KEGG   REACTION: R02353
Entry
R02353                      Reaction                               
Name
estradiol-17beta:NADP+ 17-oxidoreductase
Definition
Estradiol-17beta + NADP+ <=> Estrone + NADPH + H+
Equation
C00951 + C00006 <=> C00468 + C00005 + C00080
Comment
NAD+ (see R02352)
Reaction class
RC00001  C00005_C00006
RC00127  C00468_C00951
Enzyme
1.1.1.51        1.1.1.62
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51
     R02353  Estradiol-17beta + NADP+ <=> Estrone + NADPH + H+
    1.1.1.62
     R02353  Estradiol-17beta + NADP+ <=> Estrone + NADPH + H+
Orthology
K00044  17beta-estradiol 17-dehydrogenase [EC:1.1.1.62]
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.239]
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) [EC:1.1.1.62 1.1.1.105 1.1.1.239]
K13370  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) / 3-oxoacyl-[acyl-carrier protein] reductase alpha subunit [EC:1.1.1.62 1.1.1.239]
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]
Other DBs
RHEA: 24619

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Chemical reaction (1)   
   SABIO-RK (1)   
All databases (1)   

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