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: 18S RRNA;                                                  
COMPND   7 CHAIN: 2;                                                            
COMPND   8 MOL_ID: 3;                                                           
COMPND   9 MOLECULE: MRNA;                                                      
COMPND  10 CHAIN: 3;                                                            
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 4;                                                           
COMPND  13 MOLECULE: US2;                                                       
COMPND  14 CHAIN: A;                                                            
COMPND  15 MOL_ID: 5;                                                           
COMPND  16 MOLECULE: ES1;                                                       
COMPND  17 CHAIN: B;                                                            
COMPND  18 MOL_ID: 6;                                                           
COMPND  19 MOLECULE: US5;                                                       
COMPND  20 CHAIN: C;                                                            
COMPND  21 MOL_ID: 7;                                                           
COMPND  22 MOLECULE: US3;                                                       
COMPND  23 CHAIN: D;                                                            
COMPND  24 MOL_ID: 8;                                                           
COMPND  25 MOLECULE: ES4;                                                       
COMPND  26 CHAIN: E;                                                            
COMPND  27 MOL_ID: 9;                                                           
COMPND  28 MOLECULE: US7;                                                       
COMPND  29 CHAIN: F;                                                            
COMPND  30 MOL_ID: 10;                                                          
COMPND  31 MOLECULE: ES6;                                                       
COMPND  32 CHAIN: G;                                                            
COMPND  33 MOL_ID: 11;                                                          
COMPND  34 MOLECULE: ES7;                                                       
COMPND  35 CHAIN: H;                                                            
COMPND  36 MOL_ID: 12;                                                          
COMPND  37 MOLECULE: ES8;                                                       
COMPND  38 CHAIN: I;                                                            
COMPND  39 MOL_ID: 13;                                                          
COMPND  40 MOLECULE: US4;                                                       
COMPND  41 CHAIN: J;                                                            
COMPND  42 MOL_ID: 14;                                                          
COMPND  43 MOLECULE: ES10;                                                      
COMPND  44 CHAIN: K;                                                            
COMPND  45 MOL_ID: 15;                                                          
COMPND  46 MOLECULE: US17;                                                      
COMPND  47 CHAIN: L;                                                            
COMPND  48 MOL_ID: 16;                                                          
COMPND  49 MOLECULE: ES12;                                                      
COMPND  50 CHAIN: M;                                                            
COMPND  51 MOL_ID: 17;                                                          
COMPND  52 MOLECULE: US15;                                                      
COMPND  53 CHAIN: N;                                                            
COMPND  54 MOL_ID: 18;                                                          
COMPND  55 MOLECULE: US11;                                                      
COMPND  56 CHAIN: O;                                                            
COMPND  57 MOL_ID: 19;                                                          
COMPND  58 MOLECULE: US19;                                                      
COMPND  59 CHAIN: P;                                                            
COMPND  60 MOL_ID: 20;                                                          
COMPND  61 MOLECULE: US9;                                                       
COMPND  62 CHAIN: Q;                                                            
COMPND  63 MOL_ID: 21;                                                          
COMPND  64 MOLECULE: ES17;                                                      
COMPND  65 CHAIN: R;                                                            
COMPND  66 MOL_ID: 22;                                                          
COMPND  67 MOLECULE: US13;                                                      
COMPND  68 CHAIN: S;                                                            
COMPND  69 MOL_ID: 23;                                                          
COMPND  70 MOLECULE: ES19;                                                      
COMPND  71 CHAIN: T;                                                            
COMPND  72 MOL_ID: 24;                                                          
COMPND  73 MOLECULE: US10;                                                      
COMPND  74 CHAIN: U;                                                            
COMPND  75 MOL_ID: 25;                                                          
COMPND  76 MOLECULE: ES21;                                                      
COMPND  77 CHAIN: V;                                                            
COMPND  78 MOL_ID: 26;                                                          
COMPND  79 MOLECULE: US8;                                                       
COMPND  80 CHAIN: W;                                                            
COMPND  81 MOL_ID: 27;                                                          
COMPND  82 MOLECULE: US12;                                                      
COMPND  83 CHAIN: X;                                                            
COMPND  84 MOL_ID: 28;                                                          
COMPND  85 MOLECULE: ES24;                                                      
COMPND  86 CHAIN: Y;                                                            
COMPND  87 MOL_ID: 29;                                                          
COMPND  88 MOLECULE: ES25;                                                      
COMPND  89 CHAIN: Z;                                                            
COMPND  90 MOL_ID: 30;                                                          
COMPND  91 MOLECULE: ES26;                                                      
COMPND  92 CHAIN: a;                                                            
COMPND  93 MOL_ID: 31;                                                          
COMPND  94 MOLECULE: ES27;                                                      
COMPND  95 CHAIN: b;                                                            
COMPND  96 MOL_ID: 32;                                                          
COMPND  97 MOLECULE: ES28;                                                      
COMPND  98 CHAIN: c;                                                            
COMPND  99 MOL_ID: 33;                                                          
COMPND 100 MOLECULE: US14;                                                      
COMPND 101 CHAIN: d;                                                            
COMPND 102 MOL_ID: 34;                                                          
COMPND 103 MOLECULE: ES30;                                                      
COMPND 104 CHAIN: e;                                                            
COMPND 105 MOL_ID: 35;                                                          
COMPND 106 MOLECULE: ES31;                                                      
COMPND 107 CHAIN: f;                                                            
COMPND 108 MOL_ID: 36;                                                          
COMPND 109 MOLECULE: RACK1;                                                     
COMPND 110 CHAIN: g;                                                            
COMPND 111 MOL_ID: 37;                                                          
COMPND 112 MOLECULE: EL41;                                                      
COMPND 113 CHAIN: h;                                                            
COMPND 114 MOL_ID: 38;                                                          
COMPND 115 MOLECULE: EIF1A;                                                     
COMPND 116 CHAIN: i;                                                            
COMPND 117 ENGINEERED: YES;                                                     
COMPND 118 MOL_ID: 39;                                                          
COMPND 119 MOLECULE: EIF2 ALPHA;                                                
COMPND 120 CHAIN: j;                                                            
COMPND 121 ENGINEERED: YES;                                                     
COMPND 122 MOL_ID: 40;                                                          
COMPND 123 MOLECULE: EIF2 GAMMA;                                                
COMPND 124 CHAIN: k;                                                            
COMPND 125 ENGINEERED: YES;                                                     
COMPND 126 MOL_ID: 41;                                                          
COMPND 127 MOLECULE: EIF2 BETA;                                                 
COMPND 128 CHAIN: l;                                                            
COMPND 129 ENGINEERED: YES;                                                     
COMPND 130 MOL_ID: 42;                                                          
COMPND 131 MOLECULE: EIF1;                                                      
COMPND 132 CHAIN: m;                                                            
COMPND 133 ENGINEERED: YES;                                                     
COMPND 134 MOL_ID: 43;                                                          
COMPND 135 MOLECULE: EIF3A;                                                     
COMPND 136 CHAIN: o;                                                            
COMPND 137 ENGINEERED: YES;                                                     
COMPND 138 MOL_ID: 44;                                                          
COMPND 139 MOLECULE: EIF3C;                                                     
COMPND 140 CHAIN: p;                                                            
COMPND 141 ENGINEERED: YES;                                                     
COMPND 142 MOL_ID: 45;                                                          
COMPND 143 MOLECULE: EIF3I;                                                     
COMPND 144 CHAIN: q;                                                            
COMPND 145 ENGINEERED: YES;                                                     
COMPND 146 MOL_ID: 46;                                                          
COMPND 147 MOLECULE: EIF3B;                                                     
COMPND 148 CHAIN: r;                                                            
COMPND 149 ENGINEERED: YES;                                                     
COMPND 150 MOL_ID: 47;                                                          
COMPND 151 MOLECULE: EIF3G;                                                     
COMPND 152 CHAIN: s;                                                            
COMPND 153 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 SYNTHETIC: YES;                                                      
SOURCE   3 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE   4 ORGANISM_TAXID: 28985;                                               
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE   7 ORGANISM_TAXID: 28985;                                               
SOURCE   8 MOL_ID: 3;                                                           
SOURCE   9 SYNTHETIC: YES;                                                      
SOURCE  10 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  11 ORGANISM_TAXID: 32630;                                               
SOURCE  12 MOL_ID: 4;                                                           
SOURCE  13 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  14 ORGANISM_TAXID: 28985;                                               
SOURCE  15 MOL_ID: 5;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  17 ORGANISM_TAXID: 28985;                                               
SOURCE  18 MOL_ID: 6;                                                           
SOURCE  19 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  20 ORGANISM_TAXID: 28985;                                               
SOURCE  21 MOL_ID: 7;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  23 ORGANISM_TAXID: 28985;                                               
SOURCE  24 MOL_ID: 8;                                                           
SOURCE  25 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  26 ORGANISM_TAXID: 28985;                                               
SOURCE  27 MOL_ID: 9;                                                           
SOURCE  28 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  29 ORGANISM_TAXID: 28985;                                               
SOURCE  30 MOL_ID: 10;                                                          
SOURCE  31 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  32 ORGANISM_TAXID: 28985;                                               
SOURCE  33 MOL_ID: 11;                                                          
SOURCE  34 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  35 ORGANISM_TAXID: 28985;                                               
SOURCE  36 MOL_ID: 12;                                                          
SOURCE  37 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  38 ORGANISM_TAXID: 28985;                                               
SOURCE  39 MOL_ID: 13;                                                          
SOURCE  40 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  41 ORGANISM_TAXID: 28985;                                               
SOURCE  42 MOL_ID: 14;                                                          
SOURCE  43 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  44 ORGANISM_TAXID: 28985;                                               
SOURCE  45 MOL_ID: 15;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  47 ORGANISM_TAXID: 28985;                                               
SOURCE  48 MOL_ID: 16;                                                          
SOURCE  49 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  50 ORGANISM_TAXID: 28985;                                               
SOURCE  51 MOL_ID: 17;                                                          
SOURCE  52 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  53 ORGANISM_TAXID: 28985;                                               
SOURCE  54 MOL_ID: 18;                                                          
SOURCE  55 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  56 ORGANISM_TAXID: 28985;                                               
SOURCE  57 MOL_ID: 19;                                                          
SOURCE  58 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  59 ORGANISM_TAXID: 28985;                                               
SOURCE  60 MOL_ID: 20;                                                          
SOURCE  61 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  62 ORGANISM_TAXID: 28985;                                               
SOURCE  63 MOL_ID: 21;                                                          
SOURCE  64 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  65 ORGANISM_TAXID: 28985;                                               
SOURCE  66 MOL_ID: 22;                                                          
SOURCE  67 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  68 ORGANISM_TAXID: 28985;                                               
SOURCE  69 MOL_ID: 23;                                                          
SOURCE  70 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  71 ORGANISM_TAXID: 28985;                                               
SOURCE  72 MOL_ID: 24;                                                          
SOURCE  73 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  74 ORGANISM_TAXID: 28985;                                               
SOURCE  75 MOL_ID: 25;                                                          
SOURCE  76 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  77 ORGANISM_TAXID: 28985;                                               
SOURCE  78 MOL_ID: 26;                                                          
SOURCE  79 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  80 ORGANISM_TAXID: 28985;                                               
SOURCE  81 MOL_ID: 27;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  83 ORGANISM_TAXID: 28985;                                               
SOURCE  84 MOL_ID: 28;                                                          
SOURCE  85 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  86 ORGANISM_TAXID: 28985;                                               
SOURCE  87 MOL_ID: 29;                                                          
SOURCE  88 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  89 ORGANISM_TAXID: 28985;                                               
SOURCE  90 MOL_ID: 30;                                                          
SOURCE  91 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  92 ORGANISM_TAXID: 28985;                                               
SOURCE  93 MOL_ID: 31;                                                          
SOURCE  94 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  95 ORGANISM_TAXID: 28985;                                               
SOURCE  96 MOL_ID: 32;                                                          
SOURCE  97 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE  98 ORGANISM_TAXID: 28985;                                               
SOURCE  99 MOL_ID: 33;                                                          
SOURCE 100 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE 101 ORGANISM_TAXID: 28985;                                               
SOURCE 102 MOL_ID: 34;                                                          
SOURCE 103 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE 104 ORGANISM_TAXID: 28985;                                               
SOURCE 105 MOL_ID: 35;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE 107 ORGANISM_TAXID: 28985;                                               
SOURCE 108 MOL_ID: 36;                                                          
SOURCE 109 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE 110 ORGANISM_TAXID: 28985;                                               
SOURCE 111 MOL_ID: 37;                                                          
SOURCE 112 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS;                           
SOURCE 113 ORGANISM_TAXID: 28985;                                               
SOURCE 114 MOL_ID: 38;                                                          
SOURCE 115 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 116 ORGANISM_COMMON: YEAST;                                              
SOURCE 117 ORGANISM_TAXID: 4932;                                                
SOURCE 118 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21;                            
SOURCE 119 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE 120 EXPRESSION_SYSTEM_STRAIN: ROSETTA;                                   
SOURCE 121 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE 122 EXPRESSION_SYSTEM_PLASMID: PTYB2;                                    
SOURCE 123 MOL_ID: 39;                                                          
SOURCE 124 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 125 ORGANISM_COMMON: YEAST;                                              
SOURCE 126 ORGANISM_TAXID: 4932;                                                
SOURCE 127 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 128 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 129 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 130 MOL_ID: 40;                                                          
SOURCE 131 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 132 ORGANISM_COMMON: YEAST;                                              
SOURCE 133 ORGANISM_TAXID: 4932;                                                
SOURCE 134 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 135 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 136 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 137 MOL_ID: 41;                                                          
SOURCE 138 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 139 ORGANISM_COMMON: YEAST;                                              
SOURCE 140 ORGANISM_TAXID: 4932;                                                
SOURCE 141 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 142 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 143 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 144 MOL_ID: 42;                                                          
SOURCE 145 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 146 ORGANISM_COMMON: YEAST;                                              
SOURCE 147 ORGANISM_TAXID: 4932;                                                
SOURCE 148 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21;                            
SOURCE 149 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE 150 EXPRESSION_SYSTEM_STRAIN: ROSETTA;                                   
SOURCE 151 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE 152 EXPRESSION_SYSTEM_PLASMID: PTYB2;                                    
SOURCE 153 MOL_ID: 43;                                                          
SOURCE 154 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 155 ORGANISM_COMMON: YEAST;                                              
SOURCE 156 ORGANISM_TAXID: 4932;                                                
SOURCE 157 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 158 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 159 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 160 MOL_ID: 44;                                                          
SOURCE 161 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 162 ORGANISM_COMMON: YEAST;                                              
SOURCE 163 ORGANISM_TAXID: 4932;                                                
SOURCE 164 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 165 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 166 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 167 MOL_ID: 45;                                                          
SOURCE 168 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 169 ORGANISM_COMMON: YEAST;                                              
SOURCE 170 ORGANISM_TAXID: 4932;                                                
SOURCE 171 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 172 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 173 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 174 MOL_ID: 46;                                                          
SOURCE 175 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 176 ORGANISM_COMMON: YEAST;                                              
SOURCE 177 ORGANISM_TAXID: 4932;                                                
SOURCE 178 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 179 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 180 EXPRESSION_SYSTEM_TAXID: 4932;                                       
SOURCE 181 MOL_ID: 47;                                                          
SOURCE 182 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 183 ORGANISM_COMMON: YEAST;                                              
SOURCE 184 ORGANISM_TAXID: 4932;                                                
SOURCE 185 EXPRESSION_SYSTEM: SACCHAROMYCES CEREVISIAE;                         
SOURCE 186 EXPRESSION_SYSTEM_COMMON: YEAST;                                     
SOURCE 187 EXPRESSION_SYSTEM_TAXID: 4932                                        
KEYWDS    EUKARYOTIC TRANSLATION INITIATION, 48S, SMALL RIBOSOME SUBUNIT, 40S,  
KEYWDS   2 43S, TRANSLATION                                                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.L.LLACER,T.HUSSAIN,V.RAMAKRISHNAN                                   
REVDAT   3   18-JUL-18 3JAP    1       REMARK                                   
REVDAT   2   02-SEP-15 3JAP    1       JRNL                                     
REVDAT   1   12-AUG-15 3JAP    0                                                
JRNL        AUTH   J.L.LLACER,T.HUSSAIN,L.MARLER,C.E.AITKEN,A.THAKUR,           
JRNL        AUTH 2 J.R.LORSCH,A.G.HINNEBUSCH,V.RAMAKRISHNAN                     
JRNL        TITL   CONFORMATIONAL DIFFERENCES BETWEEN OPEN AND CLOSED STATES OF 
JRNL        TITL 2 THE EUKARYOTIC TRANSLATION INITIATION COMPLEX.               
JRNL        REF    MOL.CELL                      V.  59   399 2015              
JRNL        REFN                   ISSN 1097-2765                               
JRNL        PMID   26212456                                                     
JRNL        DOI    10.1016/J.MOLCEL.2015.06.033                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : COOT, REFMAC, UCSF CHIMERA, RELION        
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 3J81                                
REMARK   3   REFINEMENT SPACE             : RECIPROCAL                          
REMARK   3   REFINEMENT PROTOCOL          : OTHER                               
REMARK   3   REFINEMENT TARGET            : R-FACTOR, FSC                       
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : METHOD--LOCAL REFINEMENT                         
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.340                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.900                          
REMARK   3   NUMBER OF PARTICLES               : 21401                          
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: GOLD-STANDARD                                         
REMARK   4                                                                      
REMARK   4 3JAP COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 10-JUL-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000160463.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE (CRYO EM)            
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PARTIAL YEAST 48S PREINITIATION   
REMARK 245                                    COMPLEX; 40S RIBOSOME;            
REMARK 245                                    EUKARYOTIC INITIATION FACTOR      
REMARK 245                                    EIF1A; EUKARYOTIC INITIATION      
REMARK 245                                    FACTOR EIF2; EUKARYOTIC           
REMARK 245                                    INITIATION FACTOR EIF1;           
REMARK 245                                    EUKARYOTIC INITIATION FACTOR      
REMARK 245                                    EIF3; MET-TRNAI; MRNA             
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.17                              
REMARK 245   SAMPLE SUPPORT DETAILS         : QUANTIFOIL R2/2 400 MESH COPPER   
REMARK 245                                    GRIDS WITH 4-5 NM THIN CARBON     
REMARK 245                                    ON TOP                            
REMARK 245   SAMPLE VITRIFICATION DETAILS   : BLOT FOR 2.5 TO 3 SECONDS         
REMARK 245                                    BEFORE PLUNGING INTO LIQUID       
REMARK 245                                    ETHANE (FEI VITROBOT MARK I).     
REMARK 245   SAMPLE BUFFER                  : 20 MM MES-KOH, 40 MM POTASSIUM    
REMARK 245                                    ACETATE, 10 MM AMMONIUM ACETATE,  
REMARK 245                                    8 MM MAGNESIUM ACETATE, 2 MM      
REMARK 245                                    DTT                               
REMARK 245   PH                             : 6.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 04-JUL-14                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : 1500.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 4000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 27.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 59000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 104478                         
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : COMPLETE DATASET WAS           
REMARK 245  COLLECTED OVER TWO NON-CONSECUTIVE DAYS.                            
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 47-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 1, 2, 3, A, B, C, D, E, F, G,         
REMARK 350                    AND CHAINS: H, I, J, K, L, M, N, O, P,            
REMARK 350                    AND CHAINS: Q, R, S, T, U, V, W, X, Y, Z,         
REMARK 350                    AND CHAINS: a, b, c, d, e, f, g, h, i,            
REMARK 350                    AND CHAINS: j, k, l, m, o, p, q, r, s             
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       C 2   675                                                      
REMARK 465       G 3     0                                                      
REMARK 465       G 3     1                                                      
REMARK 465       A 3     2                                                      
REMARK 465       U 3    17                                                      
REMARK 465       C 3    18                                                      
REMARK 465       U 3    19                                                      
REMARK 465       C 3    20                                                      
REMARK 465       U 3    21                                                      
REMARK 465       C 3    22                                                      
REMARK 465       U 3    23                                                      
REMARK 465       C 3    24                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ILE A   210                                                      
REMARK 465     GLU A   211                                                      
REMARK 465     GLN A   212                                                      
REMARK 465     GLN A   213                                                      
REMARK 465     THR A   214                                                      
REMARK 465     ALA A   215                                                      
REMARK 465     GLU A   216                                                      
REMARK 465     GLU A   217                                                      
REMARK 465     GLU A   218                                                      
REMARK 465     ALA A   219                                                      
REMARK 465     VAL A   220                                                      
REMARK 465     ALA A   221                                                      
REMARK 465     SER A   222                                                      
REMARK 465     GLY A   223                                                      
REMARK 465     GLU A   224                                                      
REMARK 465     GLN A   225                                                      
REMARK 465     THR A   226                                                      
REMARK 465     GLU A   227                                                      
REMARK 465     GLU A   228                                                      
REMARK 465     ALA A   229                                                      
REMARK 465     VAL A   230                                                      
REMARK 465     ASP A   231                                                      
REMARK 465     ALA A   232                                                      
REMARK 465     THR A   233                                                      
REMARK 465     GLU A   234                                                      
REMARK 465     GLU A   235                                                      
REMARK 465     GLN A   236                                                      
REMARK 465     THR A   237                                                      
REMARK 465     GLU A   238                                                      
REMARK 465     ALA A   239                                                      
REMARK 465     ALA A   240                                                      
REMARK 465     GLU A   241                                                      
REMARK 465     TRP A   242                                                      
REMARK 465     ALA A   243                                                      
REMARK 465     GLU A   244                                                      
REMARK 465     GLU A   245                                                      
REMARK 465     GLY A   246                                                      
REMARK 465     GLN A   247                                                      
REMARK 465     ALA A   248                                                      
REMARK 465     GLN A   249                                                      
REMARK 465     GLU A   250                                                      
REMARK 465     GLU A   251                                                      
REMARK 465     GLU A   252                                                      
REMARK 465     TRP A   253                                                      
REMARK 465     ASN A   254                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     SER B    10                                                      
REMARK 465     LYS B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     LYS B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     GLY B    15                                                      
REMARK 465     LEU B    16                                                      
REMARK 465     LYS B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     GLU B   234                                                      
REMARK 465     ALA B   235                                                      
REMARK 465     SER B   236                                                      
REMARK 465     ALA B   237                                                      
REMARK 465     GLU B   238                                                      
REMARK 465     GLU B   239                                                      
REMARK 465     LYS B   240                                                      
REMARK 465     GLY B   241                                                      
REMARK 465     LYS B   242                                                      
REMARK 465     LYS B   243                                                      
REMARK 465     VAL B   244                                                      
REMARK 465     ALA B   245                                                      
REMARK 465     GLY B   246                                                      
REMARK 465     PHE B   247                                                      
REMARK 465     LYS B   248                                                      
REMARK 465     ASP B   249                                                      
REMARK 465     GLU B   250                                                      
REMARK 465     ILE B   251                                                      
REMARK 465     LEU B   252                                                      
REMARK 465     GLU B   253                                                      
REMARK 465     THR B   254                                                      
REMARK 465     VAL B   255                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     PRO C     4                                                      
REMARK 465     GLN C     5                                                      
REMARK 465     ALA C     6                                                      
REMARK 465     GLN C     7                                                      
REMARK 465     GLY C     8                                                      
REMARK 465     GLN C     9                                                      
REMARK 465     GLN C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     PRO C    12                                                      
REMARK 465     ARG C    13                                                      
REMARK 465     ARG C    14                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     GLY C    16                                                      
REMARK 465     PHE C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     GLY C    19                                                      
REMARK 465     ALA C    20                                                      
REMARK 465     ASN C    21                                                      
REMARK 465     ARG C    22                                                      
REMARK 465     GLY C    23                                                      
REMARK 465     GLY C    24                                                      
REMARK 465     ARG C    25                                                      
REMARK 465     GLY C    26                                                      
REMARK 465     GLY C    27                                                      
REMARK 465     ARG C    28                                                      
REMARK 465     ARG C    29                                                      
REMARK 465     GLY C    30                                                      
REMARK 465     GLY C    31                                                      
REMARK 465     ARG C    32                                                      
REMARK 465     ARG C    33                                                      
REMARK 465     ASP C    34                                                      
REMARK 465     GLN C    35                                                      
REMARK 465     GLU C    36                                                      
REMARK 465     GLU C    37                                                      
REMARK 465     LYS C    38                                                      
REMARK 465     LYS C   256                                                      
REMARK 465     LYS C   257                                                      
REMARK 465     LYS C   258                                                      
REMARK 465     LEU C   259                                                      
REMARK 465     MET D     1                                                      
REMARK 465     VAL D     2                                                      
REMARK 465     ARG D   226                                                      
REMARK 465     PRO D   227                                                      
REMARK 465     THR D   228                                                      
REMARK 465     GLU D   229                                                      
REMARK 465     PRO D   230                                                      
REMARK 465     VAL D   231                                                      
REMARK 465     GLU D   232                                                      
REMARK 465     ALA D   233                                                      
REMARK 465     ALA D   234                                                      
REMARK 465     GLU D   235                                                      
REMARK 465     SER D   236                                                      
REMARK 465     ALA D   237                                                      
REMARK 465     MET E     1                                                      
REMARK 465     MET F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     HIS F     4                                                      
REMARK 465     GLU F     5                                                      
REMARK 465     ALA F     6                                                      
REMARK 465     GLN F     7                                                      
REMARK 465     VAL F     8                                                      
REMARK 465     GLU F     9                                                      
REMARK 465     VAL F    10                                                      
REMARK 465     GLU F    11                                                      
REMARK 465     VAL F    12                                                      
REMARK 465     GLN F    13                                                      
REMARK 465     GLU F    14                                                      
REMARK 465     ASP F    15                                                      
REMARK 465     PHE F    16                                                      
REMARK 465     GLU F    17                                                      
REMARK 465     VAL F    18                                                      
REMARK 465     VAL F    19                                                      
REMARK 465     GLN F    20                                                      
REMARK 465     GLU F    21                                                      
REMARK 465     ARG G   227                                                      
REMARK 465     LYS G   228                                                      
REMARK 465     ARG G   229                                                      
REMARK 465     ARG G   230                                                      
REMARK 465     ALA G   231                                                      
REMARK 465     SER G   232                                                      
REMARK 465     SER G   233                                                      
REMARK 465     LEU G   234                                                      
REMARK 465     LYS G   235                                                      
REMARK 465     ALA G   236                                                      
REMARK 465     MET H     1                                                      
REMARK 465     SER H     2                                                      
REMARK 465     ASP H     3                                                      
REMARK 465     GLU H   188                                                      
REMARK 465     THR H   189                                                      
REMARK 465     HIS H   190                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LYS I   124                                                      
REMARK 465     LYS I   125                                                      
REMARK 465     ASN I   126                                                      
REMARK 465     THR I   127                                                      
REMARK 465     LYS I   128                                                      
REMARK 465     ALA I   129                                                      
REMARK 465     GLU I   130                                                      
REMARK 465     GLU I   131                                                      
REMARK 465     GLU I   132                                                      
REMARK 465     THR I   133                                                      
REMARK 465     ALA I   134                                                      
REMARK 465     THR I   135                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLU J   184                                                      
REMARK 465     ALA J   185                                                      
REMARK 465     ASP J   186                                                      
REMARK 465     GLU J   187                                                      
REMARK 465     GLU J   188                                                      
REMARK 465     GLY K    97                                                      
REMARK 465     ASP K    98                                                      
REMARK 465     GLN K    99                                                      
REMARK 465     ARG K   100                                                      
REMARK 465     PRO K   101                                                      
REMARK 465     GLN K   102                                                      
REMARK 465     GLY K   103                                                      
REMARK 465     LYS K   104                                                      
REMARK 465     LYS K   105                                                      
REMARK 465     TYR K   106                                                      
REMARK 465     MET L     1                                                      
REMARK 465     MET M     1                                                      
REMARK 465     SER M     2                                                      
REMARK 465     ASP M     3                                                      
REMARK 465     VAL M     4                                                      
REMARK 465     GLU M     5                                                      
REMARK 465     GLU M     6                                                      
REMARK 465     VAL M     7                                                      
REMARK 465     GLN M     8                                                      
REMARK 465     GLN M     9                                                      
REMARK 465     VAL M    10                                                      
REMARK 465     PRO M    11                                                      
REMARK 465     VAL M    12                                                      
REMARK 465     ALA M    13                                                      
REMARK 465     GLU M    14                                                      
REMARK 465     LEU M    15                                                      
REMARK 465     THR M    16                                                      
REMARK 465     ASN M    75                                                      
REMARK 465     MET N     1                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     ASN O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     VAL O     5                                                      
REMARK 465     GLN O     6                                                      
REMARK 465     ALA O     7                                                      
REMARK 465     LYS O     8                                                      
REMARK 465     ASP O     9                                                      
REMARK 465     ASN O    10                                                      
REMARK 465     MET P     1                                                      
REMARK 465     SER P     2                                                      
REMARK 465     GLU P     3                                                      
REMARK 465     ALA P     4                                                      
REMARK 465     ALA P     5                                                      
REMARK 465     ALA P     6                                                      
REMARK 465     PRO P     7                                                      
REMARK 465     ARG P     8                                                      
REMARK 465     LYS P     9                                                      
REMARK 465     ARG P    10                                                      
REMARK 465     SER P    11                                                      
REMARK 465     PHE P    12                                                      
REMARK 465     ARG P   130                                                      
REMARK 465     ALA P   131                                                      
REMARK 465     GLY P   132                                                      
REMARK 465     ALA P   133                                                      
REMARK 465     THR P   134                                                      
REMARK 465     THR P   135                                                      
REMARK 465     SER P   136                                                      
REMARK 465     ARG P   137                                                      
REMARK 465     PHE P   138                                                      
REMARK 465     ILE P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     LEU P   141                                                      
REMARK 465     ARG P   142                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     SER Q     2                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ALA R    90                                                      
REMARK 465     LEU R    91                                                      
REMARK 465     ASP R    92                                                      
REMARK 465     LEU R    93                                                      
REMARK 465     SER R    94                                                      
REMARK 465     VAL R   127                                                      
REMARK 465     ARG R   128                                                      
REMARK 465     ASP R   129                                                      
REMARK 465     ARG R   130                                                      
REMARK 465     ARG R   131                                                      
REMARK 465     PHE R   132                                                      
REMARK 465     ARG R   133                                                      
REMARK 465     LYS R   134                                                      
REMARK 465     ARG R   135                                                      
REMARK 465     ASN R   136                                                      
REMARK 465     MET S     1                                                      
REMARK 465     MET T     1                                                      
REMARK 465     MET U     4                                                      
REMARK 465     SER U     5                                                      
REMARK 465     GLN U     6                                                      
REMARK 465     VAL U     7                                                      
REMARK 465     GLU U     8                                                      
REMARK 465     LYS U     9                                                      
REMARK 465     LYS U    10                                                      
REMARK 465     SER U    11                                                      
REMARK 465     GLU U    12                                                      
REMARK 465     GLN U    13                                                      
REMARK 465     GLN U    14                                                      
REMARK 465     MET W     1                                                      
REMARK 465     MET X     1                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     PRO Z     2                                                      
REMARK 465     PRO Z     3                                                      
REMARK 465     LYS Z     4                                                      
REMARK 465     GLN Z     5                                                      
REMARK 465     GLN Z     6                                                      
REMARK 465     LEU Z     7                                                      
REMARK 465     SER Z     8                                                      
REMARK 465     LYS Z     9                                                      
REMARK 465     ALA Z    10                                                      
REMARK 465     ALA Z    11                                                      
REMARK 465     LYS Z    12                                                      
REMARK 465     ALA Z    13                                                      
REMARK 465     ALA Z    14                                                      
REMARK 465     ALA Z    15                                                      
REMARK 465     ALA Z    16                                                      
REMARK 465     MET Z    17                                                      
REMARK 465     ALA Z    18                                                      
REMARK 465     GLY Z    19                                                      
REMARK 465     GLY Z    20                                                      
REMARK 465     LYS Z    21                                                      
REMARK 465     LYS Z    22                                                      
REMARK 465     SER Z    23                                                      
REMARK 465     LYS Z    24                                                      
REMARK 465     LYS Z    25                                                      
REMARK 465     LYS Z    26                                                      
REMARK 465     TRP Z    27                                                      
REMARK 465     SER Z    28                                                      
REMARK 465     LYS Z    29                                                      
REMARK 465     LYS Z    30                                                      
REMARK 465     SER Z    31                                                      
REMARK 465     HIS Z    32                                                      
REMARK 465     LYS Z    33                                                      
REMARK 465     ASP Z    34                                                      
REMARK 465     LYS Z    35                                                      
REMARK 465     ALA Z   106                                                      
REMARK 465     SER Z   107                                                      
REMARK 465     GLU Z   108                                                      
REMARK 465     MET a     1                                                      
REMARK 465     ARG a   100                                                      
REMARK 465     PRO a   101                                                      
REMARK 465     ARG a   102                                                      
REMARK 465     PHE a   103                                                      
REMARK 465     ASN a   104                                                      
REMARK 465     ARG a   105                                                      
REMARK 465     ASP a   106                                                      
REMARK 465     ASN a   107                                                      
REMARK 465     LYS a   108                                                      
REMARK 465     VAL a   109                                                      
REMARK 465     SER a   110                                                      
REMARK 465     PRO a   111                                                      
REMARK 465     ALA a   112                                                      
REMARK 465     ASP a   113                                                      
REMARK 465     ALA a   114                                                      
REMARK 465     ALA a   115                                                      
REMARK 465     LYS a   116                                                      
REMARK 465     LYS a   117                                                      
REMARK 465     ALA a   118                                                      
REMARK 465     LEU a   119                                                      
REMARK 465     MET b     1                                                      
REMARK 465     MET c     1                                                      
REMARK 465     ASP c     2                                                      
REMARK 465     THR c     3                                                      
REMARK 465     LYS c     4                                                      
REMARK 465     THR c     5                                                      
REMARK 465     MET d     1                                                      
REMARK 465     ALA d     2                                                      
REMARK 465     HIS d     3                                                      
REMARK 465     MET e     1                                                      
REMARK 465     GLY e     2                                                      
REMARK 465     LYS e     3                                                      
REMARK 465     VAL e     4                                                      
REMARK 465     HIS e     5                                                      
REMARK 465     GLY e     6                                                      
REMARK 465     SER e     7                                                      
REMARK 465     SER e    62                                                      
REMARK 465     GLN e    63                                                      
REMARK 465     MET f     1                                                      
REMARK 465     GLN f     2                                                      
REMARK 465     ILE f     3                                                      
REMARK 465     PHE f     4                                                      
REMARK 465     VAL f     5                                                      
REMARK 465     LYS f     6                                                      
REMARK 465     THR f     7                                                      
REMARK 465     LEU f     8                                                      
REMARK 465     THR f     9                                                      
REMARK 465     GLY f    10                                                      
REMARK 465     LYS f    11                                                      
REMARK 465     THR f    12                                                      
REMARK 465     ILE f    13                                                      
REMARK 465     THR f    14                                                      
REMARK 465     LEU f    15                                                      
REMARK 465     GLU f    16                                                      
REMARK 465     VAL f    17                                                      
REMARK 465     GLU f    18                                                      
REMARK 465     SER f    19                                                      
REMARK 465     SER f    20                                                      
REMARK 465     ASP f    21                                                      
REMARK 465     THR f    22                                                      
REMARK 465     ILE f    23                                                      
REMARK 465     ASP f    24                                                      
REMARK 465     ASN f    25                                                      
REMARK 465     VAL f    26                                                      
REMARK 465     LYS f    27                                                      
REMARK 465     SER f    28                                                      
REMARK 465     LYS f    29                                                      
REMARK 465     ILE f    30                                                      
REMARK 465     GLN f    31                                                      
REMARK 465     ASP f    32                                                      
REMARK 465     LYS f    33                                                      
REMARK 465     GLU f    34                                                      
REMARK 465     GLY f    35                                                      
REMARK 465     ILE f    36                                                      
REMARK 465     PRO f    37                                                      
REMARK 465     PRO f    38                                                      
REMARK 465     ASP f    39                                                      
REMARK 465     GLN f    40                                                      
REMARK 465     GLN f    41                                                      
REMARK 465     ARG f    42                                                      
REMARK 465     LEU f    43                                                      
REMARK 465     ILE f    44                                                      
REMARK 465     PHE f    45                                                      
REMARK 465     ALA f    46                                                      
REMARK 465     GLY f    47                                                      
REMARK 465     LYS f    48                                                      
REMARK 465     GLN f    49                                                      
REMARK 465     LEU f    50                                                      
REMARK 465     GLU f    51                                                      
REMARK 465     ASP f    52                                                      
REMARK 465     GLY f    53                                                      
REMARK 465     ARG f    54                                                      
REMARK 465     THR f    55                                                      
REMARK 465     LEU f    56                                                      
REMARK 465     SER f    57                                                      
REMARK 465     ASP f    58                                                      
REMARK 465     TYR f    59                                                      
REMARK 465     ASN f    60                                                      
REMARK 465     ILE f    61                                                      
REMARK 465     GLN f    62                                                      
REMARK 465     LYS f    63                                                      
REMARK 465     GLU f    64                                                      
REMARK 465     SER f    65                                                      
REMARK 465     THR f    66                                                      
REMARK 465     LEU f    67                                                      
REMARK 465     HIS f    68                                                      
REMARK 465     LEU f    69                                                      
REMARK 465     VAL f    70                                                      
REMARK 465     LEU f    71                                                      
REMARK 465     ARG f    72                                                      
REMARK 465     LEU f    73                                                      
REMARK 465     ARG f    74                                                      
REMARK 465     GLY f    75                                                      
REMARK 465     GLY f    76                                                      
REMARK 465     GLY f    77                                                      
REMARK 465     LYS f    78                                                      
REMARK 465     LYS f    79                                                      
REMARK 465     ARG f    80                                                      
REMARK 465     LYS f    81                                                      
REMARK 465     MET g     1                                                      
REMARK 465     SER g     2                                                      
REMARK 465     GLU g   163                                                      
REMARK 465     ASP g   164                                                      
REMARK 465     GLY g   165                                                      
REMARK 465     GLU g   166                                                      
REMARK 465     GLU g   190                                                      
REMARK 465     ASP g   191                                                      
REMARK 465     MET i     1                                                      
REMARK 465     GLY i     2                                                      
REMARK 465     LYS i     3                                                      
REMARK 465     LYS i     4                                                      
REMARK 465     ASN i   116                                                      
REMARK 465     GLU i   117                                                      
REMARK 465     THR i   118                                                      
REMARK 465     ASP i   119                                                      
REMARK 465     ASN i   120                                                      
REMARK 465     PHE i   121                                                      
REMARK 465     GLY i   122                                                      
REMARK 465     PHE i   123                                                      
REMARK 465     GLU i   124                                                      
REMARK 465     SER i   125                                                      
REMARK 465     ASP i   126                                                      
REMARK 465     GLU i   127                                                      
REMARK 465     ASP i   128                                                      
REMARK 465     VAL i   129                                                      
REMARK 465     ASN i   130                                                      
REMARK 465     PHE i   131                                                      
REMARK 465     GLU i   132                                                      
REMARK 465     PHE i   133                                                      
REMARK 465     GLY i   134                                                      
REMARK 465     ASN i   135                                                      
REMARK 465     ALA i   136                                                      
REMARK 465     ASP i   137                                                      
REMARK 465     GLU i   138                                                      
REMARK 465     ASP i   139                                                      
REMARK 465     ASP i   140                                                      
REMARK 465     GLU i   141                                                      
REMARK 465     GLU i   142                                                      
REMARK 465     GLY i   143                                                      
REMARK 465     GLU i   144                                                      
REMARK 465     ASP i   145                                                      
REMARK 465     GLU i   146                                                      
REMARK 465     GLU i   147                                                      
REMARK 465     LEU i   148                                                      
REMARK 465     ASP i   149                                                      
REMARK 465     ILE i   150                                                      
REMARK 465     ASP i   151                                                      
REMARK 465     ASP i   152                                                      
REMARK 465     ILE i   153                                                      
REMARK 465     MET j     1                                                      
REMARK 465     SER j     2                                                      
REMARK 465     LYS j   175                                                      
REMARK 465     ARG j   176                                                      
REMARK 465     LEU j   177                                                      
REMARK 465     THR j   178                                                      
REMARK 465     PRO j   179                                                      
REMARK 465     GLN j   180                                                      
REMARK 465     ALA j   181                                                      
REMARK 465     MET j   211                                                      
REMARK 465     SER j   212                                                      
REMARK 465     THR j   213                                                      
REMARK 465     GLU j   214                                                      
REMARK 465     GLN j   215                                                      
REMARK 465     MET j   216                                                      
REMARK 465     GLN j   217                                                      
REMARK 465     MET j   266                                                      
REMARK 465     PRO j   267                                                      
REMARK 465     PRO j   268                                                      
REMARK 465     LYS j   269                                                      
REMARK 465     ALA j   270                                                      
REMARK 465     VAL j   271                                                      
REMARK 465     THR j   272                                                      
REMARK 465     ALA j   273                                                      
REMARK 465     THR j   274                                                      
REMARK 465     GLU j   275                                                      
REMARK 465     ASP j   276                                                      
REMARK 465     ALA j   277                                                      
REMARK 465     GLU j   278                                                      
REMARK 465     LEU j   279                                                      
REMARK 465     GLN j   280                                                      
REMARK 465     ALA j   281                                                      
REMARK 465     LEU j   282                                                      
REMARK 465     LEU j   283                                                      
REMARK 465     GLU j   284                                                      
REMARK 465     SER j   285                                                      
REMARK 465     LYS j   286                                                      
REMARK 465     GLU j   287                                                      
REMARK 465     LEU j   288                                                      
REMARK 465     ASP j   289                                                      
REMARK 465     ASN j   290                                                      
REMARK 465     ARG j   291                                                      
REMARK 465     SER j   292                                                      
REMARK 465     ASP j   293                                                      
REMARK 465     SER j   294                                                      
REMARK 465     GLU j   295                                                      
REMARK 465     ASP j   296                                                      
REMARK 465     ASP j   297                                                      
REMARK 465     GLU j   298                                                      
REMARK 465     ASP j   299                                                      
REMARK 465     GLU j   300                                                      
REMARK 465     SER j   301                                                      
REMARK 465     ASP j   302                                                      
REMARK 465     ASP j   303                                                      
REMARK 465     GLU j   304                                                      
REMARK 465     MET k     1                                                      
REMARK 465     SER k     2                                                      
REMARK 465     ASP k     3                                                      
REMARK 465     LEU k     4                                                      
REMARK 465     GLN k     5                                                      
REMARK 465     ASP k     6                                                      
REMARK 465     GLN k     7                                                      
REMARK 465     GLU k     8                                                      
REMARK 465     PRO k     9                                                      
REMARK 465     SER k    10                                                      
REMARK 465     ILE k    11                                                      
REMARK 465     ILE k    12                                                      
REMARK 465     ILE k    13                                                      
REMARK 465     ASN k    14                                                      
REMARK 465     GLY k    15                                                      
REMARK 465     ASN k    16                                                      
REMARK 465     LEU k    17                                                      
REMARK 465     GLU k    18                                                      
REMARK 465     PRO k    19                                                      
REMARK 465     VAL k    20                                                      
REMARK 465     GLY k    21                                                      
REMARK 465     GLU k    22                                                      
REMARK 465     PRO k    23                                                      
REMARK 465     ASP k    24                                                      
REMARK 465     ILE k    25                                                      
REMARK 465     VAL k    26                                                      
REMARK 465     GLU k    27                                                      
REMARK 465     GLU k    28                                                      
REMARK 465     THR k    29                                                      
REMARK 465     GLU k    30                                                      
REMARK 465     VAL k    31                                                      
REMARK 465     VAL k    32                                                      
REMARK 465     ALA k    33                                                      
REMARK 465     GLN k    34                                                      
REMARK 465     GLU k    35                                                      
REMARK 465     THR k    36                                                      
REMARK 465     GLN k    37                                                      
REMARK 465     GLU k    38                                                      
REMARK 465     THR k    39                                                      
REMARK 465     GLN k    40                                                      
REMARK 465     ASP k    41                                                      
REMARK 465     ALA k    42                                                      
REMARK 465     ASP k    43                                                      
REMARK 465     LYS k    44                                                      
REMARK 465     PRO k    45                                                      
REMARK 465     LYS k    46                                                      
REMARK 465     LYS k    47                                                      
REMARK 465     LYS k    48                                                      
REMARK 465     VAL k    49                                                      
REMARK 465     ALA k    50                                                      
REMARK 465     PHE k    51                                                      
REMARK 465     THR k    52                                                      
REMARK 465     GLY k    53                                                      
REMARK 465     LEU k    54                                                      
REMARK 465     GLU k    55                                                      
REMARK 465     GLU k    56                                                      
REMARK 465     ASP k    57                                                      
REMARK 465     GLY k    58                                                      
REMARK 465     GLU k    59                                                      
REMARK 465     THR k    60                                                      
REMARK 465     GLU k    61                                                      
REMARK 465     GLU k    62                                                      
REMARK 465     GLU k    63                                                      
REMARK 465     LYS k    64                                                      
REMARK 465     ARG k    65                                                      
REMARK 465     LYS k    66                                                      
REMARK 465     ARG k    67                                                      
REMARK 465     GLU k    68                                                      
REMARK 465     PHE k    69                                                      
REMARK 465     GLU k    70                                                      
REMARK 465     GLU k    71                                                      
REMARK 465     GLY k    72                                                      
REMARK 465     GLY k    73                                                      
REMARK 465     GLY k    74                                                      
REMARK 465     LEU k    75                                                      
REMARK 465     PRO k    76                                                      
REMARK 465     GLU k    77                                                      
REMARK 465     GLN k    78                                                      
REMARK 465     PRO k    79                                                      
REMARK 465     LEU k    80                                                      
REMARK 465     ASN k    81                                                      
REMARK 465     PRO k    82                                                      
REMARK 465     ASP k    83                                                      
REMARK 465     PHE k    84                                                      
REMARK 465     SER k    85                                                      
REMARK 465     LYS k    86                                                      
REMARK 465     LEU k    87                                                      
REMARK 465     ASN k    88                                                      
REMARK 465     PRO k    89                                                      
REMARK 465     LEU k    90                                                      
REMARK 465     SER k    91                                                      
REMARK 465     ALA k    92                                                      
REMARK 465     GLU k    93                                                      
REMARK 465     ILE k    94                                                      
REMARK 465     ILE k    95                                                      
REMARK 465     ASN k    96                                                      
REMARK 465     ARG k    97                                                      
REMARK 465     PRO k   153                                                      
REMARK 465     THR k   154                                                      
REMARK 465     CYS k   155                                                      
REMARK 465     PRO k   156                                                      
REMARK 465     GLU k   157                                                      
REMARK 465     PRO k   158                                                      
REMARK 465     ASP k   159                                                      
REMARK 465     CYS k   160                                                      
REMARK 465     TYR k   161                                                      
REMARK 465     ARG k   162                                                      
REMARK 465     SER k   163                                                      
REMARK 465     PHE k   164                                                      
REMARK 465     LYS k   165                                                      
REMARK 465     SER k   166                                                      
REMARK 465     ASP k   167                                                      
REMARK 465     LYS k   168                                                      
REMARK 465     LYS k   362                                                      
REMARK 465     ASP k   363                                                      
REMARK 465     ASP k   364                                                      
REMARK 465     LYS k   365                                                      
REMARK 465     GLY k   366                                                      
REMARK 465     LYS k   367                                                      
REMARK 465     THR k   445                                                      
REMARK 465     ASP k   446                                                      
REMARK 465     GLY k   447                                                      
REMARK 465     GLN k   448                                                      
REMARK 465     GLY k   520                                                      
REMARK 465     THR k   521                                                      
REMARK 465     THR k   522                                                      
REMARK 465     LEU k   523                                                      
REMARK 465     GLU k   524                                                      
REMARK 465     PRO k   525                                                      
REMARK 465     ILE k   526                                                      
REMARK 465     ALA k   527                                                      
REMARK 465     MET l     1                                                      
REMARK 465     SER l     2                                                      
REMARK 465     SER l     3                                                      
REMARK 465     ASP l     4                                                      
REMARK 465     LEU l     5                                                      
REMARK 465     ALA l     6                                                      
REMARK 465     ALA l     7                                                      
REMARK 465     GLU l     8                                                      
REMARK 465     LEU l     9                                                      
REMARK 465     GLY l    10                                                      
REMARK 465     PHE l    11                                                      
REMARK 465     ASP l    12                                                      
REMARK 465     PRO l    13                                                      
REMARK 465     ALA l    14                                                      
REMARK 465     LEU l    15                                                      
REMARK 465     LYS l    16                                                      
REMARK 465     LYS l    17                                                      
REMARK 465     LYS l    18                                                      
REMARK 465     LYS l    19                                                      
REMARK 465     LYS l    20                                                      
REMARK 465     THR l    21                                                      
REMARK 465     LYS l    22                                                      
REMARK 465     LYS l    23                                                      
REMARK 465     VAL l    24                                                      
REMARK 465     ILE l    25                                                      
REMARK 465     PRO l    26                                                      
REMARK 465     ASP l    27                                                      
REMARK 465     ASP l    28                                                      
REMARK 465     PHE l    29                                                      
REMARK 465     ASP l    30                                                      
REMARK 465     ALA l    31                                                      
REMARK 465     ALA l    32                                                      
REMARK 465     VAL l    33                                                      
REMARK 465     ASN l    34                                                      
REMARK 465     GLY l    35                                                      
REMARK 465     LYS l    36                                                      
REMARK 465     GLU l    37                                                      
REMARK 465     ASN l    38                                                      
REMARK 465     GLY l    39                                                      
REMARK 465     SER l    40                                                      
REMARK 465     GLY l    41                                                      
REMARK 465     ASP l    42                                                      
REMARK 465     ASP l    43                                                      
REMARK 465     LEU l    44                                                      
REMARK 465     PHE l    45                                                      
REMARK 465     ALA l    46                                                      
REMARK 465     GLY l    47                                                      
REMARK 465     LEU l    48                                                      
REMARK 465     LYS l    49                                                      
REMARK 465     LYS l    50                                                      
REMARK 465     LYS l    51                                                      
REMARK 465     LYS l    52                                                      
REMARK 465     LYS l    53                                                      
REMARK 465     LYS l    54                                                      
REMARK 465     SER l    55                                                      
REMARK 465     LYS l    56                                                      
REMARK 465     SER l    57                                                      
REMARK 465     VAL l    58                                                      
REMARK 465     SER l    59                                                      
REMARK 465     ALA l    60                                                      
REMARK 465     ASP l    61                                                      
REMARK 465     ALA l    62                                                      
REMARK 465     GLU l    63                                                      
REMARK 465     ALA l    64                                                      
REMARK 465     GLU l    65                                                      
REMARK 465     LYS l    66                                                      
REMARK 465     GLU l    67                                                      
REMARK 465     PRO l    68                                                      
REMARK 465     THR l    69                                                      
REMARK 465     ASP l    70                                                      
REMARK 465     ASP l    71                                                      
REMARK 465     ILE l    72                                                      
REMARK 465     ALA l    73                                                      
REMARK 465     GLU l    74                                                      
REMARK 465     ALA l    75                                                      
REMARK 465     LEU l    76                                                      
REMARK 465     GLY l    77                                                      
REMARK 465     GLU l    78                                                      
REMARK 465     LEU l    79                                                      
REMARK 465     SER l    80                                                      
REMARK 465     LEU l    81                                                      
REMARK 465     LYS l    82                                                      
REMARK 465     LYS l    83                                                      
REMARK 465     LYS l    84                                                      
REMARK 465     LYS l    85                                                      
REMARK 465     LYS l    86                                                      
REMARK 465     LYS l    87                                                      
REMARK 465     THR l    88                                                      
REMARK 465     LYS l    89                                                      
REMARK 465     ASP l    90                                                      
REMARK 465     SER l    91                                                      
REMARK 465     SER l    92                                                      
REMARK 465     VAL l    93                                                      
REMARK 465     ASP l    94                                                      
REMARK 465     ALA l    95                                                      
REMARK 465     PHE l    96                                                      
REMARK 465     GLU l    97                                                      
REMARK 465     LYS l    98                                                      
REMARK 465     GLU l    99                                                      
REMARK 465     LEU l   100                                                      
REMARK 465     ALA l   101                                                      
REMARK 465     LYS l   102                                                      
REMARK 465     ALA l   103                                                      
REMARK 465     GLY l   104                                                      
REMARK 465     LEU l   105                                                      
REMARK 465     ASP l   106                                                      
REMARK 465     ASN l   107                                                      
REMARK 465     VAL l   108                                                      
REMARK 465     ASP l   109                                                      
REMARK 465     ALA l   110                                                      
REMARK 465     GLU l   111                                                      
REMARK 465     SER l   112                                                      
REMARK 465     LYS l   113                                                      
REMARK 465     GLU l   114                                                      
REMARK 465     GLY l   115                                                      
REMARK 465     THR l   116                                                      
REMARK 465     PRO l   117                                                      
REMARK 465     SER l   118                                                      
REMARK 465     ALA l   119                                                      
REMARK 465     ASN l   120                                                      
REMARK 465     SER l   121                                                      
REMARK 465     SER l   122                                                      
REMARK 465     ILE l   123                                                      
REMARK 465     GLN l   124                                                      
REMARK 465     GLN l   125                                                      
REMARK 465     GLU l   126                                                      
REMARK 465     THR l   144                                                      
REMARK 465     ASN l   145                                                      
REMARK 465     ASN l   146                                                      
REMARK 465     PRO l   147                                                      
REMARK 465     GLU l   148                                                      
REMARK 465     LEU l   149                                                      
REMARK 465     ALA l   150                                                      
REMARK 465     GLY l   151                                                      
REMARK 465     ASP l   152                                                      
REMARK 465     ARG l   153                                                      
REMARK 465     SER l   154                                                      
REMARK 465     GLY l   155                                                      
REMARK 465     PRO l   156                                                      
REMARK 465     GLN l   208                                                      
REMARK 465     GLN l   250                                                      
REMARK 465     SER l   251                                                      
REMARK 465     ILE l   271                                                      
REMARK 465     LYS l   272                                                      
REMARK 465     THR l   273                                                      
REMARK 465     GLY l   274                                                      
REMARK 465     PHE l   275                                                      
REMARK 465     GLN l   276                                                      
REMARK 465     ALA l   277                                                      
REMARK 465     THR l   278                                                      
REMARK 465     VAL l   279                                                      
REMARK 465     GLY l   280                                                      
REMARK 465     LYS l   281                                                      
REMARK 465     ARG l   282                                                      
REMARK 465     ARG l   283                                                      
REMARK 465     ARG l   284                                                      
REMARK 465     MET l   285                                                      
REMARK 465     MET m     1                                                      
REMARK 465     SER m     2                                                      
REMARK 465     ILE m     3                                                      
REMARK 465     GLU m     4                                                      
REMARK 465     ASN m     5                                                      
REMARK 465     LEU m     6                                                      
REMARK 465     LYS m     7                                                      
REMARK 465     SER m     8                                                      
REMARK 465     PHE m     9                                                      
REMARK 465     ASP m    10                                                      
REMARK 465     PRO m    11                                                      
REMARK 465     PHE m    12                                                      
REMARK 465     ALA m    13                                                      
REMARK 465     ASP m    14                                                      
REMARK 465     THR m    15                                                      
REMARK 465     GLY m    16                                                      
REMARK 465     ASP m    17                                                      
REMARK 465     ASP m    18                                                      
REMARK 465     MET o     1                                                      
REMARK 465     ALA o     2                                                      
REMARK 465     PRO o     3                                                      
REMARK 465     PRO o     4                                                      
REMARK 465     PRO o     5                                                      
REMARK 465     ASP o   121                                                      
REMARK 465     ASP o   122                                                      
REMARK 465     LEU o   123                                                      
REMARK 465     GLU o   124                                                      
REMARK 465     GLY o   125                                                      
REMARK 465     GLY o   126                                                      
REMARK 465     VAL o   127                                                      
REMARK 465     THR o   128                                                      
REMARK 465     PRO o   129                                                      
REMARK 465     GLU o   130                                                      
REMARK 465     ASN o   131                                                      
REMARK 465     LEU o   132                                                      
REMARK 465     LEU o   133                                                      
REMARK 465     ILE o   134                                                      
REMARK 465     SER o   135                                                      
REMARK 465     VAL o   136                                                      
REMARK 465     TYR o   137                                                      
REMARK 465     GLU o   138                                                      
REMARK 465     SER o   139                                                      
REMARK 465     ASP o   140                                                      
REMARK 465     GLN o   141                                                      
REMARK 465     SER o   142                                                      
REMARK 465     VAL o   143                                                      
REMARK 465     ALA o   144                                                      
REMARK 465     GLY o   145                                                      
REMARK 465     PHE o   146                                                      
REMARK 465     ASN o   147                                                      
REMARK 465     ASP o   148                                                      
REMARK 465     GLU o   149                                                      
REMARK 465     LEU o   224                                                      
REMARK 465     VAL o   225                                                      
REMARK 465     ASP o   226                                                      
REMARK 465     LEU o   227                                                      
REMARK 465     ASN p   795                                                      
REMARK 465     LYS p   796                                                      
REMARK 465     GLU p   797                                                      
REMARK 465     TYR p   798                                                      
REMARK 465     LYS p   799                                                      
REMARK 465     ILE p   800                                                      
REMARK 465     ALA p   801                                                      
REMARK 465     LYS p   802                                                      
REMARK 465     GLU p   803                                                      
REMARK 465     ARG p   804                                                      
REMARK 465     LEU p   805                                                      
REMARK 465     ASN p   806                                                      
REMARK 465     PRO p   807                                                      
REMARK 465     PRO p   808                                                      
REMARK 465     SER p   809                                                      
REMARK 465     ASN p   810                                                      
REMARK 465     ARG p   811                                                      
REMARK 465     ARG p   812                                                      
REMARK 465     MET q   343                                                      
REMARK 465     GLN q   344                                                      
REMARK 465     GLU q   345                                                      
REMARK 465     ALA q   346                                                      
REMARK 465     ASN q   347                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470       A 21692    N9   C8   N7   C5   C6   N6   N1                    
REMARK 470       A 21692    C2   N3   C4                                        
REMARK 470       G 21693    N9   C8   N7   C5   C6   O6   N1                    
REMARK 470       G 21693    C2   N2   N3   C4                                   
REMARK 470       G 21694    N9   C8   N7   C5   C6   O6   N1                    
REMARK 470       G 21694    C2   N2   N3   C4                                   
REMARK 470       G 21695    N9   C8   N7   C5   C6   O6   N1                    
REMARK 470       G 21695    C2   N2   N3   C4                                   
REMARK 470       G 21696    N9   C8   N7   C5   C6   O6   N1                    
REMARK 470       G 21696    C2   N2   N3   C4                                   
REMARK 470       G 21697    N9   C8   N7   C5   C6   O6   N1                    
REMARK 470       G 21697    C2   N2   N3   C4                                   
REMARK 470       C 21698    N1   C2   O2   N3   C4   N4   C5                    
REMARK 470       C 21698    C6                                                  
REMARK 470       A 21699    N9   C8   N7   C5   C6   N6   N1                    
REMARK 470       A 21699    C2   N3   C4                                        
REMARK 470       A 21700    N9   C8   N7   C5   C6   N6   N1                    
REMARK 470       A 21700    C2   N3   C4                                        
REMARK 470       C 21701    N1   C2   O2   N3   C4   N4   C5                    
REMARK 470       C 21701    C6                                                  
REMARK 470       U 21702    N1   C2   O2   N3   C4   O4   C5                    
REMARK 470       U 21702    C6                                                  
REMARK 470       C 21703    N1   C2   O2   N3   C4   N4   C5                    
REMARK 470       C 21703    C6                                                  
REMARK 470       C 21704    N1   C2   O2   N3   C4   N4   C5                    
REMARK 470       C 21704    C6                                                  
REMARK 470       A 21705    N9   C8   N7   C5   C6   N6   N1                    
REMARK 470       A 21705    C2   N3   C4                                        
REMARK 470     LYS A  27    CG   CD   CE   NZ                                   
REMARK 470     GLU A 209    CG   CD   OE1  OE2                                  
REMARK 470     LYS B   5    CG   CD   CE   NZ                                   
REMARK 470     ASN B   6    CG   OD1  ND2                                       
REMARK 470     LYS B   7    CG   CD   CE   NZ                                   
REMARK 470     LEU B   9    CG   CD1  CD2                                       
REMARK 470     ARG B  19    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 123    CG   CD   CE   NZ                                   
REMARK 470     LEU e   8    CG   CD1  CD2                                       
REMARK 470     ASN f 123    CG   OD1  ND2                                       
REMARK 470     GLN f 149    CG   CD   OE1  NE2                                  
REMARK 470     LYS f 150    CG   CD   CE   NZ                                   
REMARK 470     TYR k 183    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU m  19    CG   CD   OE1  OE2                                  
REMARK 470     THR m  20    OG1  CG2                                            
REMARK 470     SER m  23    OG                                                  
REMARK 470     ARG p 193    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN p 196    CG   OD1  ND2                                       
REMARK 470     THR p 197    OG1  CG2                                            
REMARK 470     THR p 198    OG1  CG2                                            
REMARK 470     LYS p 199    CG   CD   CE   NZ                                   
REMARK 470     GLN p 200    CG   CD   OE1  NE2                                  
REMARK 470     ARG p 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL p 202    CG1  CG2                                            
REMARK 470     LYS p 203    CG   CD   CE   NZ                                   
REMARK 470     LYS p 204    CG   CD   CE   NZ                                   
REMARK 470     VAL p 205    CG1  CG2                                            
REMARK 470     SER p 206    OG                                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500  MG     MG 2  1876    MG     MG 2  1879              1.31            
REMARK 500   SG   CYS l   236    ZN     ZN l   301              1.63            
REMARK 500   O4     U 2  1292     N1     A 2  1321              1.89            
REMARK 500   N1     A 2   480     O4     U 2   506              1.89            
REMARK 500   N1     A 2   991     O4     U 2  1011              1.92            
REMARK 500   O    PHE l   158     N    ILE l   160              1.96            
REMARK 500   O4     U 2  1583     N1     A 2  1609              2.06            
REMARK 500   O6     G 2   763     O6     G 2   772              2.14            
REMARK 500   N2     G 2   567     N2     G 2   573              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500      A 1   1   P       A 1   1   OP3    -0.119                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      A 2 685   C2' -  C3' -  O3' ANGL. DEV. =  13.6 DEGREES          
REMARK 500    LEU I  29   CA  -  CB  -  CG  ANGL. DEV. =  16.7 DEGREES          
REMARK 500    PRO U  96   C   -  N   -  CA  ANGL. DEV. =  10.1 DEGREES          
REMARK 500    LEU W  26   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    PRO X  64   C   -  N   -  CD  ANGL. DEV. = -13.4 DEGREES          
REMARK 500    LEU j 166   CA  -  CB  -  CG  ANGL. DEV. =  15.3 DEGREES          
REMARK 500    LEU l 191   CA  -  CB  -  CG  ANGL. DEV. =  14.9 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PRO A   4       42.21    -83.98                                   
REMARK 500    SER A   5        9.72     59.48                                   
REMARK 500    PHE A   7       36.03    -89.34                                   
REMARK 500    ARG A  21       48.02     85.21                                   
REMARK 500    LYS A  27      178.91     61.80                                   
REMARK 500    GLN A  33       37.38    -86.19                                   
REMARK 500    LYS A  39      145.20     64.07                                   
REMARK 500    ALA A  95      123.35     43.84                                   
REMARK 500    THR A 103      102.12     68.64                                   
REMARK 500    ASN A 109       92.46     52.92                                   
REMARK 500    ASP A 129       30.08    -95.83                                   
REMARK 500    VAL A 139       52.89   -118.44                                   
REMARK 500    ASN A 140       -3.50     61.19                                   
REMARK 500    LEU A 149       50.90    -96.02                                   
REMARK 500    ASP A 150      -44.83   -147.79                                   
REMARK 500    PRO A 152     -177.95    -68.89                                   
REMARK 500    TYR A 155       13.28     57.12                                   
REMARK 500    VAL A 158      113.96     69.05                                   
REMARK 500    LYS A 167      -40.10     70.80                                   
REMARK 500    PRO A 194        4.38    -67.85                                   
REMARK 500    TRP A 195      144.44     67.38                                   
REMARK 500    TYR A 202     -115.24    -86.98                                   
REMARK 500    PHE A 203     -172.44     59.43                                   
REMARK 500    GLU A 208      -63.92   -134.58                                   
REMARK 500    ASP B  22       84.01     55.33                                   
REMARK 500    SER B  51       86.99    -65.35                                   
REMARK 500    LEU B  54      124.66     67.87                                   
REMARK 500    LYS B  55       70.57     74.12                                   
REMARK 500    SER B  60       58.91    -90.81                                   
REMARK 500    LEU B  61      -45.59   -138.97                                   
REMARK 500    GLU B  77        6.84    -68.08                                   
REMARK 500    ASP B  89      -36.77   -131.56                                   
REMARK 500    LYS B  94      -45.74     73.71                                   
REMARK 500    HIS B 101      -61.42    -95.66                                   
REMARK 500    TRP B 117      -29.71     74.99                                   
REMARK 500    ALA B 147       76.70    -67.18                                   
REMARK 500    ASN B 148      -33.59    178.81                                   
REMARK 500    SER B 154       83.12     53.62                                   
REMARK 500    GLN B 177      -22.72     65.86                                   
REMARK 500    SER B 179     -179.51     68.49                                   
REMARK 500    PRO B 190       42.75   -107.57                                   
REMARK 500    GLU B 191       41.66     38.46                                   
REMARK 500    LYS B 202       -8.09    -55.90                                   
REMARK 500    LEU B 207      136.08     64.23                                   
REMARK 500    LYS B 214      108.22     54.08                                   
REMARK 500    PRO B 221      -94.79    -74.20                                   
REMARK 500    LYS B 222      -88.95   -109.36                                   
REMARK 500    PHE B 223      -62.38   -144.14                                   
REMARK 500    ASP B 224      114.30     58.90                                   
REMARK 500    THR C  44      138.72     67.50                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     654 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 THR F  191     ILE F  192                 -148.30                    
REMARK 500 GLN X   63     PRO X   64                 -139.66                    
REMARK 500 HIS Y   29     PRO Y   30                 -143.91                    
REMARK 500 PHE l  158     ARG l  159                  124.78                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 610                                                                      
REMARK 610 MISSING HETEROATOM                                                   
REMARK 610 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 610 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 610 I=INSERTION CODE):                                                   
REMARK 610   M RES C SSEQI                                                      
REMARK 610     MET k  601                                                       
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21812  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 21761   OP1                                                    
REMARK 620 2   U 21769   OP1 124.1                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21828  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   C 2 360   OP2                                                    
REMARK 620 2   A 2 100   OP2  93.4                                              
REMARK 620 3   C 2 360   OP1  82.0 143.4                                        
REMARK 620 4   C 2 360   O5'  77.0 144.3  70.0                                  
REMARK 620 5   C 2  99   O3' 162.5  69.2 112.1 116.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21876  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21426   OP1                                                    
REMARK 620 2   G 21426   OP2  89.7                                              
REMARK 620 3   G 21427   OP2  97.6 147.3                                        
REMARK 620 4   C 21273   OP2 104.4  81.5 126.6                                  
REMARK 620 5   G 21426   O5'  60.3  58.8  97.5 135.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21822  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21766   OP2                                                    
REMARK 620 2   A 21760   OP2 141.2                                              
REMARK 620 3   A 21761   OP2 105.4  97.3                                        
REMARK 620 4   G 21765   O2'  54.5 139.4 114.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21879  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21427   OP2                                                    
REMARK 620 2   C 21273   OP1 138.2                                              
REMARK 620 3   G 21426   OP1  96.1 113.9                                        
REMARK 620 4   C 21273   OP2 132.7  69.9 102.8                                  
REMARK 620 5   G 21426   OP2  92.7 127.3  58.3  63.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21826  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21327   OP2                                                    
REMARK 620 2   G 21327   O5'  73.5                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21823  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2 620   OP2                                                    
REMARK 620 2   A 2 619   OP2  87.0                                              
REMARK 620 3   A 2 618   OP2 131.2  69.1                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21837  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 2 460   OP2                                                    
REMARK 620 2   G 2 460   OP1  80.4                                              
REMARK 620 3   G 2 460   O5'  68.6  66.7                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21874  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   C 21196   OP1                                                    
REMARK 620 2   C 21196   OP2  61.9                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21863  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   U 21008   OP1                                                    
REMARK 620 2   U 21008   O5'  56.3                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21880  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 21202   OP2                                                    
REMARK 620 2   A 21201   OP1  86.2                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21817  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2  28   OP2                                                    
REMARK 620 2   A 2  28   OP1  70.3                                              
REMARK 620 3   U 2  27   O3'  60.5  56.1                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN a 500  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS a  23   SG                                                     
REMARK 620 2 CYS a  77   SG  159.3                                              
REMARK 620 3 CYS a  26   SG  101.2  80.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21818  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2 604   OP2                                                    
REMARK 620 2   A 2 604   OP1  83.1                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21821  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2  47   OP2                                                    
REMARK 620 2   A 2  47   O5'  69.0                                              
REMARK 620 3   A 2  47   OP1  62.5  56.5                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21834  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21791   OP2                                                    
REMARK 620 2   G 21791   O5'  72.4                                              
REMARK 620 3   G 21790   O3'  57.8  56.8                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21814  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2 400   OP2                                                    
REMARK 620 2   A 2 399   O3'  68.4                                              
REMARK 620 3   A 2 400   OP1  67.9  59.9                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21816  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2 377   OP2                                                    
REMARK 620 2   U 2 378   OP2  89.8                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21802  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 2 402   OP1                                                    
REMARK 620 2   C 2 401   O3'  66.1                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21872  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21200   OP1                                                    
REMARK 620 2   G 21199   OP2  69.1                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21803  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 2 554   OP2                                                    
REMARK 620 2   A 2 555   OP2 109.7                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN f 501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS f 121   SG                                                     
REMARK 620 2 CYS f 139   SG  134.2                                              
REMARK 620 3 CYS f 124   SG  108.1 107.3                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21835  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   U 2  64   OP2                                                    
REMARK 620 2   U 2  64   OP1  60.2                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21815  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   U 2 607   OP2                                                    
REMARK 620 2   G 2  16   OP2  93.5                                              
REMARK 620 3   G 2  16   OP1 146.5  58.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN b 101  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS b  59   SG                                                     
REMARK 620 2 CYS b  59   O    88.3                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21850  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 2 761   O6                                                     
REMARK 620 2   A 2 760   OP2  99.3                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG k 602  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR k 137   OG1                                                    
REMARK 620 2 GCP k 603   O1G 112.2                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21805  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   A 21024   OP2                                                    
REMARK 620 2   G 2 623   OP2 109.6                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN l 301  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS l 262   SG                                                     
REMARK 620 2 SER l 264   OG  112.3                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21859  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 21540   OP2                                                    
REMARK 620 2   G 21539   OP2  85.4                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21878  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   U 21520   OP1                                                    
REMARK 620 2   G 21482   OP2 104.6                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21840  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   G 2 984   O6                                                     
REMARK 620 2   G 2 985   O6   95.9                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21853  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   C 2 529   OP1                                                    
REMARK 620 2   C 2 530   OP2 104.9                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG 21819  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1   U 21003   OP2                                                    
REMARK 620 2   U 21003   OP1  55.2                                              
REMARK 620 N                    1                                               
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1803                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1804                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1805                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1806                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1807                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1808                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1809                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1811                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1812                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1814                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1815                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1816                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1817                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1818                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1819                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1821                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1822                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1823                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1824                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1825                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1826                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1827                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1828                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1829                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1831                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1832                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1833                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1834                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1835                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1837                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1838                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1839                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1840                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1841                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1842                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1843                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1846                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1847                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1848                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1850                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1852                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1853                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1854                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1855                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1857                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1858                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1859                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1863                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1865                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1868                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1869                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: FC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1870                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1871                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1872                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1873                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1874                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1875                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1876                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1877                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1878                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: GC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1879                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG 2 1880                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN a 500                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN b 101                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN f 501                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MET k 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG k 602                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GCP k 603                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: HC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN l 301                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-3048   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-3047   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-3049   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 3J81   RELATED DB: PDB                                   
REMARK 900 PY48S                                                                
REMARK 900 RELATED ID: 3JAM   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3JAQ   RELATED DB: PDB                                   
DBREF  3JAP A    1   254  UNP    Q6CN12   RSSA_KLULA       1    254             
DBREF  3JAP B    1   255  UNP    Q6CWD0   RS3A_KLULA       1    255             
DBREF  3JAP C    1   259  UNP    Q6CKL3   Q6CKL3_KLULA     1    259             
DBREF  3JAP D    1   237  UNP    Q6CRK7   Q6CRK7_KLULA     1    237             
DBREF  3JAP E    1   261  UNP    Q6CWJ2   Q6CWJ2_KLULA     1    261             
DBREF  3JAP F    1   227  UNP    Q6CRA3   Q6CRA3_KLULA     1    227             
DBREF  3JAP G    1   236  UNP    Q6CM04   RS6_KLULA        1    236             
DBREF  3JAP H    1   190  UNP    Q6CTD6   Q6CTD6_KLULA     1    190             
DBREF  3JAP I    1   201  UNP    Q6CMG3   Q6CMG3_KLULA     1    201             
DBREF  3JAP J    1   188  UNP    Q6CM18   Q6CM18_KLULA     1    188             
DBREF  3JAP K    1   106  UNP    Q6CVZ5   Q6CVZ5_KLULA     1    106             
DBREF  3JAP L    1   156  UNP    Q6CX80   Q6CX80_KLULA     1    156             
DBREF  3JAP M    1   134  UNP    Q6CLU4   Q6CLU4_KLULA     1    134             
DBREF  3JAP N    1   151  UNP    Q6CJK0   Q6CJK0_KLULA     1    151             
DBREF  3JAP O    1   137  UNP    P27069   RS14_KLULA       1    137             
DBREF  3JAP P    1   142  UNP    Q6CKV4   Q6CKV4_KLULA     1    142             
DBREF  3JAP Q    1   143  UNP    Q875N2   RS16_KLULA       1    143             
DBREF  3JAP R    1   136  UNP    Q6CWU3   Q6CWU3_KLULA     1    136             
DBREF  3JAP S    1   146  UNP    Q6CWT9   Q6CWT9_KLULA     1    146             
DBREF  3JAP T    1   144  UNP    Q6CXM0   Q6CXM0_KLULA     1    144             
DBREF  3JAP U    4   120  UNP    Q6CIM1   Q6CIM1_KLULA     1    117             
DBREF  3JAP V    1    87  UNP    Q6CXT6   RS21_KLULA       1     87             
DBREF  3JAP W    1   130  UNP    Q6CW21   RS22_KLULA       1    130             
DBREF  3JAP X    1   145  UNP    F2Z602   F2Z602_KLULA     1    145             
DBREF  3JAP Y    1   135  UNP    Q6CU44   Q6CU44_KLULA     1    135             
DBREF  3JAP Z    1   108  UNP    Q6CW78   Q6CW78_KLULA     1    108             
DBREF  3JAP a    1   119  UNP    Q6CS01   Q6CS01_KLULA     1    119             
DBREF  3JAP b    1    82  UNP    Q6CNL2   Q6CNL2_KLULA     1     82             
DBREF  3JAP c    1    67  UNP    P33285   RS28_KLULA       1     67             
DBREF  3JAP d    1    56  UNP    Q6CPG3   RS29_KLULA       1     56             
DBREF  3JAP e    1    63  UNP    Q6CUH5   Q6CUH5_KLULA     1     63             
DBREF  3JAP f    1   150  UNP    P69061   RS27A_KLULA      1    150             
DBREF  3JAP g    1   326  UNP    Q6CNI7   Q6CNI7_KLULA     1    326             
DBREF  3JAP h    1    25  UNP    P0CX86   RL41A_YEAST      1     25             
DBREF  3JAP i    1   153  UNP    P38912   IF1A_YEAST       1    153             
DBREF  3JAP j    1   304  UNP    P20459   IF2A_YEAST       1    304             
DBREF  3JAP k    1   527  UNP    P32481   IF2G_YEAST       1    527             
DBREF  3JAP l    1   285  UNP    P09064   IF2B_YEAST       1    285             
DBREF  3JAP m    1   108  UNP    P32911   SUI1_YEAST       1    108             
DBREF  3JAP o    1   495  UNP    P38249   EIF3A_YEAST      1    495             
DBREF  3JAP p  193   206  UNP    P32497   EIF3C_YEAST    193    206             
DBREF  3JAP p  251   812  UNP    P32497   EIF3C_YEAST    251    812             
DBREF  3JAP q    1   347  UNP    P40217   EIF3I_YEAST      1    347             
DBREF  3JAP r  704   734  UNP    P06103   EIF3B_YEAST    704    734             
DBREF  3JAP s   45    96  UNP    A6ZZ25   EIF3G_YEAS7     45     96             
DBREF  3JAP 1    1    76  PDB    3JAP     3JAP             1     76             
DBREF  3JAP 2    1  1798  PDB    3JAP     3JAP             1   1798             
DBREF  3JAP 3    0    24  PDB    3JAP     3JAP             0     24             
DBREF  3JAP o    1   866  PDB    3JAP     3JAP             1    866             
DBREF  3JAP p   20   812  PDB    3JAP     3JAP            20    812             
SEQRES   1 1   75    A   G   C   G   C   C   G   U   G   G   C   G   C          
SEQRES   2 1   75    A   G   U   G   G   A   A   G   C   G   C   G   C          
SEQRES   3 1   75    A   G   G   U   C   U   C   A   U   A   A   A   C          
SEQRES   4 1   75    C   U   G   A   U   G   U   C   C   U   C   G   G          
SEQRES   5 1   75    A   U   C   G   A   A   A   C   C   G   A   G   C          
SEQRES   6 1   75    G   G   C   G   C   U   A   C   C   A                      
SEQRES   1 2 1781    U   A   U   C   U   G   G   U   U   G   A   U   C          
SEQRES   2 2 1781    C   U   G   C   C   A   G   U   A   G   U   C   A          
SEQRES   3 2 1781    U   A   U   G   C   U   U   G   U   C   U   C   A          
SEQRES   4 2 1781    A   A   G   A   U   U   A   A   G   C   C   A   U          
SEQRES   5 2 1781    G   C   A   U   G   U   C   U   A   A   G   U   A          
SEQRES   6 2 1781    U   A   A   G   C   A   A   U   U   U   A   U   A          
SEQRES   7 2 1781    C   A   G   U   G   A   A   A   C   U   G   C   G          
SEQRES   8 2 1781    A   A   U   G   G   C   U   C   A   U   U   A   A          
SEQRES   9 2 1781    A   U   C   A   G   U   U   A   U   C   G   U   U          
SEQRES  10 2 1781    U   A   U   U   U   G   A   U   A   G   U   U   C          
SEQRES  11 2 1781    C   U   U   U   A   C   U   A   C   A   U   G   G          
SEQRES  12 2 1781    A   U   A   U   C   U   G   U   G   G   U   A   A          
SEQRES  13 2 1781    U   U   C   U   A   G   A   G   C   U   A   A   U          
SEQRES  14 2 1781    A   C   A   U   G   C   U   U   A   A   A   A   U          
SEQRES  15 2 1781    C   U   C   G   A   C   C   C   U   U   U   G   G          
SEQRES  16 2 1781    A   A   G   A   G   A   U   G   U   A   U   U   U          
SEQRES  17 2 1781    A   U   U   A   G   A   U   A   A   A   A   A   A          
SEQRES  18 2 1781    U   C   A   A   U   G   U   C   U   U   C   G   G          
SEQRES  19 2 1781    A   C   U   C   C   U   U   G   A   U   G   A   U          
SEQRES  20 2 1781    U   C   A   U   A   A   U   A   A   C   U   U   U          
SEQRES  21 2 1781    U   C   G   A   A   U   C   G   C   A   U   G   G          
SEQRES  22 2 1781    C   C   U   U   G   U   G   C   U   G   G   C   G          
SEQRES  23 2 1781    A   U   G   G   U   U   C   A   U   U   C   A   A          
SEQRES  24 2 1781    A   U   U   U   C   U   G   C   C   C   U   A   U          
SEQRES  25 2 1781    C   A   A   C   U   U   U   C   G   A   U   G   G          
SEQRES  26 2 1781    U   A   G   G   A   U   A   G   U   G   G   C   C          
SEQRES  27 2 1781    U   A   C   C   A   U   G   G   U   U   U   C   A          
SEQRES  28 2 1781    A   C   G   G   G   U   A   A   C   G   G   G   G          
SEQRES  29 2 1781    A   A   U   A   A   G   G   G   U   U   C   G   A          
SEQRES  30 2 1781    U   U   C   C   G   G   A   G   A   G   G   G   A          
SEQRES  31 2 1781    G   C   C   U   G   A   G   A   A   A   C   G   G          
SEQRES  32 2 1781    C   U   A   C   C   A   C   A   U   C   C   A   A          
SEQRES  33 2 1781    G   G   A   A   G   G   C   A   G   C   A   G   G          
SEQRES  34 2 1781    C   G   C   G   C   A   A   A   U   U   A   C   C          
SEQRES  35 2 1781    C   A   A   U   C   C   U   A   A   U   U   C   A          
SEQRES  36 2 1781    G   G   G   A   G   G   U   A   G   U   G   A   C          
SEQRES  37 2 1781    A   A   U   A   A   A   U   A   A   C   G   A   U          
SEQRES  38 2 1781    A   C   A   G   G   G   C   C   C   A   U   U   C          
SEQRES  39 2 1781    G   G   G   U   C   U   U   G   U   A   A   U   U          
SEQRES  40 2 1781    G   G   A   A   U   G   A   G   U   A   C   A   A          
SEQRES  41 2 1781    U   G   U   A   A   A   U   A   C   C   U   U   A          
SEQRES  42 2 1781    A   C   G   A   G   G   A   A   C   A   A   C   U          
SEQRES  43 2 1781    G   G   A   G   G   G   C   A   A   G   U   C   U          
SEQRES  44 2 1781    G   G   U   G   C   C   A   G   C   A   G   C   C          
SEQRES  45 2 1781    G   C   G   G   U   A   A   U   U   C   C   A   G          
SEQRES  46 2 1781    C   U   C   C   A   G   U   A   G   C   G   U   A          
SEQRES  47 2 1781    U   A   U   U   A   A   A   G   U   U   G   U   U          
SEQRES  48 2 1781    G   C   A   G   U   U   A   A   A   A   A   G   C          
SEQRES  49 2 1781    U   C   G   U   A   G   U   U   G   A   A   C   U          
SEQRES  50 2 1781    U   U   G   G   G   U   C   U   G   G   U   U   G          
SEQRES  51 2 1781    U   C   C   G   G   U   C   C   G   G   U   U   U          
SEQRES  52 2 1781    U   U   C   A   A   C   C   G   G   A   U   C   U          
SEQRES  53 2 1781    U   U   C   C   U   U   C   U   G   G   C   U   A          
SEQRES  54 2 1781    A   C   C   U   G   U   A   C   U   C   C   U   U          
SEQRES  55 2 1781    G   U   G   G   G   U   G   C   A   G   G   C   G          
SEQRES  56 2 1781    A   A   C   C   A   G   G   A   C   U   U   U   U          
SEQRES  57 2 1781    A   C   U   U   U   G   A   A   A   A   A   A   U          
SEQRES  58 2 1781    U   A   G   A   G   U   G   U   U   C   A   A   A          
SEQRES  59 2 1781    G   C   A   G   G   C   G   A   A   A   G   C   U          
SEQRES  60 2 1781    C   G   A   A   U   A   U   A   U   U   A   G   C          
SEQRES  61 2 1781    A   U   G   G   A   A   U   A   A   U   G   G   A          
SEQRES  62 2 1781    A   U   A   G   G   A   C   G   U   U   U   G   G          
SEQRES  63 2 1781    U   U   C   U   A   U   U   U   U   G   U   U   G          
SEQRES  64 2 1781    G   U   U   U   C   U   A   G   G   A   C   C   A          
SEQRES  65 2 1781    U   C   G   U   A   A   U   G   A   U   U   A   A          
SEQRES  66 2 1781    U   A   G   G   G   A   C   G   G   U   C   G   G          
SEQRES  67 2 1781    G   G   G   C   A   U   C   A   G   U   A   U   U          
SEQRES  68 2 1781    C   A   A   U   U   G   U   C   A   G   A   G   G          
SEQRES  69 2 1781    U   G   A   A   A   U   U   C   U   U   G   G   A          
SEQRES  70 2 1781    U   U   U   A   U   U   G   A   A   G   A   C   U          
SEQRES  71 2 1781    A   A   C   U   A   C   U   G   C   G   A   A   A          
SEQRES  72 2 1781    G   C   A   U   U   U   G   C   C   A   A   G   G          
SEQRES  73 2 1781    A   C   G   U   U   U   U   C   A   U   U   A   A          
SEQRES  74 2 1781    U   C   A   A   G   A   A   C   G   A   A   A   G          
SEQRES  75 2 1781    U   U   A   G   G   G   G   A   U   C   G   A   A          
SEQRES  76 2 1781    G   A   U   G   A   U   C   A   G   A   U   A   C          
SEQRES  77 2 1781    C   G   U   C   G   U   A   G   U   C   U   U   A          
SEQRES  78 2 1781    A   C   C   A   U   A   A   A   C   U   A   U   G          
SEQRES  79 2 1781    C   C   G   A   C   U   A   G   G   G   A   U   C          
SEQRES  80 2 1781    G   G   G   U   G   G   U   G   U   U   U   U   U          
SEQRES  81 2 1781    C   U   U   A   U   G   A   C   C   C   A   C   U          
SEQRES  82 2 1781    C   G   G   C   A   C   C   U   U   A   C   G   A          
SEQRES  83 2 1781    G   A   A   A   U   C   A   A   A   G   U   C   U          
SEQRES  84 2 1781    U   U   G   G   G   U   U   C   U   G   G   G   G          
SEQRES  85 2 1781    G   G   A   G   U   A   U   G   G   U   C   G   C          
SEQRES  86 2 1781    A   A   G   G   C   U   G   A   A   A   C   U   U          
SEQRES  87 2 1781    A   A   A   G   G   A   A   U   U   G   A   C   G          
SEQRES  88 2 1781    G   A   A   G   G   G   C   A   C   C   A   C   C          
SEQRES  89 2 1781    A   G   G   A   G   U   G   G   A   G   C   C   U          
SEQRES  90 2 1781    G   C   G   G   C   U   U   A   A   U   U   U   G          
SEQRES  91 2 1781    A   C   U   C   A   A   C   A   C   G   G   G   G          
SEQRES  92 2 1781    A   A   A   C   U   C   A   C   C   A   G   G   U          
SEQRES  93 2 1781    C   C   A   G   A   C   A   C   A   A   U   A   A          
SEQRES  94 2 1781    G   G   A   U   U   G   A   C   A   G   A   U   U          
SEQRES  95 2 1781    G   A   G   A   G   C   U   C   U   U   U   C   U          
SEQRES  96 2 1781    U   G   A   U   U   U   U   G   U   G   G   G   U          
SEQRES  97 2 1781    G   G   U   G   G   U   G   C   A   U   G   G   C          
SEQRES  98 2 1781    C   G   U   U   C   U   U   A   G   U   U   G   G          
SEQRES  99 2 1781    U   G   G   A   G   U   G   A   U   U   U   G   U          
SEQRES 100 2 1781    C   U   G   C   U   U   A   A   U   U   G   C   G          
SEQRES 101 2 1781    A   U   A   A   C   G   A   A   C   G   A   G   A          
SEQRES 102 2 1781    C   C   U   U   A   A   C   C   U   A   C   U   A          
SEQRES 103 2 1781    A   A   U   A   G   G   G   U   U   G   C   U   G          
SEQRES 104 2 1781    G   C   A   C   U   U   G   C   C   G   G   U   U          
SEQRES 105 2 1781    G   A   C   U   C   U   U   C   U   U   A   G   A          
SEQRES 106 2 1781    G   G   G   A   C   U   A   U   C   G   G   U   U          
SEQRES 107 2 1781    U   C   A   A   G   C   C   G   A   U   G   G   A          
SEQRES 108 2 1781    A   G   U   U   U   G   A   G   G   C   A   A   U          
SEQRES 109 2 1781    A   A   C   A   G   G   U   C   U   G   U   G   A          
SEQRES 110 2 1781    U   G   C   C   C   U   U   A   G   A   C   G   U          
SEQRES 111 2 1781    U   C   U   G   G   G   C   C   G   C   A   C   G          
SEQRES 112 2 1781    C   G   C   G   C   U   A   C   A   C   U   G   A          
SEQRES 113 2 1781    C   G   G   A   G   C   C   A   G   C   G   A   G          
SEQRES 114 2 1781    U   A   C   A   A   C   C   U   U   G   G   C   C          
SEQRES 115 2 1781    G   A   G   A   G   G   U   C   U   G   G   G   U          
SEQRES 116 2 1781    A   A   U   C   U   U   G   U   G   A   A   A   C          
SEQRES 117 2 1781    U   C   C   G   U   C   G   U   G   C   U   G   G          
SEQRES 118 2 1781    G   G   A   U   A   G   A   G   C   A   U   U   G          
SEQRES 119 2 1781    U   A   A   U   U   A   U   U   G   C   U   C   U          
SEQRES 120 2 1781    U   C   A   A   C   G   A   G   G   A   A   U   U          
SEQRES 121 2 1781    C   C   U   A   G   U   A   A   G   C   G   C   A          
SEQRES 122 2 1781    A   G   U   C   A   U   C   A   G   C   U   U   G          
SEQRES 123 2 1781    C   G   U   U   G   A   U   U   A   C   G   U   C          
SEQRES 124 2 1781    C   C   U   G   C   C   C   U   U   U   G   U   A          
SEQRES 125 2 1781    C   A   C   A   C   C   G   C   C   C   G   U   C          
SEQRES 126 2 1781    G   C   U   A   G   U   A   C   C   G   A   U   U          
SEQRES 127 2 1781    G   A   A   U   G   G   C   U   U   A   G   U   G          
SEQRES 128 2 1781    A   G   G   C   C   U   C   A   G   G   A   U   U          
SEQRES 129 2 1781    U   G   C   U   U   A   G   A   G   A   A   G   G          
SEQRES 130 2 1781    G   G   G   C   A   A   C   U   C   C   A   U   C          
SEQRES 131 2 1781    U   C   A   G   A   G   C   G   A   A   G   A   A          
SEQRES 132 2 1781    U   C   U   G   G   U   C   A   A   A   C   U   U          
SEQRES 133 2 1781    G   G   U   C   A   U   U   U   A   G   A   G   G          
SEQRES 134 2 1781    A   A   C   U   A   A   A   A   G   U   C   G   U          
SEQRES 135 2 1781    A   A   C   A   A   G   G   U   U   U   C   C   G          
SEQRES 136 2 1781    U   A   G   G   U   G   A   A   C   C   U   G   C          
SEQRES 137 2 1781    G   G   A   A   G   G   A   U   C   A   U   U   A          
SEQRES   1 3   25    G   G   A   A   U   C   U   C   U   C   U   C   U          
SEQRES   2 3   25    A   U   G   C   U   C   U   C   U   C   U   C              
SEQRES   1 A  254  MET SER LEU PRO SER THR PHE ASP LEU THR SER GLU ASP          
SEQRES   2 A  254  ALA GLN LEU LEU LEU ALA ALA ARG VAL HIS LEU GLY ALA          
SEQRES   3 A  254  LYS ASN VAL GLN VAL HIS GLN GLU PRO TYR VAL TYR LYS          
SEQRES   4 A  254  ALA ARG PRO ASP GLY VAL ASN VAL ILE ASN VAL GLY LYS          
SEQRES   5 A  254  THR TRP GLU LYS ILE VAL LEU ALA ALA ARG ILE ILE ALA          
SEQRES   6 A  254  ALA ILE PRO ASN PRO GLU ASP VAL VAL ALA ILE SER SER          
SEQRES   7 A  254  ARG THR TYR GLY GLN ARG ALA VAL LEU LYS TYR ALA ALA          
SEQRES   8 A  254  HIS THR GLY ALA THR PRO ILE ALA GLY ARG PHE THR PRO          
SEQRES   9 A  254  GLY SER PHE THR ASN TYR ILE THR ARG SER PHE LYS GLU          
SEQRES  10 A  254  PRO ARG LEU VAL ILE VAL THR ASP PRO ARG SER ASP ALA          
SEQRES  11 A  254  GLN ALA ILE LYS GLU SER SER TYR VAL ASN ILE PRO VAL          
SEQRES  12 A  254  ILE ALA LEU THR ASP LEU ASP SER PRO SER GLU TYR VAL          
SEQRES  13 A  254  ASP VAL ALA ILE PRO CYS ASN ASN ARG GLY LYS HIS SER          
SEQRES  14 A  254  ILE GLY LEU ILE TRP TYR LEU LEU ALA ARG GLU VAL LEU          
SEQRES  15 A  254  ARG LEU ARG GLY ALA LEU PRO ASP ARG THR GLN PRO TRP          
SEQRES  16 A  254  ALA ILE MET PRO ASP LEU TYR PHE TYR ARG ASN PRO GLU          
SEQRES  17 A  254  GLU ILE GLU GLN GLN THR ALA GLU GLU GLU ALA VAL ALA          
SEQRES  18 A  254  SER GLY GLU GLN THR GLU GLU ALA VAL ASP ALA THR GLU          
SEQRES  19 A  254  GLU GLN THR GLU ALA ALA GLU TRP ALA GLU GLU GLY GLN          
SEQRES  20 A  254  ALA GLN GLU GLU GLU TRP ASN                                  
SEQRES   1 B  255  MET ALA VAL GLY LYS ASN LYS ARG LEU SER LYS GLY LYS          
SEQRES   2 B  255  LYS GLY LEU LYS LYS ARG VAL VAL ASP PRO PHE THR ARG          
SEQRES   3 B  255  LYS GLU TRP TYR ASP ILE LYS ALA PRO SER THR PHE GLU          
SEQRES   4 B  255  ASN ARG ASN VAL GLY LYS THR LEU VAL ASN LYS SER VAL          
SEQRES   5 B  255  GLY LEU LYS ASN ALA SER ASP SER LEU LYS GLY ARG VAL          
SEQRES   6 B  255  VAL GLU VAL CYS LEU ALA ASP LEU GLN GLY SER GLU ASP          
SEQRES   7 B  255  HIS SER PHE ARG LYS VAL LYS LEU ARG VAL ASP GLU VAL          
SEQRES   8 B  255  GLN GLY LYS ASN LEU LEU THR ASN PHE HIS GLY MET ASP          
SEQRES   9 B  255  PHE THR THR ASP LYS LEU ARG SER MET VAL ARG LYS TRP          
SEQRES  10 B  255  GLN THR LEU ILE GLU ALA ASN VAL THR VAL LYS THR SER          
SEQRES  11 B  255  ASP ASP TYR VAL LEU ARG ILE PHE ALA ILE ALA PHE THR          
SEQRES  12 B  255  ARG LYS GLN ALA ASN GLN VAL LYS ARG THR SER TYR ALA          
SEQRES  13 B  255  GLN SER SER HIS ILE ARG GLN ILE ARG LYS VAL ILE SER          
SEQRES  14 B  255  GLU ILE LEU THR ARG GLU VAL GLN ASN SER THR LEU ALA          
SEQRES  15 B  255  GLN LEU THR SER LYS LEU ILE PRO GLU VAL ILE ASN LYS          
SEQRES  16 B  255  GLU ILE GLU ASN ALA THR LYS ASP ILE PHE PRO LEU GLN          
SEQRES  17 B  255  ASN VAL HIS ILE ARG LYS VAL LYS LEU LEU LYS GLN PRO          
SEQRES  18 B  255  LYS PHE ASP LEU GLY SER LEU LEU SER LEU HIS GLY GLU          
SEQRES  19 B  255  ALA SER ALA GLU GLU LYS GLY LYS LYS VAL ALA GLY PHE          
SEQRES  20 B  255  LYS ASP GLU ILE LEU GLU THR VAL                              
SEQRES   1 C  259  MET SER ALA PRO GLN ALA GLN GLY GLN GLN ALA PRO ARG          
SEQRES   2 C  259  ARG GLY GLY PHE GLY GLY ALA ASN ARG GLY GLY ARG GLY          
SEQRES   3 C  259  GLY ARG ARG GLY GLY ARG ARG ASP GLN GLU GLU LYS GLY          
SEQRES   4 C  259  TRP VAL PRO VAL THR LYS LEU GLY ARG LEU VAL LYS ALA          
SEQRES   5 C  259  GLY LYS ILE SER SER ILE GLU GLU ILE PHE LEU HIS SER          
SEQRES   6 C  259  LEU PRO VAL LYS GLU PHE GLN ILE ILE ASP GLN LEU LEU          
SEQRES   7 C  259  PRO ASN LEU LYS ASP GLU VAL MET ASN ILE LYS PRO VAL          
SEQRES   8 C  259  GLN LYS GLN THR ARG ALA GLY GLN ARG THR ARG PHE LYS          
SEQRES   9 C  259  ALA VAL VAL VAL VAL GLY ASP SER ASN GLY HIS VAL GLY          
SEQRES  10 C  259  LEU GLY ILE LYS THR ALA LYS GLU VAL ALA GLY ALA ILE          
SEQRES  11 C  259  ARG ALA GLY ILE ILE ILE ALA LYS LEU SER VAL ILE PRO          
SEQRES  12 C  259  ILE ARG ARG GLY TYR TRP GLY THR ASN LEU GLY GLN PRO          
SEQRES  13 C  259  HIS SER LEU ALA THR LYS THR SER GLY LYS CYS GLY SER          
SEQRES  14 C  259  VAL SER VAL ARG LEU ILE PRO ALA PRO ARG GLY SER GLY          
SEQRES  15 C  259  ILE VAL ALA SER PRO ALA VAL LYS LYS LEU MET GLN LEU          
SEQRES  16 C  259  ALA GLY VAL GLU ASP VAL TYR THR SER SER THR GLY SER          
SEQRES  17 C  259  THR ARG THR LEU GLU ASN THR LEU LYS ALA ALA PHE VAL          
SEQRES  18 C  259  ALA ILE GLY ASN THR TYR GLY PHE LEU THR PRO ASN LEU          
SEQRES  19 C  259  TRP GLU VAL GLN ALA LEU THR PRO SER PRO MET ASP VAL          
SEQRES  20 C  259  TYR ALA ASP TYR ALA THR ALA SER LYS LYS LYS LEU              
SEQRES   1 D  237  MET VAL ALA ILE ILE SER LYS LYS ARG LYS LEU VAL ALA          
SEQRES   2 D  237  ASP GLY VAL PHE TYR ALA GLU LEU ASN GLU PHE PHE THR          
SEQRES   3 D  237  ARG GLU LEU ALA GLU GLU GLY TYR SER GLY VAL GLU VAL          
SEQRES   4 D  237  ARG VAL THR PRO THR LYS THR GLU ILE ILE ILE ARG ALA          
SEQRES   5 D  237  THR LYS VAL GLN ASP VAL VAL GLY GLU ASN GLY ARG ARG          
SEQRES   6 D  237  ILE ASN GLU LEU THR LEU LEU ILE GLU LYS ARG PHE LYS          
SEQRES   7 D  237  TYR LYS ARG GLY THR ILE ALA LEU TYR ALA GLU ARG VAL          
SEQRES   8 D  237  HIS ASP ARG GLY LEU SER ALA VAL ALA GLN ALA GLU SER          
SEQRES   9 D  237  MET LYS PHE LYS LEU LEU ASN GLY LEU ALA ILE ARG ARG          
SEQRES  10 D  237  ALA ALA TYR GLY VAL VAL ARG TYR VAL MET GLU SER GLY          
SEQRES  11 D  237  ALA LYS GLY CYS GLU VAL VAL ILE SER GLY LYS LEU ARG          
SEQRES  12 D  237  ALA ALA ARG ALA LYS SER MET LYS PHE ALA ASP GLY PHE          
SEQRES  13 D  237  LEU ILE HIS SER GLY GLN PRO VAL ASN ASP PHE ILE GLU          
SEQRES  14 D  237  THR ALA THR ARG HIS VAL LEU LEU ARG GLN GLY VAL LEU          
SEQRES  15 D  237  GLY ILE LYS VAL LYS ILE MET LYS ASP PRO SER ARG ASN          
SEQRES  16 D  237  THR SER GLY PRO LYS ALA LEU PRO ASP ALA VAL THR ILE          
SEQRES  17 D  237  ILE GLU PRO LYS GLU GLU GLU PRO VAL LEU GLU PRO SER          
SEQRES  18 D  237  VAL LYS ASP TYR ARG PRO THR GLU PRO VAL GLU ALA ALA          
SEQRES  19 D  237  GLU SER ALA                                                  
SEQRES   1 E  261  MET ALA ARG GLY PRO LYS LYS HIS LEU LYS ARG LEU ALA          
SEQRES   2 E  261  ALA PRO HIS HIS TRP MET LEU ASP LYS LEU SER GLY CYS          
SEQRES   3 E  261  TYR ALA PRO ARG PRO SER ALA GLY PRO HIS LYS LEU ARG          
SEQRES   4 E  261  GLU SER LEU PRO LEU ILE VAL PHE LEU ARG ASN ARG LEU          
SEQRES   5 E  261  LYS TYR ALA LEU ASN GLY ARG GLU VAL LYS ALA ILE LEU          
SEQRES   6 E  261  MET GLN ARG HIS VAL LYS VAL ASP GLY LYS VAL ARG THR          
SEQRES   7 E  261  ASP THR THR PHE PRO ALA GLY PHE MET ASP VAL ILE THR          
SEQRES   8 E  261  LEU GLU ALA THR ASN GLU ASN PHE ARG LEU VAL TYR ASP          
SEQRES   9 E  261  VAL LYS GLY ARG PHE ALA VAL HIS ARG ILE THR ASP GLU          
SEQRES  10 E  261  GLU ALA SER TYR LYS LEU ALA LYS VAL LYS LYS VAL GLN          
SEQRES  11 E  261  LEU GLY LYS LYS GLY ILE PRO TYR VAL VAL THR HIS ASP          
SEQRES  12 E  261  GLY ARG THR ILE ARG TYR PRO ASP PRO ASN ILE LYS VAL          
SEQRES  13 E  261  ASN ASP THR VAL LYS VAL ASP LEU ALA THR GLY THR ILE          
SEQRES  14 E  261  THR ASP PHE ILE LYS PHE ASP THR GLY LYS LEU VAL TYR          
SEQRES  15 E  261  VAL THR GLY GLY ARG ASN LEU GLY ARG VAL GLY THR ILE          
SEQRES  16 E  261  VAL HIS ARG GLU ARG HIS GLU GLY GLY PHE ASP LEU VAL          
SEQRES  17 E  261  HIS ILE LYS ASP SER LEU GLU ASN THR PHE VAL THR ARG          
SEQRES  18 E  261  LEU ASN ASN VAL PHE VAL ILE GLY GLU PRO GLY ARG PRO          
SEQRES  19 E  261  TRP ILE SER LEU PRO LYS GLY LYS GLY ILE LYS LEU THR          
SEQRES  20 E  261  ILE SER GLU GLU ARG ASP ARG ARG ARG ALA GLN HIS GLY          
SEQRES  21 E  261  LEU                                                          
SEQRES   1 F  227  MET SER GLU HIS GLU ALA GLN VAL GLU VAL GLU VAL GLN          
SEQRES   2 F  227  GLU ASP PHE GLU VAL VAL GLN GLU PHE VAL PRO VAL GLU          
SEQRES   3 F  227  LEU ALA THR THR ILE PRO VAL GLU ILE GLN GLN ALA GLN          
SEQRES   4 F  227  GLN GLU ILE LYS LEU PHE ASN LYS TRP SER PHE GLU ASP          
SEQRES   5 F  227  VAL GLU VAL LYS ASP ALA SER LEU VAL ASP TYR ILE GLN          
SEQRES   6 F  227  ILE SER LYS PRO ILE TYR VAL ALA HIS THR ALA GLY ARG          
SEQRES   7 F  227  TYR ALA ASN LYS ARG PHE ARG LYS ALA GLN CYS PRO ILE          
SEQRES   8 F  227  VAL GLU ARG LEU THR ASN SER LEU MET MET ASN GLY ARG          
SEQRES   9 F  227  ASN ASN GLY LYS LYS LEU LYS ALA VAL ARG ILE VAL LYS          
SEQRES  10 F  227  HIS THR LEU GLU ILE ILE ASN VAL LEU THR ASP GLN ASN          
SEQRES  11 F  227  PRO LEU GLN VAL VAL VAL ASP ALA ILE ILE ASN SER GLY          
SEQRES  12 F  227  PRO ARG GLU ASP THR THR ARG VAL GLY GLY GLY GLY ALA          
SEQRES  13 F  227  ALA ARG ARG GLN ALA VAL ASP VAL SER PRO LEU ARG ARG          
SEQRES  14 F  227  VAL ASN GLN SER ILE ALA LEU LEU THR ILE GLY ALA ARG          
SEQRES  15 F  227  GLU ALA ALA PHE ARG ASN ILE LYS THR ILE ALA GLU THR          
SEQRES  16 F  227  LEU ALA GLU GLU LEU ILE ASN ALA ALA LYS GLY SER SER          
SEQRES  17 F  227  THR SER TYR ALA ILE LYS LYS LYS ASP GLU LEU GLU ARG          
SEQRES  18 F  227  VAL ALA LYS SER ASN ARG                                      
SEQRES   1 G  236  MET LYS LEU ASN ILE SER TYR PRO ILE ASN GLY THR GLN          
SEQRES   2 G  236  LYS CYS ILE GLU ILE ASP ASP GLU HIS ARG VAL ARG VAL          
SEQRES   3 G  236  PHE TYR ASP LYS ARG ILE GLY GLN GLU VAL ASP GLY GLU          
SEQRES   4 G  236  SER VAL GLY ASP GLU PHE LYS GLY TYR VAL PHE LYS ILE          
SEQRES   5 G  236  ALA GLY GLY ASN ASP LYS GLN GLY PHE PRO MET LYS GLN          
SEQRES   6 G  236  GLY VAL LEU LEU PRO THR ARG VAL LYS LEU LEU LEU ALA          
SEQRES   7 G  236  LYS GLY HIS SER CYS TYR ARG PRO ARG ARG ASN GLY GLU          
SEQRES   8 G  236  ARG LYS ARG LYS SER VAL ARG GLY ALA ILE VAL GLY PRO          
SEQRES   9 G  236  ASP LEU ALA VAL LEU ALA LEU ILE ILE THR LYS LYS GLY          
SEQRES  10 G  236  GLU GLN GLU ILE GLU GLY ILE THR ASN ASP THR VAL PRO          
SEQRES  11 G  236  LYS ARG LEU GLY PRO LYS ARG ALA ASN ASN ILE ARG LYS          
SEQRES  12 G  236  PHE PHE GLY LEU THR LYS GLU ASP ASP VAL ARG ASP TYR          
SEQRES  13 G  236  VAL ILE ARG ARG GLU VAL THR LYS GLY ASP LYS SER TYR          
SEQRES  14 G  236  THR LYS ALA PRO LYS ILE GLN ARG LEU VAL THR PRO GLN          
SEQRES  15 G  236  ARG LEU GLN ARG LYS ARG GLN GLN LYS SER LEU LYS ILE          
SEQRES  16 G  236  LYS ASN ALA GLN ALA GLN ARG GLU ALA ALA ALA GLU TYR          
SEQRES  17 G  236  ALA GLN LEU LEU ALA LYS ARG LEU SER GLU ARG LYS ALA          
SEQRES  18 G  236  GLU LYS ALA GLU VAL ARG LYS ARG ARG ALA SER SER LEU          
SEQRES  19 G  236  LYS ALA                                                      
SEQRES   1 H  190  MET SER ASP PRO GLN ALA LYS ILE LEU SER GLN ALA PRO          
SEQRES   2 H  190  THR GLU LEU GLU LEU GLN VAL ALA GLN ALA PHE ILE ASP          
SEQRES   3 H  190  LEU GLU ASN ASN SER PRO GLU LEU LYS ALA ASP LEU ARG          
SEQRES   4 H  190  ALA LEU GLN PHE LYS SER ILE ARG GLU ILE GLU VAL ALA          
SEQRES   5 H  190  GLY GLY LYS LYS ALA LEU ALA VAL PHE VAL PRO VAL PRO          
SEQRES   6 H  190  SER LEU ALA ALA TYR HIS LYS VAL GLN ILE LYS LEU THR          
SEQRES   7 H  190  ARG GLU LEU GLU LYS LYS PHE GLN ASP ARG HIS VAL ILE          
SEQRES   8 H  190  PHE LEU ALA GLU ARG ARG ILE LEU PRO LYS PRO SER ARG          
SEQRES   9 H  190  LYS SER ARG GLN THR GLN LYS ARG PRO ARG SER ARG THR          
SEQRES  10 H  190  LEU THR ALA VAL HIS ASP LYS ILE LEU GLU ASP LEU VAL          
SEQRES  11 H  190  PHE PRO THR GLU ILE VAL GLY LYS ARG VAL ARG TYR LEU          
SEQRES  12 H  190  VAL GLY GLY ASN LYS ILE GLN LYS ILE LEU LEU ASN SER          
SEQRES  13 H  190  LYS ASP VAL GLN HIS ILE ASP ASN LYS LEU GLU SER PHE          
SEQRES  14 H  190  GLN ALA VAL TYR ASN LYS LEU THR GLY LYS GLN ILE VAL          
SEQRES  15 H  190  PHE GLU ILE PRO SER GLU THR HIS                              
SEQRES   1 I  201  MET GLY ILE SER ARG ASP SER ARG HIS LYS ARG ALA ALA          
SEQRES   2 I  201  THR GLY ALA LYS ARG ALA GLN PHE ARG LYS LYS ARG LYS          
SEQRES   3 I  201  PHE GLU LEU GLY ARG GLN ALA ALA ASN THR LYS ILE GLY          
SEQRES   4 I  201  THR LYS ARG ILE HIS PRO VAL ARG THR ARG GLY GLY ASN          
SEQRES   5 I  201  GLN LYS PHE ARG ALA LEU ARG ILE GLU THR GLY ASN PHE          
SEQRES   6 I  201  SER TRP ALA SER GLU GLY VAL ALA ARG LYS THR ARG ILE          
SEQRES   7 I  201  THR GLY VAL VAL TYR HIS PRO SER ASN ASN GLU LEU VAL          
SEQRES   8 I  201  ARG THR ASN THR LEU THR LYS ALA ALA ILE VAL GLN ILE          
SEQRES   9 I  201  ASP ALA THR PRO PHE ARG GLN TRP TYR GLU SER HIS TYR          
SEQRES  10 I  201  GLY GLN SER LEU GLY LYS LYS LYS ASN THR LYS ALA GLU          
SEQRES  11 I  201  GLU GLU THR ALA THR THR SER LYS ASN THR GLU ARG LYS          
SEQRES  12 I  201  TRP ALA ALA ARG ALA ALA GLU ALA LYS ILE GLU HIS ALA          
SEQRES  13 I  201  VAL ASP SER GLN PHE GLY ALA GLY ARG LEU TYR ALA ALA          
SEQRES  14 I  201  ILE SER SER ARG PRO GLY GLN SER GLY ARG CYS ASP GLY          
SEQRES  15 I  201  TYR ILE LEU GLU GLY GLU GLU LEU ALA PHE TYR LEU ARG          
SEQRES  16 I  201  ARG LEU THR ALA LYS LYS                                      
SEQRES   1 J  188  MET PRO ARG ALA PRO ARG THR TYR SER LYS THR TYR SER          
SEQRES   2 J  188  THR PRO LYS ARG PRO TYR GLU SER ALA ARG LEU ASP ALA          
SEQRES   3 J  188  GLU LEU LYS LEU ALA GLY GLU TYR GLY LEU LYS ASN LYS          
SEQRES   4 J  188  ARG GLU ILE TYR ARG ILE SER PHE GLN LEU SER LYS ILE          
SEQRES   5 J  188  ARG ARG ALA ALA ARG ASP LEU LEU THR ARG ASP GLU LYS          
SEQRES   6 J  188  ASP PRO LYS ARG LEU PHE GLU GLY ASN ALA LEU ILE ARG          
SEQRES   7 J  188  ARG LEU VAL ARG ILE GLY VAL LEU SER GLU ASP LYS LYS          
SEQRES   8 J  188  LYS LEU ASP TYR VAL LEU ALA LEU LYS VAL GLU ASP PHE          
SEQRES   9 J  188  LEU GLU ARG ARG LEU GLN THR GLN VAL TYR LYS LEU GLY          
SEQRES  10 J  188  LEU ALA LYS SER VAL HIS HIS ALA ARG VAL LEU ILE SER          
SEQRES  11 J  188  GLN ARG HIS ILE ALA VAL GLY LYS GLN ILE VAL ASN ILE          
SEQRES  12 J  188  PRO SER PHE MET VAL ARG LEU GLU SER GLU LYS HIS ILE          
SEQRES  13 J  188  ASP PHE ALA ARG THR SER PRO PHE GLY GLY ALA ARG PRO          
SEQRES  14 J  188  GLY ARG VAL ALA ARG LYS ARG ALA ALA ALA ALA GLY GLY          
SEQRES  15 J  188  GLU GLU ALA ASP GLU GLU                                      
SEQRES   1 K  106  MET LEU ILE PRO LYS GLU ASP ARG LYS LYS ILE TYR GLN          
SEQRES   2 K  106  HIS LEU PHE GLN GLU GLY VAL LEU VAL ALA LYS LYS ASP          
SEQRES   3 K  106  PHE ASN GLN PRO LYS HIS GLU GLU ILE ASP THR LYS ASN          
SEQRES   4 K  106  LEU PHE VAL ILE LYS ALA LEU GLN SER LEU THR SER LYS          
SEQRES   5 K  106  GLY PHE VAL LYS THR GLN PHE SER TRP GLN TYR TYR TYR          
SEQRES   6 K  106  TYR THR LEU THR GLU GLU GLY VAL VAL TYR LEU ARG GLU          
SEQRES   7 K  106  TYR LEU ASN LEU PRO GLU HIS ILE PHE PRO ALA THR TYR          
SEQRES   8 K  106  LEU ALA GLY GLN SER GLY ASP GLN ARG PRO GLN GLY LYS          
SEQRES   9 K  106  LYS TYR                                                      
SEQRES   1 L  156  MET SER THR GLU LEU THR VAL GLN SER GLU ARG ALA PHE          
SEQRES   2 L  156  GLN LYS GLN PRO HIS ILE PHE THR ASN PRO LYS ALA LYS          
SEQRES   3 L  156  ALA ASN ARG LYS THR LYS ARG TRP TYR LYS ASN VAL GLY          
SEQRES   4 L  156  LEU GLY PHE LYS THR PRO LYS THR ALA ILE GLU GLY SER          
SEQRES   5 L  156  TYR ILE ASP LYS LYS CYS PRO PHE THR GLY LEU VAL SER          
SEQRES   6 L  156  ILE ARG GLY LYS ILE LEU THR GLY THR VAL VAL SER THR          
SEQRES   7 L  156  ARG MET HIS ARG THR ILE VAL ILE ARG ARG ASP TYR LEU          
SEQRES   8 L  156  HIS TYR VAL PRO LYS TYR ASN ARG TYR GLU LYS ARG HIS          
SEQRES   9 L  156  LYS ASN VAL PRO ALA HIS VAL SER PRO ALA PHE ARG VAL          
SEQRES  10 L  156  GLN VAL GLY ASP ILE VAL THR VAL GLY GLN CYS ARG PRO          
SEQRES  11 L  156  ILE SER LYS THR VAL ARG PHE ASN VAL LEU LYS VAL ALA          
SEQRES  12 L  156  SER ALA THR GLY LYS ALA ASN LYS GLN PHE ALA LYS PHE          
SEQRES   1 M  134  MET SER ASP VAL GLU GLU VAL GLN GLN VAL PRO VAL ALA          
SEQRES   2 M  134  GLU LEU THR ILE GLU ASP ALA LEU LYS VAL VAL LEU ARG          
SEQRES   3 M  134  THR SER LEU VAL HIS ASP GLY LEU ALA ARG GLY LEU ARG          
SEQRES   4 M  134  GLU SER ALA LYS ALA LEU THR ARG GLY GLU GLY GLN LEU          
SEQRES   5 M  134  ALA VAL LEU VAL GLU SER VAL THR GLU GLU ALA ILE SER          
SEQRES   6 M  134  LYS LEU VAL GLN GLY LEU ALA THR GLU ASN ASN VAL PRO          
SEQRES   7 M  134  LEU ILE LYS VAL ALA ASP ALA LYS GLN LEU GLY GLU TRP          
SEQRES   8 M  134  ALA GLY LEU GLY LYS ILE ASP ARG ASP GLY ASN ALA ARG          
SEQRES   9 M  134  LYS VAL VAL GLY ALA SER VAL VAL VAL VAL LYS ASN TRP          
SEQRES  10 M  134  GLY ALA ASP THR GLN GLU ARG GLU ILE LEU LEU GLU HIS          
SEQRES  11 M  134  PHE SER GLN GLN                                              
SEQRES   1 N  151  MET GLY ARG MET HIS SER LYS GLY LYS GLY MET SER SER          
SEQRES   2 N  151  SER ALA ILE PRO TYR SER ARG ASN ALA PRO ALA TRP PHE          
SEQRES   3 N  151  LYS GLY SER SER ASP GLY VAL VAL GLU GLN ILE ILE LYS          
SEQRES   4 N  151  TYR ALA ARG LYS GLY LEU THR PRO SER GLN ILE GLY VAL          
SEQRES   5 N  151  LEU LEU ARG ASP ALA HIS GLY VAL THR GLN ALA LYS VAL          
SEQRES   6 N  151  ILE THR GLY ASN LYS ILE LEU ARG ILE LEU LYS SER ASN          
SEQRES   7 N  151  GLY LEU ALA PRO GLU ILE PRO GLU ASP LEU TYR PHE LEU          
SEQRES   8 N  151  ILE LYS LYS ALA VAL SER VAL ARG LYS HIS LEU GLU ARG          
SEQRES   9 N  151  ASN ARG LYS ASP LYS ASP ALA LYS PHE ARG LEU ILE LEU          
SEQRES  10 N  151  ILE GLU SER ARG ILE HIS ARG LEU ALA ARG TYR TYR ARG          
SEQRES  11 N  151  THR VAL SER VAL LEU PRO PRO ASN TRP LYS TYR GLU SER          
SEQRES  12 N  151  ALA THR ALA SER ALA LEU VAL ASN                              
SEQRES   1 O  137  MET ALA ASN VAL VAL GLN ALA LYS ASP ASN SER GLN VAL          
SEQRES   2 O  137  PHE GLY VAL ALA ARG ILE PHE ALA SER PHE ASN ASP THR          
SEQRES   3 O  137  PHE VAL HIS VAL THR ASP LEU SER GLY ARG GLU THR ILE          
SEQRES   4 O  137  ALA ARG VAL THR GLY GLY MET LYS VAL LYS ALA ASP ARG          
SEQRES   5 O  137  ASP GLU SER SER PRO TYR ALA ALA MET LEU ALA ALA GLN          
SEQRES   6 O  137  ASP VAL ALA ALA LYS CYS LYS GLU VAL GLY ILE THR ALA          
SEQRES   7 O  137  VAL HIS ILE LYS ILE ARG ALA THR GLY GLY THR ARG SER          
SEQRES   8 O  137  LYS THR PRO GLY PRO GLY GLY GLN ALA ALA LEU ARG ALA          
SEQRES   9 O  137  LEU ALA ARG SER GLY LEU ARG ILE GLY ARG ILE GLU ASP          
SEQRES  10 O  137  VAL THR PRO VAL PRO SER ASP SER THR ARG LYS LYS GLY          
SEQRES  11 O  137  GLY ARG ARG GLY ARG ARG LEU                                  
SEQRES   1 P  142  MET SER GLU ALA ALA ALA PRO ARG LYS ARG SER PHE LYS          
SEQRES   2 P  142  THR TYR SER TYR LYS GLY VAL ASP LEU GLU LYS LEU LEU          
SEQRES   3 P  142  GLU MET PRO THR GLU ASP PHE VAL LYS LEU ALA PRO ALA          
SEQRES   4 P  142  ARG VAL ARG ARG LYS PHE ALA ARG GLY LEU SER GLU LYS          
SEQRES   5 P  142  PRO ALA GLY LEU MET LYS LYS LEU ARG ALA ALA LYS LEU          
SEQRES   6 P  142  SER ALA PRO GLU ASN GLU LYS PRO ALA VAL VAL ARG THR          
SEQRES   7 P  142  HIS LEU ARG ASN MET ILE ILE VAL PRO GLU MET ILE GLY          
SEQRES   8 P  142  SER VAL VAL GLY VAL TYR ASN GLY LYS VAL PHE ASN GLN          
SEQRES   9 P  142  VAL GLU ILE ARG PRO GLU MET VAL GLY HIS TYR LEU GLY          
SEQRES  10 P  142  GLU PHE SER ILE THR TYR THR PRO VAL ARG HIS GLY ARG          
SEQRES  11 P  142  ALA GLY ALA THR THR SER ARG PHE ILE PRO LEU ARG              
SEQRES   1 Q  143  MET SER THR VAL PRO SER VAL GLN THR PHE GLY LYS LYS          
SEQRES   2 Q  143  LYS SER ALA THR ALA VAL ALA HIS VAL LYS ALA GLY LYS          
SEQRES   3 Q  143  GLY LEU ILE LYS VAL ASN GLY SER PRO ILE THR LEU VAL          
SEQRES   4 Q  143  GLN PRO GLU ILE LEU ARG PHE LYS VAL TYR GLU PRO LEU          
SEQRES   5 Q  143  LEU LEU VAL GLY LEU ASP LYS PHE ALA ASN ILE ASP ILE          
SEQRES   6 Q  143  ARG VAL LYS VAL THR GLY GLY GLY HIS VAL SER GLN VAL          
SEQRES   7 Q  143  TYR ALA ILE ARG GLN ALA ILE ALA LYS GLY LEU VAL ALA          
SEQRES   8 Q  143  TYR HIS GLN LYS PHE VAL ASP GLU GLN SER LYS ASN GLU          
SEQRES   9 Q  143  LEU LYS LYS ALA PHE THR SER TYR ASP ARG THR LEU LEU          
SEQRES  10 Q  143  ILE ALA ASP SER ARG ARG PRO GLU PRO LYS LYS PHE GLY          
SEQRES  11 Q  143  GLY ARG GLY ALA ARG SER ARG PHE GLN LYS SER TYR ARG          
SEQRES   1 R  136  MET GLY ARG VAL ARG THR LYS THR VAL LYS ARG ALA SER          
SEQRES   2 R  136  LYS ALA LEU ILE GLU LYS TYR TYR PRO LYS LEU THR MET          
SEQRES   3 R  136  ASP PHE GLN THR ASN LYS ARG LEU CYS ASP GLU ILE ALA          
SEQRES   4 R  136  THR ILE GLN SER LYS ARG LEU ARG ASN LYS ILE ALA GLY          
SEQRES   5 R  136  TYR THR THR HIS LEU MET LYS ARG ILE GLN LYS GLY PRO          
SEQRES   6 R  136  VAL ARG GLY ILE SER PHE LYS LEU GLN GLU GLU GLU ARG          
SEQRES   7 R  136  GLU ARG LYS ASP GLN TYR VAL PRO ASP VAL SER ALA LEU          
SEQRES   8 R  136  ASP LEU SER HIS SER ASN ASP VAL LEU ASN VAL ASP THR          
SEQRES   9 R  136  GLN THR ALA GLU LEU VAL ASN SER LEU GLY LEU LYS LEU          
SEQRES  10 R  136  PRO LEU SER VAL SER SER VAL SER ALA VAL ARG ASP ARG          
SEQRES  11 R  136  ARG PHE ARG LYS ARG ASN                                      
SEQRES   1 S  146  MET SER LEU VAL VAL GLN GLU GLN GLY SER PHE GLN HIS          
SEQRES   2 S  146  ILE LEU ARG LEU LEU ASN THR ASN VAL ASP GLY ASN ILE          
SEQRES   3 S  146  ASN VAL VAL TYR ALA LEU THR THR ILE ARG GLY VAL GLY          
SEQRES   4 S  146  ARG ARG TYR ALA ASN LEU VAL CYS LYS LYS ALA ASP VAL          
SEQRES   5 S  146  ASP LEU HIS LYS ARG ALA GLY GLU LEU THR GLN GLU GLU          
SEQRES   6 S  146  LEU GLU ARG ILE VAL GLN ILE MET GLN ASN PRO THR HIS          
SEQRES   7 S  146  TYR LYS ILE PRO ALA TRP PHE LEU ASN ARG GLN LYS ASP          
SEQRES   8 S  146  VAL ASN ASP GLY LYS ASP TYR HIS SER LEU ALA ASN ASN          
SEQRES   9 S  146  LEU GLU SER LYS LEU ARG ASP ASP LEU GLU ARG LEU LYS          
SEQRES  10 S  146  LYS ILE ARG SER HIS ARG GLY ILE ARG HIS PHE TRP GLY          
SEQRES  11 S  146  LEU ARG VAL ARG GLY GLN HIS THR LYS THR THR GLY ARG          
SEQRES  12 S  146  ARG ARG ALA                                                  
SEQRES   1 T  144  MET PRO GLY VAL SER VAL ARG ASP VAL PRO ALA GLN ASP          
SEQRES   2 T  144  PHE ILE ASN ASN TYR ALA SER PHE LEU GLN ARG GLN GLY          
SEQRES   3 T  144  LYS LEU GLU VAL PRO GLY TYR VAL ASP ILE VAL LYS THR          
SEQRES   4 T  144  SER ALA GLY ASN GLU LEU PRO PRO GLN ASP SER GLU GLY          
SEQRES   5 T  144  TRP PHE TYR LYS ARG ALA ALA SER VAL ALA ARG HIS ILE          
SEQRES   6 T  144  TYR LEU ARG LYS GLN VAL GLY VAL GLY LYS LEU ASN LYS          
SEQRES   7 T  144  LEU TYR GLY GLY ALA LYS ASN ARG GLY VAL ARG PRO HIS          
SEQRES   8 T  144  LYS HIS VAL ASP ALA SER GLY SER ILE ASN ARG LYS VAL          
SEQRES   9 T  144  LEU GLN SER LEU GLU LYS LEU GLY VAL VAL GLU ILE SER          
SEQRES  10 T  144  PRO LYS GLY GLY ARG ARG ILE SER ASP ASN GLY LEU ARG          
SEQRES  11 T  144  ASP LEU ASP ARG ILE ALA ALA ALA THR LEU GLU ASP GLU          
SEQRES  12 T  144  GLU                                                          
SEQRES   1 U  117  MET SER GLN VAL GLU LYS LYS SER GLU GLN GLN GLN GLU          
SEQRES   2 U  117  VAL VAL ILE HIS LYS ILE ARG ILE ASN LEU THR SER THR          
SEQRES   3 U  117  LYS VAL LYS GLN LEU GLU ASN VAL SER ALA ASN ILE ILE          
SEQRES   4 U  117  LYS ASN ALA GLU THR PHE LYS LEU VAL LYS LYS GLY PRO          
SEQRES   5 U  117  VAL ARG LEU PRO THR LYS VAL LEU LYS ILE SER THR ARG          
SEQRES   6 U  117  LYS THR PRO ASN GLY GLU GLY SER LYS THR TRP ASP THR          
SEQRES   7 U  117  TYR GLU MET ARG ILE HIS LYS ARG TYR ILE ASP LEU GLU          
SEQRES   8 U  117  ALA PRO ALA HIS ILE VAL LYS ARG ILE THR GLN ILE THR          
SEQRES   9 U  117  ILE GLU PRO GLY VAL ASP VAL GLU VAL ILE ILE ALA ALA          
SEQRES   1 V   87  MET GLU ASN ASP LYS GLY GLN LEU VAL GLU LEU TYR VAL          
SEQRES   2 V   87  PRO ARG LYS CYS SER ALA THR ASN ARG ILE ILE LYS ALA          
SEQRES   3 V   87  LYS ASP HIS SER SER VAL GLN ILE ASN ILE ALA GLN VAL          
SEQRES   4 V   87  ASP GLU GLU GLY ARG ALA ILE PRO GLY GLU TYR VAL THR          
SEQRES   5 V   87  TYR ALA LEU SER GLY TYR ILE ARG ALA ARG GLY GLU ALA          
SEQRES   6 V   87  ASP ASP SER LEU ASN ARG LEU ALA GLN GLN ASP GLY LEU          
SEQRES   7 V   87  LEU LYS ASN VAL TRP SER TYR SER ARG                          
SEQRES   1 W  130  MET THR ARG THR SER VAL LEU ALA ASP ALA LEU ASN ALA          
SEQRES   2 W  130  ILE ASN ASN ALA GLU LYS THR GLY LYS ARG GLN VAL LEU          
SEQRES   3 W  130  ILE ARG PRO SER SER LYS VAL ILE ILE LYS PHE LEU GLN          
SEQRES   4 W  130  VAL MET GLN LYS HIS GLY TYR ILE GLY GLU PHE GLU TYR          
SEQRES   5 W  130  ILE ASP ASP HIS ARG SER GLY LYS ILE VAL VAL GLN LEU          
SEQRES   6 W  130  ASN GLY ARG LEU ASN LYS CYS GLY VAL ILE SER PRO ARG          
SEQRES   7 W  130  PHE ASN VAL LYS ILE ALA ASP VAL GLU LYS TRP THR ALA          
SEQRES   8 W  130  ASN LEU LEU PRO ALA ARG GLN PHE GLY TYR VAL ILE LEU          
SEQRES   9 W  130  THR THR SER ALA GLY ILE MET ASP HIS GLU GLU ALA HIS          
SEQRES  10 W  130  ARG LYS HIS VAL SER GLY LYS ILE LEU GLY PHE VAL TYR          
SEQRES   1 X  145  MET GLY LYS GLY LYS PRO ARG GLY LEU ASN SER ALA ARG          
SEQRES   2 X  145  LYS LEU ARG VAL HIS ARG ARG ASN ASN ARG TRP ALA GLU          
SEQRES   3 X  145  THR THR TYR LYS LYS ARG LEU LEU GLY THR ALA PHE LYS          
SEQRES   4 X  145  SER SER PRO PHE GLY GLY SER SER HIS ALA LYS GLY ILE          
SEQRES   5 X  145  VAL LEU GLU LYS ILE GLY ILE GLU SER LYS GLN PRO ASN          
SEQRES   6 X  145  SER ALA ILE ARG LYS CYS VAL ARG VAL GLN LEU ILE LYS          
SEQRES   7 X  145  ASN GLY LYS LYS VAL THR ALA PHE VAL PRO ASN ASP GLY          
SEQRES   8 X  145  CYS LEU ASN PHE VAL ASP GLU ASN ASP GLU VAL LEU LEU          
SEQRES   9 X  145  ALA GLY PHE GLY ARG LYS GLY LYS ALA LYS GLY ASP ILE          
SEQRES  10 X  145  PRO GLY VAL ARG PHE LYS VAL VAL LYS VAL SER GLY VAL          
SEQRES  11 X  145  SER LEU LEU ALA LEU TRP LYS GLU LYS LYS GLU LYS PRO          
SEQRES  12 X  145  ARG SER                                                      
SEQRES   1 Y  135  MET SER ASP ALA ILE THR ILE ARG THR ARG LYS VAL ILE          
SEQRES   2 Y  135  SER ASN PRO LEU LEU ALA ARG LYS GLN PHE VAL VAL ASP          
SEQRES   3 Y  135  VAL LEU HIS PRO ASN ARG ALA ASN VAL SER LYS ASP GLU          
SEQRES   4 Y  135  LEU ARG GLU LYS LEU ALA GLU ALA TYR LYS ALA GLU LYS          
SEQRES   5 Y  135  ASP ALA VAL SER VAL PHE GLY PHE ARG THR GLN TYR GLY          
SEQRES   6 Y  135  GLY GLY LYS SER THR GLY PHE GLY LEU VAL TYR ASN SER          
SEQRES   7 Y  135  VAL ALA ASP ALA LYS LYS PHE GLU PRO ALA TYR ARG LEU          
SEQRES   8 Y  135  VAL ARG TYR GLY LEU ALA GLU LYS VAL GLU LYS ALA SER          
SEQRES   9 Y  135  ARG GLN GLN ARG LYS GLN ARG LYS ASN ARG GLY LYS LYS          
SEQRES  10 Y  135  ILE PHE GLY THR GLY LYS SER ILE ALA LYS LYS ALA ALA          
SEQRES  11 Y  135  ARG ARG ASN ALA ASP                                          
SEQRES   1 Z  108  MET PRO PRO LYS GLN GLN LEU SER LYS ALA ALA LYS ALA          
SEQRES   2 Z  108  ALA ALA ALA MET ALA GLY GLY LYS LYS SER LYS LYS LYS          
SEQRES   3 Z  108  TRP SER LYS LYS SER HIS LYS ASP LYS ALA LYS HIS ALA          
SEQRES   4 Z  108  VAL VAL LEU ASP GLN ASP LYS PHE ASP ARG ILE MET LYS          
SEQRES   5 Z  108  GLU ALA PRO THR TYR ARG TYR VAL SER VAL SER VAL LEU          
SEQRES   6 Z  108  VAL ASP ARG PHE LYS LEU GLY GLY SER LEU ALA ARG VAL          
SEQRES   7 Z  108  ALA LEU ARG HIS LEU GLU ASN GLU GLY ILE ILE LYS PRO          
SEQRES   8 Z  108  VAL SER LYS HIS SER LYS GLN ALA ILE TYR THR ARG ALA          
SEQRES   9 Z  108  THR ALA SER GLU                                              
SEQRES   1 a  119  MET PRO LYS LYS ARG ALA SER ASN GLY ARG ASN LYS LYS          
SEQRES   2 a  119  GLY ARG GLY HIS VAL LYS PRO VAL ARG CYS VAL ASN CYS          
SEQRES   3 a  119  SER ARG SER VAL PRO LYS ASP LYS ALA ILE LYS ARG MET          
SEQRES   4 a  119  ALA ILE ARG ASN ILE VAL GLU ALA ALA ALA ILE ARG ASP          
SEQRES   5 a  119  LEU SER GLU ALA SER VAL TYR ALA GLU TYR ALA LEU PRO          
SEQRES   6 a  119  LYS THR TYR ASN LYS LEU HIS TYR CYS ILE SER CYS ALA          
SEQRES   7 a  119  ILE HIS ALA ARG ILE VAL ARG VAL ARG SER ARG THR ASP          
SEQRES   8 a  119  ARG ARG ILE ARG ALA PRO PRO GLN ARG PRO ARG PHE ASN          
SEQRES   9 a  119  ARG ASP ASN LYS VAL SER PRO ALA ASP ALA ALA LYS LYS          
SEQRES  10 a  119  ALA LEU                                                      
SEQRES   1 b   82  MET VAL LEU VAL GLN ASP LEU LEU HIS PRO THR ALA ALA          
SEQRES   2 b   82  SER GLU ALA ARG LYS HIS LYS LEU LYS THR LEU VAL GLN          
SEQRES   3 b   82  SER PRO ARG SER HIS PHE LEU ASP VAL LYS CYS PRO GLY          
SEQRES   4 b   82  CYS LEU ASN ILE THR THR VAL PHE SER HIS ALA GLN THR          
SEQRES   5 b   82  ALA VAL THR CYS GLU SER CYS SER THR VAL LEU CYS THR          
SEQRES   6 b   82  PRO THR GLY GLY LYS ALA LYS LEU SER GLU GLY THR SER          
SEQRES   7 b   82  PHE ARG ARG LYS                                              
SEQRES   1 c   67  MET ASP THR LYS THR PRO VAL THR LEU ALA LYS VAL ILE          
SEQRES   2 c   67  LYS VAL LEU GLY ARG THR GLY SER ARG GLY GLY VAL THR          
SEQRES   3 c   67  GLN VAL ARG VAL GLU PHE LEU GLU ASP THR THR ARG THR          
SEQRES   4 c   67  ILE VAL ARG ASN VAL LYS GLY PRO VAL ARG GLU GLY ASP          
SEQRES   5 c   67  ILE LEU VAL LEU MET GLU SER GLU ARG GLU ALA ARG ARG          
SEQRES   6 c   67  LEU ARG                                                      
SEQRES   1 d   56  MET ALA HIS GLU ASN VAL TRP TYR SER HIS PRO ARG LYS          
SEQRES   2 d   56  PHE GLY LYS GLY SER ARG GLN CYS ARG ILE SER GLY SER          
SEQRES   3 d   56  HIS SER GLY LEU ILE ARG LYS TYR GLY LEU ASN ILE ASP          
SEQRES   4 d   56  ARG GLN SER PHE ARG GLU LYS ALA ASN ASP ILE GLY PHE          
SEQRES   5 d   56  TYR LYS TYR ARG                                              
SEQRES   1 e   63  MET GLY LYS VAL HIS GLY SER LEU ALA ARG ALA GLY LYS          
SEQRES   2 e   63  VAL LYS SER GLN THR PRO LYS VAL GLU LYS GLN GLU LYS          
SEQRES   3 e   63  PRO LYS GLN PRO LYS GLY ARG ALA TYR LYS ARG LEU LEU          
SEQRES   4 e   63  TYR THR ARG ARG PHE VAL ASN VAL THR LEU THR ASN GLY          
SEQRES   5 e   63  LYS ARG LYS MET ASN PRO SER PRO SER SER GLN                  
SEQRES   1 f  150  MET GLN ILE PHE VAL LYS THR LEU THR GLY LYS THR ILE          
SEQRES   2 f  150  THR LEU GLU VAL GLU SER SER ASP THR ILE ASP ASN VAL          
SEQRES   3 f  150  LYS SER LYS ILE GLN ASP LYS GLU GLY ILE PRO PRO ASP          
SEQRES   4 f  150  GLN GLN ARG LEU ILE PHE ALA GLY LYS GLN LEU GLU ASP          
SEQRES   5 f  150  GLY ARG THR LEU SER ASP TYR ASN ILE GLN LYS GLU SER          
SEQRES   6 f  150  THR LEU HIS LEU VAL LEU ARG LEU ARG GLY GLY GLY LYS          
SEQRES   7 f  150  LYS ARG LYS LYS LYS VAL TYR THR THR PRO LYS LYS ILE          
SEQRES   8 f  150  ARG HIS LYS HIS LYS LYS VAL LYS LEU ALA VAL LEU ASN          
SEQRES   9 f  150  TYR TYR LYS VAL ASP ASP GLU GLY LYS VAL ALA LYS LEU          
SEQRES  10 f  150  ARG LYS GLU CYS PRO ASN CYS GLY PRO GLY ILE PHE LEU          
SEQRES  11 f  150  ALA ASN HIS GLY ASP ARG PHE TYR CYS GLY LYS CYS HIS          
SEQRES  12 f  150  SER THR PHE ALA THR GLN LYS                                  
SEQRES   1 g  326  MET SER SER SER ASN ILE MET LEU VAL LEU ARG GLY THR          
SEQRES   2 g  326  LEU GLU GLY HIS ASN GLY TRP VAL THR SER LEU SER THR          
SEQRES   3 g  326  SER ALA ALA GLN PRO ASN LEU LEU VAL SER GLY SER ARG          
SEQRES   4 g  326  ASP LYS THR LEU ILE SER TRP ARG LEU THR GLU ASN GLU          
SEQRES   5 g  326  GLN GLN PHE GLY VAL PRO VAL ARG SER TYR LYS GLY HIS          
SEQRES   6 g  326  SER HIS ILE VAL GLN ASP VAL VAL VAL SER ALA ASP GLY          
SEQRES   7 g  326  ASN TYR ALA VAL SER ALA SER TRP ASP LYS THR LEU ARG          
SEQRES   8 g  326  LEU TRP ASN LEU ALA THR GLY ASN SER GLU ALA ARG PHE          
SEQRES   9 g  326  VAL GLY HIS THR GLY ASP VAL LEU SER VAL ALA ILE ASP          
SEQRES  10 g  326  ALA ASN SER SER LYS ILE ILE SER ALA SER ARG ASP LYS          
SEQRES  11 g  326  THR ILE ARG VAL TRP ASN THR VAL GLY ASP CYS ALA TYR          
SEQRES  12 g  326  VAL LEU LEU GLY HIS THR ASP TRP VAL THR LYS VAL ARG          
SEQRES  13 g  326  VAL ALA PRO LYS ASN LEU GLU ASP GLY GLU VAL ASP ASP          
SEQRES  14 g  326  GLY ARG ILE THR PHE VAL SER ALA GLY MET ASP LYS ILE          
SEQRES  15 g  326  VAL ARG SER TRP SER LEU ASN GLU ASP SER TYR ARG ILE          
SEQRES  16 g  326  GLU ALA ASP PHE ILE GLY HIS ASN ASN TYR ILE ASN VAL          
SEQRES  17 g  326  VAL GLN PRO SER PRO ASP GLY SER LEU ALA ALA SER ALA          
SEQRES  18 g  326  GLY LYS ASP GLY GLN ILE TYR VAL TRP ASN LEU LYS HIS          
SEQRES  19 g  326  LYS SER ALA PHE MET ASN PHE ASP ALA LYS ASP GLU VAL          
SEQRES  20 g  326  PHE ALA LEU ALA PHE SER PRO SER ARG PHE TRP LEU THR          
SEQRES  21 g  326  ALA ALA THR ALA SER GLY ILE LYS ILE TYR ASP LEU GLU          
SEQRES  22 g  326  ASN GLU VAL LEU ILE ASP GLU LEU LYS PRO GLU PHE ALA          
SEQRES  23 g  326  GLY TYR THR LYS ALA GLN ASP PRO HIS ALA VAL SER LEU          
SEQRES  24 g  326  ALA TRP SER ALA ASP GLY GLN THR LEU PHE ALA GLY TYR          
SEQRES  25 g  326  THR ASP ASN VAL ILE ARG VAL TRP GLN VAL MET THR ALA          
SEQRES  26 g  326  ASN                                                          
SEQRES   1 h   25  MET ARG ALA LYS TRP ARG LYS LYS ARG THR ARG ARG LEU          
SEQRES   2 h   25  LYS ARG LYS ARG ARG LYS VAL ARG ALA ARG SER LYS              
SEQRES   1 i  153  MET GLY LYS LYS ASN THR LYS GLY GLY LYS LYS GLY ARG          
SEQRES   2 i  153  ARG GLY LYS ASN ASP SER ASP GLY PRO LYS ARG GLU LEU          
SEQRES   3 i  153  ILE TYR LYS GLU GLU GLY GLN GLU TYR ALA GLN ILE THR          
SEQRES   4 i  153  LYS MET LEU GLY ASN GLY ARG VAL GLU ALA SER CYS PHE          
SEQRES   5 i  153  ASP GLY ASN LYS ARG MET ALA HIS ILE ARG GLY LYS LEU          
SEQRES   6 i  153  ARG LYS LYS VAL TRP MET GLY GLN GLY ASP ILE ILE LEU          
SEQRES   7 i  153  VAL SER LEU ARG ASP PHE GLN ASP ASP GLN CYS ASP VAL          
SEQRES   8 i  153  VAL HIS LYS TYR ASN LEU ASP GLU ALA ARG THR LEU LYS          
SEQRES   9 i  153  ASN GLN GLY GLU LEU PRO GLU ASN ALA LYS ILE ASN GLU          
SEQRES  10 i  153  THR ASP ASN PHE GLY PHE GLU SER ASP GLU ASP VAL ASN          
SEQRES  11 i  153  PHE GLU PHE GLY ASN ALA ASP GLU ASP ASP GLU GLU GLY          
SEQRES  12 i  153  GLU ASP GLU GLU LEU ASP ILE ASP ASP ILE                      
SEQRES   1 j  304  MET SER THR SER HIS CYS ARG PHE TYR GLU ASN LYS TYR          
SEQRES   2 j  304  PRO GLU ILE ASP ASP ILE VAL MET VAL ASN VAL GLN GLN          
SEQRES   3 j  304  ILE ALA GLU MET GLY ALA TYR VAL LYS LEU LEU GLU TYR          
SEQRES   4 j  304  ASP ASN ILE GLU GLY MET ILE LEU LEU SER GLU LEU SER          
SEQRES   5 j  304  ARG ARG ARG ILE ARG SER ILE GLN LYS LEU ILE ARG VAL          
SEQRES   6 j  304  GLY LYS ASN ASP VAL ALA VAL VAL LEU ARG VAL ASP LYS          
SEQRES   7 j  304  GLU LYS GLY TYR ILE ASP LEU SER LYS ARG ARG VAL SER          
SEQRES   8 j  304  SER GLU ASP ILE ILE LYS CYS GLU GLU LYS TYR GLN LYS          
SEQRES   9 j  304  SER LYS THR VAL HIS SER ILE LEU ARG TYR CYS ALA GLU          
SEQRES  10 j  304  LYS PHE GLN ILE PRO LEU GLU GLU LEU TYR LYS THR ILE          
SEQRES  11 j  304  ALA TRP PRO LEU SER ARG LYS PHE GLY HIS ALA TYR GLU          
SEQRES  12 j  304  ALA PHE LYS LEU SER ILE ILE ASP GLU THR VAL TRP GLU          
SEQRES  13 j  304  GLY ILE GLU PRO PRO SER LYS ASP VAL LEU ASP GLU LEU          
SEQRES  14 j  304  LYS ASN TYR ILE SER LYS ARG LEU THR PRO GLN ALA VAL          
SEQRES  15 j  304  LYS ILE ARG ALA ASP VAL GLU VAL SER CYS PHE SER TYR          
SEQRES  16 j  304  GLU GLY ILE ASP ALA ILE LYS ASP ALA LEU LYS SER ALA          
SEQRES  17 j  304  GLU ASP MET SER THR GLU GLN MET GLN VAL LYS VAL LYS          
SEQRES  18 j  304  LEU VAL ALA ALA PRO LEU TYR VAL LEU THR THR GLN ALA          
SEQRES  19 j  304  LEU ASP LYS GLN LYS GLY ILE GLU GLN LEU GLU SER ALA          
SEQRES  20 j  304  ILE GLU LYS ILE THR GLU VAL ILE THR LYS TYR GLY GLY          
SEQRES  21 j  304  VAL CYS ASN ILE THR MET PRO PRO LYS ALA VAL THR ALA          
SEQRES  22 j  304  THR GLU ASP ALA GLU LEU GLN ALA LEU LEU GLU SER LYS          
SEQRES  23 j  304  GLU LEU ASP ASN ARG SER ASP SER GLU ASP ASP GLU ASP          
SEQRES  24 j  304  GLU SER ASP ASP GLU                                          
SEQRES   1 k  527  MET SER ASP LEU GLN ASP GLN GLU PRO SER ILE ILE ILE          
SEQRES   2 k  527  ASN GLY ASN LEU GLU PRO VAL GLY GLU PRO ASP ILE VAL          
SEQRES   3 k  527  GLU GLU THR GLU VAL VAL ALA GLN GLU THR GLN GLU THR          
SEQRES   4 k  527  GLN ASP ALA ASP LYS PRO LYS LYS LYS VAL ALA PHE THR          
SEQRES   5 k  527  GLY LEU GLU GLU ASP GLY GLU THR GLU GLU GLU LYS ARG          
SEQRES   6 k  527  LYS ARG GLU PHE GLU GLU GLY GLY GLY LEU PRO GLU GLN          
SEQRES   7 k  527  PRO LEU ASN PRO ASP PHE SER LYS LEU ASN PRO LEU SER          
SEQRES   8 k  527  ALA GLU ILE ILE ASN ARG GLN ALA THR ILE ASN ILE GLY          
SEQRES   9 k  527  THR ILE GLY HIS VAL ALA HIS GLY LYS SER THR VAL VAL          
SEQRES  10 k  527  ARG ALA ILE SER GLY VAL GLN THR VAL ARG PHE LYS ASP          
SEQRES  11 k  527  GLU LEU GLU ARG ASN ILE THR ILE LYS LEU GLY TYR ALA          
SEQRES  12 k  527  ASN ALA LYS ILE TYR LYS CYS GLN GLU PRO THR CYS PRO          
SEQRES  13 k  527  GLU PRO ASP CYS TYR ARG SER PHE LYS SER ASP LYS GLU          
SEQRES  14 k  527  ILE SER PRO LYS CYS GLN ARG PRO GLY CYS PRO GLY ARG          
SEQRES  15 k  527  TYR LYS LEU VAL ARG HIS VAL SER PHE VAL ASP CYS PRO          
SEQRES  16 k  527  GLY HIS ASP ILE LEU MET SER THR MET LEU SER GLY ALA          
SEQRES  17 k  527  ALA VAL MET ASP ALA ALA LEU LEU LEU ILE ALA GLY ASN          
SEQRES  18 k  527  GLU SER CYS PRO GLN PRO GLN THR SER GLU HIS LEU ALA          
SEQRES  19 k  527  ALA ILE GLU ILE MET LYS LEU LYS HIS VAL ILE ILE LEU          
SEQRES  20 k  527  GLN ASN LYS VAL ASP LEU MET ARG GLU GLU SER ALA LEU          
SEQRES  21 k  527  GLU HIS GLN LYS SER ILE LEU LYS PHE ILE ARG GLY THR          
SEQRES  22 k  527  ILE ALA ASP GLY ALA PRO ILE VAL PRO ILE SER ALA GLN          
SEQRES  23 k  527  LEU LYS TYR ASN ILE ASP ALA VAL ASN GLU PHE ILE VAL          
SEQRES  24 k  527  LYS THR ILE PRO VAL PRO PRO ARG ASP PHE MET ILE SER          
SEQRES  25 k  527  PRO ARG LEU ILE VAL ILE ARG SER PHE ASP VAL ASN LYS          
SEQRES  26 k  527  PRO GLY ALA GLU ILE GLU ASP LEU LYS GLY GLY VAL ALA          
SEQRES  27 k  527  GLY GLY SER ILE LEU ASN GLY VAL PHE LYS LEU GLY ASP          
SEQRES  28 k  527  GLU ILE GLU ILE ARG PRO GLY ILE VAL THR LYS ASP ASP          
SEQRES  29 k  527  LYS GLY LYS ILE GLN CYS LYS PRO ILE PHE SER ASN ILE          
SEQRES  30 k  527  VAL SER LEU PHE ALA GLU GLN ASN ASP LEU LYS PHE ALA          
SEQRES  31 k  527  VAL PRO GLY GLY LEU ILE GLY VAL GLY THR LYS VAL ASP          
SEQRES  32 k  527  PRO THR LEU CYS ARG ALA ASP ARG LEU VAL GLY GLN VAL          
SEQRES  33 k  527  VAL GLY ALA LYS GLY HIS LEU PRO ASN ILE TYR THR ASP          
SEQRES  34 k  527  ILE GLU ILE ASN TYR PHE LEU LEU ARG ARG LEU LEU GLY          
SEQRES  35 k  527  VAL LYS THR ASP GLY GLN LYS GLN ALA LYS VAL ARG LYS          
SEQRES  36 k  527  LEU GLU PRO ASN GLU VAL LEU MET VAL ASN ILE GLY SER          
SEQRES  37 k  527  THR ALA THR GLY ALA ARG VAL VAL ALA VAL LYS ALA ASP          
SEQRES  38 k  527  MET ALA ARG LEU GLN LEU THR SER PRO ALA CYS THR GLU          
SEQRES  39 k  527  ILE ASN GLU LYS ILE ALA LEU SER ARG ARG ILE GLU LYS          
SEQRES  40 k  527  HIS TRP ARG LEU ILE GLY TRP ALA THR ILE LYS LYS GLY          
SEQRES  41 k  527  THR THR LEU GLU PRO ILE ALA                                  
SEQRES   1 l  285  MET SER SER ASP LEU ALA ALA GLU LEU GLY PHE ASP PRO          
SEQRES   2 l  285  ALA LEU LYS LYS LYS LYS LYS THR LYS LYS VAL ILE PRO          
SEQRES   3 l  285  ASP ASP PHE ASP ALA ALA VAL ASN GLY LYS GLU ASN GLY          
SEQRES   4 l  285  SER GLY ASP ASP LEU PHE ALA GLY LEU LYS LYS LYS LYS          
SEQRES   5 l  285  LYS LYS SER LYS SER VAL SER ALA ASP ALA GLU ALA GLU          
SEQRES   6 l  285  LYS GLU PRO THR ASP ASP ILE ALA GLU ALA LEU GLY GLU          
SEQRES   7 l  285  LEU SER LEU LYS LYS LYS LYS LYS LYS THR LYS ASP SER          
SEQRES   8 l  285  SER VAL ASP ALA PHE GLU LYS GLU LEU ALA LYS ALA GLY          
SEQRES   9 l  285  LEU ASP ASN VAL ASP ALA GLU SER LYS GLU GLY THR PRO          
SEQRES  10 l  285  SER ALA ASN SER SER ILE GLN GLN GLU VAL GLY LEU PRO          
SEQRES  11 l  285  TYR SER GLU LEU LEU SER ARG PHE PHE ASN ILE LEU ARG          
SEQRES  12 l  285  THR ASN ASN PRO GLU LEU ALA GLY ASP ARG SER GLY PRO          
SEQRES  13 l  285  LYS PHE ARG ILE PRO PRO PRO VAL CYS LEU ARG ASP GLY          
SEQRES  14 l  285  LYS LYS THR ILE PHE SER ASN ILE GLN ASP ILE ALA GLU          
SEQRES  15 l  285  LYS LEU HIS ARG SER PRO GLU HIS LEU ILE GLN TYR LEU          
SEQRES  16 l  285  PHE ALA GLU LEU GLY THR SER GLY SER VAL ASP GLY GLN          
SEQRES  17 l  285  LYS ARG LEU VAL ILE LYS GLY LYS PHE GLN SER LYS GLN          
SEQRES  18 l  285  MET GLU ASN VAL LEU ARG ARG TYR ILE LEU GLU TYR VAL          
SEQRES  19 l  285  THR CYS LYS THR CYS LYS SER ILE ASN THR GLU LEU LYS          
SEQRES  20 l  285  ARG GLU GLN SER ASN ARG LEU PHE PHE MET VAL CYS LYS          
SEQRES  21 l  285  SER CYS GLY SER THR ARG SER VAL SER SER ILE LYS THR          
SEQRES  22 l  285  GLY PHE GLN ALA THR VAL GLY LYS ARG ARG ARG MET              
SEQRES   1 m  108  MET SER ILE GLU ASN LEU LYS SER PHE ASP PRO PHE ALA          
SEQRES   2 m  108  ASP THR GLY ASP ASP GLU THR ALA THR SER ASN TYR ILE          
SEQRES   3 m  108  HIS ILE ARG ILE GLN GLN ARG ASN GLY ARG LYS THR LEU          
SEQRES   4 m  108  THR THR VAL GLN GLY VAL PRO GLU GLU TYR ASP LEU LYS          
SEQRES   5 m  108  ARG ILE LEU LYS VAL LEU LYS LYS ASP PHE ALA CYS ASN          
SEQRES   6 m  108  GLY ASN ILE VAL LYS ASP PRO GLU MET GLY GLU ILE ILE          
SEQRES   7 m  108  GLN LEU GLN GLY ASP GLN ARG ALA LYS VAL CYS GLU PHE          
SEQRES   8 m  108  MET ILE SER GLN LEU GLY LEU GLN LYS LYS ASN ILE LYS          
SEQRES   9 m  108  ILE HIS GLY PHE                                              
SEQRES   1 o  588  MET ALA PRO PRO PRO PHE ARG PRO GLU ASN ALA ILE LYS          
SEQRES   2 o  588  ARG ALA ASP GLU LEU ILE SER VAL GLY GLU LYS GLN ALA          
SEQRES   3 o  588  ALA LEU GLN SER LEU HIS ASP PHE ILE THR ALA ARG ARG          
SEQRES   4 o  588  ILE ARG TRP ALA THR PRO SER THR VAL GLU PRO VAL VAL          
SEQRES   5 o  588  PHE LYS PHE LEU GLU ILE GLY VAL GLU LEU LYS LYS GLY          
SEQRES   6 o  588  LYS LEU LEU LYS ASP GLY LEU HIS GLN TYR LYS LYS LEU          
SEQRES   7 o  588  ILE GLN GLY SER THR GLU GLY LEU VAL SER VAL GLY ALA          
SEQRES   8 o  588  VAL ALA ARG LYS PHE ILE ASP LEU VAL GLU SER LYS ILE          
SEQRES   9 o  588  ALA SER GLU GLN THR ARG ALA ASP GLU LEU GLN LYS GLN          
SEQRES  10 o  588  GLU ILE ASP ASP ASP LEU GLU GLY GLY VAL THR PRO GLU          
SEQRES  11 o  588  ASN LEU LEU ILE SER VAL TYR GLU SER ASP GLN SER VAL          
SEQRES  12 o  588  ALA GLY PHE ASN ASP GLU ALA ILE THR SER TRP LEU ARG          
SEQRES  13 o  588  PHE THR TRP GLU SER TYR ARG ALA VAL LEU ASP LEU LEU          
SEQRES  14 o  588  ARG ASN ASN ALA LEU LEU GLU ILE THR TYR SER GLY VAL          
SEQRES  15 o  588  VAL LYS LYS THR MET HIS PHE CYS LEU LYS TYR GLN ARG          
SEQRES  16 o  588  LYS ASN GLU PHE LYS ARG LEU ALA GLU MET LEU ARG GLN          
SEQRES  17 o  588  HIS LEU ASP ALA ALA ASN TYR GLN GLN SER LYS SER GLY          
SEQRES  18 o  588  ASN ASN LEU VAL ASP LEU SER ASP ALA ASP THR LEU GLN          
SEQRES  19 o  588  ARG TYR LEU ASP GLN ARG PHE GLN GLN VAL ASP VAL SER          
SEQRES  20 o  588  VAL LYS LEU GLU LEU TRP HIS GLU ALA TYR ARG SER ILE          
SEQRES  21 o  588  GLU ASP VAL PHE HIS LEU MET LYS ILE SER LYS ARG ALA          
SEQRES  22 o  588  PRO LYS PRO SER THR LEU ALA ASN TYR TYR GLU ASN LEU          
SEQRES  23 o  588  VAL LYS VAL PHE PHE VAL SER GLY ASP PRO LEU LEU HIS          
SEQRES  24 o  588  THR THR ALA TRP LYS LYS PHE TYR LYS LEU TYR SER THR          
SEQRES  25 o  588  ASN PRO ARG ALA THR GLU GLU GLU PHE LYS THR TYR SER          
SEQRES  26 o  588  SER THR ILE PHE LEU SER ALA ILE SER THR GLN LEU ASP          
SEQRES  27 o  588  GLU ILE PRO SER ILE GLY TYR ASP PRO HIS LEU ARG MET          
SEQRES  28 o  588  TYR ARG LEU LEU ASN LEU ASP ALA LYS PRO THR ARG LYS          
SEQRES  29 o  588  GLU MET LEU GLN SER ILE ILE GLU ASP GLU SER ILE TYR          
SEQRES  30 o  588  GLY LYS VAL ASP GLU GLU LEU LYS GLU LEU TYR ASP ILE          
SEQRES  31 o  588  ILE GLU VAL ASN PHE ASP VAL ASP THR VAL LYS GLN GLN          
SEQRES  32 o  588  LEU GLU ASN LEU LEU VAL LYS LEU SER SER LYS THR TYR          
SEQRES  33 o  588  PHE SER GLN TYR ILE ALA PRO LEU ARG ASP VAL ILE MET          
SEQRES  34 o  588  ARG ARG VAL PHE VAL ALA ALA SER GLN LYS PHE THR THR          
SEQRES  35 o  588  VAL SER GLN SER GLU LEU TYR LYS LEU ALA THR LEU PRO          
SEQRES  36 o  588  ALA PRO LEU ASP LEU SER ALA TRP ASP ILE GLU LYS SER          
SEQRES  37 o  588  LEU LEU GLN ALA ALA VAL GLU ASP TYR VAL SER ILE THR          
SEQRES  38 o  588  ILE ASP HIS GLU SER ALA LYS VAL THR PHE ALA LYS ASP          
SEQRES  39 o  588  PRO UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  40 o  588  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  41 o  588  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  42 o  588  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  43 o  588  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  44 o  588  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  45 o  588  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  46 o  588  UNK UNK UNK                                                  
SEQRES   1 p  652  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 p  652  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   3 p  652  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   4 p  652  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   5 p  652  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   6 p  652  UNK UNK UNK ARG ALA TYR ASN THR THR LYS GLN ARG VAL          
SEQRES   7 p  652  LYS LYS VAL SER UNK UNK UNK UNK UNK UNK UNK UNK GLN          
SEQRES   8 p  652  GLU ASP PHE PHE THR ARG LEU GLN THR ILE ILE ASP SER          
SEQRES   9 p  652  ARG GLY LYS LYS THR VAL ASN GLN GLN SER LEU ILE SER          
SEQRES  10 p  652  THR LEU GLU GLU LEU LEU THR VAL ALA GLU LYS PRO TYR          
SEQRES  11 p  652  GLU PHE ILE MET ALA TYR LEU THR LEU ILE PRO SER ARG          
SEQRES  12 p  652  PHE ASP ALA SER ALA ASN LEU SER TYR GLN PRO ILE ASP          
SEQRES  13 p  652  GLN TRP LYS SER SER PHE ASN ASP ILE SER LYS LEU LEU          
SEQRES  14 p  652  SER ILE LEU ASP GLN THR ILE ASP THR TYR GLN VAL ASN          
SEQRES  15 p  652  GLU PHE ALA ASP PRO ILE ASP PHE ILE GLU ASP GLU PRO          
SEQRES  16 p  652  LYS GLU ASP SER ASP GLY VAL LYS ARG ILE LEU GLY SER          
SEQRES  17 p  652  ILE PHE SER PHE VAL GLU ARG LEU ASP ASP GLU PHE MET          
SEQRES  18 p  652  LYS SER LEU LEU ASN ILE ASP PRO HIS SER SER ASP TYR          
SEQRES  19 p  652  LEU ILE ARG LEU ARG ASP GLU GLN SER ILE TYR ASN LEU          
SEQRES  20 p  652  ILE LEU ARG THR GLN LEU TYR PHE GLU ALA THR LEU LYS          
SEQRES  21 p  652  ASP GLU HIS ASP LEU GLU ARG ALA LEU THR ARG PRO PHE          
SEQRES  22 p  652  VAL LYS ARG LEU ASP HIS ILE TYR TYR LYS SER GLU ASN          
SEQRES  23 p  652  LEU ILE LYS ILE MET GLU THR ALA ALA TRP ASN ILE ILE          
SEQRES  24 p  652  PRO ALA GLN PHE LYS SER LYS PHE THR SER LYS ASP GLN          
SEQRES  25 p  652  LEU ASP SER ALA ASP TYR VAL ASP ASN LEU ILE ASP GLY          
SEQRES  26 p  652  LEU SER THR ILE LEU SER LYS GLN ASN ASN ILE ALA VAL          
SEQRES  27 p  652  GLN LYS ARG ALA ILE LEU TYR ASN ILE TYR TYR THR ALA          
SEQRES  28 p  652  LEU ASN LYS ASP PHE GLN THR ALA LYS ASP MET LEU LEU          
SEQRES  29 p  652  THR SER GLN VAL GLN THR ASN ILE ASN GLN PHE ASP SER          
SEQRES  30 p  652  SER LEU GLN ILE LEU PHE ASN ARG VAL VAL VAL GLN LEU          
SEQRES  31 p  652  GLY LEU SER ALA PHE LYS LEU CYS LEU ILE GLU GLU CYS          
SEQRES  32 p  652  HIS GLN ILE LEU ASN ASP LEU LEU SER SER SER HIS LEU          
SEQRES  33 p  652  ARG GLU ILE LEU GLY GLN GLN SER LEU HIS ARG ILE SER          
SEQRES  34 p  652  LEU ASN SER SER ASN ASN ALA SER ALA ASP GLU ARG ALA          
SEQRES  35 p  652  ARG GLN CYS LEU PRO TYR HIS GLN HIS ILE ASN LEU ASP          
SEQRES  36 p  652  LEU ILE ASP VAL VAL PHE LEU THR CYS SER LEU LEU ILE          
SEQRES  37 p  652  GLU ILE PRO ARG MET THR ALA PHE TYR SER GLY ILE LYS          
SEQRES  38 p  652  VAL LYS ARG ILE PRO TYR SER PRO LYS SER ILE ARG ARG          
SEQRES  39 p  652  SER LEU GLU HIS TYR ASP LYS LEU SER PHE GLN GLY PRO          
SEQRES  40 p  652  PRO GLU THR LEU ARG ASP TYR VAL LEU PHE ALA ALA LYS          
SEQRES  41 p  652  SER MET GLN LYS GLY ASN TRP ARG ASP SER VAL LYS TYR          
SEQRES  42 p  652  LEU ARG GLU ILE LYS SER TRP ALA LEU LEU PRO ASN MET          
SEQRES  43 p  652  GLU THR VAL LEU ASN SER LEU THR GLU ARG VAL GLN VAL          
SEQRES  44 p  652  GLU SER LEU LYS THR TYR PHE PHE SER PHE LYS ARG PHE          
SEQRES  45 p  652  TYR SER SER PHE SER VAL ALA LYS LEU ALA GLU LEU PHE          
SEQRES  46 p  652  ASP LEU PRO GLU ASN LYS VAL VAL GLU VAL LEU GLN SER          
SEQRES  47 p  652  VAL ILE ALA GLU LEU GLU ILE PRO ALA LYS LEU ASN ASP          
SEQRES  48 p  652  GLU LYS THR ILE PHE VAL VAL GLU LYS GLY ASP GLU ILE          
SEQRES  49 p  652  THR LYS LEU GLU GLU ALA MET VAL LYS LEU ASN LYS GLU          
SEQRES  50 p  652  TYR LYS ILE ALA LYS GLU ARG LEU ASN PRO PRO SER ASN          
SEQRES  51 p  652  ARG ARG                                                      
SEQRES   1 q  347  MET LYS ALA ILE LYS LEU THR GLY HIS GLU ARG PRO LEU          
SEQRES   2 q  347  THR GLN VAL LYS TYR ASN LYS GLU GLY ASP LEU LEU PHE          
SEQRES   3 q  347  SER CYS SER LYS ASP SER SER ALA SER VAL TRP TYR SER          
SEQRES   4 q  347  LEU ASN GLY GLU ARG LEU GLY THR LEU ASP GLY HIS THR          
SEQRES   5 q  347  GLY THR ILE TRP SER ILE ASP VAL ASP CYS PHE THR LYS          
SEQRES   6 q  347  TYR CYS VAL THR GLY SER ALA ASP TYR SER ILE LYS LEU          
SEQRES   7 q  347  TRP ASP VAL SER ASN GLY GLN CYS VAL ALA THR TRP LYS          
SEQRES   8 q  347  SER PRO VAL PRO VAL LYS ARG VAL GLU PHE SER PRO CYS          
SEQRES   9 q  347  GLY ASN TYR PHE LEU ALA ILE LEU ASP ASN VAL MET LYS          
SEQRES  10 q  347  ASN PRO GLY SER ILE ASN ILE TYR GLU ILE GLU ARG ASP          
SEQRES  11 q  347  SER ALA THR HIS GLU LEU THR LYS VAL SER GLU GLU PRO          
SEQRES  12 q  347  ILE HIS LYS ILE ILE THR HIS GLU GLY LEU ASP ALA ALA          
SEQRES  13 q  347  THR VAL ALA GLY TRP SER THR LYS GLY LYS TYR ILE ILE          
SEQRES  14 q  347  ALA GLY HIS LYS ASP GLY LYS ILE SER LYS TYR ASP VAL          
SEQRES  15 q  347  SER ASN ASN TYR GLU TYR VAL ASP SER ILE ASP LEU HIS          
SEQRES  16 q  347  GLU LYS SER ILE SER ASP MET GLN PHE SER PRO ASP LEU          
SEQRES  17 q  347  THR TYR PHE ILE THR SER SER ARG ASP THR ASN SER PHE          
SEQRES  18 q  347  LEU VAL ASP VAL SER THR LEU GLN VAL LEU LYS LYS TYR          
SEQRES  19 q  347  GLU THR ASP CYS PRO LEU ASN THR ALA VAL ILE THR PRO          
SEQRES  20 q  347  LEU LYS GLU PHE ILE ILE LEU GLY GLY GLY GLN GLU ALA          
SEQRES  21 q  347  LYS ASP VAL THR THR THR SER ALA ASN GLU GLY LYS PHE          
SEQRES  22 q  347  GLU ALA ARG PHE TYR HIS LYS ILE PHE GLU GLU GLU ILE          
SEQRES  23 q  347  GLY ARG VAL GLN GLY HIS PHE GLY PRO LEU ASN THR VAL          
SEQRES  24 q  347  ALA ILE SER PRO GLN GLY THR SER TYR ALA SER GLY GLY          
SEQRES  25 q  347  GLU ASP GLY PHE ILE ARG LEU HIS HIS PHE GLU LYS SER          
SEQRES  26 q  347  TYR PHE ASP PHE LYS TYR ASP VAL GLU LYS ALA ALA GLU          
SEQRES  27 q  347  ALA LYS GLU HIS MET GLN GLU ALA ASN                          
SEQRES   1 r   31  LEU HIS GLN ARG GLU LEU LEU LYS GLN TRP THR GLU TYR          
SEQRES   2 r   31  ARG GLU LYS ILE GLY GLN GLU MET GLU LYS SER MET ASN          
SEQRES   3 r   31  PHE LYS ILE PHE ASP                                          
SEQRES   1 s   52  VAL HIS LYS SER VAL ALA GLU ARG LYS ASN TRP HIS LYS          
SEQRES   2 s   52  TYR GLY SER GLU LYS GLY SER PRO ALA GLY PRO SER ALA          
SEQRES   3 s   52  VAL THR ALA ARG LEU GLY GLU GLU VAL GLU LEU ARG LEU          
SEQRES   4 s   52  SER ARG ASN TRP LYS GLN ALA GLU GLU GLU ARG ILE GLN          
HET     MG  21801       1                                                       
HET     MG  21802       1                                                       
HET     MG  21803       1                                                       
HET     MG  21804       1                                                       
HET     MG  21805       1                                                       
HET     MG  21806       1                                                       
HET     MG  21807       1                                                       
HET     MG  21808       1                                                       
HET     MG  21809       1                                                       
HET     MG  21810       1                                                       
HET     MG  21811       1                                                       
HET     MG  21812       1                                                       
HET     MG  21813       1                                                       
HET     MG  21814       1                                                       
HET     MG  21815       1                                                       
HET     MG  21816       1                                                       
HET     MG  21817       1                                                       
HET     MG  21818       1                                                       
HET     MG  21819       1                                                       
HET     MG  21820       1                                                       
HET     MG  21821       1                                                       
HET     MG  21822       1                                                       
HET     MG  21823       1                                                       
HET     MG  21824       1                                                       
HET     MG  21825       1                                                       
HET     MG  21826       1                                                       
HET     MG  21827       1                                                       
HET     MG  21828       1                                                       
HET     MG  21829       1                                                       
HET     MG  21830       1                                                       
HET     MG  21831       1                                                       
HET     MG  21832       1                                                       
HET     MG  21833       1                                                       
HET     MG  21834       1                                                       
HET     MG  21835       1                                                       
HET     MG  21836       1                                                       
HET     MG  21837       1                                                       
HET     MG  21838       1                                                       
HET     MG  21839       1                                                       
HET     MG  21840       1                                                       
HET     MG  21841       1                                                       
HET     MG  21842       1                                                       
HET     MG  21843       1                                                       
HET     MG  21844       1                                                       
HET     MG  21845       1                                                       
HET     MG  21846       1                                                       
HET     MG  21847       1                                                       
HET     MG  21848       1                                                       
HET     MG  21849       1                                                       
HET     MG  21850       1                                                       
HET     MG  21851       1                                                       
HET     MG  21852       1                                                       
HET     MG  21853       1                                                       
HET     MG  21854       1                                                       
HET     MG  21855       1                                                       
HET     MG  21856       1                                                       
HET     MG  21857       1                                                       
HET     MG  21858       1                                                       
HET     MG  21859       1                                                       
HET     MG  21860       1                                                       
HET     MG  21861       1                                                       
HET     MG  21862       1                                                       
HET     MG  21863       1                                                       
HET     MG  21864       1                                                       
HET     MG  21865       1                                                       
HET     MG  21866       1                                                       
HET     MG  21867       1                                                       
HET     MG  21868       1                                                       
HET     MG  21869       1                                                       
HET     MG  21870       1                                                       
HET     MG  21871       1                                                       
HET     MG  21872       1                                                       
HET     MG  21873       1                                                       
HET     MG  21874       1                                                       
HET     MG  21875       1                                                       
HET     MG  21876       1                                                       
HET     MG  21877       1                                                       
HET     MG  21878       1                                                       
HET     MG  21879       1                                                       
HET     MG  21880       1                                                       
HET     ZN  a 500       1                                                       
HET     ZN  b 101       1                                                       
HET     ZN  f 501       1                                                       
HET    MET  k 601       8                                                       
HET     MG  k 602       1                                                       
HET    GCP  k 603      32                                                       
HET     ZN  l 301       1                                                       
HETNAM      MG MAGNESIUM ION                                                    
HETNAM      ZN ZINC ION                                                         
HETNAM     MET METHIONINE                                                       
HETNAM     GCP PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER                     
FORMUL  48   MG    81(MG 2+)                                                    
FORMUL  28   ZN    4(ZN 2+)                                                     
FORMUL  31  MET    C5 H11 N O2 S                                                
FORMUL  33  GCP    C11 H18 N5 O13 P3                                            
HELIX    1   1 THR A   10  ARG A   21  1                                  12    
HELIX    2   2 ASN A   49  ILE A   67  1                                  19    
HELIX    3   3 ARG A   79  TYR A   81  5                                   3    
HELIX    4   4 GLY A   82  THR A   93  1                                  12    
HELIX    5   5 ASP A  129  VAL A  139  1                                  11    
HELIX    6   6 HIS A  168  GLY A  186  1                                  19    
HELIX    7   7 MET A  198  TYR A  202  5                                   5    
HELIX    8   8 PRO B   23  THR B   25  5                                   3    
HELIX    9   9 SER B   76  SER B   80  5                                   5    
HELIX   10  10 THR B  106  VAL B  114  1                                   9    
HELIX   11  11 GLN B  157  VAL B  176  1                                  20    
HELIX   12  12 THR B  180  ILE B  189  1                                  10    
HELIX   13  13 GLU B  191  LYS B  202  1                                  12    
HELIX   14  14 LEU B  225  LEU B  231  1                                   7    
HELIX   15  15 THR C   44  GLY C   53  1                                  10    
HELIX   16  16 SER C   57  SER C   65  1                                   9    
HELIX   17  17 PHE C   71  LEU C   78  1                                   8    
HELIX   18  18 GLU C  125  VAL C  141  1                                  17    
HELIX   19  19 SER C  186  GLY C  197  1                                  12    
HELIX   20  20 THR C  211  ASN C  225  1                                  15    
HELIX   21  21 SER C  243  TYR C  248  1                                   6    
HELIX   22  22 SER D    6  LEU D   29  1                                  24    
HELIX   23  23 VAL D   55  GLY D   60  1                                   6    
HELIX   24  24 GLY D   63  LYS D   78  1                                  16    
HELIX   25  25 SER D   97  GLY D  112  1                                  16    
HELIX   26  26 ALA D  114  GLY D  130  1                                  17    
HELIX   27  27 GLY D  161  ASN D  165  5                                   5    
HELIX   28  28 ASP D  191  THR D  196  1                                   6    
HELIX   29  29 PRO E   15  MET E   19  5                                   5    
HELIX   30  30 PRO E   43  ASN E   50  1                                   8    
HELIX   31  31 ASN E   57  GLN E   67  1                                  11    
HELIX   32  32 THR E  115  SER E  120  1                                   6    
HELIX   33  33 LYS E  133  GLY E  135  5                                   3    
HELIX   34  34 GLY E  185  LEU E  189  5                                   5    
HELIX   35  35 THR E  247  GLN E  258  1                                  12    
HELIX   36  36 PRO F   32  GLN F   37  1                                   6    
HELIX   37  37 GLN F   37  ILE F   42  1                                   6    
HELIX   38  38 PHE F   84  CYS F   89  5                                   6    
HELIX   39  39 PRO F   90  MET F  100  1                                  11    
HELIX   40  40 LYS F  108  LEU F  126  1                                  19    
HELIX   41  41 ASN F  130  GLY F  143  1                                  14    
HELIX   42  42 SER F  165  PHE F  186  1                                  22    
HELIX   43  43 THR F  191  LYS F  205  1                                  15    
HELIX   44  44 SER F  210  ASN F  226  1                                  17    
HELIX   45  45 ASP G   20  ARG G   25  1                                   6    
HELIX   46  46 GLY G   38  GLY G   42  1                                   5    
HELIX   47  47 GLN G   59  PHE G   61  5                                   3    
HELIX   48  48 ARG G  137  GLY G  146  1                                  10    
HELIX   49  49 THR G  180  GLU G  222  1                                  43    
HELIX   50  50 GLN H    5  LEU H    9  5                                   5    
HELIX   51  51 THR H   14  GLU H   28  1                                  15    
HELIX   52  52 ASN H   29  SER H   31  5                                   3    
HELIX   53  53 ASP H   37  LEU H   41  5                                   5    
HELIX   54  54 SER H   66  GLN H   74  1                                   9    
HELIX   55  55 GLN H   74  PHE H   85  1                                  12    
HELIX   56  56 THR H  117  VAL H  130  1                                  14    
HELIX   57  57 ASP H  158  ILE H  162  5                                   5    
HELIX   58  58 LYS H  165  THR H  177  1                                  13    
HELIX   59  59 ARG I   25  PHE I   27  5                                   3    
HELIX   60  60 ASN I   87  ASN I   94  1                                   8    
HELIX   61  61 ALA I  106  TYR I  117  1                                  12    
HELIX   62  62 SER I  137  ALA I  148  1                                  12    
HELIX   63  63 GLU I  154  GLY I  164  1                                  11    
HELIX   64  64 ARG I  173  GLY I  178  1                                   6    
HELIX   65  65 GLY I  187  LYS I  201  1                                  15    
HELIX   66  66 GLU J   20  GLY J   35  1                                  16    
HELIX   67  67 ASN J   38  ARG J   62  1                                  25    
HELIX   68  68 ASP J   66  GLY J   84  1                                  19    
HELIX   69  69 VAL J  101  ARG J  107  1                                   7    
HELIX   70  70 ARG J  108  LYS J  115  1                                   8    
HELIX   71  71 SER J  121  GLN J  131  1                                  11    
HELIX   72  72 ARG J  149  ILE J  156  5                                   8    
HELIX   73  73 ARG J  171  GLY J  182  1                                  12    
HELIX   74  74 PRO K    4  GLY K   19  1                                  16    
HELIX   75  75 LYS K   38  GLY K   53  1                                  16    
HELIX   76  76 THR K   69  ASN K   81  1                                  13    
HELIX   77  77 PRO L   45  GLY L   51  1                                   7    
HELIX   78  78 GLU M   18  ASP M   32  1                                  15    
HELIX   79  79 LEU M   38  ARG M   47  1                                  10    
HELIX   80  80 GLU M   62  GLU M   74  1                                  13    
HELIX   81  81 ASP M   84  GLY M   93  1                                  10    
HELIX   82  82 GLU M  123  SER M  132  1                                  10    
HELIX   83  83 SER N   29  GLY N   44  1                                  16    
HELIX   84  84 THR N   46  HIS N   58  1                                  13    
HELIX   85  85 GLN N   62  THR N   67  1                                   6    
HELIX   86  86 LYS N   70  GLY N   79  1                                  10    
HELIX   87  87 PRO N   85  ASN N  105  1                                  21    
HELIX   88  88 LYS N  109  SER N  133  1                                  25    
HELIX   89  89 SER N  143  ASN N  151  1                                   9    
HELIX   90  90 THR O   43  VAL O   48  1                                   6    
HELIX   91  91 ALA O   50  SER O   55  5                                   6    
HELIX   92  92 SER O   56  GLY O   75  1                                  20    
HELIX   93  93 GLY O   97  ARG O  107  1                                  11    
HELIX   94  94 GLU P   23  GLU P   27  5                                   5    
HELIX   95  95 PRO P   29  LEU P   36  1                                   8    
HELIX   96  96 PRO P   38  ARG P   47  1                                  10    
HELIX   97  97 GLY P   55  ALA P   67  1                                  13    
HELIX   98  98 TYR P  115  PHE P  119  5                                   5    
HELIX   99  99 LEU Q   44  GLY Q   56  1                                  13    
HELIX  100 100 LEU Q   57  ALA Q   61  5                                   5    
HELIX  101 101 HIS Q   74  VAL Q   97  1                                  24    
HELIX  102 102 ASP Q   98  THR Q  110  1                                  13    
HELIX  103 103 THR R    6  TYR R   20  1                                  15    
HELIX  104 104 ASP R   27  ALA R   39  1                                  13    
HELIX  105 105 LYS R   44  GLY R   64  1                                  21    
HELIX  106 106 PHE R   71  GLU R   79  1                                   9    
HELIX  107 107 ASP R  103  LEU R  113  1                                  11    
HELIX  108 108 ARG S   16  THR S   20  5                                   5    
HELIX  109 109 VAL S   28  THR S   33  1                                   6    
HELIX  110 110 GLY S   39  ASP S   51  1                                  13    
HELIX  111 111 THR S   62  ASN S   75  1                                  14    
HELIX  112 112 ASN S  104  ILE S  119  1                                  16    
HELIX  113 113 SER S  121  GLY S  130  1                                  10    
HELIX  114 114 SER T    5  VAL T    9  5                                   5    
HELIX  115 115 ALA T   11  GLN T   25  1                                  15    
HELIX  116 116 TRP T   53  ARG T   68  1                                  16    
HELIX  117 117 GLY T   72  TYR T   80  1                                   9    
HELIX  118 118 SER T   97  GLY T  112  1                                  16    
HELIX  119 119 SER T  125  GLU T  144  1                                  20    
HELIX  120 120 VAL U   31  LYS U   49  1                                  19    
HELIX  121 121 ALA U   97  GLN U  105  1                                   9    
HELIX  122 122 SER V   56  GLY V   63  1                                   8    
HELIX  123 123 GLU V   64  ASP V   76  1                                  13    
HELIX  124 124 SER W    5  GLY W   21  1                                  17    
HELIX  125 125 SER W   31  GLY W   45  1                                  15    
HELIX  126 126 ALA W   84  LEU W   94  1                                  11    
HELIX  127 127 HIS W  113  HIS W  120  1                                   8    
HELIX  128 128 ALA X   12  TRP X   24  1                                  13    
HELIX  129 129 GLU X   26  LEU X   34  1                                   9    
HELIX  130 130 GLY X   35  SER X   40  1                                   6    
HELIX  131 131 CYS X   92  ASP X   97  1                                   6    
HELIX  132 132 LEU X  132  GLU X  138  1                                   7    
HELIX  133 133 SER Y   36  GLU Y   46  1                                  11    
HELIX  134 134 GLU Y   51  ASP Y   53  5                                   3    
HELIX  135 135 SER Y   78  LYS Y   84  1                                   7    
HELIX  136 136 PRO Y   87  GLY Y   95  1                                   9    
HELIX  137 137 SER Y  104  ILE Y  118  1                                  15    
HELIX  138 138 GLY Y  122  ASP Y  135  1                                  14    
HELIX  139 139 ASP Z   43  ALA Z   54  1                                  12    
HELIX  140 140 SER Z   61  ARG Z   68  1                                   8    
HELIX  141 141 GLY Z   73  GLU Z   84  1                                  12    
HELIX  142 142 ALA a   49  SER a   57  1                                   9    
HELIX  143 143 CYS a   74  ARG a   82  1                                   9    
HELIX  144 144 THR b   11  LYS b   18  1                                   8    
HELIX  145 145 ARG d   32  LEU d   36  5                                   5    
HELIX  146 146 ARG d   40  ALA d   47  1                                   8    
HELIX  147 147 ASN d   48  ILE d   50  5                                   3    
HELIX  148 148 GLY e   12  THR e   18  1                                   7    
HELIX  149 149 GLY e   32  VAL e   45  1                                  14    
HELIX  150 150 ARG h    2  LYS h   25  1                                  24    
HELIX  151 151 LYS i   11  GLY i   15  5                                   5    
HELIX  152 152 ASN i   96  GLY i  107  1                                  12    
HELIX  153 153 SER j   91  LEU j  112  1                                  22    
HELIX  154 154 ARG j  113  GLN j  120  1                                   8    
HELIX  155 155 PRO j  122  SER j  135  1                                  14    
HELIX  156 156 ALA j  141  ASP j  151  1                                  11    
HELIX  157 157 THR j  153  ILE j  158  1                                   6    
HELIX  158 158 SER j  162  SER j  174  1                                  13    
HELIX  159 159 GLU j  196  GLU j  209  1                                  14    
HELIX  160 160 GLY j  240  LYS j  257  1                                  18    
HELIX  161 161 GLY k  112  SER k  121  1                                  10    
HELIX  162 162 ASP k  130  ASN k  135  1                                   6    
HELIX  163 163 MET k  201  ALA k  209  1                                   9    
HELIX  164 164 GLN k  226  MET k  239  1                                  14    
HELIX  165 165 GLU k  257  ILE k  270  1                                  14    
HELIX  166 166 ASN k  290  THR k  301  1                                  12    
HELIX  167 167 TYR l  131  ILE l  141  1                                  11    
HELIX  168 168 ASN l  176  HIS l  185  1                                  10    
HELIX  169 169 SER l  187  LEU l  199  1                                  13    
HELIX  170 170 LYS l  220  VAL l  234  1                                  15    
HELIX  171 171 ASP m   50  PHE m   62  1                                  13    
HELIX  172 172 ARG m   85  GLN m   95  1                                  11    
HELIX  173 173 ARG o    7  GLY o   22  1                                  16    
HELIX  174 174 LYS o   24  THR o   36  1                                  13    
HELIX  175 175 VAL o   48  LYS o   63  1                                  16    
HELIX  176 176 LYS o   64  GLN o   80  1                                  17    
HELIX  177 177 SER o   82  ASP o  120  1                                  39    
HELIX  178 178 ILE o  151  ARG o  170  1                                  20    
HELIX  179 179 GLU o  176  TYR o  193  1                                  18    
HELIX  180 180 LYS o  196  GLN o  217  1                                  22    
HELIX  181 181 ALA o  230  LEU o  250  1                                  21    
HELIX  182 182 TRP o  253  SER o  270  1                                  18    
HELIX  183 183 SER o  277  PHE o  290  1                                  14    
HELIX  184 184 ASP o  295  ASN o  313  1                                  19    
HELIX  185 185 THR o  317  THR o  335  1                                  19    
HELIX  186 186 ASP o  346  MET o  351  5                                   6    
HELIX  187 187 THR o  362  GLU o  372  1                                  11    
HELIX  188 188 ASP o  373  GLY o  378  1                                   6    
HELIX  189 189 ASP o  381  VAL o  393  1                                  13    
HELIX  190 190 ASP o  396  SER o  412  1                                  17    
HELIX  191 191 ILE o  421  PHE o  440  1                                  20    
HELIX  192 192 GLN o  445  THR o  453  1                                   9    
HELIX  193 193 SER o  461  GLU o  475  1                                  15    
HELIX  194 194 UNK o  754  UNK o  769  1                                  16    
HELIX  195 195 UNK o  773  UNK o  785  1                                  13    
HELIX  196 196 UNK o  789  UNK o  802  1                                  14    
HELIX  197 197 UNK o  807  UNK o  818  1                                  12    
HELIX  198 198 UNK o  829  UNK o  834  1                                   6    
HELIX  199 199 UNK o  838  UNK o  846  1                                   9    
HELIX  200 200 UNK o  851  UNK o  866  1                                  16    
HELIX  201 201 UNK p   21  UNK p   32  1                                  12    
HELIX  202 202 UNK p  117  UNK p  135  1                                  19    
HELIX  203 203 UNK p  140  UNK p  148  1                                   9    
HELIX  204 204 UNK p  151  UNK p  158  1                                   8    
HELIX  205 205 UNK p  171  UNK p  185  1                                  15    
HELIX  206 206 TYR p  195  SER p  206  1                                  12    
HELIX  207 207 UNK p  212  UNK p  218  1                                   7    
HELIX  208 208 GLU p  252  LYS p  267  1                                  16    
HELIX  209 209 ASN p  271  ALA p  286  1                                  16    
HELIX  210 210 LYS p  288  SER p  307  1                                  20    
HELIX  211 211 PRO p  314  ILE p  336  1                                  23    
HELIX  212 212 ASP p  337  VAL p  341  5                                   5    
HELIX  213 213 SER p  368  ILE p  387  1                                  20    
HELIX  214 214 SER p  391  LEU p  419  1                                  29    
HELIX  215 215 ASP p  421  HIS p  439  1                                  19    
HELIX  216 216 SER p  444  ILE p  459  1                                  16    
HELIX  217 217 ASP p  477  SER p  491  1                                  15    
HELIX  218 218 ASN p  495  LYS p  514  1                                  20    
HELIX  219 219 ASP p  515  GLN p  527  1                                  13    
HELIX  220 220 SER p  537  CYS p  558  1                                  22    
HELIX  221 221 LEU p  559  LEU p  567  1                                   9    
HELIX  222 222 LEU p  585  LEU p  590  1                                   6    
HELIX  223 223 ASN p  613  GLY p  639  1                                  27    
HELIX  224 224 SER p  651  LEU p  662  1                                  12    
HELIX  225 225 THR p  670  GLY p  685  1                                  16    
HELIX  226 226 TRP p  687  ILE p  697  1                                  11    
HELIX  227 227 LYS p  698  ALA p  701  5                                   4    
HELIX  228 228 MET p  706  PHE p  729  1                                  24    
HELIX  229 229 SER p  737  PHE p  745  1                                   9    
HELIX  230 230 PRO p  748  GLU p  764  1                                  17    
HELIX  231 231 ASP p  782  LEU p  794  1                                  13    
HELIX  232 232 GLU q  323  PHE q  329  1                                   7    
HELIX  233 233 GLU q  334  GLU q  341  1                                   8    
HELIX  234 234 HIS r  705  SER r  727  1                                  23    
HELIX  235 235 HIS s   46  ASN s   54  1                                   9    
HELIX  236 236 TYR s   58  LYS s   62  5                                   5    
HELIX  237 237 ASN s   86  GLN s   96  1                                  11    
SHEET    1   A 2 VAL A  37  ALA A  40  0                                        
SHEET    2   A 2 ASN A  46  ILE A  48 -1  O  VAL A  47   N  TYR A  38           
SHEET    1   B 4 THR A  96  ALA A  99  0                                        
SHEET    2   B 4 VAL A  73  SER A  77  1  N  VAL A  73   O  THR A  96           
SHEET    3   B 4 LEU A 120  VAL A 123  1  O  ILE A 122   N  ILE A  76           
SHEET    4   B 4 VAL A 143  ALA A 145  1  O  ILE A 144   N  VAL A 123           
SHEET    1   C 5 ASN B  42  ASN B  49  0                                        
SHEET    2   C 5 LYS B  27  LYS B  33 -1  N  GLU B  28   O  VAL B  48           
SHEET    3   C 5 ASN B  95  PHE B 105  1  O  LEU B  96   N  LYS B  33           
SHEET    4   C 5 ARG B  82  VAL B  91 -1  N  LYS B  83   O  ASP B 104           
SHEET    5   C 5 VAL B  65  CYS B  69 -1  N  VAL B  68   O  VAL B  84           
SHEET    1   D 3 LEU B 120  VAL B 127  0                                        
SHEET    2   D 3 VAL B 134  PHE B 142 -1  O  ILE B 137   N  VAL B 125           
SHEET    3   D 3 GLN B 208  HIS B 211 -1  O  HIS B 211   N  ILE B 140           
SHEET    1   E 3 LEU B 120  VAL B 127  0                                        
SHEET    2   E 3 VAL B 134  PHE B 142 -1  O  ILE B 137   N  VAL B 125           
SHEET    3   E 3 VAL B 215  LYS B 219 -1  O  LYS B 216   N  ARG B 136           
SHEET    1   F 4 GLU C  84  GLN C  94  0                                        
SHEET    2   F 4 GLN C  99  GLY C 110 -1  O  VAL C 106   N  MET C  86           
SHEET    3   F 4 HIS C 115  ALA C 123 -1  O  ALA C 123   N  PHE C 103           
SHEET    4   F 4 ILE C 142  PRO C 143 -1  O  ILE C 142   N  VAL C 116           
SHEET    1   G 2 ARG C 146  GLY C 147  0                                        
SHEET    2   G 2 SER C 158  LEU C 159 -1  O  SER C 158   N  GLY C 147           
SHEET    1   H 4 THR C 163  LYS C 166  0                                        
SHEET    2   H 4 SER C 171  PRO C 176 -1  O  LEU C 174   N  THR C 163           
SHEET    3   H 4 VAL C 201  THR C 203 -1  O  TYR C 202   N  ILE C 175           
SHEET    4   H 4 ILE C 183  VAL C 184  1  N  VAL C 184   O  VAL C 201           
SHEET    1   I 3 TYR D  34  VAL D  41  0                                        
SHEET    2   I 3 THR D  46  ALA D  52 -1  O  GLU D  47   N  ARG D  40           
SHEET    3   I 3 ILE D  84  ARG D  90  1  O  ALA D  85   N  THR D  46           
SHEET    1   J 4 ALA D 147  ASP D 154  0                                        
SHEET    2   J 4 CYS D 134  LYS D 141 -1  N  GLY D 140   O  LYS D 148           
SHEET    3   J 4 VAL D 181  MET D 189 -1  O  GLY D 183   N  SER D 139           
SHEET    4   J 4 ILE D 168  LEU D 176 -1  N  VAL D 175   O  LEU D 182           
SHEET    1   K 4 VAL E  70  VAL E  72  0                                        
SHEET    2   K 4 VAL E  89  LEU E  92 -1  O  THR E  91   N  LYS E  71           
SHEET    3   K 4 ASN E  98  ARG E 100 -1  O  PHE E  99   N  ILE E  90           
SHEET    4   K 4 ARG E 113  ILE E 114 -1  O  ILE E 114   N  ASN E  98           
SHEET    1   L 2 VAL E 102  TYR E 103  0                                        
SHEET    2   L 2 PHE E 109  ALA E 110 -1  O  ALA E 110   N  VAL E 102           
SHEET    1   M 5 THR E 146  ARG E 148  0                                        
SHEET    2   M 5 PRO E 137  THR E 141 -1  N  VAL E 139   O  ILE E 147           
SHEET    3   M 5 LYS E 122  LEU E 131 -1  N  GLN E 130   O  TYR E 138           
SHEET    4   M 5 THR E 159  VAL E 162 -1  O  VAL E 162   N  LYS E 122           
SHEET    5   M 5 ILE E 169  ILE E 173 -1  O  ILE E 173   N  THR E 159           
SHEET    1   N 4 VAL E 192  GLY E 193  0                                        
SHEET    2   N 4 LEU E 180  VAL E 183 -1  N  VAL E 181   O  GLY E 193           
SHEET    3   N 4 VAL E 225  GLU E 230 -1  O  ILE E 228   N  LEU E 180           
SHEET    4   N 4 ARG E 233  PRO E 234 -1  O  ARG E 233   N  GLU E 230           
SHEET    1   O 3 HIS E 197  ARG E 198  0                                        
SHEET    2   O 3 LEU E 207  ILE E 210 -1  O  HIS E 209   N  HIS E 197           
SHEET    3   O 3 PHE E 218  ARG E 221 -1  O  PHE E 218   N  ILE E 210           
SHEET    1   P 6 GLU F 146  THR F 149  0                                        
SHEET    2   P 6 GLN F 160  VAL F 164 -1  O  VAL F 162   N  ASP F 147           
SHEET    3   P 6 THR c  39  LYS c  45  1  O  LYS c  45   N  ASP F 163           
SHEET    4   P 6 VAL c  25  PHE c  32 -1  N  VAL c  28   O  ARG c  42           
SHEET    5   P 6 THR c   8  THR c  19 -1  N  THR c  19   O  VAL c  25           
SHEET    6   P 6 ILE c  53  LEU c  56 -1  O  LEU c  54   N  ALA c  10           
SHEET    1   Q 5 THR G  12  GLU G  17  0                                        
SHEET    2   Q 5 LYS G   2  TYR G   7 -1  N  TYR G   7   O  THR G  12           
SHEET    3   Q 5 LEU G 106  LYS G 115  1  O  LEU G 109   N  ASN G   4           
SHEET    4   Q 5 VAL G  49  ASP G  57 -1  N  ALA G  53   O  ALA G 110           
SHEET    5   Q 5 GLN G  34  ASP G  37 -1  N  VAL G  36   O  PHE G  50           
SHEET    1   R 2 LYS G  30  ARG G  31  0                                        
SHEET    2   R 2 ILE G 101  VAL G 102 -1  O  VAL G 102   N  LYS G  30           
SHEET    1   S 2 VAL G  73  LEU G  77  0                                        
SHEET    2   S 2 LYS G  93  VAL G  97 -1  O  VAL G  97   N  VAL G  73           
SHEET    1   T 2 ARG G 160  THR G 163  0                                        
SHEET    2   T 2 SER G 168  LYS G 171 -1  O  TYR G 169   N  VAL G 162           
SHEET    1   U 3 ILE H  46  GLU H  50  0                                        
SHEET    2   U 3 LYS H  56  VAL H  62 -1  O  ALA H  57   N  ILE H  49           
SHEET    3   U 3 VAL H  90  ALA H  94  1  O  ILE H  91   N  VAL H  60           
SHEET    1   V 6 GLN H 180  GLU H 184  0                                        
SHEET    2   V 6 LYS H 148  LEU H 154  1  N  GLN H 150   O  GLN H 180           
SHEET    3   V 6 ILE H 135  TYR H 142 -1  N  GLY H 137   O  LEU H 153           
SHEET    4   V 6 GLU W  51  ILE W  53 -1  O  TYR W  52   N  VAL H 140           
SHEET    5   V 6 LYS W  60  GLN W  64 -1  O  VAL W  62   N  GLU W  51           
SHEET    6   V 6 GLN W  24  ILE W  27 -1  N  ILE W  27   O  ILE W  61           
SHEET    1   W 2 ILE I   3  SER I   4  0                                        
SHEET    2   W 2 LEU I  29  GLY I  30 -1  O  GLY I  30   N  ILE I   3           
SHEET    1   X 2 THR I  36  LYS I  37  0                                        
SHEET    2   X 2 THR I  95  LEU I  96 -1  O  LEU I  96   N  THR I  36           
SHEET    1   Y 2 HIS I  44  THR I  48  0                                        
SHEET    2   Y 2 GLY I  51  ARG I  56 -1  O  ARG I  56   N  HIS I  44           
SHEET    1   Z 6 THR I  62  TRP I  67  0                                        
SHEET    2   Z 6 VAL I  72  TYR I  83 -1  O  THR I  76   N  GLY I  63           
SHEET    3   Z 6 ILE I 101  ILE I 104 -1  O  ILE I 101   N  VAL I  82           
SHEET    4   Z 6 LEU I 166  ILE I 170 -1  O  ALA I 168   N  VAL I 102           
SHEET    5   Z 6 ASP I 181  ILE I 184 -1  O  TYR I 183   N  ALA I 169           
SHEET    6   Z 6 THR I  62  TRP I  67  1  N  SER I  66   O  ILE I 184           
SHEET    1  AA 3 VAL K  20  LEU K  21  0                                        
SHEET    2  AA 3 TYR K  65  LEU K  68 -1  O  TYR K  66   N  LEU K  21           
SHEET    3  AA 3 VAL K  55  GLN K  58 -1  N  GLN K  58   O  TYR K  65           
SHEET    1  AB 6 ILE L  66  SER L  77  0                                        
SHEET    2  AB 6 THR L  83  ARG L  87 -1  O  VAL L  85   N  VAL L  76           
SHEET    3  AB 6 ASN L 106  HIS L 110 -1  O  ALA L 109   N  ILE L  84           
SHEET    4  AB 6 PHE L 137  VAL L 142  1  O  VAL L 139   N  HIS L 110           
SHEET    5  AB 6 ILE L 122  CYS L 128 -1  N  THR L 124   O  LYS L 141           
SHEET    6  AB 6 ILE L  66  SER L  77 -1  N  LEU L  71   O  VAL L 125           
SHEET    1  AC 2 TYR L  90  VAL L  94  0                                        
SHEET    2  AC 2 ARG L  99  ARG L 103 -1  O  ARG L 103   N  TYR L  90           
SHEET    1  AD 2 LEU M  52  LEU M  55  0                                        
SHEET    2  AD 2 VAL M 111  VAL M 114 -1  O  VAL M 112   N  VAL M  54           
SHEET    1  AE 4 THR O  26  VAL O  28  0                                        
SHEET    2  AE 4 ILE O  19  ALA O  21 -1  N  PHE O  20   O  PHE O  27           
SHEET    3  AE 4 ALA O  78  ARG O  84  1  O  ARG O  84   N  ALA O  21           
SHEET    4  AE 4 ARG O 111  ASP O 117  1  O  GLU O 116   N  ILE O  83           
SHEET    1  AF 3 VAL P  76  THR P  78  0                                        
SHEET    2  AF 3 VAL P  94  TYR P  97  1  O  GLY P  95   N  THR P  78           
SHEET    3  AF 3 PHE P 102  VAL P 105 -1  O  ASN P 103   N  VAL P  96           
SHEET    1  AG 3 VAL Q   7  THR Q   9  0                                        
SHEET    2  AG 3 ALA Q  16  ALA Q  24 -1  O  VAL Q  22   N  VAL Q   7           
SHEET    3  AG 3 LYS Q  12  LYS Q  13 -1  N  LYS Q  13   O  ALA Q  16           
SHEET    1  AH 5 VAL Q   7  THR Q   9  0                                        
SHEET    2  AH 5 ALA Q  16  ALA Q  24 -1  O  VAL Q  22   N  VAL Q   7           
SHEET    3  AH 5 ILE Q  63  THR Q  70 -1  O  THR Q  70   N  THR Q  17           
SHEET    4  AH 5 LEU Q  28  VAL Q  31  1  N  LYS Q  30   O  ILE Q  65           
SHEET    5  AH 5 SER Q  34  PRO Q  35 -1  N  SER Q  34   O  VAL Q  31           
SHEET    1  AI 2 ASN R 101  VAL R 102  0                                        
SHEET    2  AI 2 SER R 120  VAL R 121  1  O  SER R 120   N  VAL R 102           
SHEET    1  AJ 2 GLY T  81  ALA T  83  0                                        
SHEET    2  AJ 2 HIS T  93  ASP T  95 -1  O  VAL T  94   N  GLY T  82           
SHEET    1  AK 2 VAL T 114  ILE T 116  0                                        
SHEET    2  AK 2 ARG T 122  ILE T 124 -1  O  ARG T 123   N  GLU T 115           
SHEET    1  AL 4 VAL U  51  VAL U  56  0                                        
SHEET    2  AL 4 TYR U  90  GLU U  94 -1  O  GLU U  94   N  VAL U  51           
SHEET    3  AL 4 ILE U  22  THR U  27 -1  N  ILE U  22   O  LEU U  93           
SHEET    4  AL 4 ASP U 113  VAL U 116 -1  O  GLU U 115   N  ASN U  25           
SHEET    1  AM 2 LYS U  61  ARG U  68  0                                        
SHEET    2  AM 2 TRP U  79  ILE U  86 -1  O  ASP U  80   N  THR U  67           
SHEET    1  AN 2 VAL V  32  ASP V  40  0                                        
SHEET    2  AN 2 GLY V  43  LEU V  55 -1  O  LEU V  55   N  VAL V  32           
SHEET    1  AO 3 GLY W 109  ASP W 112  0                                        
SHEET    2  AO 3 TYR W 101  THR W 106 -1  N  LEU W 104   O  MET W 111           
SHEET    3  AO 3 LYS W 124  VAL W 129 -1  O  VAL W 129   N  TYR W 101           
SHEET    1  AP 7 VAL X 130  SER X 131  0                                        
SHEET    2  AP 7 LYS X 123  VAL X 127 -1  N  VAL X 127   O  VAL X 130           
SHEET    3  AP 7 GLU X 101  ALA X 105 -1  N  LEU X 103   O  VAL X 125           
SHEET    4  AP 7 ALA X  49  ILE X  57 -1  N  ALA X  49   O  LEU X 104           
SHEET    5  AP 7 CYS X  71  LEU X  76 -1  O  ARG X  73   N  GLU X  55           
SHEET    6  AP 7 LYS X  82  PHE X  86 -1  O  VAL X  83   N  VAL X  74           
SHEET    7  AP 7 LYS X 123  VAL X 127  1  O  VAL X 124   N  PHE X  86           
SHEET    1  AQ 4 THR Y   6  ASN Y  15  0                                        
SHEET    2  AQ 4 ARG Y  20  LEU Y  28 -1  O  ARG Y  20   N  ASN Y  15           
SHEET    3  AQ 4 LYS Y  68  TYR Y  76 -1  O  GLY Y  73   N  PHE Y  23           
SHEET    4  AQ 4 VAL Y  55  THR Y  62 -1  N  ARG Y  61   O  THR Y  70           
SHEET    1  AR 2 ILE Z  89  PRO Z  91  0                                        
SHEET    2  AR 2 TYR Z 101  ARG Z 103 -1  O  THR Z 102   N  LYS Z  90           
SHEET    1  AS 2 PRO a  20  ARG a  22  0                                        
SHEET    2  AS 2 SER a  29  PRO a  31 -1  O  VAL a  30   N  VAL a  21           
SHEET    1  AT 2 LYS a  37  ASN a  43  0                                        
SHEET    2  AT 2 LYS a  66  HIS a  72 -1  O  LEU a  71   N  ARG a  38           
SHEET    1  AU 3 ILE b  43  PHE b  47  0                                        
SHEET    2  AU 3 PHE b  32  LYS b  36 -1  N  VAL b  35   O  THR b  44           
SHEET    3  AU 3 SER b  78  ARG b  81 -1  O  ARG b  80   N  ASP b  34           
SHEET    1  AV 2 CYS b  64  THR b  65  0                                        
SHEET    2  AV 2 LYS b  72  LEU b  73 -1  O  LYS b  72   N  THR b  65           
SHEET    1  AW 2 VAL f 108  ASP f 109  0                                        
SHEET    2  AW 2 LYS f 113  VAL f 114 -1  O  LYS f 113   N  ASP f 109           
SHEET    1  AX 3 ALA f 131  ASN f 132  0                                        
SHEET    2  AX 3 PHE f 137  TYR f 138 -1  O  TYR f 138   N  ALA f 131           
SHEET    3  AX 3 ALA f 147  THR f 148 -1  O  THR f 148   N  PHE f 137           
SHEET    1  AY 4 ILE g   6  LEU g  14  0                                        
SHEET    2  AY 4 ILE g 317  THR g 324 -1  O  ILE g 317   N  LEU g  14           
SHEET    3  AY 4 THR g 307  TYR g 312 -1  N  ALA g 310   O  ARG g 318           
SHEET    4  AY 4 ALA g 296  ALA g 300 -1  N  VAL g 297   O  GLY g 311           
SHEET    1  AZ 4 SER g  23  LEU g  24  0                                        
SHEET    2  AZ 4 LEU g  33  GLY g  37 -1  O  GLY g  37   N  SER g  23           
SHEET    3  AZ 4 THR g  42  LEU g  48 -1  O  ILE g  44   N  SER g  36           
SHEET    4  AZ 4 GLY g  56  LYS g  63 -1  O  TYR g  62   N  LEU g  43           
SHEET    1  BA 4 VAL g  69  VAL g  74  0                                        
SHEET    2  BA 4 TYR g  80  SER g  85 -1  O  VAL g  82   N  VAL g  73           
SHEET    3  BA 4 THR g  89  ASN g  94 -1  O  TRP g  93   N  ALA g  81           
SHEET    4  BA 4 ASN g  99  VAL g 105 -1  O  ALA g 102   N  LEU g  92           
SHEET    1  BB 4 VAL g 111  ALA g 115  0                                        
SHEET    2  BB 4 ILE g 123  SER g 127 -1  O  ALA g 126   N  LEU g 112           
SHEET    3  BB 4 ILE g 132  TRP g 135 -1  O  ARG g 133   N  SER g 125           
SHEET    4  BB 4 CYS g 141  LEU g 145 -1  O  TYR g 143   N  VAL g 134           
SHEET    1  BC 4 VAL g 152  VAL g 157  0                                        
SHEET    2  BC 4 ILE g 172  GLY g 178 -1  O  VAL g 175   N  ARG g 156           
SHEET    3  BC 4 ILE g 182  LEU g 188 -1  O  ARG g 184   N  SER g 176           
SHEET    4  BC 4 ASP g 198  ILE g 200 -1  O  PHE g 199   N  VAL g 183           
SHEET    1  BD 4 VAL g 208  PRO g 211  0                                        
SHEET    2  BD 4 LEU g 217  ALA g 221 -1  O  ALA g 221   N  VAL g 208           
SHEET    3  BD 4 GLN g 226  ASN g 231 -1  O  TRP g 230   N  ALA g 218           
SHEET    4  BD 4 SER g 236  ASP g 242 -1  O  PHE g 241   N  ILE g 227           
SHEET    1  BE 4 VAL g 247  PHE g 252  0                                        
SHEET    2  BE 4 TRP g 258  THR g 263 -1  O  ALA g 262   N  PHE g 248           
SHEET    3  BE 4 ILE g 267  ASP g 271 -1  O  LYS g 268   N  ALA g 261           
SHEET    4  BE 4 LEU g 277  LEU g 281 -1  O  ILE g 278   N  ILE g 269           
SHEET    1  BF 6 GLN i  33  MET i  41  0                                        
SHEET    2  BF 6 ARG i  46  CYS i  51 -1  O  SER i  50   N  GLN i  37           
SHEET    3  BF 6 MET i  58  HIS i  60 -1  O  ALA i  59   N  VAL i  47           
SHEET    4  BF 6 GLN i  88  LYS i  94  1  O  CYS i  89   N  MET i  58           
SHEET    5  BF 6 ILE i  76  LEU i  81 -1  N  LEU i  78   O  HIS i  93           
SHEET    6  BF 6 GLN i  33  MET i  41 -1  N  ALA i  36   O  ILE i  77           
SHEET    1  BG 6 ILE j  19  ASN j  23  0                                        
SHEET    2  BG 6 GLY j  31  LEU j  36 -1  O  LYS j  35   N  ASN j  23           
SHEET    3  BG 6 GLU j  43  LEU j  47 -1  O  GLY j  44   N  VAL j  34           
SHEET    4  BG 6 ILE j  83  SER j  86  1  O  LEU j  85   N  MET j  45           
SHEET    5  BG 6 ASN j  68  VAL j  76 -1  N  VAL j  72   O  SER j  86           
SHEET    6  BG 6 ILE j  19  ASN j  23 -1  N  VAL j  22   O  ASP j  69           
SHEET    1  BH 4 LYS j 219  LEU j 222  0                                        
SHEET    2  BH 4 LEU j 227  GLN j 233 -1  O  THR j 231   N  LYS j 219           
SHEET    3  BH 4 LYS j 183  VAL j 190 -1  N  ALA j 186   O  LEU j 230           
SHEET    4  BH 4 CYS j 262  ASN j 263 -1  O  ASN j 263   N  GLU j 189           
SHEET    1  BI 6 ASN k 144  LYS k 149  0                                        
SHEET    2  BI 6 LYS k 184  ASP k 193 -1  O  VAL k 189   N  ALA k 145           
SHEET    3  BI 6 ASN k 102  GLY k 107  1  N  ILE k 103   O  SER k 190           
SHEET    4  BI 6 ALA k 213  ILE k 218  1  O  LEU k 215   N  ILE k 106           
SHEET    5  BI 6 VAL k 244  GLN k 248  1  O  LEU k 247   N  ILE k 218           
SHEET    6  BI 6 ILE k 280  PRO k 282  1  O  VAL k 281   N  GLN k 248           
SHEET    1  BJ 8 ASN k 385  LEU k 387  0                                        
SHEET    2  BJ 8 CYS k 370  ALA k 382 -1  N  LEU k 380   O  LEU k 387           
SHEET    3  BJ 8 GLY k 394  THR k 400 -1  O  GLY k 397   N  PHE k 381           
SHEET    4  BJ 8 GLY k 336  ASN k 344 -1  N  GLY k 336   O  THR k 400           
SHEET    5  BJ 8 ARG k 314  ASP k 322 -1  N  ILE k 316   O  SER k 341           
SHEET    6  BJ 8 GLN k 415  ALA k 419 -1  O  VAL k 417   N  LEU k 315           
SHEET    7  BJ 8 GLU k 352  VAL k 360 -1  N  GLU k 354   O  GLY k 418           
SHEET    8  BJ 8 CYS k 370  ALA k 382 -1  O  ILE k 373   N  ILE k 355           
SHEET    1  BK 2 PHE k 347  LYS k 348  0                                        
SHEET    2  BK 2 PHE k 389  ALA k 390 -1  O  ALA k 390   N  PHE k 347           
SHEET    1  BL 7 ASN k 425  LEU k 441  0                                        
SHEET    2  BL 7 MET k 482  THR k 493 -1  O  LEU k 485   N  ILE k 430           
SHEET    3  BL 7 THR k 469  VAL k 478 -1  N  ARG k 474   O  GLN k 486           
SHEET    4  BL 7 VAL k 461  ILE k 466 -1  N  LEU k 462   O  ALA k 473           
SHEET    5  BL 7 LYS k 498  ARG k 504 -1  O  ALA k 500   N  ASN k 465           
SHEET    6  BL 7 TRP k 509  ILE k 517 -1  O  ARG k 510   N  ARG k 503           
SHEET    7  BL 7 ASN k 425  LEU k 441 -1  N  PHE k 435   O  TRP k 514           
SHEET    1  BM 3 ILE l 173  PHE l 174  0                                        
SHEET    2  BM 3 ARG l 210  VAL l 212 -1  O  LEU l 211   N  PHE l 174           
SHEET    3  BM 3 SER l 204  ASP l 206 -1  N  ASP l 206   O  ARG l 210           
SHEET    1  BN 5 ILE m  68  LYS m  70  0                                        
SHEET    2  BN 5 GLU m  76  GLN m  81 -1  O  ILE m  77   N  VAL m  69           
SHEET    3  BN 5 LEU m  39  GLN m  43 -1  N  THR m  40   O  LEU m  80           
SHEET    4  BN 5 HIS m  27  GLN m  31 -1  N  GLN m  31   O  LEU m  39           
SHEET    5  BN 5 ILE m 105  HIS m 106  1  O  HIS m 106   N  ILE m  28           
SHEET    1  BO 3 THR o 442  SER o 444  0                                        
SHEET    2  BO 3 LYS o 488  PHE o 491 -1  O  VAL o 489   N  VAL o 443           
SHEET    3  BO 3 ILE o 480  ILE o 482 -1  N  THR o 481   O  THR o 490           
SHEET    1  BP 2 LYS p 768  LEU p 769  0                                        
SHEET    2  BP 2 PHE p 776  VAL p 777 -1  O  VAL p 777   N  LYS p 768           
SHEET    1  BQ 5 THR q 298  ILE q 301  0                                        
SHEET    2  BQ 5 SER q 307  GLY q 311 -1  O  GLY q 311   N  THR q 298           
SHEET    3  BQ 5 ILE q 317  HIS q 321 -1  O  ARG q 318   N  SER q 310           
SHEET    4  BQ 5 LYS q   2  LEU q   6 -1  N  ILE q   4   O  LEU q 319           
SHEET    5  BQ 5 THR s  72  GLU s  78 -1  O  ALA s  73   N  LYS q   5           
SHEET    1  BR 4 LEU q  13  TYR q  18  0                                        
SHEET    2  BR 4 LEU q  24  SER q  29 -1  O  CYS q  28   N  THR q  14           
SHEET    3  BR 4 ALA q  34  TYR q  38 -1  O  SER q  35   N  SER q  27           
SHEET    4  BR 4 ARG q  44  LEU q  48 -1  O  GLY q  46   N  VAL q  36           
SHEET    1  BS 4 ILE q  55  VAL q  60  0                                        
SHEET    2  BS 4 TYR q  66  SER q  71 -1  O  VAL q  68   N  ASP q  59           
SHEET    3  BS 4 SER q  75  ASP q  80 -1  O  TRP q  79   N  CYS q  67           
SHEET    4  BS 4 CYS q  86  LYS q  91 -1  O  TRP q  90   N  ILE q  76           
SHEET    1  BT 4 VAL q  96  PHE q 101  0                                        
SHEET    2  BT 4 PHE q 108  LEU q 112 -1  O  ILE q 111   N  ARG q  98           
SHEET    3  BT 4 SER q 121  ILE q 124 -1  O  ASN q 123   N  ALA q 110           
SHEET    4  BT 4 HIS q 145  ILE q 148 -1  O  ILE q 147   N  ILE q 122           
SHEET    1  BU 2 ILE q 127  ARG q 129  0                                        
SHEET    2  BU 2 LEU q 136  VAL q 139 -1  O  THR q 137   N  GLU q 128           
SHEET    1  BV 4 ALA q 156  TRP q 161  0                                        
SHEET    2  BV 4 TYR q 167  HIS q 172 -1  O  GLY q 171   N  VAL q 158           
SHEET    3  BV 4 LYS q 176  ASP q 181 -1  O  SER q 178   N  ALA q 170           
SHEET    4  BV 4 GLU q 187  ASP q 193 -1  O  GLU q 187   N  ASP q 181           
SHEET    1  BW 4 ILE q 199  PHE q 204  0                                        
SHEET    2  BW 4 TYR q 210  SER q 215 -1  O  ILE q 212   N  GLN q 203           
SHEET    3  BW 4 SER q 220  ASP q 224 -1  O  VAL q 223   N  PHE q 211           
SHEET    4  BW 4 VAL q 230  TYR q 234 -1  O  TYR q 234   N  SER q 220           
SHEET    1  BX 4 LEU q 240  ILE q 245  0                                        
SHEET    2  BX 4 PHE q 251  GLY q 256 -1  O  GLY q 255   N  ASN q 241           
SHEET    3  BX 4 ALA q 275  HIS q 279 -1  O  ARG q 276   N  LEU q 254           
SHEET    4  BX 4 GLU q 285  ARG q 288 -1  O  ILE q 286   N  PHE q 277           
LINK         OP1   A 21761                MG    MG 21812     1555   1555  1.74  
LINK         OP2   C 2 360                MG    MG 21828     1555   1555  1.76  
LINK         OP1   G 21426                MG    MG 21876     1555   1555  1.82  
LINK         OP2   G 21426                MG    MG 21876     1555   1555  1.83  
LINK         OP2   G 21766                MG    MG 21822     1555   1555  1.83  
LINK         OP2   A 21760                MG    MG 21822     1555   1555  1.84  
LINK         OP2   G 21427                MG    MG 21879     1555   1555  1.86  
LINK         OP2   G 21327                MG    MG 21826     1555   1555  1.86  
LINK         OP2   A 2 620                MG    MG 21823     1555   1555  1.88  
LINK         OP1   C 21273                MG    MG 21879     1555   1555  1.89  
LINK         OP2   G 2 460                MG    MG 21837     1555   1555  1.89  
LINK         OP1   C 21196                MG    MG 21874     1555   1555  1.91  
LINK         OP1   U 21008                MG    MG 21863     1555   1555  1.91  
LINK         OP2   A 21202                MG    MG 21880     1555   1555  1.92  
LINK         OP2   A 2  28                MG    MG 21817     1555   1555  1.92  
LINK         OP2   G 21329                MG    MG 21809     1555   1555  1.92  
LINK         SG  CYS a  23                ZN    ZN a 500     1555   1555  1.92  
LINK         OP2   A 2 604                MG    MG 21818     1555   1555  1.92  
LINK         OP1   A 2 618                MG    MG 21825     1555   1555  1.92  
LINK         OP2   G 21427                MG    MG 21876     1555   1555  1.92  
LINK         OP2   A 21761                MG    MG 21822     1555   1555  1.92  
LINK         OP2   A 2  47                MG    MG 21821     1555   1555  1.92  
LINK         OP2   C 2  49                MG    MG 21807     1555   1555  1.92  
LINK         OP1   G 21426                MG    MG 21879     1555   1555  1.93  
LINK         OP1   U 21769                MG    MG 21812     1555   1555  1.93  
LINK         OP2   G 21791                MG    MG 21834     1555   1555  1.93  
LINK         OP2   A 2 400                MG    MG 21814     1555   1555  1.93  
LINK         OP2   A 2 377                MG    MG 21816     1555   1555  1.93  
LINK         OP1   G 2 402                MG    MG 21802     1555   1555  1.93  
LINK         OP1   G 21200                MG    MG 21872     1555   1555  1.94  
LINK         OP1   A 2 604                MG    MG 21818     1555   1555  1.94  
LINK         OP1   U 21268                MG    MG 21875     1555   1555  1.96  
LINK         OP2   A 2 554                MG    MG 21803     1555   1555  1.96  
LINK         OP2   A 2 100                MG    MG 21828     1555   1555  1.97  
LINK         OP2   A 2 619                MG    MG 21823     1555   1555  1.97  
LINK         SG  CYS f 121                ZN    ZN f 501     1555   1555  2.01  
LINK         OP2   U 2 378                MG    MG 21816     1555   1555  2.01  
LINK         OP2   A 2 978                MG    MG 21848     1555   1555  2.02  
LINK         OP2   U 2  64                MG    MG 21835     1555   1555  2.03  
LINK         SG  CYS f 139                ZN    ZN f 501     1555   1555  2.05  
LINK         OP1   G 2 460                MG    MG 21837     1555   1555  2.07  
LINK         OP2   U 2 607                MG    MG 21815     1555   1555  2.11  
LINK         OP2   U 21768                MG    MG 21831     1555   1555  2.12  
LINK         OP1   C 2 360                MG    MG 21828     1555   1555  2.14  
LINK         OP1   C 2 624                MG    MG 21839     1555   1555  2.18  
LINK         SG  CYS b  59                ZN    ZN b 101     1555   1555  2.19  
LINK         O5'   C 2 360                MG    MG 21828     1555   1555  2.21  
LINK         O5'   G 21791                MG    MG 21834     1555   1555  2.23  
LINK         OP2   G 2 466                MG    MG 21838     1555   1555  2.26  
LINK         O5'   G 21327                MG    MG 21826     1555   1555  2.27  
LINK         OP1   A 2 100                MG    MG 21804     1555   1555  2.27  
LINK         OP1   A 21201                MG    MG 21880     1555   1555  2.30  
LINK         OP1   C 21455                MG    MG 21871     1555   1555  2.31  
LINK         OP2   G 2  16                MG    MG 21815     1555   1555  2.38  
LINK         OP2   A 2 928                MG    MG 21811     1555   1555  2.38  
LINK         O3'   C 2  99                MG    MG 21828     1555   1555  2.39  
LINK         OP1   U 21282                MG    MG 21868     1555   1555  2.41  
LINK         O6    G 2 761                MG    MG 21850     1555   1555  2.41  
LINK         O5'   A 2  47                MG    MG 21821     1555   1555  2.42  
LINK         OP2   G 2  95                MG    MG 21832     1555   1555  2.44  
LINK         O5'   G 2 460                MG    MG 21837     1555   1555  2.44  
LINK         OG1 THR k 137                MG    MG k 602     1555   1555  2.44  
LINK         O3'   A 2 399                MG    MG 21814     1555   1555  2.46  
LINK         OP1   A 2  28                MG    MG 21817     1555   1555  2.47  
LINK         OP2   A 21024                MG    MG 21805     1555   1555  2.50  
LINK         OP2   C 21273                MG    MG 21879     1555   1555  2.51  
LINK         OP2   A 2 555                MG    MG 21803     1555   1555  2.54  
LINK         OP2   G 2 623                MG    MG 21805     1555   1555  2.54  
LINK         OP2   C 21273                MG    MG 21876     1555   1555  2.55  
LINK         O3'   C 2 401                MG    MG 21802     1555   1555  2.56  
LINK         OP1   A 2 400                MG    MG 21814     1555   1555  2.57  
LINK         SG  CYS l 262                ZN    ZN l 301     1555   1555  2.58  
LINK         SG  CYS f 124                ZN    ZN f 501     1555   1555  2.59  
LINK         O6    G 21539                MG    MG 21877     1555   1555  2.62  
LINK         O   CYS b  59                ZN    ZN b 101     1555   1555  2.62  
LINK         OG  SER l 264                ZN    ZN l 301     1555   1555  2.63  
LINK         OP2   G 21540                MG    MG 21859     1555   1555  2.65  
LINK         O2'   C 21429                MG    MG 21873     1555   1555  2.66  
LINK         O6    G 21293                MG    MG 21854     1555   1555  2.66  
LINK         OP1   U 21520                MG    MG 21878     1555   1555  2.67  
LINK         O6    G 2 984                MG    MG 21840     1555   1555  2.67  
LINK         O6    G 2 561                MG    MG 21824     1555   1555  2.67  
LINK         O6    G 2 985                MG    MG 21840     1555   1555  2.68  
LINK         OP1   C 2 529                MG    MG 21853     1555   1555  2.70  
LINK        MG    MG k 602                 O1G GCP k 603     1555   1555  2.70  
LINK         OP2   A 2 760                MG    MG 21850     1555   1555  2.71  
LINK         OP2   U 21302                MG    MG 21847     1555   1555  2.72  
LINK         SG  CYS a  77                ZN    ZN a 500     1555   1555  2.74  
LINK         OP2   G 21482                MG    MG 21878     1555   1555  2.74  
LINK         OP2   U 21003                MG    MG 21819     1555   1555  2.77  
LINK         OP1   U 21003                MG    MG 21819     1555   1555  2.77  
LINK         OP1   A 2  47                MG    MG 21821     1555   1555  2.81  
LINK         O3'   U 2  27                MG    MG 21817     1555   1555  2.82  
LINK         OP1   U 2 988                MG    MG 21857     1555   1555  2.82  
LINK         OP1   G 2  16                MG    MG 21815     1555   1555  2.83  
LINK         OP2   C 21196                MG    MG 21874     1555   1555  2.84  
LINK         OP2   U 21054                MG    MG 21865     1555   1555  2.87  
LINK         O5'   G 21426                MG    MG 21876     1555   1555  2.87  
LINK         OP1   U 2  64                MG    MG 21835     1555   1555  2.87  
LINK         SG  CYS a  26                ZN    ZN a 500     1555   1555  2.90  
LINK         OP1   A 21025                MG    MG 21827     1555   1555  2.91  
LINK         OP2   A 21004                MG    MG 21808     1555   1555  2.91  
LINK         OP2   A 2 618                MG    MG 21823     1555   1555  2.92  
LINK         O3'   G 21790                MG    MG 21834     1555   1555  2.92  
LINK         OP2   C 2 530                MG    MG 21853     1555   1555  2.93  
LINK         OP2   G 21539                MG    MG 21859     1555   1555  2.94  
LINK         O2'   G 21765                MG    MG 21822     1555   1555  2.94  
LINK         O5'   U 21008                MG    MG 21863     1555   1555  2.98  
LINK         OP2   G 2 548                MG    MG 21842     1555   1555  2.98  
LINK         OP2   G 21199                MG    MG 21872     1555   1555  2.98  
LINK         OP2   G 21426                MG    MG 21879     1555   1555  2.99  
SITE     1 AC1  1   G 2 361                                                     
SITE     1 AC2  2   C 2 401    G 2 402                                          
SITE     1 AC3  2   A 2 554    A 2 555                                          
SITE     1 AC4  3   U 2  44    U 2  45    A 2 100                               
SITE     1 AC5  2   G 2 623    A 21024                                          
SITE     1 AC6  2   G 2 556    C 2 582                                          
SITE     1 AC7  2   C 2  49    G 2 387                                          
SITE     1 AC8  2   U 21003    A 21004                                          
SITE     1 AC9  2   G 21329    C 21418                                          
SITE     1 BC1  1   A 2 928                                                     
SITE     1 BC2  3   A 21761    G 21766    U 21769                               
SITE     1 BC3  3   A 2 399    A 2 400  LYS I  23                               
SITE     1 BC4  2   G 2  16    U 2 607                                          
SITE     1 BC5  3   G 2 376    A 2 377    U 2 378                               
SITE     1 BC6  2   U 2  27    A 2  28                                          
SITE     1 BC7  3   A 2 603    A 2 604    G 2 606                               
SITE     1 BC8  3   G 2 996    A 2 997    U 21003                               
SITE     1 BC9  2   U 2  44    A 2  47                                          
SITE     1 CC1  4   A 21760    A 21761    G 21765    G 21766                    
SITE     1 CC2  3   A 2 618    A 2 619    A 2 620                               
SITE     1 CC3  2   G 2 560    G 2 561                                          
SITE     1 CC4  2   A 2 618    G 21790                                          
SITE     1 CC5  3   G 21327    A 21328    G 21329                               
SITE     1 CC6  1   A 21025                                                     
SITE     1 CC7  4   C 2  99    A 2 100    A 2 359    C 2 360                    
SITE     1 CC8  1   G 2  20                                                     
SITE     1 CC9  1   U 21768                                                     
SITE     1 DC1  2   U 2  94    G 2  95                                          
SITE     1 DC2  2   G 21725    U 21726                                          
SITE     1 DC3  3   U 21628    G 21790    G 21791                               
SITE     1 DC4  2   G 2  63    U 2  64                                          
SITE     1 DC5  2   A 2 459    G 2 460                                          
SITE     1 DC6  2   U 2 465    G 2 466                                          
SITE     1 DC7  1   C 2 624                                                     
SITE     1 DC8  3   G 2 984    G 2 985    G 21013                               
SITE     1 DC9  2   U 21412    G 21416                                          
SITE     1 EC1  1   G 2 548                                                     
SITE     1 EC2  1   A 2 104                                                     
SITE     1 EC3  1   G 2 403                                                     
SITE     1 EC4  1   U 21302                                                     
SITE     1 EC5  2   A 2 977    A 2 978                                          
SITE     1 EC6  3   U 2 759    A 2 760    G 2 761                               
SITE     1 EC7  3   C 2 826    A 2 843    G 2 844                               
SITE     1 EC8  2   C 2 529    C 2 530                                          
SITE     1 EC9  3   G 21293    U 21302   MG 21855                               
SITE     1 FC1  1  MG 21854                                                     
SITE     1 FC2  1   U 2 988                                                     
SITE     1 FC3  1   A 2 212                                                     
SITE     1 FC4  2   G 21539    G 21540                                          
SITE     1 FC5  2   U 21008  LYS O 129                                          
SITE     1 FC6  2   U 21053    U 21054                                          
SITE     1 FC7  2   C 21158    U 21282                                          
SITE     1 FC8  2   A 21467  ASN T  85                                          
SITE     1 FC9  3   G 21443  THR f  86  PRO f  88                               
SITE     1 GC1  1   C 21455                                                     
SITE     1 GC2  2   G 21199    G 21200                                          
SITE     1 GC3  2   C 21429    U 21435                                          
SITE     1 GC4  2   A 21195    C 21196                                          
SITE     1 GC5  2   G 21267    U 21268                                          
SITE     1 GC6  5   C 21273    A 21425    G 21426    G 21427                    
SITE     2 GC6  5  MG 21879                                                     
SITE     1 GC7  4   G 21539    G 21540    C 21566    A 21567                    
SITE     1 GC8  2   G 21482    U 21520                                          
SITE     1 GC9  5   C 21273    G 21426    G 21427   MG 21876                    
SITE     2 GC9  5 ASN i  17                                                     
SITE     1 HC1  3   A 21201    A 21202    C 21597                               
SITE     1 HC2  4 CYS a  23  CYS a  26  CYS a  74  CYS a  77                    
SITE     1 HC3  3 CYS b  56  CYS b  59  THR b  61                               
SITE     1 HC4  3 CYS f 121  CYS f 124  CYS f 139                               
SITE     1 HC5  7   A 1  76  PHE k 321  PHE k 381  ALA k 382                    
SITE     2 HC5  7 GLU k 383  LEU k 395  GLY k 397                               
SITE     1 HC6  3 SER k 114  THR k 137  GCP k 603                               
SITE     1 HC7 18 HIS k 108  HIS k 111  GLY k 112  LYS k 113                    
SITE     2 HC7 18 SER k 114  THR k 115  ILE k 136  THR k 137                    
SITE     3 HC7 18 CYS k 194  GLY k 196  ASN k 249  ASP k 252                    
SITE     4 HC7 18 ALA k 285  GLN k 286   MG k 602  THR l 238                    
SITE     5 HC7 18 SER l 264  THR l 265                                          
SITE     1 HC8  5 CYS l 236  THR l 238  CYS l 259  CYS l 262                    
SITE     2 HC8  5 SER l 264                                                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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