KEGG   PATHWAY: rno04914
rno04914                    Pathway                                

Progesterone-mediated oocyte maturation - Rattus norvegicus (rat)
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Organismal Systems; Endocrine system
Pathway map
rno04914  Progesterone-mediated oocyte maturation

Other DBs
GO: 0001556
Rattus norvegicus (rat) [GN:rno]
25154  Pgr; progesterone receptor [KO:K08556]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
25272  Mapk10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:]
50658  Mapk9; mitogen-activated protein kinase 9 isoform 2 [KO:K04440] [EC:]
116554  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:]
81649  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:]
60352  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:]
29513  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
689314  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:]
261730  Aurka; aurora kinase A [KO:K11481] [EC:]
293056  Cpeb1; cytoplasmic polyadenylation element-binding protein 1 [KO:K02602]
303010  Cpeb4; cytoplasmic polyadenylation element-binding protein 4 [KO:K02602]
309510  Cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X2 [KO:K02602]
360949  Cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
192209  Spdya; speedy protein A [KO:K08694]
498146  Spdye4; speedy protein E4 [KO:K08694]
499886  uncharacterized protein LOC499886 [KO:K08694]
362817  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
54237  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:]
114494  Ccna2; cyclin-A2 [KO:K06627]
295052  Ccna1; cyclin-A1 [KO:K06627]
24559  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:]
299331  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
301252  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
81771  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:]
117269  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:]
501560  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:]
317203  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:]
287101  Pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:]
25203  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
363088  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100364016  G2/mitotic-specific cyclin-B2 [KO:K21770]
317389  Ccnb3; G2/mitotic-specific cyclin-B3 isoform X2 [KO:K21771]
29398  Stk10; serine/threonine-protein kinase 10 [KO:K08837] [EC:]
25515  Plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:]
171102  Cdc25a; M-phase inducer phosphatase 1 [KO:K06645] [EC:]
171103  Cdc25b; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:]
307511  Cdc25c; M-phase inducer phosphatase 3 [KO:K05867] [EC:]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
24482  Igf1; insulin-like growth factor I isoform d preproprotein [KO:K05459]
25718  Igf1r; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:]
29516  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:]
24525  Kras; GTPase KRas [KO:K07827]
64363  Araf; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:]
114486  Braf; serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:]
296137  Bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:]
680006  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
297176  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
313702  Mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
314642  Fzr1; fizzy-related protein homolog [KO:K03364]
311412  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
296558  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
360643  Cdc27; cell division cycle protein 27 homolog [KO:K03350]
305420  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
288671  Anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
290875  Cdc16; cell division cycle protein 16 homolog [KO:K03353]
304490  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
291689  Cdc23; cell division cycle protein 23 homolog [KO:K03355]
361389  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
498030  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
366381  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
685029  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
293502  Kif22; kinesin-like protein KIF22 [KO:K10403]
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Schmitt A, Nebreda AR.
Signalling pathways in oocyte meiotic maturation.
J Cell Sci 115:2457-9 (2002)
Cato AC, Nestl A, Mink S.
Rapid actions of steroid receptors in cellular signaling pathways.
Sci STKE 2002:RE9 (2002)
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Biol Cell 93:27-33 (2001)
Nebreda AR, Ferby I.
Regulation of the meiotic cell cycle in oocytes.
Curr Opin Cell Biol 12:666-75 (2000)
Ferrell JE Jr.
Xenopus oocyte maturation: new lessons from a good egg.
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J 369:227-38 (2003)
Duckworth BC, Weaver JS, Ruderman JV.
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Proc Natl Acad Sci U S A 99:16794-9 (2002)
Abrieu A, Doree M, Fisher D.
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
J Cell Sci 114:257-67 (2001)
rno04010  MAPK signaling pathway
rno04110  Cell cycle
KO pathway

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