KEGG REACTION: R04866

REACTION: R04866

Entry

R04866                      Reaction

Name

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Definition

S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine

Equation

C00019 + C05544 <=> C00021 + C05545

Reaction class

RC00003

C00019_C00021

RC00181

C05544_C05545

Enzyme

2.1.1.59        2.1.1.60        2.1.1.354       2.1.1.355
2.1.1.356       2.1.1.357       2.1.1.359       2.1.1.360
2.1.1.362       2.1.1.368       2.1.1.370       2.1.1.371
2.1.1.372

Pathway

rn00310

Lysine degradation

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.59
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.60
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.354
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.355
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.356
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.357
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.359
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.360
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.362
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.368
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.370
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.371
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine
    2.1.1.372
     R04866  S-Adenosyl-L-methionine + Protein N6-methyl-L-lysine <=> S-Adenosyl-L-homocysteine + Protein N6,N6-dimethyl-L-lysine

Orthology

K06101

[histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]

K09186

[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]

K09187

[histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]

K09188

[histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]

K09189

[histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]

K11419